Genetic association of lipid and lipid-lowing drug targets with uterine fibroids by Mei Wu, Qiannan Lin, Siyu Li, Huiyan Wang, Wenbo Zhou

“…Drug-targeted MR analysis results indicated that genetically predicted inhibition of cholesteryl ester transfer protein (CETP) was associated with a lower UF risk (OR = 0.95, 95 % CI: 0.92–0.98, P = 7.83E-4), as well as reduced levels or risk of other UF-associated clinical traits, including estradiol level, excessive menstruation, abdominal and pelvic pain, myomectomy, and miscarriage. …”
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Mapping Nanoscale‐To‐Single‐Cell Phosphoproteomic Landscape by Chip‐DIA by Gul Muneer, Sofani Tafesse Gebreyesus, Ciao‐Syuan Chen, Tzu‐Tsung Lee, Fengchao Yu, Chih‐An Lin, Min‐Shu Hsieh, Alexey I. Nesvizhskii, Chao‐Chi Ho, Sung‐Liang Yu, Hsiung‐Lin Tu, Yu‐Ju Chen

“…Abstract Protein phosphorylation plays a crucial role in regulating disease phenotypes and serves as a key target for drug development. …”
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Network Pharmacology Suggests Mechanisms for Therapeutic Effects of Caulis Sinomenii on Avian Gout by Guanyang Li, Junfei Xu, Huanhuan Li, Wenxin Yan, Fengting Chen, Anwen Yuan, Juzuo Zhang

“…These targets may exert therapeutic effects on AG through four pathways: the nucleotide-binding oligomerization domain (NOD)-like receptor, mammalian target of rapamycin, TLR, and mitogen-activated protein kinase signaling pathways. In summary, C. sinomenii has potential therapeutic efficacy against AG through multicomponent, multi-target, and multi-pathway mechanisms.…”
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Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction by Longxiang Su, Lin Feng, Qing Song, Hongjun Kang, Xingang Zhang, Zhixin Liang, Yanhong Jia, Dan Feng, Changting Liu, Lixin Xie

“…To describe the dynamics changes of sCD163, soluble serum triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), and C-reactive protein (CRP) during the course of sepsis, as well as their outcome prediction. …”
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Effect of partial and total replacement of fishmeal by soybean meal in feed on growth and gut performance of Penaeus vannamei by Chanadda Kasamechotchung, Natthinee Munkongwongsiri, Pichet Plaipetch, Kanokwan Lertsiri, Siripong Thitamadee, Rapeepun Vanichviriyakit, Siriwan Khidprasert, Kallaya Sritunyalucksana, Felipe Nobre Façanha, Thanapong Kruangkum

“…Abstract This study evaluated the growth and gut performance of shrimp fed three isonitrogenous diets (37% crude protein) with varying inclusions of fish meal (FM) and soybean meal (SBM): F1 (27.5% FM), F2 (10% FM + 23.5% SBM), and F3 (38% SBM). …”
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Intercropping of Saccharum spp. with Dictyophora indusiata: effects on microbial communities and metabolite profiles during bagasse degradation by Mingzheng Duan, Mingzheng Duan, Xiaojian Wu, Shengfeng Long, Hairong Huang, Xiang Li, Yijie Li, Changning Li, Bin Feng, Jiafu Chen, Defa Zhong, Zhendong Chen, Zeping Wang

“…Understanding the process by which D. indusiata degrades bagasse is key to optimizing this method.AimsThis study aims to clarify the microbial and metabolic processes involved in bagasse degradation by D. indusiata in the sugarcane intercropping system.MethodsChemical composition analysis, metabarcoding sequencing, and metabolomic profiling were conducted on D. indusiata-degraded bagasse (DIBA) and naturally degraded bagasse (BA).ResultsAnalysis of chemical composition revealed that only acid detergent fiber (ADF) and crude protein content differed significantly between the DIBA and BA treatments. …”
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Endometrial factors in the implantation failure spectrum: protocol of a MUltidisciplinary observational cohort study in women with Repeated Implantation failure and recurrent Misca... by Servaas Morré, Ron van Golde, Andrea Romano, Linda Stevens Brentjens, Denise Habets, Janneke Den Hartog, Salwan Al-Nasiry, Lotte Wieten, Aafke Van Montfoort

