PD-L1 monoclonal antibody alleviated MI injury of left ventricular function via modulating CD47/SHP2/SIRPα/SYK/FcγR signalings in tumor associated macrophages by Deyou Kong, Yongzhen Chen, Yajuan Yin, Zhikun Liu, Fang Yang, Xiaohong Li, Dongxing Shen, Jun Zhang

“…In vitro experiments involved dividing macrophages, treated with different inducers, into 8 groups. Protein expression levels in each group were analyzed by Western blotting, and the macrophages were transplanted into experimental mice for observation. …”
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Correlation analysis between epicardial adipose tissue and acute coronary syndrome by Gao Zhihong, Zuo Yuqiang, Jia Linyi, Yin Yuling, Yang Xu, Xu Lei, Hao Zengfang

“…Systolic blood pressure, EATV, EATD, fasting blood glucose, triglycerides, and high-sensitivity C-reactive protein were significantly elevated in the ACS group compared with the non-ACS group (all p < 0.05). …”
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Variation in Nutritional Qualities and Antioxidant Capacity of Different Leaf Mustard Cultivars by Wenjuan Cheng, Anqi Luo, Hongxia Li, Zhifeng Chen, Zhongrong Guan, Victor Hugo Escalona, Duchen Liu, Yu’nong Zhou, Fen Zhang, Zhi Huang, Yi Tang, Huanxiu Li, Bo Sun, Kehao Liang, Xuena Yu

“…Cultivar YB2 showed higher contents of soluble sugar, soluble protein, ABTS antioxidant capacity, and total glucosinolates. …”
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Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis by Xiaohan Liu, Yang Zhang, Youzhao Wang, Yujie Yang, Zhe Qiao, Ping Zhan, Huiying Jin, Qianqian Xu, Wei Tang, Yu Sun, Yan Zhang, Fan Yi, Min Liu

“…Myeloid‐derived growth factor (MYDGF), a novel secreted protein, plays important roles in multiple cardiovascular diseases, but the function of MYDGF in tubular epithelial cells remains unknown. …”
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Projections from thalamic nucleus reuniens to hippocampal CA1 area participate in context fear extinction by affecting extinction-induced molecular remodeling of excitatory synapse... by Magdalena Ziółkowska, Narges Sotoudeh, Anna Cały, Monika Puchalska, Roberto Pagano, Malgorzata Alicja Śliwińska, Ahmad Salamian, Kasia Radwanska

“…We also observe CFE-specific structural changes of excitatory synapses and expression of the synaptic scaffold protein, PSD-95, in both strata innervated by RE, but not in SR. …”
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γ-Aminobutyric Acid (GABA) Metabolic Bypass Plays a Crucial Role in Stress Tolerance and Biofilm Formation in <i>C. sakazakii</i> ATCC 29544 by Jiangchao Wu, Yigang Yu, Fengsong Liu, Yifang Cao, Jiahao Ren, Yiting Fan, Xinglong Xiao

“…Gamma-aminobutyric acid (GABA) is a kind of non-protein amino acid that acts as an osmoprotectant. …”
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Inhibitory effects of oxyresveratrol on ERK and Smad1/2 phosphorylation and HSC activation in preventing carbon tetrachloride-induced rat liver fibrosis by Guliang Yang, Jianfeng Zhan, Yiwen Yang, Li Yuan, Peilei Wang, Chi-Tang Ho, Shiming Li

“…Furthermore, the mRNA transcription levels of α-smooth muscle actinn (α-SMA), desmin, and two MMPs (MMP2 and MMP9) were reduced and the expression levels of transforming growth factor β1 (TGF-β1), p- small mother against decapen-taplegic protein (Smad)1/2 and p-extracellular signal-regulated kinases (ERK)1/2 in the liver tissue down-regulated dramatically. …”
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Innovative strategies for valorization of byproducts from soybean industry: A review on status, challenges, and sustainable approaches towards zero-waste processing systems by Ahasanul Karim, Emmanuel Freddy Osse, Seddik Khalloufi

“…Various commercially viable products derived from repurposing the carbohydrate and protein fractions of diverse soy byproducts are highlighted. …”
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Frozen Fermented Dairy Snacks with Probiotics and Blueberry Bagasse: Stability, Bioactivity, and Digestive Viability by Alejandra Hurtado-Romero, Andrea Zepeda-Hernández, Javier Cárdenas-Rangel, Ricardo Aguilar-Márquez, Luis Eduardo Garcia-Amezquita, Danay Carrillo-Nieves, Tomás García-Cayuela

“…Four formulations (LA5, LGG, LA5-BERRY, and LGG-BERRY) were analyzed for their nutritional, physicochemical, functional, and sensory properties. High protein content (>17% d.w.) and increased dietary fiber (5.77–5.88% d.w.) were observed in bagasse-containing formulations. …”
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The extremely halotolerant black yeast Hortaea werneckii - a model for intraspecific hybridization in clonal fungi by Polona Zalar, Jerneja Zupančič, Cene Gostinčar, Janja Zajc, G. Sybren de Hoog, Filomena De Leo, Armando Azua-Bustos, Nina Gunde-Cimerman

“…Due to the limited number of phylogenetically informative characters in the ribosomal DNA dataset, the partial genes encoding for β-tubulin (BTB) and mini-chromosome maintenance protein (MCM7) were also sequenced. The use of these genes was hampered by ambiguous sequences obtained by Sanger sequencing, as a consequence of the diploid and highly heterozygous genome of many H. werneckii strains. …”
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Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro i... by Shiya Yu, Shiyao Zheng, Jinwei Qiu, Hongming Lin, Xiaojuan Yu, Huiyan Chen, Junhong Wu, Weihang Wu, Jiong Chen, Yongyuan Chen, Jianwei Chen, Hu Zhao, Yu Wang

