IGF2BP2 Regulates the Progression of Alzheimer's Disease Through m6A‐Mediated NLRP3 Inflammasome by Wu Jingrui, Yang Haihui, Yan Jinjin, Fang Le

“…Aims The present study aimed to explore the effect of human insulin‐like growth factor 2 (IGF2) mRNA binding proteins 2 (IGF2BP2), one of the m6A‐binding proteins on the progression of AD. …”
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Single-cell RNA-seq reveals immune cell heterogeneity and increased Th17 cells in human fibrotic skin diseases by Cheng-Cheng Deng, Xue-Yan Xu, Yan Zhang, Long-Can Liu, Xuan Wang, Jun-Yi Chen, Liu-Yi Yao, Ding-Heng Zhu, Bin Yang

“…However, upregulated genes in keloid M1 macrophages, M2 macrophages, and cDC2 are associated with the MHC class II protein complex assembly and antigen assembly, indicating that macrophages and cDC2 are active in keloids. …”
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WIPI-1 Positive Autophagosome-Like Vesicles Entrap Pathogenic Staphylococcus aureus for Lysosomal Degradation by Mario Mauthe, Wenqi Yu, Oleg Krut, Martin Krönke, Friedrich Götz, Horst Robenek, Tassula Proikas-Cezanne

“…By automated fluorescence-based high content analyses, we demonstrate that Staphylococcus aureus strains (USA300, HG001, SA113) stimulate autophagy and become entrapped in intracellular PtdIns(3)P-enriched vesicles that are decorated with human WIPI-1, an essential PtdIns(3)P effector of canonical autophagy and membrane protein of both phagophores and autophagosomes. Further, agr-positive S. aureus (USA300, HG001) strains were more efficiently entrapped in WIPI-1 positive autophagosome-like vesicles when compared to agr-negative cells (SA113). …”
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The Health Effects of Dietary Nitrate on Sarcopenia Development: Prospective Evidence from the UK Biobank by Jigen Na, Yuefeng Tan, Yanan Zhang, Xiaona Na, Xiaojin Shi, Celi Yang, Zhihui Li, John S. Ji, Ai Zhao

“…Mediation analyses indicated that protein homeostasis and blood pressure might mediate these associations. …”
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Meat Production in a Feedlot System of Zebu—Holstein Steers and Heifers with Dairy Genetics: Productive and Biological Analyses by Gustavo Chamon de Castro Menezes, Sebastião de Campos Valadares Filho, José Reinaldo Mendes Ruas, Edenio Detmann, Arismar de Castro Menezes, Diego Zanett, Lays Débora Silva Mariz, Luciana Navajas Rennó, Jarbas Miguel da Silva Junior

“…The net energy requirements for maintenance are 67 kcal/EBW0.75/d, and the net requirements of energy (NEg) and protein (NPg) for gain can be estimated by the following equations: NEg(Mcal/d)=0.067×EBW0.75×  EBG1.095 and NPg=162×EBG-5.62×RE for the two sexes.…”
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Immobilization of purified pectinase from Aspergillus nidulans on chitosan and alginate beads for biotechnological applications by Hamed M. El-Shora, Sabah A. Abo-Elmaaty, Gharieb S. El-Sayyad, Widad M. Al-Bishri, Ahmed I. El-Batal, Mervat G. Hassan

“…With a yield of 30.4%, the final specific activity was 400 units mg−1 protein and 125-fold purification. Using SDS-PAGE to validate the purification of the pectinase, a single band showing the homogeneity of the purified pectinase with a molecular weight of 50 kD was found. …”
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Evaluating SCUBE-1 as Predictive Biomarker for Hypertension-Mediated Organ Damage: A Comparative Study by Betül Ayça Yamak, Mustafa Candemir, Emrullah Kızıltunç, Hüseyin Baran Özdemir, Özlem Gülbahar, Asife Şahinarslan

“…Serum signal peptide, CUB (complement C1r/C1s, Uegf, and Bmp1) domain, and epidermal growth factor-like domain-containing protein 1 (SCUBE-1), a novel biomarker implicated in vascular pathology, shows promise for detecting HMOD. …”
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First two mitochondrial genomes for the order Filobasidiales reveal novel gene rearrangements and intron dynamics of Tremellomycetes by Qiang Li, Zhijie Bao, Ke Tang, Huiyu Feng, Wenying Tu, Lijiao Li, Yunlei Han, Mei Cao, Changsong Zhao

“…Positive selection was observed in several protein-coding genes (PCGs) in the Agaricomycotina, Pucciniomycotina, and Ustilaginomycotina species, including cob, cox2, nad2, and rps3 genes. …”
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Upregulated miR-206 Aggravates Deep Vein Thrombosis by Regulating GJA1-Mediated Autophagy of Endothelial Progenitor Cells by Yan Li, Jingping Ge, Yuanyuan Yin, Ruowen Yang, Jie Kong, Jianping Gu

