Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson’s Disease Animal Models from a Molecular Signaling Perspective by Lucas Udovin, Cecilia Quarracino, María I. Herrera, Francisco Capani, Matilde Otero-Losada, Santiago Perez-Lloret

“…Another major pathway involves IκB kinase (IKK) downregulation by ARL6ip5 (ADP-ribosylation-like factor 6 interacting protein 5, encoded by the cell differentiation-associated, JWA, gene). …”
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Blood Cell Ratio Combinations for Diagnosing Periprosthetic Joint Infections: A Preliminary Study by Yu Y, Wen Y, Xia J, Dong G, Niu Y

“…Various preoperative biomarkers were analyzed and compared, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), neutrophil-to-lymphocyte ratio (NLR), CRP-to-albumin ratio (CAR), CRP-Albumin-lymphocyte ratio (CALLR), platelet-to-lymphocyte ratio (PLR), platelet-to-albumin ratio (PAR), and neutrophil-to-albumin ratio (NAR). …”
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Anti-Inflammatory and Anti-Migratory Effects of Morin on Non-Small-Cell Lung Cancer Metastasis via Inhibition of NLRP3/MAPK Signaling Pathway by Punnida Arjsri, Kamonwan Srisawad, Sonthaya Umsumarng, Pilaiporn Thippraphan, Songyot Anuchapreeda, Pornngarm Dejkriengkraikul

“…Specifically, it decreased the expression of NLRP3 and ASC proteins and reduced caspase-1 activity, while reducing the phosphorylation of ERK, JNK, and p38 proteins. …”
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Assessment of Plasma Sodium to Potassium Ratio, Renal Function, Markers of Oxidative Stress, Inflammation, and Endothelial Dysfunction in Nigerian Hypertensive Patients by Oloruntoba A. Ekun, Folasade Daniel, Philip Adebola, Adeola Ajibare, Oyeronke O. Ekun, Oluwafunso O Omogoroye, Oluwafemi S. Ilori, Bankole J. Oluwasayo, Mary F. Oshundun, Sade R. Oyegbami

“…Glutathione, superoxide dismutase, nitric oxide (NO), and catalase were significantly reduced (p<0.001) while malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), and ferritin were raised significantly (p<0.001) in hypertensive participants. …”
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Preserved Expression of Skin Neurotrophic Factors in Advanced Diabetic Neuropathy Does Not Lead to Neural Regeneration despite Pancreas and Kidney Transplantation by František Saudek, Monika Cahová, Terezie Havrdová, Klára Zacharovová, Helena Daňková, Luděk Voska, Věra Lánská, Nurcan Üçeyler, Claudia Sommer

“…Compared to DM and HC groups, we found a significantly higher (p < 0.05–0.001) expression of NGF (nerve growth factor), NGFR (NGF receptor), NTRK1 (neurotrophic receptor tyrosine kinase 1), GDNF (glial cell-derived neurotrophic factor), GFRA1 (GDNF family receptor alpha 1), and GFAP (glial fibrillary acidic protein) in both transplant groups (Tx1 and Tx2). …”
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Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced... by Yoon-Young Sung, Won-Kyung Yang, Jong Hoon Kim, Dongseok Shin, Seok June Son, Seung-Hyung Kim

“…RelA decreased the expression of interleukin (IL)-17, chemokine (C-X-C motif) ligand (CXCL)-1, thymus and activation-regulated chemokine, macrophage inflammatory protein-2, IL-1α, TNF-α, mucin 5AC, cyclooxygenase-2, and transient receptor potential cation channel subfamily A or V member 1 in BALF and lung, and inhibited IL-1α and macrophage marker F4/80 localization in lung of PM10D-induced mice. …”
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Effects of Ginseng Peptides on Laxative in Mice by Qiannan WANG, Wen YANG, Tingfang XUE, Jiaqi ZOU, Tao FENG, Lei YU, Yunfeng BI, Lina WANG

“…Methods: Sixty adult male ICR mice were randomly divided into 6 groups, they were normal group (NG), constipation group (CG), whey protein group (WPG), low-dose GPs group (LG), medium-dose GPs group (MG), high-dose GPs group (HG). …”
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Human Umbilical Cord Perivascular Cells Prevent Tumor Growth in a Melanoma Tumor-Bearing Mouse Model and Modulate Breast Cancer and Melanoma Cells in a Cell Line-Dependent Manner I... by Lianet Lopez, Hannah Shuster-Hyman, Eden Marco, Hasna Khan, Avishai Gasner, Aleksandra Uzelac, Brandon Wyse, Poonam Mander, Mugundhine Sangaralingam, Joseph Fish, Ariel Gorodensky, Samar Mouazz, Amanda Kauffman, Denis Gallagher, Andrée Gauthier-Fisher, Clifford L. Librach

“…Serum tumor necrosis factor alpha and C-reactive protein levels were measured using enzyme-linked immunosorbent assays. …”
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Molecular Docking Appraisal of Phytochemicals as Potential Inhibitors of PI3K/Akt Pathway for Breast Cancer Treatment by Magdalene Eno Effiong, Mercy Bella-Omunagbe, Israel Sunmola Afolabi, Shalom Nwodo Chinedu

“…Phosphoinositide 3-kinase, phosphatase and tensin homolog (PTEN), mTOR, Akt, 3-phosphoinositide-dependent kinase 1 (PDK1), FoxO1, glycogen synthase kinase 3 (GSK-3), mouse double minute 2 (MDM2), H-Ras, and proapoptotic B-cell lymphoma 2 (BCL-2) family protein (BAD) proteins are key drivers of this pathway and potential therapeutic targets. …”
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Guillain-Barré syndrome following falciparum malaria infection: a case report by Molla Asnake Kebede, Alemayehu Beharu Tekle, Misikir Alemu Eshetu, Erkyehun Pawlos Shash, Melaku Tsediew Berhanu, Elias Tabiet Ahmed, Hashime Meketa Negatie

