TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD by Zhuhe Liu, Yunmeng Bai, Bingtian Xu, Haixia Wen, Kechun Chen, Jingfang Lin, Yuanyuan Wang, Jiangping Xu, Haitao Wang, Fudong Shi, Jigang Wang, Honghao Wang

“…Abstract Abnormality in transactivating response region DNA binding protein 43 (TDP43) is well-recognized as the pathological hallmark of neurodegenerative diseases. …”
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The PHD transcription factor Cti6 is involved in the fungal colonization and aflatoxin B1 biological synthesis of Aspergillus flavus by Zhang Mengjuan, Lin Guanglan, Pan Xiaohua, Song Weitao, Tan Can, Chen Xuan, Yang Yanling, Zhuang Zhenhong

“…The results of the current study elucidate the roles of PHD domain containing proteins in the mechanism of the infection of crops by A. flavus, and provided a novel target for effectively controlling the contamination of Aspergillus spp. to crops.…”
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Differentiations in Illness Duration, Thyroid-Stimulating Hormone, Glucose and P300 Latency Between Drug-Naïve Unipolar and Bipolar Depression: A Comparative Cross-Sectional S... by Li C, Yang L, Zhang Q, Zhang Y, Li R, Jia F, Wang L, Ma X, Yao K, Tian H, Liu Z, Zhuo C

“…Fasting serum levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), as well as fasting plasma glucose (FPG), lipid, C-reactive protein (CRP), and uric acid (UA) indicators were measured.Results: Patients with BD had longer illness duration and P300 latency and lower FT3 levels, but higher levels of TSH and FPG than patients with UD (all P< 0.05). …”
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A study on the effect of biostimulant application on yield and quality of tomato under long-lasting water stress conditions by Cristina Patanè, Alessandra Pellegrino, Alessandro Saita, Silvio Calcagno, Salvatore L. Cosentino, Alessio Scandurra, Valeria Cafaro

“…In this regard, a two-year experiment was conducted in open field on four cultivars of tomato (two commercial tomatoes and two local landraces of long shelf-life tomato), to assess the crop response, in terms of fruit yield and quality traits, to the foliar application of two plant-derived biostimulants based on protein hydrolysates (PH), under opposite water regimes (no irrigation and full irrigation), in a semi-arid environment of South Italy. …”
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Dysfunctional β-cell autophagy induces β-cell stress and enhances islet immunogenicity by Matthew C. Austin, Charanya Muralidharan, Saptarshi Roy, Justin J. Crowder, Jon D. Piganelli, Amelia K. Linnemann, Amelia K. Linnemann

“…Interestingly, we also observed upregulation of proteins involved in MHC-I presentation, suggesting that defective β-cell autophagy may alter the immunopeptidome, or antigen repertoire, and enhance β-cell immune visibility. …”
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The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise T... by Magdalena Dudek, Marta Kałużna-Oleksy, Filip Sawczak, Agata Kukfisz, Aleksandra Soloch, Jacek Migaj, Maciej Lesiak, Ewa Straburzyńska-Migaj

“…<b>Conclusions</b>: The concentration of sST2 protein is substantially associated with the clinical severity of heart failure with reduced left ventricular ejection fraction assessed by functional capacity through CPET.…”
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Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model by Zigui Chen, Chunyuan Zhang, Yuhua Fang, He Zhang, Jiawei Luo, Changfeng Miao, Jiale Li, Jun Peng, Yingqi Qiu, Ying Xia, Qisheng Luo

“…Moreover, we also observed elevated phosphorylation of PI3K/AKT and suppressed BAX protein expression. Meanwhile, OM-MSCsNrf2 inhibited the levels of pro-inflammatory genes and affected the glycolysis in PC12 cells. …”
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大鼠缺血缺氧过程脑皮质神经化学物质的变化

