Gut Dysbiosis and Abnormal Bile Acid Metabolism in Colitis-Associated Cancer by Li Liu, Min Yang, Wenxiao Dong, Tianyu Liu, Xueli Song, Yu Gu, Sinan Wang, Yi Liu, Zaripa Abla, Xiaoming Qiao, Wentian Liu, Kui Jiang, Bangmao Wang, Jie Zhang, Hailong Cao

“…Given bile acid receptors, the ileum farnesoid X receptor-fibroblast growth factor 15 (FXR-FGF15) axis was downregulated, while Takeda G-protein receptor 5 (TGR5) was overexpressed in colonic tumor tissues. …”
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High BMP7 Expression May Worsen Airway Disease in COPD by Altering Epithelial Cell Behavior by Dong W, Xie M, Ming C, Li H, Xu X, Cui L, Wang W, Li Y

“…Wenyan Dong,1,* Mengshuang Xie,2,* Chunjie Ming,3 Haijun Li,2 Xia Xu,2 Liwei Cui,4 Wei Wang,5 Yi Li6 1Department of General Practice, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 2Department of Geriatric Medicine, Laboratory of Gerontology and Anti-aging Research, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 3National Key Laboratory for Innovation and Transformation of Luobing Theory, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 5Medical Integration and Practice Center, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 6Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Wang; Yi Li, Email styw28@163.com; 202062009073@email.sdu.edu.cnPurpose: Airway disease is the main pathological basis of chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are unknown. Bone morphogenetic protein-7 (BMP7) is a multi-functional growth factor that belongs to the transforming growth factor superfamily, which affects the regulation of proliferation, differentiation, and apoptosis. …”
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Buffalo genetic improvement program in Vene- zuela by José A. Aranguren-Méndez, Rafael M. Román-Bravo, Ricardo A. Briceño-Rojas, Mauricio G. Briceño-Rojas, Luis A. Pacheco-Díaz

“…It is an integral part of most breeding programs based on two fundamental pillars: phenotypic data (milk production, fat, protein, or morphological traits) and genealogical information (through the availability of a pedigree). …”
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Bacterial community improves the volatile components coupled with abiotic factors during the spontaneous fermentation of Chinese strong-aroma Baijiu by Bin Lin, Jie Tang, Qun Li, Liping Zhu, Wei Jiang, Hanbing Ke, Zhang Wen, Huaichen Liu, Shengzhi Yang, Qiang Yang, Shenxi Chen, Peijie Han

“…Pathways related to lipid, protein and secondary metabolite metabolism were enriched during the middle and later stages of grain fermentation. …”
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Exploring the Mechanisms of Iron Overload-Induced Liver Injury in Rats Based on Transcriptomics and Proteomics by Yujia Shu, Xuanfu Wu, Dongxu Zhang, Shuxia Jiang, Wenqiang Ma

“…The result found that FAC treatment can significantly increase the BRL-3A cell’s Fe²⁺ content (<i>p</i> < 0.05), ROS <i>(p</i> < 0.01), lipid ROS (<i>p</i> < 0.01) levels, and the expression of the HO-1 gene and protein (<i>p</i> < 0.01), aligning with proteomic and transcriptomic findings. …”
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The levels of osteopontin in human milk of Chinese mothers and its associations with maternal body composition by Huijuan Ruan, Qingya Tang, Xuan Zhao, Yajie Zhang, Xuelin Zhao, Yi Xiang, Wei Geng, Yi Feng, Wei Cai

“…The content of OPN in breast milk was determined by enzyme-linked immunosorbent assay (ELISA). Determination of protein content in human milk was performed via the BCA method. …”
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Dual-immunomodulatory effects on RAW264.7 macrophages and structural elucidation of a polysaccharide isolated from fermentation broth of Paecilomyces hepiali by Baoming Tian, Renjian Liu, Qi Li, Hanshan Xu, Ming Cai, Rongfa Guan, Peilong Sun, Kai Yang

