Structural Characterization of B-DNA d(CGTGAATTCACG)₂ in Complex with the Specific Minor Groove Binding Fluorescent Marker Hoechst 33342 by Hristina Sbirkova-Dimitrova, Rusi Rusew, Hristo Gerginov, Annie Heroux, Boris L. Shivachev

“…The coordinates and structure factors are deposited in the RCSB Protein Data Bank (PDB) under entry 9FT8. The structure is nearly isomorphous with that of previously reported crystal structures of the oligonucleotide d(CGTGAATTCACG)₂ alone (PDB ID: 5JU4) and with that in complexes with DAPI (5T4W). …”
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On the nature of picobirnaviruses by A. Yu. Kashnikov, N. V. Epifanova, N. A. Novikova

“…The primary structure of the gene encoding the viral capsid protein responsible for the presence or absence of specific proteolytic properties of the virus that determine its ability for independent horizontal transmission into new cells may also be a decisive factor.…”
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Effects of Cranberry Extract (Vaccinium macrocarpon) Supplementation on Lipid Peroxidation and Inflammation in Patients with Chronic Kidney Disease (Stages 3-4): A Randomized Contr... by Laís de Souza Gouveia Moreira, Karla Thaís Resende Teixeira, Ludmila F. M. F. Cardozo, Livia Alvarenga, Bruna Regis, Jessyca Sousa de Brito, Viviane de Oliveira Leal, Natalia Alvarenga Borges, Isabela de Souza da Costa Brum, José Carlos Carraro-Eduardo, Giovanna B. Borini, Andresa A. Berretta, Marcelo Ribeiro-Alves, Denise Mafra

“…Interleukin-6 (IL-6) plasma levels were assessed by enzyme-linked immunosorbent assay and C-reactive protein (CRP) by immunoturbidimetric method. Results. …”
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Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype. by Florence E McLean, Brian R Omondi, Nouhoum Diallo, Stanley Otoboh, Carolyne Kifude, Abdirahman I Abdi, Rivka Lim, Thomas D Otto, Ashfaq Ghumra, J Alexandra Rowe

“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding of infected erythrocytes to human cells and plays a key role in parasite immune evasion and malaria pathology. …”
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Cerebellar lipid dysregulation in SCA3: A comparative study in patients and mice by Alexandra F. Putka, Varshasnata Mohanty, Stephanie M. Cologna, Hayley S. McLoughlin

“…Spinocerebellar ataxia type 3 (SCA3) is the most common dominantly inherited ataxia and belongs to the family of nine diseases caused by a polyglutamine expansion in the disease-causing protein. In SCA3, a polyglutamine expansion in ATXN3 causes neuron loss in disease-vulnerable brain regions, resulting in progressive loss of coordination and ultimately death. …”
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Palmitic Acid Induces Production of Proinflammatory Cytokines Interleukin-6, Interleukin-1β, and Tumor Necrosis Factor-α via a NF-κB-Dependent Mechanism in HaCaT Keratinocytes by Bing-rong Zhou, Jia-an Zhang, Qian Zhang, Felicia Permatasari, Yang Xu, Di Wu, Zhi-qiang Yin, Dan Luo

“…Secretion levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), NF-κB nuclear translocation, NF-κB activation, Stat3 phosphorylation, and peroxisome proliferator-activated receptor alpha (PPARα) mRNA and protein levels, as well as the cell proliferation ability were measured at the end of the treatment and after 24 hours of recovery. …”
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Preparation and In Vivo Expression of CS-PEI/pCGRP Complex for Promoting Fracture Healing by Chun-Liang Li, Feng Qin, Rong-rong Li, Jia Zhuan, Hai-Yong Zhu, Yu Wang, Kai Wang