“…同时采用免疫组织化学的方法,对该脑皮质区域内的胶质纤维酸性蛋白(glial fibrillary acidic protein, GFAP)的变化进行观察?【结果】 与对照组相比较,所检测的实验组大鼠脑皮质的主要神经化学物质中(mmol/kg)Lac(10.97 ± 1.07)?…”
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TOPBP1 as a potential predictive biomarker for enhanced combinatorial efficacy of olaparib and AZD6738 in PDAC by Xiao-Mei Tang, Min-Min Shi, Jia-Cheng Wang, Yi-Jin Gu, Yu-Ting Dai, Qin-Xin Yang, Jia Liu, Ling-Jie Ren, Xin-Yun Liu, Chun Yang, Fang-Fang Ma, Ji-Bing Liu, Hong Yu, Da Fu, Yun-Feng Wang

“…DNA topoisomerase II-binding protein 1 (TOPBP1) plays a supportive role in regulating the DDR pathway, and its overexpression has been linked to the tumorigenesis of various cancers. …”
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Study on the antioxidant and antiosteoporotic activities of the oyster peptides prepared by ultrasound-assisted enzymatic hydrolysis by Zhengze Quan, Zonghan Wang, Zixu Wang, Zuoxu Hou, Bin Liu, Xiaoming Guo, Beiwei Zhu, Yuanyuan Hu

“…Results showed that ultrasound-assisted enzymatic hydrolysis significantly enhanced the peptide content, free radical scavenging ability, and ferric reducing antioxidant power of total oyster protein hydrolysate (TOPH), with optimal results achieved at 200 W (TOPH-200). …”
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Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression by Yu-Fei Cao, Hui Wang, Yong Sun, Bei-Bei Tong, Wen-Qi Shi, Liu Peng, Yi-Meng Zhang, Yu-Qiu Wu, Teng Fu, Hua-Yan Zou, Kai Zhang, Li-Yan Xu, En-Min Li

“…Abstract Anillin (ANLN), a mitotic protein that regulates contractile ring assembly, has been reported as an oncoprotein. …”
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Helicobacter pylori reduces METTL14-mediated VAMP3 m6A modification and promotes the development of gastric cancer by regulating LC3C-mediated c-Met recycling by Xixi Cui, Mingjie Chang, Yuqiong Wang, Jiayi Liu, Zenghui Sun, Qiyu Sun, Yundong Sun, Juchao Ren, Wenjuan Li

“…Downregulation of METTL14 inhibits Vesicle-associated membrane protein-3 (VAMP3) by reducing the m6A modification level of VAMP3 mRNA and the stability of IGF2BP2-dependent mRNA. …”
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Effect of Processed Coffee Husk on Feed Intake, Nutrient Digestibility, Body Weight Changes and Economic Feasibility of Bonga Sheep Fed on Natural Pasture Hay as a Basal Diet by Lidya Marew, Fentahun Meheret, Bimrew Asmare

“…The chemical compositions of the CM had maximum crude protein (22%), followed by boiled coffee husk (14.74%), which was higher than natural pasture hay (6.91%) and raw coffee husk (12.4%). …”
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Evaluation of Serum Leucine-Rich Alpha-2 Glycoprotein as a New Inflammatory Biomarker of Inflammatory Bowel Disease by Tetsuhiro Yoshimura, Keiichi Mitsuyama, Ryosuke Sakemi, Hidetoshi Takedatsu, Shinichiro Yoshioka, Kotaro Kuwaki, Atsushi Mori, Shuhei Fukunaga, Toshihiro Araki, Masaru Morita, Kozo Tsuruta, Hiroshi Yamasaki, Takuji Torimura

“…The serum LRG levels were higher during active disease than during inactive disease; additionally, serum LRG levels were positively correlated with clinical disease activity, C-reactive protein (CRP) levels, and other laboratory parameters in patients with UC and CD and with endoscopic disease activity in UC. …”
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Physico-chemical characterization of natural nano calcium extracted from different fish bones in catfish (Clarias gariepinus) and snakehead fish (Channa striata) by Sri Fatmawati, Siti Mualimatul Istiqomah, Nur Hasanah, Maria Elfiana Ina Kewa Helan, Mardi Santoso, Zjahra Vianita Nugraheni, Nurul Jadid, Annis Catur Adi, Heni Rachmawati

