MT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2 by Fang-Yuan Liu, Young-Lai Cho, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Anita Limanjaya, Mi-Hye Kwon, Jiyeon Ock, Seon-Jin Lee, Guo Nan Yin, Nam-Kyung Lee, Ji-Kan Ryu

“…Here, we developed a human Tie2-agonistic antibody (MT-100) that not only resists Ang-2 antagonism and activates Tie2 signaling but also regulates a novel target, sushi repeat-containing protein X-linked 2 (Srpx2). This regulation led to the survival of vascular and neuronal cells, a reduction in the production of reactive oxygen species (ROS), activation of the PI3K/AKT/eNOS signaling pathway, increased expression of neurotrophic factors, and ultimately alleviation of ED in diabetic mice. …”
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Bushen Huoxue formula protects against renal fibrosis and pyroptosis in chronic kidney disease by inhibiting ROS/NLRP3-mediated inflammasome activation by Lin Liao, Pengyu Tao, Qiming Xu, Jie Chen, Weiwei Liu, Jing Hu, Jianrao Lu

“…Related markers of fibrosis and NOD-like receptor protein 3 (NLRP3) inflammasome activation were measured using western blotting and enzyme-linked immunosorbent assay. …”
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Physical, Textural, Rheological, and Sensory Characteristics of Amaranth-Based Wheat Flour Bread by Sahreen Nasir, Farhana Mehraj Allai, Murtaza Gani, Shaiq Ganaie, Khalid Gul, Aabida Jabeen, Darakshan Majeed

“…AF supplementation increased the moisture (31.06 to 33.24%), ash (0.92 to 1.51%), protein (12.17 to 13.11%), fat (2.16 to 2.77%), and crude fibre content (1.11 to 1.72%) of the bread while the nitrogen-free extract and alkali water retention capacity decreased from 52.58 to 47.65% and 136.00 to 112.02%, respectively. …”
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Dynamic Monitoring of sTREM-1 and Other Biomarkers in Acute Cholangitis by Jiahui Jiang, Xiaolei Wang, Tongtong Cheng, Mingyue Han, Xinxin Wu, Haitong Wan, DaojunYu

“…Our study is aimed at exploring the significance of white blood cell (WBC), C-reactive protein (CRP), procalcitonin (PCT), soluble triggering receptor expressed on myeloid cells 1 (sTREM-1), and temperature (T) alone or combined together in early identification and curative effect monitoring of AC with or without sepsis. …”
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Asthma-associated prostate enlargement and bladder smooth muscle hypercontractility: unveiling a potential link to LUTS by Peibin Cen, Ming Chen, Xin Qiu, Wenbin Guo, Hongyu Lan, Xingyu Zhou, Ming Lei, Guohua Zeng, Qingfeng Yu

“…Prostatic smooth muscle contraction-related and synthesis-related protein levels were assessed using western blotting. …”
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First Report on Microbial-Derived Polydeoxyribonucleotide: A Sustainable and Enhanced Alternative to Salmon-Based Polydeoxyribonucleotide by Doobyeong Chae, Sae-Woong Oh, Yoon-Seo Choi, Dae-Jung Kang, Chun-Woong Park, Jongsung Lee, Won-Sang Seo

“…Mechanistic studies confirmed that L-PDRN activates the focal adhesion kinase (FAK) and protein kinase B (AKT) signaling pathway through the A2A receptor, similar to PDRN, while also engaging alternative pathways for p38 and ERK phosphorylation, highlighting its signaling versatility. …”
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<i>In silico</i> search for and analysis of R gene variation in primitive cultivated potato species by A. A. Gurina, M. S. Gancheva, N. V. Alpatieva, E. V. Rogozina

“…Homologs of all investigated protein-coding sequences were discovered in PCPS with a relatively high degree of similarity (85–100 %). …”
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Changes in the hematology and blood metabolites of guinea pigs (Cavia porcellus) under intensive rearing system in humid tropical conditions by Daniel Paredes-López, Rizal Robles-Huaynate, Uriel Aldava-Pardave, Miguel Morales-Cauti

“…In serum, profiles of glucose, total protein (TP), albumin, total cholesterol (TC), triglycerides, total bilirubin (TB), and direct bilirubin (DB), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. …”
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TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma by Ziqing Yu, Lihua Zhong, Wangyang Tang, Wenfang Zhang, Ting Lin, Weifeng Zhu, Gang Chen, Jianchao Wang

“…Downregulation TET2 resulted in decreased 5hmC levels and facilitated the progression of the cell cycle in ALCL cell lines. hMeDIP-seq and subsequent functional analyses demonstrated the involvement of thioredoxin interacting protein (TXNIP) in the regulation of ALCL cells. Further mechanistic studies revealed that 5hmC levels influenced TXNIP expression. …”
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Phylogenetic analysis and detection of positive selection in the SIRT gene family across vertebrates by Qiuxi Zhou, Xiongtao Yang, Da Li, Jing Li, Ling Peng, Wenwu He

“…Abstract SIRT6, a member of the sirtuin protein family, is recognized as a tumor suppressor. …”
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Anesthetic Isoflurane Posttreatment Attenuates Experimental Lung Injury by Inhibiting Inflammation and Apoptosis by Jun-tang Li, Hui Wang, Wei Li, Li-feng Wang, Li-chao Hou, Jing-lan Mu, Xin Liu, Hui-juan Chen, Ke-lang Xie, Nan-lin Li, Chun-fang Gao

