Clinical Usefulness of Bioavailable Vitamin D and Impact of GC Genotyping on the Determination of Bioavailable Vitamin D in a Korean Population by Hyun-Young Kim, Jin Hyun Kim, Myeong Hee Jung, In Ae Cho, Youngjin Kim, Min-Chul Cho

“…The purpose of this study was to determine the utility of bioavailable 25(OH)D in assessing vitamin D status when vitamin D-binding protein (VDBP) was significantly altered by pregnancy and liver cirrhosis (LC). …”
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The Role of Neuroglial Crosstalk and Synaptic Plasticity-Mediated Central Sensitization in Acupuncture Analgesia by Zhongxi Lyu, Yongming Guo, Yinan Gong, Wen Fan, Baomin Dou, Ningcen Li, Shenjun Wang, Yuan Xu, Yangyang Liu, Bo Chen, Yi Guo, Zhifang Xu, Xiaowei Lin

“…These factors are regulated by acupuncture through the activation of multiple signaling pathways, including mitogen-activated protein kinase signaling (e.g., the p38, extracellular signal-regulated kinases, and c-Jun-N-terminal kinase pathways), which contribute to the activation of nociceptive neurons. …”
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Decreased Frequencies of Th17 and Tc17 Cells in Patients Infected with Avian Influenza A (H7N9) Virus by Jiaqi Bao, Dawei Cui, Xiaochen Wang, Qianda Zou, Dejian Zhao, Shufa Zheng, Fei Yu, Li Huang, Yuejiao Dong, Xianzhi Yang, Guoliang Xie, Weizhen Chen, Yu Chen

“…In this study, we found that the frequencies of Th17 and Tc17 cells among human peripheral blood mononuclear cells (PBMCs) as well as IL-17A protein and mRNA levels were markedly decreased in patients with acute H7N9 virus infection. …”
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Transcriptome analysis of jejunal mucosal tissue in breeder hens exposed to acute heat stress by Yongcai Zhu, Satoshi Kubota, Phocharapon Pasri, Sitthipong Rakngam, Supattra Okrathok, Chayanan Pukkung, Shenglin Yang, Sutisa Khempaka

“…Of these, 75 genes including heat shock proteins (HSPs) showed upregulated expression, while 63 genes including a key bile acid transport molecule (SLC10A2) exhibited downregulated expression. …”
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Utilizing sc-linker to integrate single-cell RNA sequencing and human genetics to identify cell types and driver genes associated with non-small cell lung cancer by Yangfan Zhou, Liang Zhao, Meimei Cai, Doudou Luo, Yizhen Pang, Jianhao Chen, Qicong Luo, Qin Lin

“…We found that the Ras-related protein Rab-31 (RAB31) was significantly overexpressed in tumor-associated fibroblasts compared to that in normal fibroblasts and was closely associated with poor prognosis in patients with NSCLC. …”
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Transcriptome analysis reveals modulations in glycosylation profiles of the mucosal barrier and their potential interaction with gut microbiota in weaned piglets by Hao Cheng, Hao Li, Yujie Zhao, Kai Yang, Jing Wang, Bie Tan, Xiaokang Ma

“…Through comparative analysis of differentially glycosylated genes and their associated functions, this study highlights the potential role of reduced expression of GALNT1 and KMT2C genes, involved in O-linked protein and glycan reactions, in impairing the intestinal barrier function of DLY piglets. …”
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Neutrophil extracellular traps (NETs) are increased in rheumatoid arthritis-associated interstitial lung disease by Jing Xue, Miaomiao Nian, Yangyang Liang, Zeqin Zhu, Zhenyu Hu, Yuanyuan Jia, Shuhong Chi, Juan Chen

“…ROC curve analysis further revealed that the combination of plasma MPO-DNA, rheumatoid factor (RF), and anti-citrullinated protein (anti-CCP) and the combination of Cit-H3, RF, and anti-CCP were superior diagnostic panels for NSIP and UIP in RA-ILD patients, respectively. …”
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A Subanesthetic Dose of Isoflurane during Postconditioning Ameliorates Zymosan-Induced Neutrophil Inflammation Lung Injury and Mortality in Mice by Hui Wang, Jing Fan, Nan-lin Li, Jun-tang Li, Shi-fang Yuan, Jun Yi, Ling Wang, Jiang-hao Chen, Yong-gang Lv, Qing Yao, Ting Wang, Yu-cai Wang, Rui Ling

“…We found that ISO improved the survival rate of mice and mitigated lung injury as characterized by the histopathology, wet-to-dry weight ratio, protein leakage, and lung function index. ISO significantly attenuated ZY-induced lung neutrophil recruitment and inflammation. …”
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Ten days of supplementation with a standardized Boswellia serrata extract attenuates soreness and accelerates recovery after repeated bouts of downhill running in recreationally ac... by Dawna Salter, Himana Yalamanchi, Aiswarya Yalamanchi, Amulya Yalamanchi

“…The SBS-supplemented subjects reported less knee joint pain after DHR than the PLA group (p < 0.05 on days 8, 9, and 10). C-reactive protein and interleukin-6 increased after DHR, but by day 10, SBS reduced these markers compared to the PLA (p < 0.05). …”
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Description of Weight-Related Content and Recommended Dietary Behaviors for Weight Loss Frequently Reposted on X (Twitter) in English and Japanese: Content Analysis by Fumi Oono, Mai Matsumoto, Risa Ogata, Mizuki Suga, Kentaro Murakami