“…Moreover, CS-PEI/pCGRP significantly enhanced the mRNA and protein levels of downstream RUNX2 and ALP. Conclusion. …”
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Analysis of Nucleotide Variations in Genes of Iron Management in Patients of Parkinson's Disease and Other Movement Disorders by Emanuela Castiglioni, Dario Finazzi, Stefano Goldwurm, Gianni Pezzoli, Gianluca Forni, Domenico Girelli, Federica Maccarinelli, Maura Poli, Maurizio Ferrari, Laura Cremonesi, Paolo Arosio

“…In the search of DNA sequence variations affecting the individual predisposition to develop movement disorders, we scanned by DHPLC the exons and intronic boundary regions of ceruloplasmin, iron regulatory protein 2, hemopexin, hepcidin and hemojuvelin genes in cohorts of subjects affected by Parkinson's disease and idiopathic neurodegeneration with brain iron accumulation (NBIA). …”
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Zingiber striolatum phytochemicals ameliorated hyperglycemia symptoms by modulating gut microbial communities in mice with type 2 diabetes mellitus by Tingting Liu, Xiaodong Ge, Lu Song, Huanhuan Wu, Xue Qian, Bowen Jia, Chao Zhao, Yi Zhuang

“…The remaining 48 mice were employed T2DM model, and then randomly assigned to four groups: the model group, a low-dose ZSE group (ZSE-L, 100 mg/kg/day), a high-dose ZSE group (ZSE-H, 300 mg/kg/day), and a positive control group treated with metformin hydrochloride (MET, 100 mg/kg/day).ResultsAfter a 4-week intervention, the results revealed that ZSE significantly ameliorated fasting blood glucose (FBG), area under the curve of oral glucose tolerance test (AUC of OGTT) and glycated serum protein (GSP) in T2DM mice. Moreover, the high-dose (ZSE-H) treatment increased the relative abundance of beneficial bacteria such as Faecalibaculum, while reducing harmful bacteria such as Bilophila, thereby alleviating insulin resistance. …”
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Effect of probiotics on the growth, blood profile, and nutritional-metabolic profile of feedlot cattle by Flavia I. Mansilla, María C. Aristimuño Ficoseco, María H. Miranda, Marcela D’Urso Villar, Graciela M. Vignolo, María E. F. Nader-Macías

“…Blood and serum parameters were within referential ranges for the control and probiotics-supplemented groups; however, mean values of hematocrit were higher, while the serum glucose, lipid profile, and C-reactive protein values were lower in all the groups. In addition, the multistrain probiotic formulation exhibited higher numbers of cultivable lactic acid bacteria and a slight decrease in the number of enterobacteria in feces at the end of the trial. …”
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Traditional Knowledge and Efficacy Analysis of an Emerging Medicinal Food Plant: <i>Disporopsis aspersa</i> by Qingyu Chen, Miaomiao Wang, Xian Hu, Jihai Zhang, Qing Zhang, Congli Xu, Chunlin Long

“…This study aims to determine the nutritional content and evaluate the antioxidant and anti-inflammatory activities of the aerial parts extracts of <i>D. aspersa</i>. The levels of protein, amino acids, vitamins, and minerals were measured and compared to those of common vegetables. …”
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PRMT5 Inhibitor EPZ015666 Decreases the Viability and Encystment of <i>Entamoeba invadens</i> by Rigoberto Ortiz-Hernández, Elmer Joel Millán-Casarrubias, Jeni Bolaños, Susana Munguía-Robledo, Carlos Vázquez-Calzada, Elisa Azuara-Licéaga, Jesús Valdés, Mario Alberto Rodríguez

“…Protein arginine methyltransferase 5 (PRMT5) is an enzyme that produces monomethyl arginine (MMA) and symmetric dimethyl arginine (sDMA), post-translational modifications that regulate several cellular processes, including stage conversion in parasitic protozoans. …”
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Case Study of Somaclonal Variation in Resistance Genes Mlo and Pme3 in Flaxseed (Linum usitatissimum L.) Induced by Nanoparticles by Inese Kokina, Ilona Mickeviča, Marija Jermaļonoka, Linda Bankovska, Vjačeslavs Gerbreders, Andrejs Ogurcovs, Inese Jahundoviča