“…Guillain-Barré Syndrome is also suggested by elevated protein levels and a lack of cells in the cerebrospinal fluid. …”
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GWAS identifies a polyembryony locus in mango: development of KASP and PACE markers for marker-assisted breeding by Gul Shad Ali, Shamseldeen Eltaher, Shamseldeen Eltaher, Jin Li, Barbie Freeman, Sukhwinder Singh

“…This locus contains the MiRWP/MiRKD4 gene, which codes for an RWP–RK domain-containing protein previously implicated in citrus apomixis. …”
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The Effective Compound Combination of Bufei Yishen Formula III Improves the Mitochondrial Dysfunction via Inhibiting JNK/Sab Pathway in COPD Mice by Song M, Han M, Zhang H, Yang Y, Tian Y, Li J, Zhao J

“…Furthermore, ECC-BYF III ameliorated mitochondrial dysfunction by restoring the mitochondrial membrane potential, increasing mitochondrial complex I activity, and decreasing tumor necrosis factor-α (TNF-α) level and protein expressions of SH3BP5 (Sab), Phospho-JNK (P-JNK), and cleaved CASP3.Conclusion: The results suggest that the potential therapeutic benefit of ECC-BYF III against mitochondrial dysfunction in COPD is due to the inhibition of the JNK/Sab pathway, which will help to further understand the potential mechanisms of ECC-BYF III in the treatment of COPD. …”
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Risk factors and characteristics of preoperative heart failure in elderly patients with hip fracture and the influence of anemia on prognosis by Aoying Min, Wei Zhao, Wei Li, Weining Li, Zhiyong Hou, Zhiqian Wang

“…Age, coronary artery disease, chronic atrial fibrillation, Age-Adjusted Charlson Comorbidity Index (ACCI), admission anemia, admission albumin < 40 g/dl, and admission C-reactive protein (CRP) were all significantly different between those with AHF and those without. …”
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Exogenous organic acids promoted phytoremediation by Hydrangea macrophylla in cadmium‑contaminated soil by Yunjing Song, Qian Cheng, Bing Zhao

“…By boosting superoxide dismutase (SOD), peroxidase (POD), and catalase activities (CAT), elevating levels of proline (Pro), non-protein thiol (NPT), glutathione (GSH) and phytochelatins (PCs), exogenous organic acids promoted the Cd tolerance of H. macrophylla. …”
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Development of a novel multi-epitope subunit mRNA vaccine candidate to combat Acinetobacter baumannii by Shiyang Ma, Fei Zhu, Peipei Zhang, Yizhong Xu, Ziyou Zhou, Hang Yang, Caixia Tan, Jie Chen, Pinhua Pan

“…We screened 11 immunodominant epitopes for cytotoxic T cells, 5 for helper T cells, and 10 for Linear B-cell based on promising candidate proteins omp33-36, ompA and ompW, the selection of these three proteins is based on reverse vaccinology screening and previous work by other researchers. …”
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POVEIKIS IR ATSAKAS BIOLOGINIUOSE VYKSMUOSE by Jonas Rubikas

“…This situation is illustrated by putative examples: DNA replication, DNA transcription and protein synthesis. One of the most important conditionalities is the genetic regulation. …”
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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease by Giuseppe Verdile, Kevin N. Keane, Vinicius F. Cruzat, Sandra Medic, Miheer Sabale, Joanne Rowles, Nadeeja Wijesekara, Ralph N. Martins, Paul E. Fraser, Philip Newsholme

“…As a cause or consequence, the chronic inflammatory response and oxidative stress associated with T2DM, amyloid-β (Aβ) protein accumulation, and mitochondrial dysfunction link T2DM and AD.…”
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The carbon footprint of pasture-based buffalo milk production in Colombia by Andrés F. Pérez, Felipe Vélez S., Juan F. Naranjo R.

“…Two functional units were used for measurement: tons of CO 2 -equivalents (CO 2e ) per hectare (ha) and kilograms of CO 2e per kilogram of fat-and-protein-corrected milk (FPCM). Greenhouse gas emissions were calculated using the 2019 Refinement to the 2006 IPCC guidelines, with emission factors sourced from databases. …”
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Curcumin Alters Neural Plasticity and Viability of Intact Hippocampal Circuits and Attenuates Behavioral Despair and COX-2 Expression in Chronically Stressed Rats by Ga-Young Choi, Hyun-Bum Kim, Eun-Sang Hwang, Seok Lee, Min-Ji Kim, Ji-Young Choi, Sung-Ok Lee, Sang-Seong Kim, Ji-Ho Park

“…In addition, the influence of oral curcumin administration on rat behavior was assessed with the forced swim test (FST). Finally, protein expression levels of brain-derived neurotrophic factor (BDNF) and cyclooxygenase-2 (COX-2) were measured by Western blot in chronically stressed rats. …”
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Assessment of the Effects of Newly Fabricated CaO, CuO, ZnO Nanoparticles on Callus Formation Maintenance of <i>Alfalfa</i> (<i>Medicago sativa</i> L.) Under In Vitro Salt Stress by Mustafa Akçay, Merve Simsek Geyik, Busra Yazicilar, Fatma Boke, Hayrunnisa Nadaroglu, Okkes Atıcı, İsmail Bezirganoğlu

“…The callus induction stage, without salt treatments, showed the best results with 0.8 ppm CaO NPs for both H₂O₂ levels and peroxidase (POX) activity compared to the other NPs. The highest protein rate was obtained from the callus induction stage and callus formation stage after 50 mM treatment NaCl with 0.8 ppm CuO. …”
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