DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism by Xinrong Wu, Yifan Li, Weiwei Wang, Jiale Xu, Bei Zhao, Wenqi Sun, Dan Ge, Longying Xiong, Xiaotan Dou, Xiaoping Zou, Lei Wang, Min Chen

“…DNA damage-regulated autophagy modulator 1 (DRAM1) encodes a hexameric transmembrane protein that is predominantly located in lysosomes and induces autophagy; however, its mechanism of action in gastric cancer remains unclear. …”
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Characterization of serum metabolome and respiratory microbiota in children with influenza A virus infection by Xinyi Shi, Shenghao Hua, Zeyuan Chen, Weiyi Cao, Mengqing Xiao, Wenlong Pei, Zhe Cao, Zhan Zhang, Haibing Yang, Haibing Yang, Xuejun Shao, Yu Xia, Yu Xia

“…Additionally, IAV infection increased serum concentrations of total protein, albumin and lipase, while decreasing the contents of calcium, triglyceride, total bilirubin, direct bilirubin, indirect bilirubin and gamma-glutamyltransferase. …”
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Inhibition of inflammatory cell infiltration by antagonistic peptides that specifically bind to CCR5 via regulation of the NF-kB signaling pathway in rats with colitis by Yang-Da Song, Yi-Hang Song, Si-Xue Liu, Hua-Rong Huang, Ying-Qiang Zhong

“…The expression of NF-kB-related genes, including p105, p100, IKK and TNF-α, was reduced after GH and HY peptide administration (p < 0.01), and the protein level of TNF-α and the phosphorylation of IKK, IkBα and p65 were also suppressed. …”
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The Effect of Laminin-1-Doped Nanoroughened Implant Surfaces: Gene Expression and Morphological Evaluation by Humberto Osvaldo Schwartz-Filho, Kostas Bougas, Paulo G. Coelho, Ying Xue, Mariko Hayashi, Rafael Silveira Faeda, Rosemary Adriana Chiérici Marcantonio, Daisuke Ono, Fumio Kobayashi, Kamal Mustafa, Ann Wennerberg, Ryo Jimbo

“…The test implants demonstrated higher expression of inflammatory markers interleukin-10 (1.53-fold) and tumour necrosis factor-α (1.61-fold) relative to controls. Conclusion. The protein-doped surface showed higher gene expression of typical genes involved in the osseointegration cascade than the control surface.…”
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MicroRNA-21-5p Reduces Hypoxia/Reoxygenation-Induced Neuronal Cell Damage through Negative Regulation of CPEB3 by Bin Wang, Ping Yu, Wei Lin, Zhaohui Zhai

“…Besides, the apoptosis-related proteins including BAX, BCL2, cleaved caspase-3, and caspase-3 as well as proteins of EGFR/PI3K/AKT signaling pathways were measured by Western blot. …”
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Biodegradation of aflatoxin B1 by a novel mined aldo–keto reductase from Meyerozyma guilliermondii AF01 by Wan Zhang, Xiaojiao Chang, Yangying Han, Tiantian Li, Jianpeng Dou, Wen Du, Wenfu Wu, Wei Wang, Zhongjie Zhang, Changpo Sun

“…The gene was heterologously expressed in Escherichia coli Rosetta DE3, and the recombinant protein, Mg aldo–keto reductase (AKR), reacted with AFB1 in vitro. …”
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Effects and function of citric acid on fermentation quality and microbial community in sugarcane tops silage with high and low water-soluble carbohydrate content by Qichao Gu, Jie Zhang, Bo Lin, Hao Ding, Qi Yan, Caixiang Wei, Yipei Yao, Ruizhanghui Wang, Caixia Zou

“…The results showed that high-WSC STS had lower crude protein (CP) content and higher DM, neutral detergent fiber (NDF), and acid detergent fiber (ADF) contents, whether treated with CA or not. …”
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Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea by Zishen Lin, Yue Feng, Jinping Wang, Zhaoyue Men, Xi Ma

“…LKB1 binds with P53 based on protein interaction, ultimately resists to apoptosis and diarrhea. …”
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Foodborne toxin Aflatoxin B1 induced glomerular podocyte inflammation through proteolysis of RelA, downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway by Jie Zhang, Shuang Yang, Baocai Xu, Zihui Qin, Xinyi Guo, Ben Wei, Qinghua Wu, Kamil Kuca, Tushuai Li, Wenda Wu

“…Reduction of RelA resulted in decreasing microRNA-9 (miR-9) and activating the chemokine receptor 4 (CXCR4), thioredoxin interacting protein (TXNIP), and NOD-like receptor pyrin domain-containing 3 (NLRP3) signaling axis (CXCR4/TXNIP/NLRP3 pathway), leading to podocyte inflammation. …”
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Lacticaseibacillus paracasei K56 inhibits lipid accumulation in adipocytes by promoting lipolysis by Silu Wang, Jinxing Li, Wei-Hsien Liu, Niya Li, Huijing Liang, Weilian Hung, Qiuyue Jiang, Ruyue Cheng, Xi Shen, Fang He

