S100A8/A9 Molecular Complexes Promote Cancer Migration and Invasion via the p38 MAPK Pathway in Nasopharyngeal Carcinoma by Ning Xu, Bei-Bei Zhang, Xia-Ning Huang, Xiang Yi, Xue-Min Yan, Yan Cai, Qin He, Zi-Jian Han, Yuan-Jiao Huang, Wei Liu, Ai-Jun Jiao

“…Intriguingly, exogenous S100A8/A9 protein stimulation could dramatically enhance NPC migration and invasion abilities. …”
Get full text

Comparative analysis of galectin-1, galectin-3, and galectin-8 signatures in normal and choriocarcinoma trophoblast cell lines by Jovanović Krivokuća Milica, Legner Janko, Ćujić Danica, Vilotić Aleksandra, Grubiša Ivana, Vićovac Ljiljana, Bojić-Trbojević Žanka

“…Expression levels of these galectins at both mRNA and protein levels were evaluated using PCR, qPCR, and Western blotting, while their cellular localization and distribution were assessed through immunocytochemistry, subcellular fractionation, and Western blotting. …”
Get full text

ERF114/115/109 are essential for jasmonate-repressed non-canonical JAZ8 activity in JA signaling by Jiaxuan Sui, Qianlan Yin, Yiying Chen, Min Sun, Xianzheng Yuan, Zhaojun Ding, Xiangpei Kong

“…Summary: Jasmonate (JA), a key plant hormone, regulates various aspects of plant development and stress responses, primarily through the degradation of canonical jasmonate-ZIM domain (JAZ) proteins by the SCFCOI1 complex. While JAZ8, a non-canonical JAZ protein lacking the degron signal, has been shown to repress JA responses, the mechanism by which JA inhibits JAZ8 activity remains unclear. …”
Get full text

Enhancing immunotherapy efficacy in colorectal cancer: targeting the FGR-AKT-SP1-DKK1 axis with DCC-2036 (Rebastinib) by Xiguang Chen, Qiting Zeng, Liyang Yin, Bingru Yan, Chen Wu, Jianbo Feng, Ying Wu, Jun He, Wenjun Ding, Jing Zhong, Yingying Shen, Xuyu Zu

“…Through comprehensive multi-omics investigations, significant shifts in both gene and protein expression profiles were detected, notably a marked decrease in DKK1 levels. …”
Get full text

SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis by Mario Saare, Uku Hämarik, Rainis Venta, Marina Panarina, Chiara Zucchelli, Maire Pihlap, Anu Remm, Kai Kisand, Urve Toots, Kaidi Möll, Riina Salupere, Giovanna Musco, Raivo Uibo, Pärt Peterson

“…The widely expressed SP100 and the leukocyte-specific proteins SP110 and SP140 have been associated with transcriptional regulation and various human diseases. …”
Get full text

Using network pharmacology and molecular docking technology, proteomics and experiments were used to verify the effect of Yigu decoction (YGD) on the expression of key genes in ost... by Kun Yan, Rui-Kun Zhang, Jia-Xin Wang, Hai-Feng Chen, Yang Zhang, Feng Cheng, Yi Jiang, Min Wang, Ziqi Wu, Xiao-Gang Chen, Zhi-Neng Chen, Gui-Jin Li, Xin-Miao Yao

“…This study confirmed that it may promote osteoblast proliferation and protect osteoblast function by up-regulating the expression of proteins related to HIF signal pathway.…”
Get full text

Prevalence, influencing factors, and prediction model construction of anemia in ankylosing spondylitis based on real-world data: An exploratory study. by Yifan Gong, Kun Yang, Zhaoyang Geng, Hongxiao Liu

“…There were significant differences in gender, ossification, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) indicators, and clinical assessment scale results between the two groups (P < 0.05). …”
Get full text

Effects of Different Levels of <i>Lycium barbarum</i> Flavonoids on Growth Performance, Immunity, Intestinal Barrier and Antioxidant Capacity of Meat Ducks by Minhang Tu, Gentan Cai, Longfei Ma, Leyan Yan, Tian Wang, Zhendan Shi, Chao Wang, Zhe Chen

“…Dietary supplementation with 500 mg/kg LBFs significantly up-regulated the mRNA expression of genes associated with intestinal barrier function and antioxidant capacity in the jejunal and ileal mucosa, as well as the protein expression of these antioxidant genes, and led to a significant reduction in the mRNA expression of pro-apoptotic and inflammatory-related genes. …”
Get full text

Iconography of abnormal non-neuronal cells in pediatric focal cortical dysplasia type IIb and tuberous sclerosis complex by Joyce Zhang, Deneen Argueta, Xiaoping Tong, Harry V. Vinters, Gary W. Mathern, Carlos Cepeda

“…In addition, due to the heterogeneity of these cells, a new classification scheme based on morphological, electrophysiological, and gene/protein expression in FCDIIb and TSC cases seems warranted.…”
Get full text

Polytene chromosomes reflect functional organization of the Drosophila genome by D. S. Sidorenko, T. Yu. Zykova, V. A. Khoroshko, G. V. Pokholkova, S. A. Demakov, J. Larsson, E. S. Belyaeva, I. F. Zhimulev

“…The smallest fourth chromosome of Drosophila with an atypical protein composition of chromatin is a special case.  …”
Get full text

