Viscosol Treatment Ameliorates Insulin-Mediated Regulation of Dyslipidemia, Hepatic Steatosis, and Lipid Metabolism by Targeting PTP1B in Type-2 Diabetic Mice Model by Idrees Raza, Aamir Sohail, Hamza Muneer, Hajra Fayyaz, Zia Uddin, Amany I. Almars, Waheeb S. Aggad, Hailah M. Almohaimeed, Imran Ullah

“…Type 2 diabetes mellitus (T2DM), a metabolic disorder, has the hallmarks of persistent hyperglycemia, insulin resistance, and dyslipidemia. Protein-tyrosine phosphatase 1B (PTP1B) was found to be overexpressed in many tissues in the case of T2DM and involved in the negative regulation of insulin signaling. …”
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Striatal Injury with 6-OHDA Transiently Increases Cerebrospinal GFAP and S100B by Cristiane Batassini, Núbia Broetto, Lucas Silva Tortorelli, Milene Borsoi, Caroline Zanotto, Fabiana Galland, Tadeu Mello Souza, Marina Concli Leite, Carlos-Alberto Gonçalves

“…Both glial fibrillary acidic protein (GFAP) and S100B have been used as markers of astroglial plasticity, particularly in brain injury; however, they do not necessarily change in the same time frame or direction. …”
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Unveiling the nutritional and antioxidant properties of brown algae resources (Dictyota J.V. Lamouroux) from the Bay of Bengal and Arabian Sea, Indian coast by P. Chellamanimegalai, Geetanjali Deshmukhe, Amjad K. Balange, P. Layana

“…The analysis revealed significant levels of protein (6.67–19.27 %), ash (16.48–52.55 %), lipids (1.37–4.55 %), carbohydrates (25.98–57.07 %), and digestible energy (186.43–311.88 Kcal/100 g), indicating their potential as functional foods. …”
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The Role of Dectin-1-Mediated M1 Macrophage Polarization in Cerebral Ischemia-Reperfusion Injury by Chen Zongyun, Lin Bixia, Ding Fadian, Hong Xiaoping, Chen Hongbin, Deng Yu, Liu Qicai, Ye Xiaoyi, Zeng Kai

“…C57BL/6 was blindly divided into four groups including the sham-operated group and the three different kinds of middle cerebral artery occlusion (MCAO) groups (after 6 hours, 12 hours, and 24 hours after plug removal). The protein expression levels of dectin-1, proapoptosis molecule, and antiapoptosis molecule were measured by using western blot analysis. …”
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Favorable Nonclinical Safety Profile of RSVpreF Bivalent Vaccine in Rats and Rabbits by Jun Zhou, Christopher J. Bowman, Vicki R. Markiewicz, Balasubramanian Manickam, Emily Gomme, Rani S. Sellers, Cynthia M. Rohde

“…Pfizer has developed Abrysvo^®, an unadjuvanted bivalent recombinant protein subunit vaccine containing prefusion-stabilized fusion (F) proteins representing RSV A and RSV B subgroups (RSVpreF). …”
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Changes in Gastric Smooth Muscle Cell Contraction during Pregnancy: Effect of Estrogen by Othman A. Al-Shboul, Hanan J. Al-Rshoud, Ahmed N. Al-Dwairi, Mohammad A. Alqudah, Mahmoud A. Alfaqih, Ayman G. Mustafa, Mohammad Jaafar

“…Single GSMC from early-pregnant and late-pregnant Sprague-Dawley rats were used. Protein and mRNA expression levels of ERs were measured via specifically designed enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR), respectively. …”
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Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin by Bardees M. Foda, Bardees M. Foda, Annika E. Baker, Annika E. Baker, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig, Richard R. Neubig, Richard R. Neubig

“…Here, we investigate the role of apoptosis and the protein pirin in CCG-257081-mediated suppression of drug resistance.MethodsUsing naïve and resistant mouse YUMMER melanoma cells, we studied the effect of the BRAF inhibitor Vem with or without CCG-257081 on real-time growth and apoptosis (activation of caspase, Propidium iodide (PI) staining, and PARP cleavage). …”
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Comprehensive study of Tilapia skin collagen peptide on ileal injury and intestinal flora in rats induced by high altitude hypoxia by Jingyi Wang, Hao Wang, Chunxia Li, Xiaojuan Zhang, Jin Liu, Yanzhou Hu, Ping Qian

“…The results showed that CP could reduce the Disease active index (DAI), increase the mRNA expression level of tight junction protein, and reduce the content of D-lactic acid (D-LA) and Diamine oxidase (DAO) in the serum of rats, and thus alleviate the mechanical injury of intestinal mucosa induced by hypoxia. …”
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Dual Regulation of Ionic Effect on <i>Zostera marina</i> L. Seed Germination and Leaf Differentiation in Low-Salinity Conditions by Peilong Li, Yaping Gao, Zengjie Jiang, Linjie Wang, Xiaoli Sun, Jiaqi Wang, Jing Wang, Haidong Sui, Junwei Wang, Yitao Zhang

“…The total soluble sugar and soluble protein in the seeds decreased. Antioxidant enzyme activities were activated under low-salinity conditions, which supported germination within a tolerable oxidative stress range.…”
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The development of initial material of spring common wheat for breeding for resistance to stem rust (Puccinia graminis Pers. f. sp. tritici), uncluding race Ug99, in Russia by I. F. Lapochkina, O. A. Baranova, V. P. Shamanin, G. V. Volkova, N. R. Gainullin, A. V. Anisimova, D. N. Galinger, E. N. Lazareva, E. V. Gladkova, O. F. Vaganova

