The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling by Wang C, Lu Z, She G, Chen K, Zhou H, Zhan X, Yu H, Pi L, Zuo L, Che D

“…We performed the proximity barcoding assay (PBA) to analyze single exosome surface proteins, which allowed us to identify individual exosomes related to the development of RA as well as the major subpopulations of exosomes. …”
Get full text

Effects of olive leaf extract on exercise performance and muscle mitochondrial response in young healthy adults by Clément Lanfranchi, Nadège Zanou, Jérôme Feige, Umberto DeMarchi, Aurélie Hermant, Ornella Cominetti, Eugenia Migliavacca, Alba Moreno-Asso, Astrid Hostrman, Sara Mistro, Nicolas Place

“…Targeted investigation of selected proteins involved in the oxidative phosphorylation pathway showed an overall decrease of expression immediately after exercise but did not reveal any differences between placebo and OLE. …”
Get full text

Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro by Gang Shen, Haiyun Wen, Huijuan Li, Xuetao Zhang, Bowen Lan, Xuanchi Dong, Peng Ge, Yalan Luo, Hailong Chen

“…Real-time polymerase chain reaction (PCR), Western blot (WB), and immunofluorescence were used to find the expressions of related mRNAs and proteins in the lung tissue or A549 cells. Results The findings demonstrated that suppressing Nrf2 expression exacerbated the inflammatory response brought on by SAP and the pathological alterations of SAP-ALI. …”
Get full text

Development and optimization of a new competitive ELISA using recombinant (rPSA D15 and rCag11) antigens for the detection of Helicobacter pylori infection. by Biniam Moges Eskeziyaw, Naomi Maina, Rebecca Waihenya, Matthew Mutinda Munyao, Tonny Teya Nyandwaro, Shingo Inoue, Samson Muuo Nzou

“…Therefore, this study aimed to develop and validate a competitive enzyme-linked immunosorbent assay (cELISA) assay for detecting H. pylori infections by targeting the Protective Surface Antigen (PSA) and Cytotoxic-Associated Gene Pathogenesis Island (Cag11) proteins in H. pylori stool antigen sample. In the current study, the optimal conditions including the dilution of anti-rPSA D15 and anti-rCag11 antibodies at 1:1000, coating antigens (rPSA D15 and rCag11) at a concentration of 1 μg/well, the dilution of HRP-labelled antibody at 1:5000 and H. pylori stool antigen dilution at 1:1000 with a 1hour incubation and color development time of 30 minutes for cELISA were determined using an ELISA checkerboard titration assay. …”
Get full text

Regulation and Mechanism of miR-518d through the PPARα-Mediated NF-κB Pathway in the Development of Gestational Diabetes Mellitus by Hui Qiu, Xuemin Liu, Shenshen Yao, Jiaren Zhou, Xue Zhang, Juan Du

“…In this study, we validated that miR-518d negatively regulates the expression of PPARα and triggers the nuclear transport process of NF-κB and phosphorylation of pathway-associated proteins leading to an inflammatory response and the development of GDM.…”
Get full text

Le stress thermique environnemental dans l’espèce bovine : 2. Effets physiologiques, pathologiques, comportementaux, alimentaires, immunitaires et sur la production laitière by Christian Hanzen, Pauline Delhez, Jean-Luc Hornick, Françoise Lessire, Djellel Eddine Gherissi

“…La diminution de la production laitière est une autre conséquence importante d’un stress thermique qui s’accompagne par ailleurs d’une diminution de la concentration en protéines, matière grasse et lactose du lait. Diverses altérations comportementales sont également observées : diminution de la position couchée et augmentation des stations debout, recherche d’ombre et d’eau, etc. …”
Get full text

Unveiling the Mechanisms of a Remission in Major Depressive Disorder (MDD)-like Syndrome: The Role of Hippocampal Palmitoyltransferase Expression and Stress Susceptibility by Careen A. Schroeter, Anna Gorlova, Michael Sicker, Aleksei Umriukhin, Alisa Burova, Boris Shulgin, Sergey Morozov, Joao P. Costa-Nunes, Tatyana Strekalova

“…Post-translational modifications of proteins via palmitoylation, a thioester linkage of a 16-carbon fatty acid to a cysteine residue, reversibly increases their affinity for cholesterol-rich lipid rafts in membranes, changing their function. …”
Get full text

Contribution à l’étude du régime alimentaire du Chimpanzé, Pan troglodytes verus (Schwarz, 1934), à Fongoli (Kédougou, Sénégal) by Landing Badji, Papa Ibnou Ndiaye, Stacy Marie Lindshield, Cheikh Tidiane Bâ, Jill Pruetz

“…Ils sont aussi insectivores et consomment des protéines d’origine animale. L’analyse nutritive des aliments montre un régime riche en sucre provenant essentiellement des fruits, une quantité importante de fibres et de matière grasse. …”
Get full text

Borrelia burgdorferi radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology by Andrés F. Londoño, Ajay Sharma, Jared Sealy, Vipin S. Rana, Shelby D. Foor, Vera Y. Matrosova, Elena K. Gaidamakova, Robert P. Volpe, Michael J. Daly, Brian M. Hoffman, Utpal Pal, J. Stephen Dumler

“…We then explored the influence of the Mn2+-decapeptide-phosphate antioxidant complex MDP, known to shield proteins during irradiation, and showed that treatment with MDP preserves B. burgdorferi’s epitopes at 5 kGy irradiation, which crucially prevents cell proliferation. …”
Get full text

Therapeutic Potential of <i>Cajanus cajan</i> (L.) <i>Millsp</i>. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease by Mingzhang Lin, Linghua Piao, Zhendong Zhao, Li Liao, Dayong Wang, Haiwen Zhang, Xiande Liu

