Diversity, Physicochemical and Technological Characterization of Elite Cassava (Manihot esculenta Crantz) Cultivars of Bantè, a District of Central Benin by Abadjayé Faouziath Sanoussi, Laura Yéyinou Loko, Hyacinthe Ahissou, Adidjath Koubourath Adjahi, Azize Orobiyi, Angelot Paterne Agré, Paulin Azokpota, Alexandre Dansi, Ambaliou Sanni

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Isolation, Characterization, and Safety Evaluation of Human Skin-Derived Precursors from an Adherent Monolayer Culture System by Ru Dai, Wei Hua, Wei Chen, Lidan Xiong, Li Li, Yiming Li

“…Methods. tSKPs generated from our adherent monolayer culture system were investigated for protein expression and differentiation capacity. The aggregated cells and the proliferative cells within tSKP spheres were detected by mix-culturing FBs expressing two different fluorescent proteins and BrdU- or EdU-positive cells, respectively. …”
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PGC1α Activators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control by So-Young Lee, Jun Mo Kang, Dong-Jin Kim, Seon Hwa Park, Hye Yun Jeong, Yu Ho Lee, Yang Gyun Kim, Dong Ho Yang, Sang Ho Lee

“…Moreover, in renal proximal tubular cells, increased PGC1α activity correlated with the reversal of changes in Drp1, Mfn1, and LC3-II protein expression in a high-glucose environment. …”
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20(S)-Ginsenoside Rg3 Protects Kidney from Diabetic Kidney Disease via Renal Inflammation Depression in Diabetic Rats by Tong Zhou, Lin Sun, Shuo Yang, You Lv, Yue Cao, Xiaokun Gang, Guixia Wang

“…Through periodic acid-Schiff staining, we observed that the change in renal histology was improved and renal tubular epithelial cell apoptosis decreased significantly by treatment with 20(S)-Rg3. Plus, the urine protein decreased in the rats with the 20(S)-Rg3 treatment. …”
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Inhibition of Viability, Proliferation, Cytokines Secretion, Surface Antigen Expression, and Adipogenic and Osteogenic Differentiation of Adipose-Derived Stem Cells by Seven-Day Ex... by Jian Wang, Bo Xiang, Jixian Deng, Darren H. Freed, Rakesh C. Arora, Ganghong Tian

“…The SMF slightly downregulated the expression of cytokines including Vascular Endothelial Growth Factor (VEGF), Insulin-like Growth Factor-1 (IGF-1), Transforming Growth Factor Beta 1 (TGF-β1), genetic markers comprising Stem Cell Antigen-1 (Sca1), Octamer-4 (Oct-4), ATP-binding Cassette Subfamily B Member 1 (ABCB1), adipogenic marker genes containing Lipoprotein Lipase (LPL), Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ), and osteogenic marker genes including Secreted Phosphor-protein 1 (SPP1) and Osterix (OSX). Exposure to 0.5 T SMF for seven days inhibited viability, proliferation, surface antigen expression, cytokine secretion, stem cell genetic marker expression, and adipogenic and osteogenic differentiation but did not affect the DNA integrity in ASCs with or without SPIO labeling.…”
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Ready-to-eat mango and peanut bar as a value-added alternative for producers and market demand by Dominique Moreno-Ayala, María Dolores Muy-Rangel, José Basilio Heredia, Diego Alonso Gastelum-Chavira, Josefina León-Félix, Octavio Valdez Lafarga, José Benigno Valdez-Torres

“…The mango bars showed good microbiological quality, aw values of <0.6, significant protein, dietary fiber, minerals, and carotenoid content of 19 µg/g. …”
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Combined Replacement of Fishmeal and Fish Oil by Poultry Byproduct Meal and Mixed Oil: Effects on the Growth Performance, Body Composition, and Muscle Quality of Tiger Puffer by Lili Zhao, Lin Li, Feiran Zhang, Peng Li, Yanlu Li, Jian Liu, Yuliang Wei, Mengqing Liang, Qiang Ma, Houguo Xu

“…In serum, there were no significant differences in contents of triglyceride, total cholesterol, total bile acid, and protein carbonyl among groups, but the malondialdehyde content was reduced by MO. …”
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Co-housing with Tibetan chickens improved the resistance of Arbor Acres chickens to Salmonella enterica serovar Enteritidis infection by altering their gut microbiota composition by Qianyun Zhang, Qidong Zhu, Yunqi Xiao, Qinghua Yu, Shourong Shi

“…Co-housing with Tibetan chickens significantly increased the height of villi and number of goblet cells (P < 0.05), as well as the expression of claudin-1 (P < 0.05), a tight junction protein, in the jejunum of AA chickens. Further analysis revealed that co-housing altered the gut microbiota composition in AA chickens; specifically, the relative abundances of harmful microbes, such as Intestinimonas, Oscillibacter, Tuzzerella, Anaerotruncus, Paludicola, and Anaerofilum were reduced (P < 0.05). …”
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Clinical management of bleeding manifestations in a family with the thrombomodulin C1611>A (p.Cys537Stop) mutation by Serge Pierre-Louis, Johalene Rabout, Octavio Labrada, Fatima Radouani, Emeline Chonville, Beatrice Ferrey, Olivier Pierre-Louis, Yesim Dargaud

“…Background: The bleeding disorder described here is due to a heterozygous autosomal dominant C1611>A variant in the thrombomodulin (TM) gene that significantly elevates plasma TM levels, which enhances the activation of protein C. This activation inhibits factors VIIIa and Va, reducing thrombin generation and potentially leading to severe hemorrhagic manifestations. …”
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Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence by Valentina Gonzalez-Jaramillo, Eliana Portilla-Fernandez, Marija Glisic, Trudy Voortman, Mohsen Ghanbari, Wichor Bramer, Rajiv Chowdhury, Tamar Nijsten, Abbas Dehghan, Oscar H. Franco, Jana Nano

