Effects of Different Voided Urine Sample Storage Time, Temperature, and Preservatives on Analysis with Multiplex Bead-Based Oncuria Bladder Cancer Immunoassay by Sunao Tanaka, Kaoru Murakami, Toru Sakatani, Riko Lee, Wayne Hogrefe, Fernando Siguencia, Charles J. Rosser, Hideki Furuya

“…The Oncuria simultaneously quantifies 10 protein analytes in urine to generate a bladder cancer diagnostic signature. …”
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Blimp-1 orchestrates macrophage polarization and metabolic homeostasis via purine biosynthesis in sepsis by Wenjuan Peng, Qiushi Qin, Rui Li, Yujia Liu, Lan Li, Yue Zhang, Liuluan Zhu

“…Macrophage polarization plays a critical role in pathogenesis of sepsis, and the influence of B lymphocyte-induced maturation protein-1 (Blimp-1) on this polarization is an underexplored yet pivotal aspect. …”
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A novel anti-epileptogenesis strategy of temporal lobe epilepsy based on nitric oxide donor by Xian-Hui Zhu, Ya-Ping Zhou, Qiao Zhang, Ming-Yi Zhu, Xiao-Wei Song, Jun Li, Jiang Chen, Yun Shi, Kang-Jian Sun, Yong-Jie Zhang, Jing Zhang, Tian Xia, Bao-Sheng Huang, Fan Meng, Qi-Gang Zhou

“…Replenishment of hilar nNOS protein blocked epileptogenic development and memory impairment in pilocarpine-induced TLE mice. …”
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Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms by Vladan P. Čokić, Olivera Mitrović-Ajtić, Bojana B. Beleslin-Čokić, Dragana Marković, Marijana Buač, Miloš Diklić, Nada Kraguljac-Kurtović, Svetozar Damjanović, Pavle Milenković, Mirjana Gotić, Puri K. Raj

“…IL-6 cytokine levels were increased in plasma, as well as IL-6 protein levels in bone marrow stroma of MPNs, dependent on JAK2V617F mutation presence in ET and PMF patients. …”
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Frailty and Sarcopenia Assessment in Patients with Advanced Chronic Liver Disease in a Tertiary Center in Romania by Petruta Violeta Filip, Denisa Cuciureanu, Corina Silvia Pop, Andreea Nicoleta Marinescu, Florentina Furtunescu, Laura Sorina Diaconu

“…Biomarkers like albumin, sodium, C-reactive protein, bilirubin, and platelets were statistically significant as mortality predictors in all four groups. …”
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A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1 by Zhen Zhang, Yinghui Hu, Ningning Xu, Wenjun Zhou, Lei Yang, Rongping Chen, Rui Yang, Jia Sun, Hong Chen

“…The GLP1 receptor antagonist exendin (9-39) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) family inhibitor LY294002 not only suppressed protein kinase B (Akt), pancreatic and duodenal homeobox 1 (Pdx1), forkhead box O 1 (FoxO1), and mast cell function-associated antigen A (MafA) mRNA expression but also increased MAFB expression. …”
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FXR Activation Accelerates Early Phase of Osteoblast Differentiation Through COX-2-PGE₂-EP4 Axis in BMP-2-Induced Mouse Mesenchymal Stem Cells by Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno

“…In this study, we investigated the regulatory mechanism underlying FXR-activated osteoblast differentiation using bone morphogenetic protein-2 (BMP-2)-induced mouse ST-2 mesenchymal stem cells. …”
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Altered Expression of Hematopoiesis Regulatory Molecules in Lipopolysaccharide-Induced Bone Marrow Mesenchymal Stem Cells of Patients with Aplastic Anemia by Chandra Prakash Chaturvedi, Naresh Kumar Tripathy, Ekta Minocha, Akhilesh Sharma, Khaliqur Rahman, Soniya Nityanand

“…., macrophage inflammatory protein (MIP)-1α, tumor necrosis factor (TNF)-α, granulocyte colony-stimulating factor (G-CSF), stromal cell-derived factor (SDF)-1α, stem cell factor (SCF), and transforming growth factor (TGF)-β in lipopolysaccharide-induced bone marrow mesenchymal stem cells (BM-MSCs) and levels of their soluble forms in the culture supernatants of BM-MSCs and BM plasma of patients with acquired aplastic anemia (AA) (n=29) and controls (n=29). …”
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NMDA Reduces Tau Phosphorylation in Rat Hippocampal Slices by Targeting NR2A Receptors, GSK3β, and PKC Activities by Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicotte

“…Accordingly, we found that GSK3β inactivation by a protein kinase C- (PKC-) dependent mechanism is involved in the NMDA-induced reduction of Tau phosphorylation at Ser199-202 epitopes. …”
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Synergistic Activations of REG Iα and REG Iβ Promoters by IL-6 and Glucocorticoids through JAK/STAT Pathway in Human Pancreatic β Cells by Akiyo Yamauchi, Asako Itaya-Hironaka, Sumiyo Sakuramoto-Tsuchida, Maiko Takeda, Kiyomi Yoshimoto, Tomoko Miyaoka, Takanori Fujimura, Hiroki Tsujinaka, Chikatsugu Tsuchida, Hiroyo Ota, Shin Takasawa

