Interactive effects of triploidy induction and culture densities on growth performance and stress, immune, and metabolic responses in juvenile rainbow trout (Oncorhynchus mykiss) by Roghayeh Mahmoudi, Mahdi Naderi, Hakimeh Dopeikar, Seyed Ali Khorasaninasab, Seyed Hadi Seyedalhosseini

“…After 9 weeks, final weight, weight gain, specific growth rate, and protein efficiency ratio (PER) in fish cultured at 20, 30, and 40 kg/m3 were significantly higher and feed conversion ratio (FCR) was lower compared to those cultured at 50 kg/m3 (P < 0.05). …”
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FBR2 modulates ferroptosis via the SIRT3/p53 pathway to ameliorate pulmonary fibrosis by Yu Cheng, Yang Jiao, Wan Wei, Mengjia Kou, Yaodong Cai, Yang Li, Hao Li, Tonghua Liu

“…Assessments encompassed histopathology, ELISA for cytokine detection, IHC and Western blot for protein expression analysis, and qRT-PCR for gene expression quantification. …”
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Biochemical Composition and Seasonal Variations of the Madagascar Algae <i>Eucheuma denticulatum</i> (<i>Solieriaceae</i>, Rhodophyta) by Elando Fréda Zamanileha, Anne-Sophie Burlot, Thomas Latire, Christel Marty, Philippe Douzenel, Laurent Vandanjon, Nathalie Bourgougnon, Pierre Ravelonandro, Gilles Bedoux

“…Finally, the principal component analysis (PCA) showed a correlation between protein content and environmental parameters. The nutritional characteristics therefore confirmed that <i>E. denticulatum</i> could potentially be used as a nutritious and functional food and could be incorporated in the diet of local populations.…”
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Efficacy and Safety of Recombinant Human Thrombopoietin (rhTPO) on Coagulation Function and Inflammatory Factors in the Treatment of Patients with Sepsis-Related Thrombocytopenia by Huijuan Wang MD, Dong Chen MD, Ming He MD

“…Coagulation function indicators, including activated partial thromboplastin time (APTT), fibrinogen (FIB), plasminogen activator inhibitor-1 (PAI-1), antithrombin III (AT-III), protein C, thrombomodulin (TM), and Plt factor 4 (PF4), showed greater improvement in the Group R compared to the Group C ( P  < 0.05). …”
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Safety and efficacy of switching from adalimumab to sarilumab in patients with rheumatoid arthritis in the ongoing MONARCH open-label extension by Gerd R Burmester, Mark C Genovese, Vibeke Strand, Gregory St John, Andrea Rubbert-Roth, Howard Amital, Tatiana Raskina, Antonio Gómez-Centeno, Claudia Pena-Rossi, Leon Gervitz, Karthinathan Thangavelu, Susan Boklage

“…Among switch patients, improvement in disease activity was evident at OLE week 12: 47.1%/34.8% had changes ≥1.2 in Disease Activity Score (28 joints) (DAS28)-erythrocyte sedimentation rate/DAS28-C-reactive protein. In switch patients achieving low disease activity (LDA: Clinical Disease Activity Index (CDAI) ≤10; Simplified Disease Activity Index (SDAI) ≤11) by OLE week 24, 70.7%/69.5% sustained CDAI/SDAI LDA at both OLE weeks 36 and 48. …”
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Affecting of Glyphosate Tolerance and Metabolite Content in Transgenic <i>Arabidopsis thaliana</i> Overexpressing <i>EPSPS</i> Gene from <i>Eleusine indica</i> by Jingchao Chen, Zhiling Li, Haiyan Yu, Hailan Cui, Xiangju Li

“…The results showed that the average resistance index of the transgenic lines was 4.7 and the exogenous <i>E. indica EPSPS</i> expression levels were 265.3- to 532.0-fold higher than those in the wild-type (WT) line. The EPSPS protein ranged from 148.5 to 286.2 μg g⁻¹, which was substantially higher than that in the WT line (9.1 μg g⁻¹). 103 metabolites associated with flavone and flavonol biosynthesis, the metabolism of aromatic amino acids, energy metabolism, and auxin synthesis were significantly higher in the transgenic glyphosate-resistant individuals (R) than in the WT individuals. …”
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Robust collection and processing for label-free single voxel proteomics by Reta Birhanu Kitata, Marija Velickovic, Zhangyang Xu, Rui Zhao, David Scholten, Rosalie K. Chu, Daniel J. Orton, William B. Chrisler, Tong Zhang, Jeremy V. Mathews, Benjamin M. Bumgarner, Demirkan B. Gursel, Ronald J. Moore, Paul D. Piehowski, Tao Liu, Richard D. Smith, Huiping Liu, Clive H. Wasserfall, Chia-Feng Tsai, Tujin Shi

