Haptoglobin Gene Polymorphism among Sickle Cell Patients in West Cameroon: Hematological and Clinical Implications by Christian Bernard Kengne Fotsing, Constant Anatole Pieme, Prosper Cabral Biapa Nya, Jean Paul Chedjou, Samuel Ashusong, Gisele Njindam, Jocelyn Tony Nengom, Georges Teto, Carine Nguemeni, Wilfred Fon Mbacham, Donatien Gatsing

“…Haptoglobin is a protein involved in protecting the body from the harmful effects of free hemoglobin. …”
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Integrated Microbiome and Metabolome Analysis Reveals Correlations Between Gut Microbiota Components and Metabolic Profiles in Mice With Mitoxantrone-Induced Cardiotoxicity by Zhang Q, Liang D, Zhang C, Ye L, Sun P, Zhu H, Zhao Y, Li Y, Guan Y, Zhang H

“…MTX primarily affected the processes of protein digestion and absorption, mineral absorption, membrane transport, production of aminoacyl-transfer RNA (tRNA), metabolism of nucleotides, lipids, and amino acids, as well as autophagy. …”
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Associations of Serum Urate and Cardiovascular Events in a Clinical Trial of Interleukin-1β Blockade by Nicholas H. Adamstein, MD, Jean G. MacFadyen, BA, Brittany N. Weber, MD, PhD, Peter Libby, MD, Daniel H. Solomon, MD, MPH, Paul M Ridker, MD, MPH

“…Methods: This study is a subanalysis of the Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS), which randomized 10,061 patients with prior myocardial infarction and elevated high-sensitivity C-reactive protein to 3 doses of canakinumab or placebo. SU was measured at baseline. …”
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Threats of zoonotic pathogens in food chain: Current status and gaps in IndiaKey public health Message: by Madhuchhanda Das, Anup Kumar Ojha, Venencia Albert, Saradi Borah, Thandavarayan Ramamurthy, Samaresh Das, Tapan Kumar Dutta, Hosterson Kylla, Rajkumari Mandakini, Sarangthem Indira Devi

“…Factors like increasing population, deforestation, high demand for animal protein, and trade of sub-clinically infected animals are the main causes of the spread of infections from asymptomatic animals to humans. …”
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Characterizing immune biomarkers and effector CD8+ T-cell exhaustion in pancreatic adenocarcinoma via single-cell RNA sequencing profiling by Rawaa AlChalabi, Raghda Makia, Semaa A. Shaban, Ahmed AbdulJabbar Suleiman

“…Drug repurposing of oxaprozin and celecoxib showed favorable binding interactions with both wild and mutant IL7R proteins. Conclusions: The K110N mutation, despite not causing significant structural changes, may impact T-cell and B-cell homeostasis and development. …”
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Phthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer by Yuh-Shyan Tsai, Yeong-Chin Jou, Ian Seng Cheong, Hsiu-Ting Tung, Lin-Nei Hsu, Hsin-Tzu Tsai, Tzong-Shin Tzai

“…In vitro assays in prostate cancer cells showed that DEHP enhanced Nrf-2 protein expression and its downstream signaling molecules (i.e., SOD2, Heme oxygenase-1, and EGR-1) while increasing GDF15 mRNA expression via EGR-1 regulation in a dose- and time-dependent manner. …”
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Detection of CRISPR‒Cas and type I R–M systems in Klebsiella pneumoniae of human and animal origins and their relationship to antibiotic resistance and virulence by Xue Li, Ling Wang, Jinghuan Lin, Yingjuan Gu, Zhihua Liu, Jing Hu

“…ABSTRACT The clustered regularly interspaced short palindromic repeats (CRISPR)‒CRISPR-associated protein (Cas) and restriction‒modification (R–M) systems are important immune systems in bacteria. …”
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Effects of dietary hemp co-product inclusion on laying hens performances and on egg nutritional and functional profile by D. Lanzoni, M. Skřivan, M. Englmaierová, E. Petrosillo, L. Marchetti, V. Skřivanová, V. Bontempo, R. Rebucci, A. Baldi, C. Giromini

