Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors by Yu Huang, Yusuke Sakai, Takanobu Hara, Takeshi Katsuda, Takahiro Ochiya, Tomohiko Adachi, Masaaki Hidaka, Wei-Li Gu, Susumu Eguchi

“…The 3D cysts also expressed functional multidrug resistance protein 1 (Mdr1), as indicated by epithelial efflux of rhodamine. …”
Get full text

Impact of commercial gut health interventions on caecal metagenome and broiler performance by Gladys Maria Pangga, Banaz Star-Shirko, Androniki Psifidi, Dong Xia, Nicolae Corcionivoschi, Carmel Kelly, Callie Hughes, Ursula Lavery, Anne Richmond, Umer Zeeshan Ijaz, Ozan Gundogdu

“…GHI supplementation generally affected the abundance of microbial enzymes relating to carbohydrate and protein digestion and metabolic pathways relating to energy, nucleotide synthesis, short-chain fatty acid synthesis, and drug-transport systems. …”
Get full text

Human Umbilical Cord Mesenchymal Stem Cells Attenuate Ocular Hypertension-Induced Retinal Neuroinflammation via Toll-Like Receptor 4 Pathway by Shangli Ji, Jie Xiao, Jian Liu, Shibo Tang

“…The expression levels of glial fibrillary acidic protein (GFAP), ionized calcium binding adapter molecule 1 (iba-1), and toll-like receptor 4 (TLR4) were assessed via immunohistochemistry, real-time quantitative PCR, and Western blot. …”
Get full text

Mitochondrial DNA from endothelial cells activated the cGAS-STING pathway and regulated pyroptosis in lung ischaemia reperfusion injury after lung transplantation by Ying-nan Ju, Hu Li, Zi-peng Zhuo, Qing Yang, Wei Gao

“…Finally, we administered an agonist of STING and an inhibitor of cathepsin B to the normal endothelium and investigated pyroptosis and pyroptotic proteins. Results: After 24 h of reperfusion, the expression of cGAS-STING-TBK1-IRF3 and pyroptotic proteins was significantly increased, and inhibitors of cGAS or STING ameliorated lung injury and reduced pyroptotic protein levels. …”
Get full text

Polytrauma in Older Adults Leads to Significantly Increased TIMP-1 Levels in the Early Posttraumatic Period by Mareen Braunstein, Thomas Kusmenkov, Wolf Mutschler, Christian Kammerlander, Wolfgang Böcker, Viktoria Bogner-Flatz

“…The aim of this study was to evaluate the differences in serum protein dynamics in older and younger polytraumatized adults. …”
Get full text

Circulating CTRP1 Levels in Type 2 Diabetes and Their Association with FGF21 by Sora Han, Jong Dai Kim, Sunyi Lee, Ae Lee Jeong, Jeong Su Park, Hyo Jeong Yong, Ariundavaa Boldbaatar, Hye In Ka, Eun-Jung Rhee, Won-Young Lee, Young Yang

“…The goal of this study was to investigate whether circulating C1q/TNF-α-related protein 1 (CTRP1) levels are associated with diabetes. …”
Get full text

Impact of “Enhanced Recovery After Surgery” (ERAS) protocols vs. traditional perioperative care on patient outcomes after colorectal surgery: a systematic review by Vaishnavi Kannan, Najeeb Ullah, Sunitha Geddada, Amir Ibrahiam, Zahraa Munaf Shakir Al-Qassab, Osman Ahmed, Iana Malasevskaia

“…Additionally, nutritional recovery in ERAS patients was enhanced, with elevated albumin and total protein levels, alongside decreased inflammatory markers and improved immune function. …”
Get full text

Observation on the Efficacy of Ginkgo Ketone Ester Drop Pill in Improving Hypertension Combined with Carotid Atherosclerotic Plaque by Jie Zhang, Yingli Ma