“…The nutritional analysis indicated that catfish FBP contained more ash, lipids, calcium, and phosphorus, while snakehead FBP was richer in protein (53.25 ± 0.94 %). These results suggest that nanotechnology enhances the calcium content in fish bones, transforming what is typically considered waste into a valuable natural source of nano-calcium to address deficiencies and improve bone health.…”
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Chemotherapy plus therapeutic plasmapheresis with 4% human albumin solution in multiple myeloma patients with acute kidney injury: a prospective, open-label, proof-of-concept study by Tianzhi Wu, Dandan Liu, Shangqin Liu, Hui Xiao, Bei Xiong, Yi Zhou, Yafen Xiong, Qin Cui, Jiang Wu, Minghui Liu, Hongli Liu, Yiming Li, Meixin Wang, Xueqin Bao, Ye Li, Fuling Zhou

“…Among the 119 patients included in the analysis, 108 experienced renal reactions. The M protein (absolute changes: median −12.12%, interquartile ranges (IQRs) −18.62 to −5.626) and creatine (median −46.91 μmol/L, IQR −64.70 to −29.12) levels decreased, whereas the estimated glomerular filtration rate (eGFR) increased (median 20.66 mL/(min·1.73 m2), IQR 16.03–25.29). …”
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Water-Based Supplementation Technology for Grazing Cattle in the Tropics: A Large-Scale Commercial Case Study by Eliéder Prates Romanzini, Vivienne McCollum, Sarah Mcilveen, Evandro Maia Ferreira, William Luiz de Souza, Marcelo Augusto Oliveira Castro, Priscila Arrigucci Bernardes, Ryan J. Batley, Mark G. Trotter, Diogo Fleury Azevedo Costa

“…Early mechanical dispensers for nutrients, such as non-protein nitrogen (NPN) and phosphorus (P), were prone to malfunction, leading to inconsistent dosing and potential livestock health risks. …”
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The alphavirus determinants of intercellular long extension formation by Caroline K. Martin, Judy J. Wan, Peiqi Yin, Thomas E. Morrison, William B. Messer, Vanessa Rivera-Amill, Jonathan R. Lai, Nina Grau, Félix A. Rey, Thérèse Couderc, Marc Lecuit, Margaret Kielian

“…Our results showed that both the viral E2 and E1 envelope proteins were required for ILE formation, while viral proteins 6K and transframe, and cytoplasmic nucleocapsid formation were dispensable. …”
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Diagnostic value of the MZXBTCH scoring system for acute complex appendicitis by Tianyi Ma, Qian Zhang, Hongwei Zhao, Peng Zhang

“…Multivariate logistic regression analysis identified preoperative body temperature (odds ratio (OR) = 1.104; 95% confidence interval (CI) 1.067–1.143; P < 0.001), preoperative C-reactive protein (CRP) level (OR = 1.002; 95% CI 1.001–1.002; P < 0.001), lymphocyte percentage (OR = 0.994; 95% CI 0.990–0.996; P < 0.001), appendiceal fecal stones (OR = 1.127; 95% CI 1.068–1.190; P < 0.001), periappendiceal fat stranding (OR = 1.133; 95% CI 1.072–1.198; P < 0.001), and appendix diameter (OR = 1.013; 95% CI 1.004–1.022; P < 0.001) as independent risk factors for complex appendicitis. …”
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Subcytotoxic transepidermal delivery using low intensity cold atmospheric plasma by Ga Ram Ahn, Hyung-Joon Park, Yu Jin Kim, Min Gyo Song, Hye Sung Han, Woo Geon Lee, Hyuck Ki Hong, Kwang Ho Yoo, Joon Seok, Kyu Back Lee, Beom Joon Kim

“…Within the determined safety range, mechanistic analyses were conducted to examine LICAP-enhanced delivery pathways. mRNA expression and protein levels of tight and adherens junction genes were quantified, and changes in ultramicroscopic morphology of HaCaT monolayers were investigated. …”
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