“…Including up to 9% hemp co-product in diets did not affect dry matter and protein digestibility but improved the functional profile. …”
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Better understanding the phenotypic effects of drugs through shared targets in genetic disease networks by Elena Díaz-Santiago, Aurelio A. Moya-García, Jesús Pérez-García, Raquel Yahyaoui, Raquel Yahyaoui, Christine Orengo, Florencio Pazos, James R. Perkins, James R. Perkins, James R. Perkins, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea, Juan A. G. Ranea

“…Gaining traction in this field is the use of disease data linking genes with pathological phenotypes and combining this with drugtarget interaction data.MethodsWe introduce methodology to associate drugs with effects, both intended and adverse, using a tripartite network approach that combines drug-target and target-phenotype data, in which targets can be represented as proteins and protein domains.ResultsWe were able to detect associations for over 140,000 ChEMBL drugs and 3,800 phenotypes, represented as Human Phenotype Ontology (HPO) terms. …”
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The role of oxidized non-coding RNAs of the epigenome in the development of human diseases (literature review) by S.S. Ostrovska, Ye.N. Dychko, T.Ye. Shumna, G.I. Titov, O.S. Trushenko, P.G. Gerasymchuk, I.Y. Burega

“…The attention of scientists to the role of the epigenome in the development of human diseases is associated with the discovery of new non-coding RNA molecules of the epigenome that affect gene expression with changes in protein function and the development of diseases. …”
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WAC Facilitates Mitophagy‐mediated MSC Osteogenesis and New Bone Formation via Protecting PINK1 from Ubiquitination‐Dependent Degradation by Shuai Fan, Jinteng Li, Guan Zheng, Ziyue Ma, Xiaoshuai Peng, Zhongyu Xie, Wenjie Liu, Wenhui Yu, Jiajie Lin, Zepeng Su, Peitao Xu, Peng Wang, Yanfeng Wu, Huiyong Shen, Guiwen Ye

“…While the WW domain‐containing coiled‐coil adaptor (WAC) protein is primarily associated with transcriptional regulation and autophagy, its involvement in MSC osteogenesis remains unclear. …”
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The Development of a Novel Broad-Spectrum Influenza Polypeptide Vaccine Based on Multi-Epitope Tandem Sequences by Song Zhao, Junhao Luo, Wenhui Guo, Li Li, Siyu Pu, Libo Dong, Wenfei Zhu, Rongbao Gao

“…This study aimed to identify and evaluate the efficacy of a novel influenza universal vaccine candidate consisting of multiple polypeptides derived from highly conserved regions of influenza virus proteins hemagglutinin (HA), neuraminidase (NA), and matrix protein 2 (M2). …”
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Assembly and comparative analysis of the complete mitochondrial genome of red raspberry (Rubus idaeus L.) revealing repeat-mediated recombination and gene transfer by Huajie Zhang, Minghui Yan, Lijuan Li, Zhuo Jiang, Ye Xiong, Yusheng Wang, Caleb Onoja Akogwu, Olutayo Mary Tolulope, Hao Zhou, Yanxia Sun, Hengchang Wang

“…Furthermore, 52 homologous sequences between the mitogenome and plastome were identified, including six complete protein-coding genes and 12 tRNA genes. We also detected 828 homologous fragments between the nuclear genome and mitogenome, including one trnM-CAU gene. …”
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Development of a machine learning-based prediction model for extremely rapid decline in estimated glomerular filtration rate in patients with chronic kidney disease: a retrospectiv... by Shingo Fukuma, Yukio Yuzawa, Daijo Inaguma, Hiroki Hayashi, Ryosuke Yanagiya, Akira Koseki, Toshiya Iwamori, Michiharu Kudo

“…The random forest model identified haemoglobin, albumin and C reactive protein as important characteristics.Conclusions The random forest model could be useful in identifying patients with extremely rapid eGFR decline.Trial registration UMIN 000037476; This study was registered with the UMIN Clinical Trials Registry.…”
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Genetic Nurture Effects on Type 2 Diabetes Among Chinese Han Adults: A Family-Based Design by Xiaoyi Li, Zechen Zhou, Yujia Ma, Kexin Ding, Han Xiao, Tao Wu, Dafang Chen, Yiqun Wu