“…., tumor necrosis factor-α, interleukin- (IL-) 1β, IL-6, and macrophage inflammatory protein-2) in bronchoalveolar lavage fluid and of their mRNA expression in lung tissues. …”
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Strategies for H-score Normalization of Preanalytical Technical Variables with Potential Utility to Immunohistochemical-Based Biomarker Quantitation in Therapeutic Reponse Diagnost... by William E. Pierceall, Michele Wolfe, Jessica Suschak, Hua Chang, Yan Chen, Kam M. Sprott, Jeffery L. Kutok, Stella Quan, David T. Weaver, Brian E. Ward

“…Digital quantitative immunohistochemical analysis of protein biomarker expression offers a broad dynamic range against which clinical outcomes may be measured. …”
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Genomic insights into a multidrug-resistant pandoraea apista clinical isolate carrying blaOXA-153 from China by Lirong Li, Yawen Zhang, Fang He, Ningjun wu

“…Results: The genome sequence of P. apista strain PA167 comprises 5,580,873 bp, with 4,926 protein-coding sequences, 4 ncRNAs, 59 tRNAs, and 3 rRNA operons. …”
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Understanding the Impact of Salt Stress on Plant Pathogens Through Phenotypic and Transcriptomic Analysis by Hyejung Jung, Gil Han, Duyoung Lee, Hyun-Kyoung Jung, Young-Sam Kim, Hee Jeong Kong, Young-Ok Kim, Young-Su Seo, Jungwook Park

“…Uniquely upregulated patterns in <i>Pcc</i> were associated with enhanced survival under high salinity, such as protein quality control, osmotic equilibrium, and iron acquisition. …”
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Effect of total replacement of inorganic with organic sources of key trace minerals on performance and health of high producing dairy cows by P.H. Pomport, H.E. Warren, J. Taylor-Pickard

“…The cows in the ORG group had the highest milk yield (32.6 kg; P=0.0165) with the INORG group the least (31.3 kg), production (energy corrected milk 31.5 kg (P=0.008) vs CON 31.0 kg and INORG 30.7 kg), protein synthesis (ORG 1,024 g/d (P<0.0001) vs CON 1,013 g/d and INORG 982 g/d) and ORG had the highest (P<0.01) milk lactose content. …”
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Pengaruh Likopen terhadap Kadar Soluble FMS-Like Tyrosine Kinase 1 pada Preeklamsi by Vaulinne Basyir, Prima Nanda Fauziah, Akhmad Yogi Pramatirta, Yanwirasti Yanwirasti, Johanes C. Mose, Fadil Oenzil

“…Kriteria inklusi adalah pasien yang telah didiagnosis preeklamsi berdasarkan pemeriksaan tekanan darah dan protein urin, dan kriteria eksklusi adalag pasien yang tidak datang kontrol atau tidak bisa dihubungi. …”
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Bioaccumulation and Health Risk Assessments of Heavy Metals in Mussels Collected from Madura Strait, Indonesia by Defri Yona, Aida Sartimbul, Muhammad Arif Rahman, Syarifah Hikmah Julinda Sari, Priyanka Mondal, Abdullah Hamid, Tsania Humairoh

“…Highlight • Heavy metals (Cu, Zn, Pb, and Cd) in the seawater, sediment, and soft part of marine mussels were analyzed • Bioaccumulation Factor (BAF), Estimated Daily Intake and Target Hazard Quotient (THQ) were calculated • Heavy metals in the seawater, sediment and marine mussels were found in varying concentrations • Health risk assessment indexes showed low values which means insignificant health hazard Abstract Marine mussels are known as one of the biological indicators of heavy metals pollution in the aquatic environment and the sources of protein for human consumption. This study aimed to investigate the concentration of heavy metals (Cu, Zn, Pb, and Cd) in the seawater, sediment, and soft parts of the marine mussels (Perna viridis, Meretrix sp., and Anadara granosa), as well as to evaluate its health risk of consumption from Madura Strait, Indonesia. …”
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Lack of Association of C677T Methylenetetrahydrofolate Reductase Polymorphism with Breast Cancer Risk in Mali by Brehima Diakite, Yaya Kassogue, Mamoudou Maiga, Guimogo Dolo, Oumar Kassogue, Jane L. Holl, Brian Joyce, Jun Wang, Kadidiatou Cisse, Fousseyni Diarra, Mamadou L. Keita, Cheick B. Traore, Bakarou Kamate, Sidi B. Sissoko, Bourama Coulibaly, Adama S. Sissoko, Drissa Traore, Fatoumata M. Sidibe, Sekou Bah, Ibrahim Teguete, Madani Ly, Sellama Nadifi, Hind Dehbi, Kyeezu Kim, Robert Murphy, Lifang Hou

“…Imbalance in methionine and S-adenosylmethionine synthesis affects protein synthesis and methylation. These changes, which affect gene expression, may ultimately promote the development of breast cancer. …”
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Serum Apelin Levels and Correlation with illness Severity in Nonobese Patients with Bronchial Asthma by Rohan Pattanaik, Pratima Kumari Sahu, Monalisa Mohapatro, Jeetendra Kumar Patra, Nirjharini Dhal

“…Apelin, a bioactive peptide belonging to the adipokines group, is identified as an endogenous ligand of an orphan G-protein coupled receptor named Apelin receptor (AR or APJ). …”
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Effects of dietary Acremonium terricola culture on production performance, serum biochemical parameters, egg quality and yolk amino acid contents of Beijing You-chicken by Jianzhong Wang, Cun Liu, Xiaowei Gong, Yanhan Liu

“…The average egg weight, albumen height, and Haugh unit representing egg quality of Beijing You-chickens in the experimental group were increased significantly (P < 0.05) compared with the CON group at both time periods, while the egg shape index and yolk weight were only increased significantly (P < 0.05) in the second stage. The protein content in the yolk was increased significantly at both time periods (P < 0.05). …”
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