“…It can reveal spatially resolved protein signatures and region-specific signaling pathways. …”
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Urinary NGAL and RBP Are Biomarkers of Normoalbuminuric Renal Insufficiency in Type 2 Diabetes Mellitus by Aimei Li, Bin Yi, Yan Liu, Jianwen Wang, Qing Dai, Yuxi Huang, Yan Chun Li, Hao Zhang

“…Levels of urinary neutrophil gelatinase-associated lipocalin (NGAL), retinol-binding protein (RBP), plasminogen activator inhibitor-1 (PAI-1), vascular cell adhesion molecule-1 (VCAM-1), and E-cadherin were detected, and their correlations with eGFR, plasma TNF-α, IL-6, endothelin-1 (ET-1), and 8-hydroxydeoxyguanosine (8-OHdG) were assessed. …”
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Genome polymorphism of the synthetic species xTrititrigia cziczinii Tsvel. inferred from AFLP analysis by A. A. Trifonova, K. V. Boris, L. V. Dedova, V. A. Melnik, L. P. Ivanova, N. P. Kuzmina, S. V. Zavgorodniy, V. P. Upelniek

“…×T. cziczinii has unique characteristics, as it is a perennial species, with the ability to grow after mowing, high adaptability, resistance to diseases and pests, high protein and gluten content in the grain. All this makes it a promising new crop for agriculture. …”
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The efficacy and safety of induction chemotherapy combined with sintilimab followed by concurrent chemoradiotherapy plus sintilimab sequencing maintaining with sintilimab for patie... by Ruifeng Wang, Tianhui Guo, Qi Wang, Wen Gao, Yimiao Yu, Jun Zhang, Wenqian Fu, Haiji Wang, Biyuan Zhang

“…Abstract Purpose To evaluate the efficacy and safety of induction chemotherapy combined with programmed death protein 1 (PD-1) inhibitor (sintilimab) followed by concurrent chemoradiotherapy (CCRT) plus sintilimab, and subsequent maintenance with sintilimab (IC-ICCRT-IO) for patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC) in a retrospective study. …”
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Toward autism spectrum disorders and Williams-Beuren syndrome co-occurrence condition in Tunisian patients: Genetic insights by Rim Khelifi, Afef Jelloul, Houda Ajmi, Wafa Slimani, Sarra Dimassi, Khouloud Rjiba, Manel Dardour, Moez Gribaa, Ali Saad, Soumaya Mougou-Zerelli

“…Further analysis of the extended region deletion identified a gene closely located in the deleted region, the HIP1 gene, involved in the central nervous system trafficking protein.DiscussionThe recurrent deletion in WBS, as well as the mirror duplication, may contribute to ASD development in some cases, suggesting a potential involvement of the ASD genes pathway in this region. …”
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Plastid genome comparison and phylogenetic analyses of the Chinese group of medicinal species and related taxa within Asparagus genus by Pingxuan Xie, Tinglu Wang, Jiawei Tan, Linyuan Fan, Changkun Liu, Hanjing Yan

“…However, accurate authentication of these medicinal species and their phylogenetic relationships with related taxa remains unresolved.MethodsTo identify simple sequence repeats (SSRs) and divergence hotspot regions appropriate for future authentication studies, as well as to infer the phylogenetic relationships among Asparagus species, we employed a plastid genome (plastome) dataset consisting of 25 Asparagus species (21 newly sequenced and four retrieved from GenBank), encompassing 12 Chinese medicinal species, for comparative and phylogenetic analyses.ResultsAll Asparagus plastomes displayed a typical quadripartite structure with sizes ranging from 155,948 bp to 157,128 bp and harbored 114 unique genes (80 protein-coding genes, 30 tRNA genes, and four rRNA genes). …”
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Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis by Georgios K. Vasileiadis, Yuan Zhang, Tahzeeb Fatima, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Grondal, Kim Hørslev‐Petersen, Kristina Lend, Marte S. Heiberg, Merete Lund Hetland, Michael Nurmohamed, Till Uhlig, Tuulikki Sokka‐Isler, Anna Rudin, Cristina Maglio