“…Reg (Regenerating gene) gene was originally isolated from rat regenerating islets and its encoding protein was revealed as an autocrine/paracrine growth factor for β cells. …”
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Impaired Glucose Metabolisms of Patients with Obstructive Sleep Apnea and Type 2 Diabetes by Ye Zhang, Yanpeng Xing, Haibo Yuan, Xiaokun Gang, Weiying Guo, Zhuo Li, Guixia Wang

“…This group additionally underwent a steamed bread meal test and measurement of HbA1c, C-reactive protein, tumor necrosis factor-α, interleukin 6, morning plasma cortisol, and growth hormone. …”
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Inhibition of miR-182-5p Targets FGF9 to Alleviate Osteoarthritis by Yang Sun, Sanmao Su, Mengjun Li, Ang Deng

“…The gene expression of miR-182-5p and FGF9 was calculated. The protein FGF9 was tested by western blotting. Cell counting kit-8 (CCK8), plate cloning assay, and flow cytometry were conducted to evaluate cell proliferation and apoptosis. …”
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Interleukin-10 Polymorphisms in Association with Prognosis in Patients with B-Cell Lymphoma Treated by R-CHOP by Min Kyeong Kim, Kyong-Ah Yoon, Eun Young Park, Jungnam Joo, Eun Young Lee, Hyeon-Seok Eom, Sun-Young Kong

“…Previous studies have revealed that the transcription of IL10 mRNA and its protein expression may be infl uenced by several single-nucleotide polymorphisms in the promoter and intron regions, including rs1800896, rs1800871, and rs1800872. …”
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Quality of bread rolls fortified with date fruit pomace: Structure, proximate composition, staling, and sensory evaluation by Alaa Almoumen, Huda Mohamed, Bhawna Sobti, Mutamed Ayyash, Rabih Kamleh, Ali H. Al-Marzouqi, Afaf Kamal-Eldin

“…The proximate composition (on dry basis %) ranged as follows: protein (15.4–16.6 %), ash (2.1–2.7 %), fat (1.8–2.8 %), carbohydrates (73.6–57.5 %), and total dietary fibre (5.7–22.4 %). …”
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Exploring diazotrophic diversity: unveiling Nif core distribution and evolutionary patterns in nitrogen-fixing organisms by Bruno Thiago de Lima Nichio, Roxana Beatriz Ribeiro Chaves, Fábio de Oliveira Pedrosa, Roberto Tadeu Raittz

“…Previous studies have established a minimal set of Nif proteins, known as the Nif core, which includes NifH, NifD, NifK, NifE, NifN, and NifB. …”
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Thickness of Subcutaneous Fat Is a Predictive Factor of Incisional Surgical Site Infection in Crohn’s Disease Surgery: A Retrospective Study by Xingchen Cai, Weisong Shen, Zhen Guo, Yi Li, Lei Cao, Jianfeng Gong, Weiming Zhu

“…Additionally, C-reactive protein (CRP) concentrations (OR 1.059, P=0.003) were also possible predictors of iSSI, as indicated by both univariate and multivariate analysis. …”
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Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease by Caterina Oriana Aragona, Egidio Imbalzano, Federica Mamone, Valentina Cairo, Alberto Lo Gullo, Angela D’Ascola, Maria Adriana Sardo, Michele Scuruchi, Giorgio Basile, Antonino Saitta, Giuseppe Mandraffino

“…MEDLINE was searched using keywords related to “endothelial progenitor cells” and “endothelium” and, for the different categories, respectively, “smoking”; “blood pressure”; “diabetes mellitus” or “insulin resistance”; “dyslipidemia”; “aging” or “elderly”; “angina pectoris” or “myocardial infarction”; “stroke” or “cerebrovascular disease”; “homocysteine”; “C-reactive protein”; “vitamin D”. Study Selection. Database hits were evaluated against explicit inclusion criteria. …”
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Polyurethane-Keratin Membranes: Structural Changes by Isocyanate and pH, and the Repercussion on Cr(VI) Removal by María D. Manrique-Juárez, Ana L. Martínez-Hernández, Oscar F. Olea-Mejía, Jaime Flores-Estrada, José L. Rivera-Armenta, Carlos Velasco-Santos

“…When pH in keratin solution is low (2.5), the protein separates from water, and a more closed cell in the membrane is obtained affecting its mechanical properties. …”
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Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies by Yang Yang, Ying Zhang, Yuan Li, Xinjin Zhou, Kazuho Honda, Dedong Kang, Muxi Wang, Jing-Hua Yang, Zongping Xia, Yuan Wei, Lu Liu, Ruimin Hu, Takashi Takaki, Guolan Xing

“…The glomerular abundances of three proteins related to classical pathway (CP) (C1q, C1r, C1s), five proteins related to alternative pathway (AP) (CFB, CFH, CFHR1, CFHR3, CFHR5), one common protein related to CP and lectin pathway (LP) (C4), and six proteins related to terminal complement pathway (C3, C5, C6, C7, C8, C9) were significantly increased in DKD. …”
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Apigenin suppresses osteoarthritis progression by inhibiting pyroptosis via SIRT1/mTOR pathway-mediated mitophagy by Jiahao Ying, Shijie Li, Anna Ying, Yindong Ding, Xiaoyin Zhu, Jiahao Lin, Kehe Yu

“…Techniques such as Western blot analysis, Enzyme-linked Immunosorbent Assay (ELISA), and immunofluorescence staining were applied to examine protein level changes in vitro experiments. In vitro assays indicated that Api significantly reduces the levels of pro-inflammatory mediators and prevents the degradation of the ECM. …”
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