First Report of SNPs Detection in TMEM154 Gene in Sheep from Poland and Their Association with SRLV Infection Status by Magdalena Materniak-Kornas, Katarzyna Piórkowska, Katarzyna Ropka-Molik, Adrianna Dominika Musiał, Joanna Kowalik, Anna Kycko, Jacek Kuźmak

“…Recent reports revealed several candidates, including gene encoding transmembrane protein 154 (TMEM154). Several single nucleotide polymorphisms (SNPs) are found within this gene in sheep of different breeds, but only some can be considered as resistant markers. …”
Get full text

Ginsenoside Rk2 alleviates hepatic ischemia/reperfusion injury by enhancing AKT membrane translocation and activation by Hong Shen, Jiajun Fu, Jiayue Liu, Toujun Zou, Kun Wang, Xiao‐Jing Zhang, Jian‐Bo Wan

“…Integrated approaches, including network pharmacology, molecular docking, transcriptome analysis, and isothermal titration calorimetry, along with experimental validation, indicated that Rk2 protects against hepatic IRI by targeting and activating the AKT (RAC serine/threonine protein kinase) signaling pathway. Pharmacological inhibition of AKT pathway or knockdown of AKT1 effectively diminished protective effects of Rk2. …”
Get full text

Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis by Wenlong Liu, Li Deng, Yanqiu Chen, Changzhi Sun, Jie Wang, Lifeng Zhou, Huabin Li, Renzhong Luo

“…Our results also showed that IL-37b downregulated Th2 cytokine expressed by PBMCs and this modulation was through mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathway. …”
Get full text

Prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy: a retrospective study of 420 biopsy-proven cas... by Haitao Lu, Qianqian Xu, Guming Zou, Hongmei Gao, Yue Yang, Wenge Li, Li Zhuo

“…The anti-PLA2R antibody-positive group displayed higher levels of urine protein (p < .05), serum cholesterol (p < .01), and IgG4 subtypes (p < .05) compared to the negative group. …”
Get full text

Serum Sclerostin as a Possible Biomarker in Ankylosing Spondylitis: A Case-Control Study by Fabio Massimo Perrotta, Fulvia Ceccarelli, Cristiana Barbati, Tania Colasanti, Antonia De Socio, Silvia Scriffignano, Cristiano Alessandri, Ennio Lubrano

“…BASDAI, ASDAS-CRP, BASMI, BASFI, patient and physician VAS, and C-reactive protein were evaluated at baseline visit. Spinal damage was assessed using the mSASSS on radiographs performed within 3 months from baseline. …”
Get full text

Genetic aspects of potato resistance to phytophthorosis by T. S. Frolova, V. A. Cherenko, O. I. Sinitsyna, A. V. Kochetov

“…On the part of P. infestans, fungal cellulose synthase proteins and haustorium-specific membrane protein were markers of infection. …”
Get full text

S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism by Min Yang, Weiwei Cui, Xiaoting Lv, Gaozhong Xiong, Caiyu Sun, Haocheng Xuan, Wei Ma, Xiuling Cui, Yeping Cheng, Lihui Han, Bo Chu

“…Here, our study confirms that S100 calcium binding protein P (S100P), which is significantly up-regulated in ferroptosis-resistant HCC cells, efficiently inhibits ferroptosis. …”
Get full text

Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against Pseudomonas aeruginosa by Dorota Kuc-Ciepluch, Karol Ciepluch, Daria Augustyniak, Grzegorz Guła, Barbara Maciejewska, Artur Kowalik, Ewelina Jop, Zuzanna Drulis-Kawa, Michał Arabski

“…We assume that leveraging pyroptosis induction in monocytic cells to augment the bactericidal activity of endolysins may be limited.IMPORTANCERecombinant GSDMDNterm protein was able to efficiently permeabilize P. aeruginosa outer membranes and increase endolysin activity against bacteria, producing either long LPS O-chains or lack them entirely. …”
Get full text

