Perinatal Factors Associated with Cardiovascular Disease Risk among Preschool-Age Children in the United States: An Analysis of 1999–2008 NHANES Data by Sarah E. Messiah, Kristopher L. Arheart, Steven E. Lipshultz, Emmalee S. Bandstra, Tracie L. Miller

“…We examined the relationships between selected perinatal and early infancy factors (maternal smoking during pregnancy, infant low birthweight, breastfeeding, and early introduction of solid foods [<6 months of age] and increased BMI [≥85th, ≥95th percentiles for age, sex]), waist circumference (WC), C-reactive protein (CRP), triglycerides, total cholesterol, low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (HDL) cholesterol, and decreased HDL cholesterol during early childhood. …”
Get full text

Endophytic Colletotrichum siamense for Biocontrol and Resistance Induction in Guarana Seedlings by Luana L. Casas, José O. Pereira, Pedro Q. Costa-Neto, José F. Silva, Lucas N. Almeida, Roberto A. Bianco, João L. Azevedo

“…Therefore, the present study verified whether C. siamense, an endophytic fungus infected with a mycovirus, could protect the seedlings and reduce or eliminate the characteristic symptoms. Total proteins and enzymatic activities of pathogenesis-related proteins (PRPs), including peroxidase (POX), chitinase (CHI), and phenylalanine ammonia lyase (PAL), were quantified. …”
Get full text

Macrophage P2X7 Receptor Function Is Reduced during Schistosomiasis: Putative Role of TGF-β1 by Suellen D’arc Santos Oliveira, Hayandra Ferreira Nanini, Luiz Eduardo Baggio Savio, Mariana Caldas Waghabi, Claudia Lucia Martins Silva, Robson Coutinho-Silva

“…Western blot and qRT-PCR data showed no difference in P2X7 protein and mRNA between uninfected, infected, and TGF-β1-treated groups. …”
Get full text

Comparative proteomics analysis reveals the domesticated Lepista sordida primordium differentiation regulation mechanism and the subsequent different development patterns in the pi... by Xiuqing Yang, Meijie Liu, Yanjiao Zhang, Lizhong Guo, Junqi Wang, Sizhu Li, Yan Zhang, Xiaobo Li, Lili Xu, Hao Yu

“…The mycelium before the primordium differentiation mainly expressed high levels of mitochondrial functional proteins and carbon dioxide concentration regulatory proteins. …”
Get full text

Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax by Caroline A. Coughlin, Dhanvantri Chahar, Marianna Lekakis, Abdessamad A. Youssfi, Lingxiao Li, Evan Roberts, Natalia Campos Gallego, Claude-Henry Volmar, Ola Landgren, Shaun Brothers, Anthony J. Griswold, Catalina Amador, Daniel Bilbao, Francesco Maura, Jonathan H. Schatz

“…Here, we build on recent findings implicating gain-of-function mutations in the BCL10 signaling protein as drivers of resistance to Bruton’s tyrosine kinase (BTK) inhibitors. …”
Get full text

Aspergillus fumigatus is responsible for inflammation in a murine model of chronic obstructive pulmonary disease exacerbation by Alexandra Bouyssi, Alexis Trecourt, Tanguy Déméautis, Florence Persat, Olivier Glehen, Martine Wallon, Gilles Devouassoux, Abderrazzak Bentaher, Jean Menotti

“…Moreover, a Bio-Plex approach on bronchoalveolar lavage of cigarette smoke and A. fumigatus-treated mice showed significant increases in multiple inflammatory proteins secreted in the lung. Conclusions There was a stronger inflammatory response after cigarette smoke exposure with A. fumigatus compared to cigarette smoke alone. …”
Get full text

Quantifying intratumoral biomarker heterogeneity in tubo-ovarian high-grade serous carcinoma to optimize clinical translation by Aline Talhouk, Derek S. Chiu, Liliane Meunier, Kurosh Rahimi, Cécile Le Page, Monique Bernard, Diane Provencher, David G. Huntsman, Anne Marie Mes Masson, Martin Köbel

“…We provide power calculations to achieve reliability of > 0.60 and recommend testing emerging protein biomarkers to see whether they reach a clinically acceptable benchmark level of ITH.…”
Get full text

RIPK3-Mediated Necroptosis and Neutrophil Infiltration Are Associated with Poor Prognosis in Patients with Alcoholic Cirrhosis by Zhenzhen Zhang, Guomin Xie, Li Liang, Hui Liu, Jing Pan, Hao Cheng, Hua Wang, Aijuan Qu, Yan Wang

“…Recent data suggests that receptor-interacting protein kinase-3- (RIPK3-) mediated necroptosis plays an important role in alcoholic cirrhosis. …”
Get full text

Estimation of cytoprotective effect of bismuth tripotassium dicitrate on gastric mucosa at <i>H. pylori</i> eradication and long-term drug intake by A. V. Kononov, S. I. Mozgovoi, L. B. Rybkina, S. S. Bunova, A. G. Shimanskaya

“…Cells with damaged DNA were revealed by immunehistochemical detection of Р53 protein.Results. No correlation between neutrophilic infiltration of SM and р53-positive cells quantity in generative zone (–0,14≤r≤0,08) was revealed in both groups. …”
Get full text

Antimicrobial Properties of α-MSH and Related Synthetic Melanocortins by A. Catania, G. Colombo, C. Rossi, A. Carlin, A. Sordi, C. Lonati, F. Turcatti, P. Leonardi, P. Grieco, S. Gatti

“…It is remarkable that this mechanism of action in yeast mimics the influences of α-MSH in mammalian cells in which the peptide binds to G-protein-linked melanocortin receptors, activates adenylyl cyclase, and increases cAMP. …”
Get full text