“…The nitric oxide (NO) production, phagocytosis activity, and cytokine secretion were significantly increased (P < 0.05) after PHP40-2 treatment; however, PHP40-2 could inhibit NO production and cytokine secretion in LPS-induced RAW264.7 macrophages (P < 0.05). After mRNA and protein expression analysis, toll-like receptor 4 (TLR4)/nuclear factor-κB (NF-κB) signaling pathway was discovered to play an important role in the dual-immunomodulatory effects of PHP40-2. …”
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Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic live... by Nikolina Canová, Jana Šípková, Mahak Arora, Zuzana Pavlíková, Zuzana Pavlíková, Tomáš Kučera, Ondřej Šeda, Tijana Šopin, Tomáš Vacík, Ondřej Slanař

“…Moreover, the inhibitor of sterol regulatory element-binding protein 1/2 (SREBP1/2), fatostatin, was also tested to compare its influence on the galaninergic system with celastrol.ResultsThe study demonstrates that celastrol treatment was safe and led to a reduction in food and energy intake, body fat and liver weights, and MASLD-to-MASH progression and improved glucose tolerance, serum biochemistry markers, and hepatic lipid peroxidation in mice. …”
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Evaluation of mineral and near-infrared forecasting of wheat yield varieties using spectrophotometric techniques by H.A. Pardhe, N. Krishnaveni, B.K. Chekraverthy, S. Patel, S. Naveen, V. Rashmi, P.C. Govinden

“…To achieve these objectives, different spectrometric methods were employed to analyze the wheat samples.METHODS: Proximate and mineral quantification were carried out following standard Association of Official Analytical Chemists methods using ultraviolet-visible spectrophotometry, atomic absorption spectrometry, inductive coupled plasma-mass spectroscopy, and prediction was carried out using near-infrared spectra combined with chemometrics.FINDINGS: The samples had moisture content (1.1 - 4.5 percent), protein (18.0 - 22.6 percent), fat (0.3 - 0.6 percent), gluten (6.3 - 10.3 percent), fiber (0.3 - 1.4 percent), alcoholic acidity (0.04 - 0.08 percent), ash (0.9 - 1.7 percent), and carbohydrate (71.1 - 75.2 percent). …”
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Larvicidal activity of Bacillus thuringiensis strains against Aedes aegypti and Culex quinquefasciatus mosquitoes by Prakai Rajchanuwong, Sawaporn Peaboon, Ratchadawan Ngoen-Klan, Atsalek Rattanawannee, Atirat Noosidum, Boonhiang Promdonkoy, Jariya Chanpaisaeng, Theeraphap Chareonviriyaphap

“…Scanning electron microscopy revealed that JC690, JC691, and JC699 are rod-shaped, have oval spores, and produce bi-pyramidal crystal proteins. Protein profile analysis using SDS-PAGE demonstrated distinct differences between these Thailand strains (JC690, JC691, and JC699) and the reference Bti strain. …”
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Depot-specific acetylation profiles of adipose tissues—therapeutic targets for metabolically unhealthy obesity by Haoyue Guo, Zhiyi Zhang, Juntao Yang, Jiangfeng Liu, Hongwei Lin, Ningbei Yin

“…Results A total of 281 differentially expressed proteins and 147 differentially modified Kac sites were identified among 6,201 quantifiable proteins and 1,826 quantifiable Kac sites. …”
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Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus by Chen-xing Zhang, You-ying Mao, Yu-pin Tan, Mei-yu Zhang, Kang Shao, Shu-jun Wang, Ping Ji, Jia-yuan Wang, Lei Yin, Ying Wang

“…Surface expression of lysosome-associated membrane protein 1 (LAMP-1; CD107a) and secretion of granzyme B of CD8+T cells was measured in SLE and HC with or without IFN-α co-stimulation/PI3K inhibitor. …”
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Association between sex steroid hormones and α-klotho: Results from the NHANES 2013-2016 and Mendelian randomization study by Andong Guo, Pengcheng Chen, Jishuang Cao, Chenrui Wu, Sentai Ding