Luteolin Pretreatment Ameliorates Myocardial Ischemia/Reperfusion Injury by lncRNA-JPX/miR-146b Axis by Tongda Xu, Yuanyuan Zhang, Gege Liao, Haochen Xuan, Jie Yin, Jieli Bao, Yang Liu, Dongye Li

“…Western blot was utilized to examine apoptosis-related protein expression levels, including cleaved caspase-9, caspase-9, cleaved caspase-3, caspase-3, Bcl-2, Bax, and BAG-1. …”
Get full text

Similarities and Differences between Clavicular Bacterial Osteomyelitis and Nonbacterial Osteitis: Comparisons of 327 Reported Cases by Nan Jiang, Ping Zhang, Wei-ran Hu, Zi-long Yao, Bin Yu

“…However, no significant differences were identified regarding the serological levels of white blood cell count (P=0.06), erythrocyte sedimentation rate (P=0.27), or C-reactive protein (P=0.33) between BO and NBO patients before therapy. …”
Get full text

Physiopathological effects of entrance versus distal spread-out Bragg peak on mouse spinal cord neurons by Filippo Torrisi, Francesco Paolo Cammarata, Valentina Bravatà, Marco Calvaruso, Cristiana Alberghina, Anna Maria Pavone, Giada Petringa, Giuseppe Antonio Pablo Cirrone, Simona Denaro, Anna Gervasi, Simona D’Aprile, Nunzio Vicario, Emanuele Scifoni, Pietro Pisciotta, Giorgio Russo, Rosalba Parenti

“…Results showed changes in the expression of synaptophysin, a presynaptic protein crucial for synaptic plasticity. Our findings suggest that examining early radiation-induced physiopathological effects on late-responding tissues can provide valuable insights into neuronal plasticity, informing clinical treatment planning for proton beam positioning.…”
Get full text

A higher order PUF complex is central to regulation of C. elegans germline stem cells by Chen Qiu, Sarah L. Crittenden, Brian H. Carrick, Lucas B. Dillard, Stephany J. Costa Dos Santos, Venkata P. Dandey, Robert C. Dutcher, Elizabeth G. Viverette, Robert N. Wine, Jennifer Woodworth, Zachary T. Campbell, Marvin Wickens, Mario J. Borgnia, Judith Kimble, Traci M. Tanaka Hall

“…Abstract PUF RNA-binding proteins are broadly conserved stem cell regulators. …”
Get full text

Causal links between obesity, lipids, adipokines, and cognition: a bidirectional Mendelian-randomization analysis by Meng Gong, Haichao Liu, Zhixiang Liu, Yongshen Wang, Shiyi Qi, Hong Guo, Song Jin

“…BackgroundThe aim of this study was to explore the genetic level association between obesity, lipids, adipokines, and cognitive ability using bidirectional Mendelian randomization (MR) strategies.MethodsSummary data for three obesity indicators [body mass index (BMI), body fat percentage (BFP) and waist-hip ratio (WHR)], three lipid indicators [HDL cholesterol (HDL), LDL cholesterol (LDL) and triglycerides (TG)], three adipokines [circulating leptin (LEP), Agouti-related protein (AgRP) and Adiponectin (APDN)], and four cognitive ability indicators [cognitive function (CF), cognitive performance (CP), simple reaction time (SRT) and fluid intelligence score (FIS)] were collected. …”
Get full text

Predicting dry matter intake in Pelibuey sheep using machine learning methods by Enrique Camacho-Perez, Cem Tirink, Ricardo Garcia-Herrera, Ángel T. Piñeiro-Vazquez, Fernando Casanova-Lugo, Jorge R. Canul-Solis, Antonio Leandro Chaves-Gurgel, Ceyhun Yücel, Einar Vargas-Bello-Pérez, Alfonso J. Chay-Canul

“…To create the database, the following data were recorded: % concentrate in the diet (CON), initial body weight (IBW, kg), final BW (FBW, kg), mean metabolic BW (MBW0.75, kg0.75), daily weight gain (ADG, g/d), crude protein (CP) and neutral detergent fibre (NDF). Multivariate Adaptive Regression Splines (MARS), Classification and Regression Tree (CART), and Support Vector Regression (SVR) were used for the development of a predictive algorithm. …”
Get full text