“…Pregnancy-associated plasma protein-A(PAPPA) is thought to play an important role in the occurrence and progression of cancer, yet its significance in the development of GC has not been reported. …”
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Nutritional and Flavor Characteristics of Lactobacillus rhamnosus Fermented Goji Berry Juice and Its Antioxidant Activity and in Vitro Inhibition of Xanthine Oxidase Activity by Xin AN, Tongtong LI, Jiaxue HU, Huiyan LIU, Haitian FANG, Xiaobo WEI

“…Compared with unfermented goji berry juice, the content of soluble protein, total phenols, and total flavonoids in fermented goji berry juice was significantly reduced (P<0.05), while the total sugar content was increased. …”
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Investigating the production and synergistic antibacterial activity of bacteriocin-like substance from Brevibacillus laterosporus SA-14 (TISTR 2453) for enhanced wound healing by Husna Madoromae, Apichart Atipairin, Malatee Tayeh, Monthon Lertcanawanichakul

“…The BLS was precipitated with 80 % ammonium sulfate, achieving a 38.09 % yield and a protein concentration of 6.97 ± 1.12 mg/mL. The SDS-PAGE analysis revealed five bands of proteins with molecular weights of 25–250 kDa. …”
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Associations of plasma biomarkers with cerebral perfusion and structure in Alzheimer’s disease by Yong He, Xiaojiao Liu, Fang Liu, Ping Che, Yanxin Zhang, Ruxue Fan, Yuan Li, Wen Qin, Nan Zhang

“…Forty-eight AD patients whose diagnosis was supported by amyloid-β (Aβ) PET received measurement of plasma biomarkers with a single molecular array, including Aβ42, phosphorylated tau 181 (P-tau181), neurofilament light (NfL), total tau (T-tau), and glial fibrillary acidic protein (GFAP), and both baseline and one-year follow-up magnetic resonance imaging, including pseudo-continuous arterial spin labeling, T1-weighted imaging, and diffusion tensor imaging. …”
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Hematologic and clinical chemistry reference intervals for six species of wild birds frequently rescued in the Republic of Korea by Myeongsu Kim, Myeongsu Kim, Zun Zun Wut Hmohn, Woochan Jang, Woochan Jang, Geonwoo Baek, Geonwoo Baek, Jae-Ik Han, Jae-Ik Han

“…One-way ANOVA was performed to compare hematologic and clinical chemistry parameters among species.ResultsThe total protein levels in carnivorous birds (Eurasian eagle owl, brown hawk-owl, and common kestrel) were significantly higher than those in omnivorous birds (Oriental turtle dove and domestic pigeon). …”
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Bionic Silk Fibroin Film Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells by Activating Focal Adhesion Kinase by Kang Lu, Xiaodie Chen, Hong Tang, Mei Zhou, Gang He, Zhisong Lu, Kanglai Tang

“…FAK inhibitors blocked the enhanced expression of tenogenic genes and proteins. Conclusion. SF films with a bionic microstructure may serve as a scaffold, provide biophysical cues to alter the cellular adherence arrangement and cell morphology, and enhance the tenogenic gene and protein expression in TSPCs. …”
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Elevated POSTN expression predicts poor prognosis and is associated with radioresistance in cervical cancer patients treated with radical radiotherapy by Cui-qin Huang, Wen-tao Xiao, Xiang-rong Yao, Zhi-min Li, Jun-yan He

“…Periostin (POSTN), a matricellular protein within the tumor microenvironment, has been implicated in the promotion of tumor progression and treatment resistance, particularly through mechanisms such as epithelial-mesenchymal transition (EMT). …”
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Suppression of Proinflammatory Cytokines and Mediators in LPS-Induced RAW 264.7 Macrophages by Stem Extract of Alternanthera sessilis via the Inhibition of the NF-κB Pathway by Katyakyini Muniandy, Sivapragasam Gothai, Khaleel M. H. Badran, S. Suresh Kumar, Norhaizan Mohd Esa, Palanisamy Arulselvan

“…Inflammation is a natural process of the innate immune system, accompanied with the increase in the level of proinflammatory mediators, for example, nitric oxide (NO) and prostaglandin (PGE2); cytokines such as interleukin 6 (IL-6), interleukin 1β (IL-1β), and tumor necrosis factor alpha (TNFα); and enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) via the activation and nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit p65 due to the phosphorylation of inhibitory protein, IκBα. Inflammation over a short period of time is essential for its therapeutic effect. …”
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Alcohol promotes CPT1A-induced lipid metabolism disorder to sentinel-regulate acute pancreatitis by Zenghui Li, Xinghui Li, Hui Jiang, Jingdong Li, Bin Xiao, Yong Chen, Shunhai Jian, Mei Zeng, Xiaoming Zhang

“…Methods Proteomics was performed to analyze the differentially expressed proteins in pancreatic tissues from a rat model of pancreatitis. …”
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Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion by Mirjana Babić Leko, Vera Župunski, Jason Kirincich, Dinko Smilović, Tibor Hortobágyi, Patrick R. Hof, Goran Šimić

“…The proposed molecular mechanisms by which C9orf72 repeat expansions induce neurodegenerative changes are C9orf72 loss-of-function through haploinsufficiency, RNA toxic gain-of-function, and gain-of-function through the accumulation of toxic dipeptide repeat proteins. However, many more cellular processes are affected by pathological processes in C9FTD/ALS, including nucleocytoplasmic transport, RNA processing, normal function of nucleolus, formation of membraneless organelles, translation, ubiquitin proteasome system, Notch signalling pathway, granule transport, and normal function of TAR DNA-binding protein 43 (TDP-43). …”
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