Ischemic colitis presenting as a colonic mass: a case report and diagnostic challenges by Lin Xu, Yuqi Wu, Yuqi Wu, Shangjin Li, Shangjin Li, Xinbo Chen, Dong Zhang, Boqian Chen, Shaoju Guo

“…Diagnosis is supported by elevated levels of white blood cells, lactate, and C-reactive protein (CRP). Computed tomography (CT) imaging typically reveals wall thickening and fat stranding in watershed areas. …”
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The Role of SUMO1 Modification of SOX9 in Cartilage Development Stimulated by Zinc Ions in Mice by Na Xue, Jing Zhao, Jing Yin, Liang Liu, Zhong Yang, Shuchao Zhai, Xiyun Bian, Xiang Gao

“…Our investigation was centered on elucidating the impact of zinc deficiency on cartilage maturation by modulating SUMO1 and UBC9 at both the protein and mRNA levels. We administered a regimen inducing zinc deficiency to gravid mice from E0.5 until euthanasia. …”
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A report on the physicochemical and antioxidant properties of three Indonesian forest honeys produced by Apis dorsata by Mahani, Pamungkas Rizki Ferdian, Habil Muhammad Ghibran, Amirah Fathia Herlina, Siti Nurhasanah, Nunung Nurjanah, Rizki Rabeca Elfirta, Avry Pribadi, Raden Lia Rahadian Amalia, I Made Samudra

“…Key physicochemical parameters include moisture, color, electrical conductivity (EC), total dissolved solids (TDS), total suspended solids (TSS), density, diastase number (DN), hydroxymethylfurfural (HMF), pH, total acidity, ash content, protein content, and reducing sugars. Antioxidant properties, assessed through total phenolic content (TPC), total flavonoid content (TFC), DPPH radical scavenging activity, ascorbic acid equivalent antioxidant capacity (AEAC), and ferric reducing power (FRP), revealed significant regional variability. …”
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EI24 Suppresses Tumorigenesis in Pancreatic Cancer via Regulating c-Myc by Yi Zang, Lei Zhu, Tong Li, Qi Wang, Juanjuan Li, Yuting Qian, Lumin Wei, Mingping Xie, Wen-Hao Tang, Xu Liu, Ying Zhu, Lifu Wang

“…The EI24 autophagy-associated transmembrane protein is frequently associated with tumor growth and patient survival. …”
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Enhancing the Ability of Escherichia coli to Synthesise L-Isoleucine Using λ-Red Recombinant Technology Combined with Complex Mutagenesis by Jipeng WANG, Tengteng ZHU, Lu LIU, Cheng MA, Xiaobo WEI, Huiyan LIU, Haitian FANG

“…Firstly, taking E. coli NXA as the original strain, λ-Red homologous recombination was used to knock out the coding gene brnQ of branched chain amino acid transport protein to obtain mutant strain E. coli NXA1. Secondly, E. coli NXA1 was subjected to multiple rounds of complex mutagenesis with atmospheric room temperature plasma (ARTP), ultraviolet (UV), and nitrosoguanidine (NTG), which was screened to obtain the mutant strain E. coli NXA2 with α-AB being structural analogue. …”
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Production of a Complementary Food: Influence of Cowpea Soaking Time on the Nutritional, Antinutritional, and Antioxidant Properties of the Cassava-Cowpea-Orange-Fleshed Potato Ble... by Abiola Folakemi Olaniran, Clinton Emeka Okonkwo, Omorefosa Osarenkhoe Osemwegie, Yetunde Mary Iranloye, Yemisi Tokunbo Afolabi, Omokolade Oluwaseyi Alejolowo, Charles Obiora Nwonuma, Toluwanimi Esther Badejo

“…The blends were significantly different (P≤0.05) in terms of their protein, fiber, fat, ash, and carbohydrate contents. …”
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Developing non-invasive molecular markers for early risk assessment of Alzheimer's disease by Tapas K. Sur, Tanmoy Mondal, Zarish Noreen, Jheannelle Johnson, Gail Nunlee-Bland, Christopher A. Loffredo, Brent E. Korba, Vijay Chandra, Siddhartha S. Jana, Bernard Kwabi-Addo, Sumit Sarkar, Somiranjan Ghosh