“…The study parameters are the steroid profile (steroid levels and mRNA levels, protein expression and activity of steroid enzymes) in endometrial tissue and peripheral blood, as well as the activating or inhibitory phenotype of uNK cells based on receptor expression in menstrual blood and endometrial tissue and determination of the vaginal and endometrial microbiome using the inter spacer bacterial profiling technique.Ethics and dissemination The protocol is approved by the local medical ethical review committee at the Maastricht University Medical Centre. …”
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Infarct‐like myocarditis with coronary vasculitis and aneurysm formation caused by Epstein–Barr virus infection by Cristina Chimenti, Romina Verardo, Claudia Grande, Marco Francone, Andrea Frustaci

“…At histology, a lymphocytic myocarditis with necrotizing coronary vasculitis sustained by a positive real‐time polymerase chain reaction for EBV, detectable in cardiomyocytes and inflamed intramural vessels by positive immunohistochemistry for EBV latent membrane protein 1 antigen, was observed. Myocardial EBV infection is an unusual cause of acute heart failure and cardiac aneurysms, increasing the risk of electrical instability, cardiac perforation, and sudden death.…”
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The Fatty Acid Content, Health Lipid Indices, and Instrumental, Histological, and Sensory Quality of Hare Meat (<i>Lepus europaeus</i> Pallas) by Gabriela Frunză, Marius-Mihai Ciobanu, Otilia Cristina Murariu, Răzvan-Mihail Radu-Rusu, Paul-Corneliu Boișteanu

“…Shear force was influenced by the ratio between muscle and connective tissue, and the proportion of collagen and protein was related to the number of muscle fibers. …”
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Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study by Jijo Francis, Honey Sebastian, Saley Daniel, Leyon Varghese, Sareena Gilvaz, Ragitha Thenkattil Sankarankutty, Siji Susan George, Pulikkottil Raphael Varghese, Suresh Kumar Raveendran

“…Chronic inflammation plays a pivotal role in PCOS pathogenesis.The monocyte chemoattractant protein-1 (MCP-1) is an important chemotactic factor for inflammatory response ofmonocytes. …”
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Antioxidant Responses in Chromium-Stressed Maize as Influenced by Foliar and Root Applications of Fulvic Acid by Farwa Iftikhar, Asma Zulfiqar, Atif Kamran, Ammara Saleem, Muhammad Zeeshan Arshed, Usman Zulfiqar, Ivica Djalovic, P. V. Vara Prasad, Walid Soufan

“…Furthermore, while chromium stress enhanced antioxidant enzyme activities, FA application further boosted total soluble protein levels and antioxidant enzyme activities under stress conditions. …”
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Hubungan Kebugaran Jasmani dengan Prestasi Belajar pada Siswa Sekolah Menengah Atas di Semarang by Indriana Rahma Nidya, Apoina Kartini, Suyatno Suyatno

“…Hasil: Sebagian besar siswa memiliki asupan gizi yang tergolong rendah, meliputi konsumsi energi (55,8%), karbohidrat (76,7%), protein (45,3%), dan zat besi (64%). Sementara itu, untuk asupan lemak, mayoritas siswa berada dalam kategori berlebih (39,5%). …”
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Infectious Aortitis with Abdominal Aortic Aneurysm in a 47-Year-Old Female with Systemic Lupus Erythematosus by Valerie R. Ramiro, Carmegie C. Saliba, John Anthony D. Tindoc, Marinette R. Jambaro, Enrique M. Chua, Donna Ricca M. Hornilla, Maria Teresa B. Abola

“…Complete blood count showed slight leukocytosis and elevated C-reactive protein. Abdominal imaging revealed a saccular infrarenal aneurysm with dissection. …”
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Characterization of diabetic kidney disease in 235 patients: clinical and pathological insights with or without concurrent non-diabetic kidney disease by Mengjie Jiang, Hongyu Chen, Jing Luo, Jinhan Chen, Li Gao, Qin Zhu