“…Purpose: This study aimed to explore the association and causal links between sex steroid hormones and the anti-aging protein α-Klotho, extending to investigate the mediation effects of potential mediators. …”
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CircPRMT5, a Potential Salivary Biomarker, Facilitates the Progression of Head and Neck Squamous Cell Carcinoma via the IGF2BP3-SERPINE1 Pathway by Jiang S, Ou L, Wang Y, Su K, Chen Z, He L, Xu X, Cheng B, Xia J, Fan Z

“…Mechanistically, circPRMT5 was demonstrated to directly bind to and stabilize the insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), which, subsequently, binds to and stabilizes the serpin family E member 1 (SERPINE1) mRNA, thereby enhancing SERPINE1 expression. …”
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Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19 by Huan Wang, Liyuan Tao, Liyan Cui, Yahong Chen, Dongyang Liu, Lixiang Xue, Yuping Yang, Yang Lv, Fuchun Zhang, Tiancheng Wang, Xiaoxiao Wang, Wanqiong Yuan, Hao Liu, Jie Huang, Yanfang Jiang, Na Liu, Lijuan Yang, Yunjing Hu, Yanfang Li, Yuling Gao, Haiyan Li, Baohua Li, Chunli Song

“…The concentration of serum 25-hydroxyvitamin D (25(OH)D), C-reaction protein (CRP), complement component C1q and inflammatory cytokines were measured. …”
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Nutritional and antioxidative characterization, antimicrobial and sensorial stability of flaxseed powder supplemented mutton patties by Raheel Suleman, Hira Choudhary, Muhammad Waseem, Jaza Maqbl Alshammari, Muhammad Muzamil, Huan Liu, Tariq Ismail, Muhammad Ammar Khan, Muhammad Qamar, Crossby Osei Tutu

“…The results exhibited significant increase (p < 0.05) in protein, and ash contents from 10.7 to 20.6 and 1.3–2.4 (g/100 g) on addition of FP at 2–8 % in mutton patties, respectively. …”
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Longitudinal genetic studies of cognitive characteristics by R. N. Mustafin, A. V. Kazantseva, R. F. Enikeeva, S. B. Malykh, E. K. Khusnutdinova

“…The content, quantity and arrangement of transposable elements in human genome, which do not affect changes in nucleotide sequences of protein encoding genes, but affect their expression, can be transmitted to the next generation.…”
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Prognostic significance of p27 in colorectal cancer: a meta-analysis and bioinformatics analysis by Jing Zou, Dong Wang, Gaoping Yin, Kexiang Lu, Kaibin Chang, He Li

“…In addition, we used Gene Expression Profiling Interactive Analysis (GEPIA), University of Alabama at Birmingham’s Cancer Data Analysis Portal (UALCAN), and the Human Protein Atlas (HPA) to validate our results.ResultsThrough an extensive examination of four prominent databases, a total of 21 original articles encompassing a cohort of 3,378 patients were identified. …”
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Clinical impact of proteinuria on renal function and treatment outcomes in patients with radioiodine-refractory thyroid cancer treated with lenvatinib by Naoki Fukuda, Kazuhisa Toda, Hirotaka Suto, Ryosuke Oki, Xiaofei Wang, Tetsuya Urasaki, Yasuyoshi Sato, Kenji Nakano, Makiko Ono, Junichi Tomomatsu, Hiroki Mitani, Shunji Takahashi

“…When proteinuria was observed, the dose and schedule of lenvatinib were adjusted to achieve a urine protein-to-creatinine ratio (UPCR) of less than 3.5 g/gCre according to the study protocols of recent pivotal trials. …”
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P-glycoprotein-independent cytotoxic effects of 5-aminopyrazole in L1210 leukemia cells by Lucia Sofrankova, Jana Spaldova, Pavol Stefik, Branislav Pavilek, Dusan Bortnak, Lucia Pavlikova, Ivana Zidekova, Daniel Vegh, Viktor Milata, Albert Breier, Zdena Sulova

“…All derivatives, except A5, suppressed P-gp activity, though they did not alter P-gp expression at the mRNA or protein level. Cell cycle analysis showed changes in the G0/G1 and S phases. …”
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