CDK4/6 inhibitors promote PARP1 degradation and synergize with PARP inhibitors in non-small cell lung cancer by Carlos M Roggero, Anwesha B Ghosh, Anvita Devineni, Shihong Ma, Eliot Blatt, Ganesh V. Raj, Yi Yin

“…Mechanistically, we showed that CDK4/6is promote PARP1 protein degradation, which lead to decreased availability of DNA repair factors involved in homologous recombination and suppression of DNA repair competency. …”
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Preparation and characterization of new silica-based heterofunctional biocatalysts utilizing low-cost lipase Eversa® Transform 2.0 and evaluation of their catalytic performance in... by Wagner C. A. Carvalho, Rayane A. S. Freitas, Milson S. Barbosa, Ariela V. Paula, Ernandes B. Pereira, Adriano A. Mendes, Elton Franceschi, Cleide M. F. Soares

“…In a solvent-free medium, the AmG-70h support performed best in the esterification reaction, at around 90% conversion, with a load of 1.65 mg of protein in the reaction. Moreover, it obtained a productivity around 4.45 times that of free ET2.0 lipase, maintaining its original activity until the fourth cycle. …”
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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…HK-2 and 786-O cells were used, with 786-O cells divided into control, vector, and oe-PTEN groups. PTEN and related protein levels were detected using RT-qPCR and Western blot. …”
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Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats by Karoline Klumpp, Frauke Lange, Alexandra S. Muscher-Banse, Nadine Schnepel, Kathrin Hansen, Adrian L. Lifschitz, Laura Mate, Mirja R. Wilkens

“…In addition, a downregulation of P-glycoprotein (P-gp) and breast cancer resistance protein was found in the brain. Taken together, the stimulating effects of vitamin D metabolites on the expression of genes involved in the metabolism and elimination of xenobiotics reported previously for rodents and sheep could not be reproduced. …”
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Different Approaches to requesting Consent for Routine data linkage in Neonatal follow-up (ACORN): protocol for a 2×2 factorial randomised trial by Jane E Harding, Barry Milne, Jenny Rogers, Greg Gamble, Jane Marie Alsweiler, Christopher McKinlay, Gavin Brown, Aakash Bajirao Rajay, Caroline Anne Crowther, Nike Franke, Trecia Wouldes

“…Reported rates of consent to data linkage for children ranged from 21% to 96%, but no studies have investigated different approaches to seeking consent for data linkage for school-age children.Methods and analysis The Approaches to Consent for Routine Data Linkage in Neonatal Follow-up (ACORN) trial is a 2×2 factorial randomised trial to assess whether, for children who participated in neonatal randomised trials (pre-hypoglycaemia Prevention with Oral Dextrose Gel (hPOD), hPOD and The Impact of Protein Intravenous Nutrition on Development in Extremely Low Birth Weight Babies (ProVIDe)) and are approached to participate in an in-person assessment at 6–7 years of age, parental consent to data linkage is higher if consent is sought (1) after the in-person assessment (delayed) or concurrently and (2) for health and education data combined or separately. …”
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SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

“…Manipulating SHP2 expression or its target protein β-catenin may offer a novel approach to TNBC therapy.…”
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Spectroscopic and Thermooxidative Analysis of Organic Okra Oil and Seeds from Abelmoschus esculentus by Geórgia de Sousa Ferreira Soares, Vinicius de Morais Gomes, Anderson dos Reis Albuquerque, Manoel Barbosa Dantas, Raul Rosenhain, Antônio Gouveia de Souza, Darlene Camati Persunh, Carlos Alberto de Almeida Gadelha, Maria José de Carvalho Costa, Tatiane Santi Gadelha

“…Similar to Okra varieties from the Middle East and Central America, Brazilian Okra has significant amounts of protein (22.14%), lipids (14.01%), and high amounts of unsaturated lipids (66.32%), especially the oleic (20.38%) and linoleic acids (44.48%). …”
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Hubungan Ketahanan Pangan, Pola Asuh, dan Tingkat Kecukupan Gizi dengan Kejadian Stunting Balita 6-59 Bulan di Puskesmas Dawe, Kabupaten Kudus by Tarisca Rahmatika, Dina Rahayuning Pangestuti, Alfi Fairuz Asna

“…Hasil: Hasil menunjukkan pola asuh ibu balita kategori baik (58,1%), keluarga tahan pangan (74,4%), tingkat kecukupan gizi balita pada energi (73,3%), zinc (91,9%), kalsium (57%), zat besi (54,7%), dan vitamin D (38,4%) cukup dan semua balita tercukupi pada protein dan vitamin A. Faktor pola asuh (p-value=0,004), ketahanan pangan (p-value=0,006), tingkat kecukupan energi (p-value<0,001) dan kalsium (p-value<0,001) berkorelasi dengan stunting. …”
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Valorization of vermicompost with bacterial fermented chicken feather hydrolysate for the yield improvement of tomato plant: A novel organic combination by Ishita Biswas, Debasis Mitra, Ansuman Senapati, Debanjan Mitra, Sourav Chattaraj, Murshed Ali, Goutam Basak, Periyasamy Panneerselvam, Pradeep K. Das Mohapatra

“…Purpose Chicken feather protein hydrolysate (CFPH) has drawn a significant attention as a component/type of biofertilizer in recent years, because of the beneficial impact on the growth of the plant. …”
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V-ATPase in glioma stem cells: a novel metabolic vulnerability by Alessandra Maria Storaci, Irene Bertolini, Cristina Martelli, Giorgia De Turris, Nadia Mansour, Mariacristina Crosti, Maria Rosaria De Filippo, Luisa Ottobrini, Luca Valenti, Elisa Polledri, Silvia Fustinoni, Manuela Caroli, Claudia Fanizzi, Silvano Bosari, Stefano Ferrero, Giorgia Zadra, Valentina Vaira