“…Clinical correlation analysis revealed associations between glomerular grading, tubulointerstitial lesions, renal arteriolar vitelliform lesions, renal vascular atherosclerosis, and clinical parameters such as 24-hour urine protein, hemoglobin, and urinary specific gravity. …”
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Levels of blood pressure, cardiovascular biomarkers and their correlations in women with previous pre-eclamptic pregnancy within 7 years postpartum: a cross-sectional study in Thai... by Tippawan Liabsuetrakul, Annetine Staff, Jarawee Sukmanee, Penkae Rothmanee, Wilaiwan Sriwimol

“…Eligible women were interviewed, examined for body mass index (BMI) and blood pressure, and donated morning spot urine and blood samples.Primary outcome measures Serum high-sensitivity C reactive protein, creatinine, fasting blood glucose (FBS), glycated haemoglobin (HbA1c), low-density lipoprotein (LDL) cholesterol, urine microalbumin to creatinine ratio (UACR) and sodium were measured. …”
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Evaluation of the immunological functions of placental alkaline phosphatase in vivo using ALPP transgenic mice by Tse-Ching Chen, Kwai-Fong Ng, Ning Chen, Yi-Ling Pan, Chun-An Cheng, Hsiao-Chun Wu, Yi-Jen Hsueh, Nien-Yi Chiang, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin, Hsi-Hsien Lin

“…ALP is also considered as an anti-inflammatory protein due to its ability to dephosphorylate and inactivate inflammation-triggering molecules such as lipopolysaccharide (LPS). …”
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A Review of the Utility of Established Cell Lines for Isolation and Propagation of the Southern African Territories Serotypes of Foot-and-Mouth Disease Virus by Kitsiso Gaboiphiwe, Tshephang Iris Kabelo, Petronella Thato Mosholombe, Joseph Hyera, Elliot Mpolokang Fana, Kabo Masisi, Kebaneilwe Lebani

“…This review highlights how different receptors and molecules—integrins, heparan sulphate (HS), and the Jumonji C-domain containing Protein 6 (JMJD6)—found on the surface of different cell types contribute to differences experienced with susceptibility and sensitivity of the cells to infection with different serotypes of FMDV. …”
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Molecular Network Associated with MITF in Skin Melanoma Development and Progression by Ichiro Yajima, Mayuko Y. Kumasaka, Nguyen Dinh Thang, Yuji Goto, Kozue Takeda, Machiko Iida, Nobutaka Ohgami, Haruka Tamura, Osamu Yamanoshita, Yoshiyuki Kawamoto, Keiko Furukawa, Masashi Kato

“…These first triggers alter the conditions of numerous genes and proteins, and they induce and/or reduce gene expression and activate and/or repress protein stability and activity, resulting in melanoma progression. …”
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Wheat flour as carbon source on water quality, growth performance, hemolymph biochemical and immune parameters of Pacific white shrimp (Penaeus vannamei) juveniles in biofloc techn... by Mohammad Hossein Khanjani, Jamshid Eslami, Maurício Gustavo Coelho Emerenciano

“…Adding wheat flour to the rearing system improved the biochemical composition of shrimp bodies, so that the control group had the lowest level of protein (75.31 % DW), lipid (6.81 % DW), and ash (11.48 % DW) (P < 0.05). …”
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Advance in identified targets of berberine by Penghai Sun, Ziyuan Wang, Yinchao Ma, Yuan Liu, Yintong Xue, Yan Li, Xiang Gao, Yuedan Wang, Ming Chu, Ming Chu, Ming Chu, Ming Chu

“…To further elucidate the multifaceted pharmacological mechanisms of berberine, we reviewed 7 targets of berberine identified through co-crystal structure analysis, including filamentous temperature-sensitive protein Z (FtsZ), QacR, BmrR, phospholipase A2 (PLA2), RamR, NIMA-related kinase 7 (NEK7), and mesenchymal-epithelial transition (MET). …”
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