“…Tissue enrichment of type 2 diabetes-associated genes on different genetic effect types was performed using publicly available gene expression data from the Human Protein Atlas database. We observed significant gene enrichment in paternal genetic nurture effects in the gallbladder, smooth muscle, and adrenal gland tissues. …”
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Effects of compost from food waste on growth of lettuce ( Lactuca sativa Var. Crispa L.) by Aunkamol Kumngen, Jutarut Iewkittayakorn, Usmana Meehae, Sudarat Suwannarat, Sujunya Anuchan, Wilaiwan Chotigeat, Pattamavadee Kunwanlee, Noodchanath Kongchouy, Siwapong Leunram, Seppo Karrila

“…Growth characteristics and nutrient contents were investigated.Results The BA compost improved the soil nutrients. 10% BA compost in soil gave the highest growth parameters among the proportions tested, with the highest root length (21.83 ± 0.83 cm), plant length (30.00 ± 1.00 cm), number of leaves (23.33 ± 1.15 leaves), thickness (12.47 ± 0.57 mm), width of bush (26.33 ± 0.58 mm), fresh plant weight (113.03 ± 1.28 g), dry plant weight (4.58 ± 0.14 g), chlorophyll a and b (0.38 and 0.38 mg/mL), carotenoid (155.28 mg/mL), protein (443.38 μg/mL), carbohydrate (4,321.31 μg/mL) and reducing sugar (683.33 μg/mL).Conclusion BA compost from food waste demonstrated its potential in sustainable food waste management and could be used as a fertilizer. …”
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Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung by Yuanyuan Jia, Xuehong You, Ningxia Ma, Hui Li, Guopan Liu, Ying Wang, Jing Xue, Juan Shi, Jun Wei, Yong Li, Jiali Yang, Xiaoming Liu

“…The BrdU-labeled epithelial cells also expressed keratin 14, mucin 5AC, or prosurfactant protein C (ProSP-C); among them, the keratin 14-positive cells were the most frequent BrdU-labeled epithelial cell type as determined by immunohistochemical and immunofluorescence staining. …”
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The efficacy of Artichoke leaf extract conjugated with organic zinc nanoparticles on growth, carcass traits and blood biochemical parameters of broilers by Elwy A. Ashour, Ahmed K. Aldhalmi, Mahmoud Kamal, Salem S. Salem, Samir A. Mahgoub, Abdulmohsen H. Alqhtani, Mahmoud Madkour, Ahmed A. Elolimy, Mohamed E. Abd El-Hack, Ayman A. Swelum

“…In addition, we found significant differences in total protein, albumin, and globulin levels between treatments, with the control group showing higher levels compared to the other two groups. …”
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Formalin Fixation as Tissue Preprocessing for Multimodal Optical Spectroscopy Using the Example of Human Brain Tumour Cross Sections by Mona Stefanakis, Anita Lorenz, Jörg W. Bartsch, Miriam C. Bassler, Alexandra Wagner, Marc Brecht, Axel Pagenstecher, Jens Schittenhelm, Barbara Boldrini, Sabrina Hakelberg, Susan Noell, Christopher Nimsky, Marcos Tatagiba, Rainer Ritz, Karsten Rebner, Edwin Ostertag

“…However, formalin fixation results in alterations of the tissue chemistry and morphology for example by protein cross-linking. As optical spectroscopy is sensitive to these variations, we evaluate the effects of formalin fixation on multimodal brain tumour data in this proof-of-concept study. …”
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Soil-plant-animal relationships and their effect on pasture-based milk production in Hacienda Cuba, Colombia by María A. López G., Ana G. Quintero M., Juan J. Zúñiga E., Felipe Vélez S., Juan F. Naranjo R., Óscar A. Sáenz R., Andrés F. Pérez R.

“…On average, these forages exhibited the following nutritional quality characteristics: crude protein of 10.25%, neutral detergent fiber of 65.60%, the in vitro digestibility of dry matter was 56.45%, and the metabolizable energy was 2.75 Mcal Kg DM-1. …”
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