“…Results At baseline, levels of adiponectin and leptin were not associated with markers of RA activity, whereas participants with higher resistin levels had higher C‐reactive protein (CRP) levels, swollen joint count, and Disease Activity Score in 28 joints based on CRP compared to participants with lower resistin. …”
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Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences by Gregory C. Antell, Will Dampier, Benjamas Aiamkitsumrit, Michael R. Nonnemacher, Vanessa Pirrone, Wen Zhong, Katherine Kercher, Shendra Passic, Jean Williams, Yucheng Liu, Tony James, Jeffrey M. Jacobson, Zsofia Szep, Brian Wigdahl, Fred C. Krebs

“…Vpr is an HIV-1 accessory protein that plays numerous roles during viral replication, and some of which are cell type dependent. …”
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A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line by Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati

“…Determination of GLUT1 and GLUT3 mRNA and protein expression in SW1736 cells was performed by qRT-PCR and western blotting. …”
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Glucose‐induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma by Yanfang Liu, Junjiao Song, Qili Shi, Bing Chen, Wenying Qiu, Yizhe Liu, Shenglin Huang, Xianghuo He

“…Mechanistically, LINC01419 directly interacted with Y‐box binding protein 1 (YBX1) in the cytoplasm and facilitated its binding to PDK1 mRNA, thus enhancing PDK1 mRNA stability and increasing lactate production. …”
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Generation of a genetically engineered porcine melanoma model featuring oncogenic control through conditional Cre recombination by Dongjin Oh, Nayoung Hong, Kiyoung Eun, Joohyeong Lee, Lian Cai, Mirae Kim, Hyerin Choi, Ali Jawad, Jaehyung Ham, Min Gi Park, Bohye Kim, Sang Chul Lee, Changjong Moon, Hyunggee Kim, Sang-Hwan Hyun

“…We demonstrated that Cre recombination-mediated oncogene activation remarkably triggered the mitogen-activated protein kinase pathway in vitro. Notably, intradermal injection of 4-hydroxytamoxifen activated oncogene cassettes in vivo, resulting in melanocytic lesions resembling hyperpigmented nevi with increased proliferative properties similar to early human melanomas. …”
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Dietary rosemary oil with/without zymogen forte improves water quality, growth hormones, immune-physiological response, stress resilience, and health status of Chelon ramada grown... by Ashraf I. G. Elhetawy, Mohammed F. El Basuini, Ahmed I. A. Mansour, Shimaa A. Shahin, Amira A. Omar, Mohamed M. Zayed, Mohamed M. Abdel-Rahim

“…Furthermore, there were increases in plasma heat shock proteins HSP70 and HSP90, as well as enhanced antioxidant activity. …”
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Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice by Han Wang, Lizi Zhang, Xing Chen, Lingzi Hong, Junjie Zhao, Wen Qian, Lam Khue Pham, Belinda Willard, Xiaoxia Li, Katarzyna Bulek, Xiao Li

“…Summary: Six-transmembrane protein of prostate 4 (Steap4), highly expressed in adipose tissue, is associated with metabolic homeostasis. …”
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Biomineralized PEEK cages containing osteoinductive CaP bioceramics promote spinal fusion in goats by Qiujiang Li, Bowen Hu, Linan Wang, Lei Wang, Cong Feng, Zhuang Zhang, Zhipeng Deng, Yang Xiao, Bo Yuan, Xiangdong Zhu, Xiangfeng Li, Xi Yang, Yueming Song, Xingdong Zhang

“…In vitro experiments showed that biomineralized PEEK cages and CaP bioceramics regulate immunity and promote angiogenesis and bone integration via activation of hypoxia-inducible factor 1-alpha and cyclic guanosine monophosphate/protein kinase G signaling pathways. In vivo goat spinal fusion experiments demonstrated that PEEK cages filled with CaP bioceramics resulted in good bone growth and spinal fusion. …”
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