“…The results demonstrated that K56-CM promoted the expression of peroxisome proliferator-activated receptor-γ (PPAR-γ), CCAAT/enhancer binding protein α (C/EBPα), and other adipogenesis-related markers, which resulted in the upregulation of lipolysis markers, such as hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL). …”
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The first two mitochondrial genomes for the genus Ramaria reveal mitochondrial genome evolution of Ramaria and phylogeny of Basidiomycota by Qiang Li, Lijiao Li, Ting Zhang, Peng Xiang, Qian Wu, Wenying Tu, Zhijie Bao, Liang Zou, Cheng Chen

“…In addition, the evolutionary rates of different core protein coding genes (PCGs) in Phallomycetidae mitogenomes varied. …”
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Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized... by Azizeh Farshbaf-Khalili, Alireza Ostadrahimi, Mojgan Mirghafourvand, Khatereh Ataei-Almanghadim, Sara Dousti, Amir Mehdi Iranshahi

“…Serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), and high sensitivity C-reactive protein (hs-CRP) were measured at baseline and after the intervention. …”
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Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR by Ewa Wunsch, Marta Klak, Urszula Wasik, Malgorzata Milkiewicz, Malgorzata Blatkiewicz, Elzbieta Urasinska, Olivier Barbier, Dariusz Bielicki, Dimitrios P. Bogdanos, Elwyn Elias, Piotr Milkiewicz

“…Results. Increased PXR protein was observed in both PSC and PBC compared to controls and was accompanied by a significant increase of SULT2A1 in PBC but not in PSC. …”
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<i>Clostridium difficile</i>-associated disease by V. T. Ivashkin, O. S. Shifrin, A. S. Tertycnhy, Ye. A. Poluektova, T. L. Lapina, O. S. Lyashenko, K. V. Ivashkin

“…C. difficile toxins A and B are protein molecules, classified as glycosyltransferases. …”
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DNMT1-driven methylation of RORA facilitates esophageal squamous cell carcinoma progression under hypoxia through SLC2A3 by Wenjian Yao, Linlin Shang, Yinghao Wang, Lei Xu, Yu Bai, Mingyu Feng, Xiangbo Jia, Sen Wu

“…Mechanistically, RORA was found to inactivate the transcription of glucose transporter protein SLC2A3 by interacting with its promoter F1 region. …”
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Collection of microorganisms of ICG SB RAS as a genetic resource for biotechnology by A. V. Bryanskaya, Y. E. Uvarova, A. S. Rozanov, N. M. Slynko, V. N. Shlyakhtun, K. V. Starostin, E. A. Demidov, E. V. Lazareva, O. P. Taran, S. E. Peltek

“…The creation of personal mass spectra of protein profiles of the studied strains of the collection was carried out. …”
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Physicochemical and Sensory Evaluation of Gummy Candies Fortified with Microcapsules of Guinea Pig (<i>Cavia porcellus</i>) Blood Erythrocytes and Tumbo (<i>Passiflora tarminiana</... by Carlos A. Ligarda-Samanez, Eliana Villano-Limache, Williams Pichihua-Oscco, David Choque-Quispe, Reynaldo Sucari-León, Dante Fermín Calderón Huamaní, Germán De la Cruz, Rober Luciano-Alipio, Wilber Cesar Calsina Ponce, Yolanda Aroquipa-Durán, María José Victoria Campos-Huamaní

“…The results showed a significant decrease in the moisture content (52.02% in F1 to 43.27% in F3) and increases in protein (11.44% in F3) and iron (2.63 mg Fe/g in F3) contents when higher EEGPB levels were used. …”
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Portulaca oleracea L. (purslane) extract ameliorates intestinal inflammation in diet-induced obese mice by inhibiting the TLR4/NF-κB signaling pathway by Lingchao Miao, Meng Sam Cheong, Haolin Zhang, Haroon Khan, Haroon Khan, Hongxun Tao, Yuxiao Wang, Wai San Cheang

“…Then, intestinal tissues were detached from the mice for detecting protein expressions through Western blot and immunohistochemical analyses. …”
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Aerobic exercise attenuates high-fat diet-induced glycometabolism impairments in skeletal muscle of rat: role of EGR-1/PTP1B signaling pathway by Liangzhi Zhang, Xiaojie Liu, Jing Hu, Helong Quan, Sang Ki Lee, Mallikarjuna Korivi, Lifeng Wang, Ting Li, Wei Li

“…Next, the decreased IRS1 (phosphorylated/total), AKT (phosphorylated/total), and GLUT4, and increased GSK-3β proteins with HFD were significantly reversed by exercise. …”
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Structural insights into the mechanism of phosphate recognition and transport by XPR1 by Wenhui Zhang, Yanke Chen, Zeyuan Guan, Yong Wang, Meng Tang, Zhangmeng Du, Jie Zhang, Meng Cheng, Jiaqi Zuo, Yan Liu, Qiang Wang, Yanjun Liu, Delin Zhang, Ping Yin, Ling Ma, Zhu Liu

“…Abstract XPR1 is the sole protein known to transport inorganic phosphate (Pi) out of cells, a function conserved across species from yeast to mammals. …”
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