Development of a Copro-RPA-CRISPR/Cas12a assay to detect Echinococcus granulosus nucleic acids isolated from canine feces using NaOH-based DNA extraction method. by Guoqing Shao, Xiaowei Zhu, Ruiqi Hua, Yanxin Chen, Guangyou Yang

“…<h4>Methods</h4>We combined recombinase polymerase amplification (RPA) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) with a CRISPR-associated protein 12a (Cas12a) system, forming the RPA-CRISPR/Cas12a assay. …”
Get full text

Seasonal dynamics of dissolved organic matter in a small tropical estuary-coastal bay continuum: distribution, transformation, flux, and global perspectives by Pengfei Liu, Kuan Jiang, Qi Tan, Fajin Chen, Renming Jia, Chao Wang, Chao Wang, Chao Wang, Chao Wang

“…Conversely, seawater DOM, enriched in protein-like FDOM, varied with the West-Guangdong Coastal Current and its associated primary production. …”
Get full text

Nystose attenuates bone loss and promotes BMSCs differentiation to osteoblasts through BMP and Wnt/β-catenin pathway in ovariectomized mice by Qi Zhang, Sijing Hu, Jianjun Wu, Peng Sun, Quanlong Zhang, Yang Wang, Qiming Zhao, Ting Han, Luping Qin, Qiaoyan Zhang

“…Furthermore, we found that NST increased osteogenic differentiation, inhibited adipogenic differentiation of BMSCs in vitro, and upregulated the expression of the key proteins of BMP and Wnt/β-catenin pathways. In addition, Noggin and Dickkopf-related protein-1 (DKK-1) reversed the effect of NST on osteogenic differentiation and expression of the key proteins in BMP and Wnt/β-catenin pathway. …”
Get full text

Enhanced bioaccumulation and toxicity of Fenpropathrin by polystyrene nano(micro)plastics in the model insect, silkworm (Bombyx mori) by Abrar Muhammad, Zhaoyi Qian, Yu Li, Xiaoyu Lei, Junaid Iqbal, Xiaoqiang Shen, Jintao He, Nan Zhang, Chao Sun, Yongqi Shao

“…Additionally, the pollutants caused physical and oxidative damage to the midgut and altered gene expression related to juvenile hormone (JH) and silk protein synthesis. The gut microbiome analysis revealed significant changes and reduced abundance of potentially beneficial bacteria. …”
Get full text

Nutritional contents and antimicrobial activity of the culinary-medicinal mushroom Leccinum scabrum by M.L. Gargano, G. Balenzano, G. Venturella, M.M. Cavalluzzi, N.P. Rotondo, G. Lentini, F. Cirlincione, G. Mirabile, E. Zapora, M. Wołkowycki, L. Pecoraro, V. Ferraro

“…The analysis of a dry sample of L. scabrum showed a significant content of vitamins and minerals and also a remarkable content of carbohydrates, protein, dietary fibre, total sugars, total free amino acids, and polyunsaturated fatty acids. …”
Get full text

Effects of oxidation and precursors (lysine, glyoxal and Schiff base) on the formation of Nε-carboxymethyl-lysine in aged, stored and thermally treated chicken meat by Suhong Huang, Xiaoli Dong, Yulong Zhang, Ming Huang, Yuandong Zheng

“…Furthermore, CML was extremely positively correlated with fat oxidation (R2 = 0.793, P < 0.01), protein oxidation (R2 = 0.917, P < 0.01) and glyoxal (R2 = 0.678, P < 0.05), and was negatively correlated with lysine (R2 = 0.536, P < 0.05). …”
Get full text

Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer by Yun Teng, Hongmei Zhao, Guoqing Xue, Guohui Zhang, Yanbin Huang, Wei Guo, Kun Zou, Lijuan Zou

“…DNA damage in irradiated cells with MICAL2 knockdown or overexpression was evaluated using the comet assay, while γ-H2AX and Rad51 protein levels were detected by WB. In vivo experiments validated the tumorigenic and radioresistance functions of MICAL2. …”
Get full text

ZSH‐2208: A novel retinoid with potent anti‐tumour effects on ESCC stem cells via RARγ–TNFAIP3 axis by Ruoxue Chen, Xuan Huang, Jiayun Hou, Junjie Ni, Wenrui Zhao, Quanlin Li, Heng Jiao, Xin Cao

“…Low levels of TNFIP3 protein may be associated with improved survival probability in ESCC patients.…”
Get full text

Multilocation Test of Prospective Composite Sticky Corn Varieties With High Production in Indonesia by null Edy, Andi Takdir Makkulawu, null Aminah, St Subaedah

“…Based on the approximate test, JPI-1, JPI-3, and JPI-4 had superior protein content of 11.64, 11.69%–11.86% than the 3 comparative varieties, respectively. …”
Get full text

Integrative evidence reveals a new species of Hysterothylacium (Nematoda: Ascaridoidea), with the characterization of its complete mitochondrial genome by Hui-Xia Chen, Hai-Xia Qiao, Wen-Ting Zhao, Xiao-Hong Gu, Liang Li

“…The mitogenome of H. hainanense sp. n. is 14059 bp in length, including 12 protein coding genes (missing atp8), 22 tRNA genes, 2 rRNA genes and 2 non-coding regions, which has 67.0% of overall A + T content, and represents the lowest level of A + T content in the ascaridoid mitogenomes reported so far. …”
Get full text