Elucidating the expression and role of cGAS in pan-cancer using integrated bioinformatics and experimental approaches by Zhen Lian, Xue Liu, Xue Li

“…The HPA database was used to explore the protein levels of cGAS in normal tissues and cancers. …”
Get full text

Evaluation of selected agricultural by-products as potential feeds for rearing edible grasshopper, Ruspolia differens (Serville) (Orthoptera: Tettigoniidae) by Amos Acur, Geoffrey Maxwell Malinga, Philip Nyeko

“…Abstract Background Crop residues and agro-industrial by-products constitute an enormous pool of unused and often neglected resources that could be productively utilized for rearing edible insects to meet the global demand for animal-based protein. Utilizing such products as feedstocks can lower the cost of edible insect production and reduce associated environmental pollution. …”
Get full text

Effects of anti-CD4 antibody treatment on calcium ions influx in peanut-sensitized C3H/HeJ mice by Junjuan Wang, Cui Zhou, Shiwen Han, Zainabu Majid, Na Sun, Huilian Che

“…C3H/HeJ mice sensitized with peanut protein extract (PPE) were injected with anti-CD4 antibodies for 4 weeks. …”
Get full text

Effects of Cellulase and <i>Lactiplantibacillus plantarum</i> on Chemical Composition, Fermentation Characteristics, and Bacterial Community of <i>Pennisetum giganteum</i> z.x.lin... by Zhili Wu, Xiongfei Zhang, Rongnuo Li, Jingtao Hui, Lu Deng, Inho Kim, Jie Wei, Junhu Yao, Xinjian Lei

“…Compared with CON, LP exhibited higher (<i>p</i> < 0.05) levels of water-soluble carbohydrate (WSC), crude protein (CP), and lactic acid (LA), along with a higher (<i>p</i> < 0.05) ratio of LA/acetic acid (AA). …”
Get full text

Characterization and pathogenicity of a novel avian orthoreovirus in China by Shunyan Chen, Jialin Yang, Li Li, Yawei Guo, Shenghua Yang, Zetao Su, Sucan Zhao, Xuesong Li, Wencheng Lin, Yunping Du, Lijuan Yin, Lianxiang Wang, Feng Chen

“…Notably, 50 unique amino acid substitutions were identified in the sigma C protein. Pathogenicity tests demonstrated that FJ202311 caused severe arthritis and tenosynovitis in broilers. …”
Get full text

The Combined Use of Platelet-Rich Plasma Clot Releasate and Allogeneic Human Umbilical Cord Mesenchymal Stem Cells Rescue Glucocorticoid-Induced Osteonecrosis of the Femoral Head by Yanxue Wang, Shuo Luan, Ze Yuan, Shaoling Wang, Shengnuo Fan, Chao Ma, Shaoling Wu

“…Moreover, the PRCR and UC-MSC application significantly improved the alkaline phosphatase (ALP) and alizarin red (ALR) staining of BMSCs and tube formation capacity of HUVECs and promoted the protein expression of RUNX2 in BMSCs and VEGF in HUVECs. …”
Get full text

Efficacy of Group O Washed Red Blood Cell Transfusion on Vital Signs and Hematologic Stability in Trauma Patients With Different Blood Types by Gou XJ, Li LF, He XL, Chen X, Yu AY, Tian WY

“…Significant changes were noted in platelet count (PLT), activated partial thromboplastin time (APTT), and C-reactive protein (CRP) following transfusion (P < 0.05). Both blood pressure and SI enhanced significantly after transfusion (P < 0.05), although no significant change in heart rate (HR) was detected (P = 0.87). …”
Get full text

Modulation of hormonal, metabolic, inflammatory and oxidative stress biomarkers in women with polycystic ovary syndrome following combined (resistant and endurance) training: a ran... by Masoud Nasiri, Amirabbas Monazzami, Solmaz Alavimilani, Zatollah Asemi

“…At the baseline and end-of-intervention, metabolic profiles including fasting plasma glucose, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), lipid profiles, testosterone, free androgen index (FAI), sex hormone binding globulin, anti-Müllerian hormone, malondialdehyde, total antioxidant capacity, and high Sensitive-C reactive protein were evaluated. Results After eight-week intervention in training group, insulin (P < 0.001), HOMA-IR (P < 0.001), total cholesterol (P < 0.001), LDL-cholesterol (P < 0.001), total testosterone (P < 0.001), AMH ( P = 0.02),MDA (P = 0.04) and FAI (P < 0.001) were significantly decreased, while QUICKI (P = 0.002) was remarkably increased compared with the control group. …”
Get full text

Moroccan Monofloral Bee Pollen: Botanical Origin, Physicochemical Characterization, and Antioxidant Activities by El Ghouizi Asmae, El Menyiy Nawal, Meryem Bakour, Badiaa Lyoussi

“…Potassium and magnesium were the most abundant minerals in bee pollen samples; heavy metals were not detected except for two samples (P5 and P6) where a very small amount of lead was found. The protein content in these samples varied between 19.86 ± 0.36 mg/100 g and 30.32 ± 0.12 mg/100 g of bee pollen. …”
Get full text

PD-1 suppresses human CD38+ circulating Tfr cells and regulates humoral immunity by Heng Zhang, Hui Zheng, Lin Guo, Ying Tong, Xiaolu Ma, Yanchun Wang, Renquan Lu, Cuncun Chen, Suhong Xie

“…Background Anti-programmed cell death protein 1 (anti-PD-1) antibodies have achieved revolutionary success in cancer therapy. …”
Get full text