“…The most popular dietary component recommended to increase was vegetables in both English (n=31, 40.8%) and Japanese (n=48, 28.2%), followed by protein and fruits in English and grains or potatoes and legumes in Japanese. …”
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Disruption of zinc homeostasis reverses tigecycline resistance in Klebsiella pneumoniae by Jinyu Wang, Jinyu Wang, Cuiping Xia, Cuiping Xia, Zhaoxin Xia, Zhaoxin Xia, Jilu Shen, Jilu Shen

“…IntroductionZinc exhibits potent antimicrobial properties due to its ability to compromise bacterial structure and protein functionality, effectively inhibiting and eradicating bacteria. …”
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Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…MMP-3 and MMP-9 mRNA and protein levels in the treatment groups were decreased relative to the control group after 4 weeks.Conclusion: Combination BMSC and carbon dioxide laser therapy was more effective than either of these therapeutic approaches in isolation as a treatment for photoaged skin. …”
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Wild pink bayberry free phenolic extract induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest through p38/MAPK and PI3K/Akt pathway in MDA-MB-231 cancer cells by Wen Xia, Er-sheng Gong, Yanyun Lin, Bisheng Zheng, Wenhan Yang, Tong Li, Sheng Zhang, Peng Li, Rui-hai Liu

“…Further study of the upstream protein, we found that WPBFE down-regulated TRAF2, while upregulated p-ASK1, p-p38 and p-p53. …”
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Lymphadenopathies: A Retrospective Study of Epidemiology, Characteristics, Diagnosis and Treatment Outcomes of Patients in a Tertiary Hospital in Mogadishu-Somalia by Kıratlı K, Bulut M, Ali MA, Aysin M, Ali AM, Mohamed Hirsi I, Bashir AM

“…White blood cell value (p< 0.001), erythrocyte sedimentation rate (p< 0.001), and C-reactive protein (p:0.001) revealed differences across the diagnostic groups.Conclusion: Almost two-thirds of patients were diagnosed with tuberculosis lymphadenitis. …”
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Protective Effect of Rosmarinic Acid on Endotoxin-Induced Neuronal Damage Through Modulating GRP78/PERK/MANF Pathway by Li Q, Zheng JW, Wang ZY, Liao SP, Zhu L, Wang X, Wan LH

“…However, 40 mg/kg RA treatment significantly decreased the hippocampal level of PERK protein and increased MANF in CA1 and DG in mice. …”
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Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites by Yexun Zhou, Yexun Zhou, Liang Chen, Hui Han, Hui Han, Bohui Xiong, Ruqing Zhong, Yue Jiang, Lei Liu, Haiqing Sun, Jiajian Tan, Xiaowei Cheng, Martine Schroyen, Yang Gao, Yong Zhao, Hongfu Zhang

“…We discovered that TAX increased sperm motility significantly in Duroc boars by the elevation of the protein levels such as ZAG, PKA, CatSper, and p-ERK for sperm quality. …”
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CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High Accuracy by Samya Jezine Da Silva, Mauro Jorge Cabral-Castro, Luiz Claudio Faria, Carolina Rosadas, Maria Fernanda Lopes de Araújo, Ana Caroline Soares Dutra, Yoshihisa Yamano, Graham Taylor, Marzia Puccioni-Sohler

“…Results: Higher white cell counts and concentrations of protein, neopterin, and CXCL-10 in CSF were detected in group A (patients with HAM) and group B (<i>p</i> < 0.05). …”
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Ergosterol alleviates hepatic steatosis and insulin resistance via promoting fatty acid β-oxidation by activating mitochondrial ACSL1 by Zu-Guo Zheng, Yi-Ping Zhang, Xiao-Yu Zhang, Meng-Yao Qin, Yin-Yue Xu, He Wu, Run-Qing Liu, Qiu-Yi Wu, Ming-Su Wang, Chong Zhang, Yue-Qin Zheng, Jian-Ye Dai, Ping Li, Hua Yang

“…Summary: Sterols target sterol-sensing domain (SSD) proteins to lower cholesterol and circulating and hepatic triglyceride levels, but the mechanism remains unclear. …”
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The Role of Matrix Metalloproteinases (MMP-2 and MMP-9) in Ageing and Longevity: Focus on Sicilian Long-Living Individuals (LLIs) by Patrizia Cancemi, Anna Aiello, Giulia Accardi, Rosalia Caldarella, Giuseppina Candore, Calogero Caruso, Marcello Ciaccio, Laura Cristaldi, Francesca Di Gaudio, Valentina Siino, Sonya Vasto

“…Extracellular matrix metalloproteinases (MMPs) are a group of proteins that activate substrates by enzymatic cleavage and, on the basis of their activities, have been demonstrated to play a role in ageing. …”
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Developing a ceRNA-based lncRNA-miRNA-mRNA regulatory network to uncover roles in skeletal muscle development by Wang Wenlun, Wang Wenlun, Yu Chaohang, Huang Yan, Li Wenbin, Zhou Nanqing, Hu Qianmin, Wu Shengcai, Yuan Qing, Yu Shirui, Zhang Feng, Zhu Lingyun

“…Despite bioinformatics challenges, our research underscores the significant roles of lncRNAs in muscle protein synthesis, degradation, cell proliferation, differentiation, function, and metabolism under both normal and microgravity conditions. …”
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