“…While most of the studies have been focused on C-reactive protein, further efforts should investigate other inflammatory markers.…”
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Sequence Variation in Toxoplasma gondii rop17 Gene among Strains from Different Hosts and Geographical Locations by Nian-Zhang Zhang, Ying Xu, Si-Yang Huang, Dong-Hui Zhou, Rui-Ai Wang, Xing-Quan Zhu

“…The present study examined sequence variation in rhoptry protein 17 (ROP17) gene among T. gondii isolates from different hosts and geographical regions. …”
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Detection of Mycobacterium tuberculosis DNA in intraocular fluid of 11 suspected tuberculous uveitis patients by multiplex PCR by Huirong Xu, Min Xu, Fang Chen, Hong Chen, Wei Du, Jing Yu

“…T-cell spot test (T-SPOT) results were positive in 11 patients (100%), while purified protein derivative (PPD) tests were positive in 5 patients (45.5%). …”
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Assessment of factors implicated in bone fusion after percutaneous endoscopic lumbar intervertebral fusion by Zheng Huang, Xialin Li, Weihong Yi, Junfeng Gong, Yue Zhou, Yu Tang

“…Data on age, operative time, blood loss, drainage, hospital stay, surgical level, osteoporosis, endplateitis, body mass index, lumbar curvature, and bone morphogenetic protein (BMP) use were collected. Univariate tests (chi-square, Student’s t-test, and analysis of variance) were employed to compare factors between groups. …”
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Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention by Rodrigo Fonseca, Yuan Xiao Zhu, Laura A. Bruins, Joseph Ahmann, Cecilia de Bonolo Campos, Esteban Braggio, Xianfeng Chen, Mariano Arribas, Susie Darvish, Seth Welsh, Erin Meermeier, Kiran K. Mangalaparthi, Richard K. Kandasamy, Greg Ahmann, J. Erin Wiedmeier-Nutor, Akhilesh Pandey, Marta Chesi, P. Leif Bergsagel, Rafael Fonseca

“…Transcriptomic and proteomic analysis revealed that resistance was largely associated with BCL-2 family protein dysregulation, including upregulation of anti-apoptotic proteins such as MCL-1, BCL-XL, BCL-2, and downregulation of pro-apoptotic members. …”
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Muramyl Dipeptide Enhances Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption through Increased RANKL Expression in Stromal Cells by Masahiko Ishida, Hideki Kitaura, Keisuke Kimura, Haruki Sugisawa, Tomo Aonuma, Haruhiko Takada, Teruko Takano-Yamamoto

“…MDP also enhanced LPS-induced mitogen-activated protein kinase (MAPK) signaling, including ERK, p38, and JNK, in stromal cells. …”
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The concept of natural genome reconstruction. Part 1. Basic provisions of the “natural genome reconstruction” concept. Changing the genome of hematopoietic stem cells using several... by L. A. Yakubov, O. S. Taranov, S. V. Sidorov, S. D. Nikonov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…Specific groups of glycocalyx factors, including glycoproteins/proteoglycans, glycosylphosphatidylinositol-anchored proteins and scavenger receptors, take part in the internalization event. …”
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VARIASI JUMLAH SEL NEUTROFIL DAN SEL LIMFOSIT: INDIKATOR KESEHATAN PADA ANAK JALANAN DI KOTA KEDIRI JAWA TIMUR by Mely Purnadianti, Anik Handayani, Nita Ermawati, Novia Agustina, Nandya Zahra Putri Hakim

“…Anak Jalanan mempunyai kadar markerinflamasi lebih tinggi seperti leukosit, Chess Reaktif Protein (CRP), dan fibrinogen. Respon inflamasi seringkali umumnya diukur dari jumlah total leukosit. …”
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Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival by Sandra Bien-Möller, Ellen Balz, Susann Herzog, Laura Plantera, Silke Vogelgesang, Kerstin Weitmann, Carolin Seifert, Matthias A. Fink, Sascha Marx, Angela Bialke, Chitra Venugopal, Sheila K. Singh, Wolfgang Hoffmann, Bernhard H. Rauch, Henry W. S. Schroeder

“…Nevertheless, a search for more specific marker proteins is urgently needed.…”
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The Antimicrobial Peptide Lysozyme Is Induced after Multiple Trauma by Tim Klüter, Stefanie Fitschen-Oestern, Sebastian Lippross, Matthias Weuster, Rolf Mentlein, Nadine Steubesand, Claudia Neunaber, Frank Hildebrand, Thomas Pufe, Mersedeh Tohidnezhad, Andreas Beyer, Andreas Seekamp, Deike Varoga

“…Toll-like receptor 2, a classic receptor of Gram-positive bacterial protein, was detected as a possible target for lysozyme induction.…”
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Generation and characterization of chicken monocyte-derived dendritic cells by Elie Ngantcha Tatchou, Elie Ngantcha Tatchou, Romane Milcamps, Romane Milcamps, Guillaume Oldenhove, Bénédicte Lambrecht, Fiona Ingrao

“…Upon NDV stimulation for 6 h, MoDCs upregulated antiviral pathways, including retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), melanoma differentiation-associated protein 5 (MDA5) and laboratory of genetics and physiology 2 (LGP2), alongside increased production of type I interferons (IFNs), and the pro-inflammatory cytokines tumor necrosis factor-α (TNF-α), IL-1β, and IL-6. …”
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