Novel genes involved in vascular dysfunction of the middle temporal gyrus in Alzheimer’s disease: transcriptomics combined with machine learning analysis by Meiling Wang, Aojie He, Yubing Kang, Zhaojun Wang, Yahui He, Kahleong Lim, Chengwu Zhang, Li Lu

“…Finally, combining bulk RNA sequencing data and two machine learning algorithms (least absolute shrinkage and selection operator and random forest), four characteristic Alzheimer’s disease feature genes were identified: somatostatin (SST), protein tyrosine phosphatase non-receptor type 3 (PTPN3), glutinase (GL3), and tropomyosin 3 (PTM3). …”
Get full text

Characterization of food wastes from the hotel industry as a potential feedstock for energy production by Emily Machuma Muchele, Booker Osodo, Isaiah Omosa, Emmanuel Yeri Kombe

“…The average feedstock characteristics were observed to be moisture content (6.0%, p < .001, R2 = 90.70 %), total solid (93.7%, p < .001, R2 = 99.97 %), volatile solid (84.3%, p < .001, R2 = 99.80 %), ash content (4.2%, p = .005, R2= 48.54 %), fixed carbon (5.4%, p < .001, R2 = 88.61%), nitrogen (3.6%, p = .04, R2 = 36.81 %), carbon to nitrogen ratio C/N (4.0), crude protein (22.4%, p = .004, R2 = 49.36 % ), crude lipids (12.1%, p < .001, R2 = 89.06 %), total organic carbon (44%, p < . 001, R2 = 94.70%), potassium (0.6%), sodium (1.2%), calcium (0.2%), and phosphorus (0.4%). …”
Get full text

Physicochemical Properties of Soluble Dietary Fiber from Passion Fruit Peel Based on Various Extraction Methods by Ya Song, Yunxin Shi, Yuting Liu, Yue Ma, Chenwenyi Lin, Ninglang Nie, Xuqin Song, Jian Yang

“…The results indicated that the acid-assisted extraction method (AAE-1) was the most effective at protein removal among the six methods, and the SDF derived from this method had the highest extraction yield (17.05%), cation exchange capacity (1.17 mL/g), total monosaccharide content (92.6620 µg/mg), xylose (3.2187 µg/mg), and mannose (3.7334 µg/mg). …”
Get full text

Highly Pathogenic Avian Influenza (HPAI) H5N1 virus in Finland in 2021–2023 – Genetic diversity of the viruses and infection kinetics in human dendritic cells by Eda Altan, Veera Avelin, Kirsi Aaltonen, Essi Korhonen, Larissa Laine, Erika Lindh, Ilkka Julkunen, Niina Tammiranta, Tiina Nokireki, Tuija Gadd, Laura Kakkola, Tarja Sironen, Pamela Österlund

“…Although the isolate from pheasant (a wild bird) showed weakly reduced replication and viral protein expression in human cells compared to mammalian isolates, no discernible differences in virus replication in moDCs was observed. …”
Get full text

SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development by Fabrizio Angius, Silvia Puxeddu, Silvio Zaimi, Serena Canton, Sepehr Nematollahzadeh, Andrea Pibiri, Ilenia Delogu, Gualtiero Alvisi, Meng Ling Moi, Aldo Manzin

“…SARS-CoV-2 is characterized by rapidly evolving mutations, especially in (but not limited to) the spike protein, complicating predictions about its evolutionary trajectory. …”
Get full text

Integrated technique of buffalo fertility management in Nepal by Bhuminand Devkota, Shatrughan Shah, Gokarna Gautam

“…Putting together all those information, we developed an integrated technique of buffalo fertility management that includes anthelmintic treatment at least one month prior to the initiation of specific timed artificial insemination (TAI) protocol and nutritional management by means of providing vitamin–mineral supplementation in addition to improving the roughage supply and energy-protein content in the ration soon after anthelmintic treatment until two weeks after AI. …”
Get full text