“…This paper shows the results of somaclonal variation in two resistance genes pectin methylesterase and Mlo-like protein in all tissue culture development stages, as donor plant, calluses, and regenerants of Linum usitatissimum induced by gold and silver nanoparticles. …”
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Single-cell transcriptomics analysis reveals dynamic changes and prognostic signature in tumor microenvironment of PDAC by Yongsheng Li, Zhilong Ding, Tingxin Cheng, Yihuai Hu, Fei Zhong, Shiying Ren, Shiyan Wang

“…Finally, molecular docking studies validated their potential by confirming stable binding with key protein targets. This study not only provides insights into the evolving TME of PDAC but also offers a new prognostic model and potential therapeutic strategies, contributing to improved management and treatment of this aggressive cancer.…”
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Near-infrared fluorogenic RNA for in vivo imaging and sensing by Zhenyin Chen, Wei Chen, Cun Xu, Haozhi Song, Xin Ji, Haodong Jiang, Hongtao Duan, Zehao Li, Wankai Gao, Tuoxin Yao, Zhongxuan Zhang, Liuqin He, Yulong Yin, Nanyang Yang, Wenjing Tian, Jiahui Wu, Xing Li

“…To address this issue, we identify and modulate red fluorescent protein-like fluorophores to bind Squash, a highly folded fluorogenic RNA. …”
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Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Fac... by Qie Guo, Xiao Li, Meng-Na Cui, Yu Liang, Xiang-Peng Li, Jun Zhao, Li-Na Wei, Xiao-Lei Zhang, Xiang Hua Quan

“…Mitomycin C (MMC) is an antineoplastic antibiotic that inhibits DNA, RNA, and protein synthesis. In recent years, although MMC has proven useful for the treatment of pterygium, its application has been controversial because of its clear toxicity and the possibility of ocular complications. …”
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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation by Iona Davies, Alice E. Adriaenssens, William R. Scott, David Carling, Kevin G. Murphy, James S. Minnion, Stephen R. Bloom, Ben Jones, Tricia M-M. Tan

“…Objectives: There is renewed interest in targeting the glucose-dependent insulinotropic polypeptide receptor (GIPR) for treatment of obesity and type 2 diabetes. G-protein coupled receptor desensitisation is suggested to reduce the long-term efficacy of glucagon-like-peptide 1 receptor (GLP-1R) agonists and may similarly affect the efficacy of GIPR agonists. …”
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Impaired fracture healing is associated with callus chondro-osseous junction abnormalities in periostin-null and osteopontin-null mice by Marc Teitelbaum, Marc Teitelbaum, Maya D. Culbertson, Charlene Wetterstrand, J. Patrick O’Connor, J. Patrick O’Connor

“…Periostin and osteopontin are matricellular proteins abundantly expressed in bone fracture callus. …”
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Comparison of Osteogenesis between Adipose-Derived Mesenchymal Stem Cells and Their Sheets on Poly-ε-Caprolactone/β-Tricalcium Phosphate Composite Scaffolds in Canine Bone Defects... by Yongsun Kim, Seung Hoon Lee, Byung-jae Kang, Wan Hee Kim, Hui-suk Yun, Oh-kyeong Kweon

“…The ALP, runt-related transcription factor 2, osteopontin, and bone morphogenetic protein 7 mRNA levels were upregulated in O-MSCs and OCS as compared to U-MSCs. …”
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The association between Vitamin D deficiency and clinical pregnancy rate in IVF patients with different age by Keyan Wang, Fangli Dong, Shuxia Ma, Zhiqin Bu

“…In addition, the expression of HOXA10 was analyzed using quantitative RT-PCR (qRT-PCR) and western blot in mRNA and protein levels, respectively.ResultsA total of 1459 patients were included. …”
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