“…The observation indexes were the improvement of blood pressure (systolic blood pressure (SBP) and diastolic blood pressure (DBP)), blood lipids (low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and total cholesterol (TC)), vascular endothelial function (nitric oxide (NO) and endothelin-1 (ET-1)), inflammatory factors (C-reactive protein (CRP) and interleukin-6 (IL-6)), plaque (intimal medial thickness (IMT) of carotid artery and plaque area), and efficacy after intervention and adverse effects during intervention in both groups. …”
Get full text

Luteolin Regulates the Differentiation of Regulatory T Cells and Activates IL-10-Dependent Macrophage Polarization against Acute Lung Injury by Ke Xie, Yu-sen Chai, Shi-hui Lin, Fang Xu, Chuan-jiang Wang

“…The levels of Treg-related cytokines in serum and bronchoalveolar lavage fluid (BALF) of mice were detected. The protein levels of NF-κB p65 in lung tissues were measured. …”
Get full text

The Relationship Between the Modified Glasgow Prognostic and SYNTAX Scores in Patients with Non-ST Elevation Myocardial Infarction by Ahmet KARADUMAN, Cemalettin YILMAZ, Mustafa Ferhat KETEN, Ismail BALABAN, Zeynep Esra GUNER, Mehmet CELIK

“…Objective: This study investigated the modified Glasgow prognostic score (mGPS) to determine its predictive value and how it could be compared with various inflammatory markers, including C-reactive protein (CRP) to albumin ratio and neutrophil-to-lymphocyte ratio, for determining the extent and severity of coronary artery disease (CAD) in patients with non-ST-elevated myocardial infarction (NSTEMI). …”
Get full text

Low Circulating TRAIL Levels Are Associated with Increase of Resistin and Lipocalin-2/ngal Adipokines in Postmenopausal Women by Veronica Tisato, Paola Secchiero, Gloria Bonaccorsi, Carlo Bergamini, Pantaleo Greco, Giorgio Zauli, Carlo Cervellati

“…The panel of adipokines included interleukin- (IL-) 6, IL-8, IL-1β, adipsin, lipocalin-2/neutrophil gelatinase-associated lipocalin (ngal), TNF-alpha, monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, hepatocyte growth factor, resistin, leptin, adiponectin, and nerve growth factor. …”
Get full text

Severe Guillain-Barré syndrome with concurrent optic neuritis in a pediatric patient: a case report by Xin Xue, Yingcun Bao, Yakun Yu, Qun Li, Mei Liu, Xiaoling Li

“…Initial cerebrospinal fluid (CSF) analysis was normal, but subsequent testing revealed elevated protein levels typical of GBS. Neurophysiological studies indicated widespread demyelinating and axonal damage.Interventions and outcomesThe patient received intravenous immunoglobulin (IVIG) therapy, high-dose corticosteroids, and, given the severe progression, rituximab. …”
Get full text

Intermittent enteral nutrition shortens the time to achieve nutritional goals in critically ill patients by Ondrej Hrdy, Kamil Vrbica, Jaroslav Duba, Martin Slezak, Eva Strazevska, Viktor Agalarev, Milos Duba, Radka Stepanova, Adam Svobodnik, Roman Gal

“…Animal data have suggested that intermittent feeding decreases protein catabolism. This study was aimed at determining whether the mode of enteral nutrition administration might lead to differences in meeting nutritional goals, tolerance, and complications. …”
Get full text

The Importance of the Prenyl Group in the Activities of Osthole in Enhancing Bone Formation and Inhibiting Bone Resorption In Vitro by Yuan-Kun Zhai, Ya-Lei Pan, Yin-Bo Niu, Chen-Rui Li, Xiang-Long Wu, Wu-Tu Fan, Ting-Li Lu, Qi-Bing Mei, Cory J. Xian