“…Cell extracts, proximity-ligation assay and advanced microscopy was used to analyze subcellular presence of proteins. A metabolomic screening was performed using Biocrates p180 kit, whereas transcriptomic analysis was performed using Nanostring panels. …”
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Natural Concurrent Infections with Black Spot Disease and Multiple Bacteriosis in Farmed Nile Tilapia in Central Kenya by Daniel W. Wanja, Paul G. Mbuthia, Robert M. Waruiru, Lilly C. Bebora, Helena A. Ngowi

“…Nile tilapia (Oreochromis niloticus) is the most cultured and available fish for Kenyan consumers, and therefore, any tilapine disease deprives them the valuable source of protein. Nile tilapia farm was diagnosed with severe concurrent black spot disease and multiple bacteriosis using gross lesions and parasitological, histopathology, and standard bacteriological procedures. …”
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Longitudinal Associations between Obesity, Inflammation, and the Incidence of Type 2 Diabetes Mellitus among US Black and White Adults in the CARDIA Study by Sharon H. Jackson, Anna Bellatorre, Timothy McNeel, Anna María Nápoles, Kelvin Choi

“…We performed a series of multivariable logistic regression analyses to assess the relative influence of obesity (waist circumference) and individual inflammatory biomarkers (i.e., C-reactive protein, fibrinogen, and sex-specific serum uric acid and gamma-glutamyltransferase) on the odds of developing incident T2DM between waves 7 and 8. …”
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MicroRNA-541-3p/Rac2 signaling bridges radiation-induced lung injury and repair by Jiandong Zhang, Lei Ma, Limin He, Quanxiao Xu, Yan Ding, Lidong Wang

“…MicroRNA-541-3p and Rac2 regulate the expression of Tgf-beta1 and its encoded proteins. Conclusions: The Rac2 gene synchronously regulates TNFRSF10B-RIPK1/RIPK3-MLKL and TGFβ1 signaling. …”
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The Prognostic Significance of the CALLY Index in Ampullary Carcinoma: An Inflammation-Nutrition Retrospective Analysis by Xi P, Huang G, Huang K, Qin D, Yao Z, Jiang L, Zhu Q, He C

“…Pu Xi,1,&ast; Guizhong Huang,1,&ast; Kewei Huang,2,&ast; Dailei Qin,1 Zehui Yao,1 Lingmin Jiang,1 Qi Zhu,1 Chaobin He1 1Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2State Key Laboratory of Oncology in South China, Department of Clinical Laboratory, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chaobin He, Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, 651 Dongfeng Road E, Guangzhou, Guangdong, 510060, People’s Republic of China, Email hechb@sysucc.org.cnBackground: As a novel inflammatory-nutritional biomarker, the C-reactive protein–albumin–lymphocyte (CALLY) index has demonstrated significant prognostic value in various malignancies. …”
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Noninvasive Evaluation of EGFR Expression of Digestive Tumors Using 99mTc-MAG3-Cet-F(ab′)2-Based SPECT/CT Imaging by Dai Shi, Yiqiu Zhang, Zhan Xu, Zhan Si, Yuan Cheng, Dengfeng Cheng, Guobing Liu

“…Cet-F(ab′)2 was synthesized using immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS) protease and purified with protein A beads. The product and its in vitro stability in normal saline and 1% bovine serum albumin were analyzed with sodium dodecyl sulfate–polyacrylamide gel electrophoresis. …”
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A Study of Molecular Mimicry and Immunological Cross-reactivity between Hepatitis B Surface Antigen and Myelin Mimics by Dimitrios-Petrou Bogdanos, Heather Smith, Yun Ma, Harold Baum, Giorgina Mieli-Vergani, Diego Vergani

“…On the basis of the reported association between hepatitis B vaccination (HBvacc) and autoimmune demyelinating complications such as multiple sclerosis (MS), we have looked for aminoacid similarities between the small hepatitis B virus surface antigen (SHBsAg), and the MS-autoantigens myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) that could serve as targets of immunological cross-reactivity. …”
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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

“…Finally, using the proteomic correlates of iLGS, we identified protein markers associated with exceptional longevity irrespective of chronological age and prioritized drugs with repurposing potentials for gerotherapeutics. …”
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Different Activity of the Biological Axis VEGF-Flt-1 (fms-Like Tyrosine Kinase 1) and CXC Chemokines between Pulmonary Sarcoidosis and Idiopathic Pulmonary Fibrosis: A Bronchoalveo... by Katerina M. Antoniou, Giannoula Soufla, Athanasia Proklou, George Margaritopoulos, Christiana Choulaki, Rena Lymbouridou, Katerina D. Samara, Demetrios A. Spandidos, Nikolaos M. Siafakas

“…Moreover, a statistically significant decrease has been found in Flt-1 protein levels in pulmonary sarcoidosis in comparison with IPF (𝑃=.03). …”
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The influence of external factors on the development of olfactory disorders in patients with the coronavirus disease 2019: an immunomorphological assessment by I.S. Shponka, O.M. Usova

“…Mucosal samples were stained with standard hematoxylin and eosin and using an immunohistochemical method with antibodies to neuron-specific beta-III tubulin (TuJ-1), olfactory marker protein (OMP) and angiotensin-converting enzyme (ACE-2). …”
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Whole transcriptome analysis and construction of gene regulatory networks of granulosa cells from patients with polycystic ovary syndrome (PCOS) by Yuan Yuan, Daiterigele, Qian Zhang, Chen Du

“…The target genes were mainly enriched in metabolic pathways such as mitogen-activated protein kinase (MAPK), Wnt, transforming growth factor-beta (TGF-β), and the cell cycle. …”
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