“…Current improvements have unveiled the disease's pathophysiology and clinical diagnostic tests, targeting the neurological changes (neurodegeneration, amyloid precursor protein metabolism and tangle pathology) with precise PET/MRI imaging and xMAP/SIMOA (Multiplex simultaneous detection/single molecule array) to identify and quantify β-amyloids (Aβ40, Aβ42), total tau (T-tau) and phosphorylated tau (P-tau) proteins in the brain and cerebrospinal fluid (CSF) of patients. …”
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Decrease of NAD+ Inhibits the Apoptosis of OLP T Cells via Inducing Mitochondrial Fission by Zhang ZY, Wang F, Zhou G

“…OLP T cells and OLP plasma-exposed Jurkat T cells were treated with either β-nicotinamide mononucleotide (an NAD+ synthesis precursor) or FK866 (an NAD+ synthesis inhibitor) to assess the effect of NAD+ regulation on mitochondrial remodeling and T cell apoptosis.Results: OLP T cells exhibited fragmented mitochondria with elevated dynamin-related protein 1 (Drp1) and reduced mitofusin 2 (Mfn2) expression, accompanied by decreased apoptosis. …”
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Early Biomarkers for Detecting Subclinical Exposure to Fumonisin B1, Deoxynivalenol, and Zearalenone in Broiler Chickens by Laharika Kappari, Todd J. Applegate, Anthony E. Glenn, Abhijeet Bakre, Revathi Shanmugasundaram

“…On d21, T2 to T6 birds exhibited reduced serum phosphorus, glucose, and potassium, while total protein, FITC-d, AST, and CK levels increased compared to control (<i>p</i> < 0.05). …”
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Designing and evaluating alternative livelihoods for shark conservation: a case study on thresher sharks in Alor Island, Indonesia by Rafid A. Shidqi, Dewi R. Sari, Jeheskiel Alopen, Yodhikson M. Bang, Igo Arianto, Primiaty N. S. Kopong, Vivekananda Gitandjali TD, Etoile Smulders, Hollie Booth

“…Indonesia is the world's largest shark fishing nation, and in Alor Island, thresher sharks have been a primary target for small-scale fishing communities for decades, sustaining subsistence livelihoods and serving as a protein source. With thresher shark populations continuously declining, there is a need for conservation measures to reduce shark mortality from fishing, while also securing the well-being of coastal communities. …”
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Dose-dependent role of AMH and AMHR2 signaling in male differentiation and regulation of sex determination in Spotted knifejaw (Oplegnathus punctatus) with X1X1X2X2/X1X2Y chromosom... by Haixia Zhao, Jun Li, Zhizhong Xiao, Yongshuang Xiao

“…Notably, the specific mRNA expression of amhr2 is significantly enriched in amhr2cy, whose extracellular domain exhibits the highest binding affinity for Amh protein, with sexual expression differences manifesting as early as 5 dph. …”
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New inflammatory markers associated with disease activity in rheumatoid arthritis: pan-immune-inflammation value, systemic immune-inflammation index, and systemic inflammation resp... by İpek Okutan, Recai Aci, Âdem Keskin, Melek Bilgin, Halit Kızılet

“…Additionally, C-reactive protein and erythrocyte sedimentation rate measurements were included in the study. …”
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Deciphering In Vitro and In Vivo Pharmacological Properties of Seed and Fruit Extracts of Flacourtia jangomas (Lour.) Raeusch by Farhana Alam Ripa, Fowzia Alam, Fahmida Haque Riya, Yesmin Begum, Sharmin Akter Eti, Nusratun Nahar, Zebunnesa Ahmed, Sabrina Sharmin