“…In this study we found that osthole exerted a potent ability to promote proliferation and osteogenic function of rat bone marrow stromal cells and osteoblasts, including improved cell viability, alkaline phosphatase activity, enhanced secretion of collagen-I, bone morphogenetic protein-2, osteocalcin and osteopontin, stimulated mRNA expression of insulin-like growth factor-1, runt-related transcription factor-2, osterix, OPG (osteoprotegerin), RANKL (receptor activator for nuclear factor-κB ligand), and the ratio of OPG/RANKL, as well as increasing the formation of mineralized nodules. …”
Get full text

Association between guidelines and medical practitioners’ perception of best management for patients attending with an apparently uncomplicated acute sore throat: a cross-sectional... by Alastair D Hay, Mark H Ebell, Ronny Gunnarsson, Pär-Daniel Sundvall, Katarina Hedin, Hannelore Wächtler, Naveen Manchal, Lynne Reid, Stefan Malmberg, Sean Hawkey

“…Objective To investigate the relationship between guidelines and the medical practitioners’ perception of optimal care for patients attending with an apparently uncomplicated acute sore throat in five countries (Australia, Germany, Sweden, UK and USA).Design International cross-sectional survey.Setting Primary healthcare (PHC).Participants Medical practitioners working in PHC.Main outcome measures ORs for: (A) perception of throat swabs as important, (B) perception of blood tests (C reactive protein, B-ESR and B-leucocytes) as important and (C) antibiotic prescriptions if no pathogenic bacteria isolated on throat swab.Results Guidelines differed significantly; those recommending throat swabs (Sweden and USA) were associated with practitioners perceiving them as important. …”
Get full text

FOSL2 activates TGF‐β1‐mediated GLUT1/mTOR signaling to promote diabetic kidney disease by Xuelin He, Min Xia, Guanghui Ying, Qien He, Zhaogui Chen, Li Liu, Qiao Zhang, Jianxin Cai

“…Knockdown of FOSL2 reduced the mRNA expression of TGF‐β1 to decrease the protein expression of GLUT1 and mTOR in the kidney tissues of DKD mice, and TGF‐β1 reversed the effects caused by knockdown of FOSL2. …”
Get full text

Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics by Isy Petit, Quentin Faucher, Jean-Sébastien Bernard, Perrine Giunchi, Antoine Humeau, François-Ludovic Sauvage, Pierre Marquet, Nicolas Védrenne, Florent Di Meo

“…We assessed transporters mRNA expression, cellular polarization and protein expression via immunofluorescence, and monitored the transcellular transport of prototypic xenobiotics by determining their efflux ratios. …”
Get full text

Transcriptomic and physiological analyses reveal that cytokinin is involved in the compound leaf development of alfalfa by Hongyao Mei, Jiajun Yan, Xuexin Jia, Weilin Wang, Shuangshuang Li, Ruiqi Sun, Hongjiao Jiang, Lijun Xie, Chuanen Zhou, Shiqie Bai, Lu Han

“…Analyses of forage quality traits indicated significant differences in crude protein (CP), acid detergent fiber (ADF), crude fat (CF), water-soluble sugars (WSS), carbon content, ash composition content, and phosphorus content between Chuancao No.7 alfalfa and wild-type. …”
Get full text

The complete chloroplast genome sequences of monotypic genus Pseudogalium, and comparative analyses with its relative genera by Wei Yu, Xiao-Juan Li, Zhen Lv, Li-E Yang, De-Li Peng

“…Additionally, we identified 60 dispersed repeat sequences, 61–63 simple sequence repeats, and 30 codons within the 82 protein-coding genes that exhibited RSCU values greater than one. …”
Get full text

Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats by Anderson Kiyoshi Kaga, Pedro Octavio Barbanera, Nágilla Orleanne Lima do Carmo, Lucas Rodolfo de Oliveira Rosa, Ana Angélica Henrique Fernandes

“…NAC decreased (p<0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (p<0.01) in treated diabetic rats (DM+NAC). …”
Get full text