“…Additionally, the levels of tight junction proteins (ZO-1, Occludin) and oxidative stress enzymes (iNOS, SOD1, CAT) were investigated by qPCR. …”
Get full text

Safety, Tolerability, and Immunogenicity of the Invaplex_AR-Detox <i>Shigella</i> Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protoc... by Geert V. T. Roozen, Nsofwa Sukwa, Masuzyo Chirwa, Jessica A. White, Marcus Estrada, Nicole Maier, Kevin R. Turbyfill, Renee M. Laird, Akamol E. Suvarnapunya, Aicha Sayeh, Flavia D’Alessio, Candice Marion, Laura Pattacini, Marie-Astrid Hoogerwerf, Rajagopal Murugan, Manuela Terrinoni, Jan R. Holmgren, Sodiomon B. Sirima, Sophie Houard, Michelo Simuyandi, Meta Roestenberg

“…Invaplex_AR-Detox is an injectable Shigella vaccine that uses a novel combination of conserved invasion plasmid antigen proteins and a serotype-specific bacterial lipopolysaccharide attenuated for safe intramuscular administration. …”
Get full text

Apheresis for the treatment of relapses in MS and NMOSD: reduced antibody reactivities, gene expression changes and potential clinical response indicators by Michael Hecker, Brit Fitzner, Isis Ludwig-Portugall, Friederike Bohne, Edmar Heyland, Juliane Klehmet, Matthias Grothe, Matthias Schwab, Alexander Winkelmann, Stefanie Meister, Ales Dudesek, Hannah Wurm, Ilya Ayzenberg, Ingo Kleiter, Ingo Kleiter, Corinna Trebst, Martin W. Hümmert, Bernhard Neumann, Bernhard Neumann, Klaus Eulitz, Dirk Koczan, Uwe K. Zettl

“…We then measured (1) concentrations of the immunoglobulin isotypes IgG, IgM and IgA, (2) antibody reactivities against 12 peptides derived from potential autoantigens and Epstein-Barr virus proteins, (3) frequencies of CD19+ B cells, CD3+ T cells and CD14+ monocytes, (4) transcriptome profiles of CD19+ B cells and CD4+ T cells and (5) mRNA levels of 7 cytotoxicity-related genes in CD4+ T cells. …”
Get full text

Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis by Samuel R. Moen, Jeffrey R. Misialek, Timothy M. Hughes, Craig W. Johnson, Mark J. Sarnak, Sarah N. Forrester, W.T. Longstreth, Jr., Mercedes R. Carnethon, James S. Pankow, Sanaz Sedaghat

“…Kidney function is commonly estimated using inputs of blood proteins alongside demographic inputs of age, sex at birth, and race. …”
Get full text

IFN-<inline-formula><math display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula> Maintains Immune Tolerance by Promoting M2 Macrophage Polarization... by Xinyu Feng, Cheng Yang, Ting Wang, Jinxin Zhang, Han Zhou, Bin Ma, Ming Xu, Ganzhen Deng

“…Furthermore, we found that SOCS1 restrained the expression of the key proteins p65 and p-P65 in the NF-κB pathway. Causing, the wide range of cross-species activities of IFN-<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>τ</mo></mrow></semantics></math></inline-formula>, therefore we established a pregnant mouse model for the future confirmation of the above mechanism. …”
Get full text

CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson’s disease models by Felipe Saceanu Leser, Flavio de Souza Júnyor, Iohanna Bianca Pagnoncelli, Anna Beatriz Delgado, Isabelle Medeiros, Ana Clara Campanelli Nóbrega, Brenda da Silva Andrade, Maiara Nascimento de Lima, Nícolas Emanoel da Silva, Laurent Jacob, Kevin Boyé, Luiz Henrique Medeiros Geraldo, Alessandra Mendonça Teles de Souza, Tatiana Maron-Gutierrez, Hugo Castro-Faria-Neto, Cristian Follmer, Carolina Braga, Gilda Angela Neves, Anne Eichmann, Luciana Ferreira Romão, Flavia Regina Souza Lima

Get full text

Grain Yield Stability Analysis of Lentil Genotypes by AMMI Indices by Payam Pezeshkpour, Reza Amiri, Iraj Karami, Amir Mirzaei

“…Lentils are a significant source of food proteins, minerals (potassium, phosphorus, iron, and zinc), carbohydrates, and vitamins in human nutrition and have high health benefits due to their low fat content and glycemic index. …”
Get full text

Screening of Genes Related to Resistance to Bacterial Leaf Blight in Oryza officinalis by using RNA-seq Technology by Yayun YANG, Feifei ZHANG, Famei ZHANG, Xinxiang A, Chao DONG, Cuifeng TANG, Chunyun YANG, Luyuan DAI

“…KEGG enrichment analysis showed that 19 KEGG pathways were significantly enriched in the resistant and susceptible O. officinalis materials, among which KEGG pathways related to disease resistance to proteins were significantly enriched and increased. …”
Get full text

Investigating the hatchability and nauplii biometry of Artemia franciscana in unconventional waters of Sistan region, Southeast Iran by Hashem Khandan Barani, Abdolali Rahdari, Narjes Sanchooli, Ali Khosravanizadeh

“…It plays an important role in the aquatic food chain due to containing a variety of high nutrients such as proteins, amino acids, fatty acids, vitamins and antioxidants. …”
Get full text

Effect of Sucrose Spray on some Phytochemical Characteristics of Stevia (Stevia rebaudiana Bertoni) under Field Conditions by Vahid Akbarpour, Hossein Aruei, Kambiz Mashayekhi, Majid Azizi Arani, Mohammad Ali Bahmanyar

“…Extended Abstract Background: Sugars are one of the important components in the human diet, along with fats and proteins, which provide about 60-70% of their energy. …”
Get full text