“…The thrombolytic activity was assessed through rapid clot analysis of human blood samples, revealing that SFJC demonstrated the highest thrombolytic activity (60.99 ± 2.28%) compared to streptokinase (72.89 ± 2.19%). In the protein denaturation antiarthritic test, the PFJE and SFJC extracts exhibited significant potency, achieving results of 74.28 ± 1.16% and 79.25 ± 0.83%, respectively, at a dose of 500 μg/mL. …”
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Sex-based differences in lung cancer susceptibility and molecular genetics in the 2020s by Berta Mosleh, Pavla Sarova, Sonja Zehetmayer, Felicitas Oberndorfer, Joachim Widder, Helmut Prosch, Marco Idzko, Clemens Aigner, Mir Alireza Hoda, Daniela Gompelmann

“…There were no significant differences in age at diagnosis, body mass index, lung function parameters, histological subtypes, PD-L1 protein expression, disease stage, and survival between men and women (all p > 0.05). …”
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Stimulation of Alpha7 Nicotinic Acetylcholine Receptor Attenuates Nicotine-Induced Upregulation of MMP, MCP-1, and RANTES through Modulating ERK1/2/AP-1 Signaling Pathway in RAW264... by Liping Liu, Hongxian Wu, Qunan Cao, Zhenzhen Guo, Anmin Ren, Qiuyan Dai

“…Pretreatment with U0126 significantly suppressed phosphorylation of ERK1/2 and further attenuated nicotine-induced activation of c-Jun and upregulation of MMP-2, MMP-9, monocyte chemotactic protein- (MCP-) 1, and regulated upon activation normal T cell expressed and secreted (RANTES). …”
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CLINICAL AND LABORATORY FEATURES OF LYME ARTHRITIS AND ARTHRITIDES OF OTHER ETIOLOGIES IN CHILDREN OF LVIV REGION by Halyna Lytvyn, Natella Basa

“…ELISA and immunoblot to B.burgorferi, complete blood count, C-reactive protein, interleukin-6, and creatine phosphokinase-MB were used to identify the cause of the joint syndrome. …”
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Identification of MYC and STAT3 for early diagnosis based on the long noncoding RNA-mRNA network and bioinformatics in colorectal cancer by Kunhou Yao, Hao Fan, Tiancheng Yang, Can Yang, Guibin Wang, Xingwang Li, Xin-Ying Ji, Qun Wang, Shaojiang Lv, Shihao Guo

“…Quantitative Real-Time PCR (qRT-PCR) was performed to validate MYC and STAT3 expression levels, and findings were further confirmed using the Human Protein Atlas (HPA) database.ResultsDatabase analysis revealed significant differential expression of MYC and STAT3 between normal and CRC tissues. …”
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Serum Glial Cell Line-Derived Neurotrophic Factor (sGDNF) Is a Novel Biomarker in Predicting Cirrhosis in Patients with Chronic Hepatitis B by Guangyue Yang, Liping Zhuang, Tiantian Sun, Yee Hui Yeo, Le Tao, Wei Zhang, Wenting Ma, Liu Wu, Zongguo Yang, Yanqin Yang, Dongying Xue, Jie Zhang, Rilu Feng, Ebert Matthias P., Steven Dooley, Ekihiro Seki, Ping Liu, Cheng Liu

“…Findings from the serum protein level and hepatic mRNA expression were consistent. …”
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The Impact of Targeted Therapies on Red Blood Cell Aggregation in Patients with Chronic Lymphocytic Leukemia Evaluated Using Software Image Flow Analysis by Anika Alexandrova-Watanabe, Emilia Abadjieva, Lidia Gartcheva, Ariana Langari, Miroslava Ivanova, Margarita Guenova, Tihomir Tiankov, Velichka Strijkova, Sashka Krumova, Svetla Todinova

“…Despite advances in therapies targeting Bruton’s tyrosine kinase and anti-apoptotic protein BCL-2, little is known about their effect on red blood cell (RBC) aggregation in blood flow. …”
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Hsa-miR-105-1 Regulates Cisplatin-Resistance in Ovarian Carcinoma Cells by Targeting ANXA9 by Xinxin Kou, Hui Ding, Lei Li, Hongtu Chao

“…Furthermore, the expression levels of several apoptosis-related proteins, including P53, P21, E2F1, Bcl-2, Bax, and caspase-3, were examined by western blot analysis. …”
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