“…The lines resistant to these diseases were estimated as to the other economically valuable features: plant height, number of days before heading, ear productivity, weight of 1,000 grains, protein and gluten content in grain, 71 spring wheat line with multiple resistance to two or three diseases and the development of best agronomic characters were selected for the Central region and 20 lines were selected for West Siberia for further testing of their competitiveness with the best varieties and lines in the breeding nurseries. …”
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Exploring the impact of deleterious missense nonsynonymous single nucleotide polymorphisms in the DRD4 gene using computational approaches by Dipto Kumer Sarker, Pallobi Ray, Fayad Bin Abdus Salam, Shaikh Jamal Uddin

“…From the dbSNP database, we found 677 nsSNPs, and then we analyzed their functional consequences, disease associations, and effects on protein stability with fifteen in silico tools. Five variants, including L65ICL1P (rs1459150721), V1163.33D (rs761875546), I1293.46S (rs751467198), I1564.46T (rs757732258), and F2015.47S (rs199609858), were identified as the most deleterious mutations that were also present in the conserved region and showed lower interactions with neighboring residues. …”
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Assessing clenbuterol’s modulation of metabolic and inflammatory pathways in Nile tilapia (Oreochromas niloticous) fed high fat diet by Aya G. Rashwan, Doaa H. Assar, Abdallah S. Salah, Muyassar H. Abualreesh, Shimaa M. R. Salem, Norah Althobaiti, Zizy I. Elbialy

“…The results revealed that compared to the control group, HFD exhibited a marked reduction in FBW, BWG, PER, and body protein percent but significantly increased the FCR, IPF, liver fat percent, and body ash percent with altered hematological parameters, raised serum biomarkers of hepatic and renal injury. …”
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Protection Effect of Endomorphins on Advanced Glycation End Products Induced Injury in Endothelial Cells by Jing Liu, Liping Yan, Ruilan Niu, Limin Tian, Qi Zhang, Jinxing Quan, Hua Liu, Suhong Wei, Qian Guo

“…The expression of p38 mitogen-activated protein kinase (p38 MAPK) was detected by immunofluorescence assay. …”
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Copy number amplification of FLAD1 promotes the progression of triple-negative breast cancer through lipid metabolism by Xiao-Qing Song, Tian-Jian Yu, Yang Ou-Yang, Jia-Han Ding, Yi-Zhou Jiang, Zhi-Ming Shao, Yi Xiao

“…LSD1 subsequently promotes the expression of sterol regulatory element-binding protein 1 (SREBP1) by demethylating dimethyl histone H3 lysine 9 (H3K9me2). …”
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Influence of malting and fermentation on the nutritional composition, thermal stability, structural and physicochemical properties of a gluten-free flour blend of Digitaria exilis... by Oluwatobi Victoria Obayomi, Abiola Folakemi Olaniran, Stephen Olugbemiga Owa

“…The results showed significant changes in the proximate composition. The protein content ranged from 1.77 in FFS to 3.13 % in MFF, while the fat content fat content increased significantly with the addition of date fruit, reaching 1.10 % in MFDF. …”
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Manifestation of agronomically valuable traits in the progeny of a sorghum mutant carrying the genetic construct for RNA silencing of the γ-kafirin gene by L. A. Elkonin, N. V. Borisenko, T. E. Pylaev, O. A. Kenzhegulov, S. Kh. Sarsenova, N. Yu. Selivanov, V. M. Panin

“…One of the reasons for the low nutritional value of sorghum grain is the resistance of its storage proteins (kafirins) to proteolytic digestion, which is due, among other things, to the structural organization of protein bodies, in which γ-kafirin, the most resistant to proteases, is located on the periphery, encapsulating more easily digested α-kafirins. …”
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MRSA PBP2a表达的影响因素及 MecA 基因的检测价值 by 吴本权, 唐英春, 张扣兴, 张天托

“…【目的】探讨温度、pH、盐浓度对甲氧西林耐药金葡菌(methicillin-resistant staphylococcus aureus, MRSA)青霉素结 合蛋白2a( penicillin-binding protein,PBP)表达的影响, 以及 PBP2a编码基因 MecA 的检测价值。【方法】采用聚合酶链式反应 ( PCR)检测 M RSA 特异性 MecA 基因和美国临床实验室标准委员会(NCCLS)推荐的琼脂板稀释法( 32℃,pH7. 2,40 g/L NaCl 苯唑西林 MIC≥4 mg/L)筛选 MRSA。…”
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Utilizing AI for the Identification and Validation of Novel Therapeutic Targets and Repurposed Drugs for Endometriosis by Bonnie Hei Man Liu, Yuezhen Lin, Xi Long, Sze Wan Hung, Anna Gaponova, Feng Ren, Alex Zhavoronkov, Frank W. Pun, Chi Chiu Wang

“…Using an artificial intelligence (AI)‐driven target discovery platform, two unreported therapeutic targets, guanylate‐binding protein 2 (GBP2) and hematopoietic cell kinase (HCK) are identified, along with a drug repurposing target, integrin beta 2 (ITGB2) for the treatment of endometriosis. …”
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Preparation of recombinant myoglobin and investigation of the liquid antigen stability for quality control materials by Yu-Hui Wang, Xi-Feng Sun, Chun-Xin Xu, Feng-Qiang Sun, Rong-Rong Wang, Xiao-Kun Bian, Zhan-Zhao Wang, Qiang Wu

“…This study aimed to evaluate the stability of liquid Mb as quality control materials for Mb determination. Mb protein was expressed in Escherichia coli system and purified using Ni2+ chelate affinity chromatography. …”
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Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway by Mingming Xu, Jiyuan Chen, Lin Gao, Shaoxi Cai, Hangming Dong

“…There are several cytokines involved in the inflammatory response of asthma. Heat shock protein 90α(HSP90α) is one of cytokines involving in inflammation which is a member of the HSPs family. …”
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