“…The levels of autophagy-related proteins as well as the level of GJA1 in EPCs and vascular tissues were evaluated by western blotting. …”
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Palm Tocotrienol Activates the Wnt3a/β-Catenin Signaling Pathway, Protecting MC3T3-E1 Osteoblasts from Cellular Damage Caused by Dexamethasone and Promoting Bone Formation by Norfarahin Abdullah Sani, Nur Aqilah Kamaruddin, Ima Nirwana Soelaiman, Kok-Lun Pang, Kok-Yong Chin, Elvy Suhana Mohd Ramli

“…The expression of Wnt3a, β-catenin, collagen 1α1, alkaline phosphatase, osteocalcin, low-density lipoprotein receptor-related protein 6, and runt-related transcription factor-2 were significantly increased in the PTT-treated groups compared to the vehicle control group, especially at 0.5 µg/mL of PTT (<i>p</i> < 0.05) and on day 6 of treatment. …”
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Quality and Safety of Green Mussel (Perna viridis) at Ketapang, Tangerang Regency, Indonesia by Permadi Aef, Asriani, Yuniarti Tatty, Sumandiarsa I Ketut, Budi Purnamasari Heny, Dharmayanti Niken, Zachro Nurbani Siti, Sayuti Mohammad, Salampessy Randi B.S., Sipahutar Yuliati H., Ruminta Siregar Resmi, Ayu Afifah Rufnia, Hidayah Nur, Maulani Aghitia, Prasetyo Handoko Yudi, Masengi Simson, Wina Lestari Andini, Nuriyah Dinda

“…The different sizes of green mussel shells significantly affected the protein and fat content. As for the carbohydrate content, a significant difference was only shown by green mussels with shell sizes 51-60 mm and 71-80 mm. …”
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PAI-1: An Integrator of Cell Signaling and Migration by Ralf-Peter Czekay, Cynthia E. Wilkins-Port, Stephen P. Higgins, Jennifer Freytag, Jessica M. Overstreet, R. Matthew Klein, Craig E. Higgins, Rohan Samarakoon, Paul J. Higgins

“…., vitronectin), the low-density lipoprotein receptor-related protein-1 (LRP1), and the uPA/uPA receptor complex have dramatic consequences on the migratory phenotype and may underlie the pathophysiologic sequalae of PAI-1 deficiency and overexpression. …”
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Advances in Serological Diagnosis of Neurocysticercosis in Korea by Chun-Seob Ahn, Jeong-Geun Kim, Sun Huh, Insug Kang, Yoon Kong

“…Two glycoproteins of 150 and 120 kDa that induce strong antibody responses against sera from patients with active-stage NC have been elucidated. The 150 kDa protein showed hydrophobic-ligand binding activities and might be critically involved in the acquisition of host-derived lipid molecules. …”
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Agroecological mapping of livestock feed resources for sustain productivity and climate resilience in Benin (West Africa) by Marthe Montcho, Alassan S. Assani, Jean de Dieu Ainamon, André B. Aboh, Pascal A. Olounladé, Brice Sinsin

“…The study of the availability of fodder resources revealed a positive fodder balance for dry matter (DM) in each agroecological zone, but a negative balance in all AEZs for metabolizable energy (ME) and digestible crude protein (DCP). Thus, with an average annual availability of almost 3.15 million tons of DM across all Benin AEZs, zones 2, 3 and 5 had the highest DM availability rates, while AEZs 1, 7 and 8 had the lowest DM availability. …”
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Simultaneous Determination of 34 Amino Acids in Tumor Tissues from Colorectal Cancer Patients Based on the Targeted UHPLC-MS/MS Method by Yang Yang, Feng Zhang, Shouhong Gao, Zhipeng Wang, Mingming Li, Hua Wei, Renqian Zhong, Wansheng Chen

“…The sample was pretreated based on tissue homogenate and protein precipitation with a 100 mg aliquot sample. …”
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Microalga <i>Nannochloropsis gaditana</i> as a Sustainable Source of Bioactive Peptides: A Proteomic and In Silico Approach by Samuel Paterson, Laura Alonso-Pintre, Esperanza Morato-López, Sandra González de la Fuente, Pilar Gómez-Cortés, Blanca Hernández-Ledesma

“…The impact of the world’s growing population on food systems and the role of dietary patterns in the management of non-communicable diseases underscore the need to explore sustainable and dietary protein sources. Although microalgae have stood out as alternative sources of proteins and bioactive peptides, some species such as <i>Nannochloropsis gaditana</i> remain unexplored. …”
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Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer’s disease by regulating microglia homeostasis and inhibiting HMGB... by Yuan Xu, Naiyuan Shao, Feng Zhi, Ronghua Chen, Yilin Yang, Jiahui Li, Ying Xia, Ya Peng

“…Gene expression profiling further revealed that the alternations in DOR/MOR are closely associated with microglial homeostatic signatures and high mobility group protein B1 (HMGB1) in AD. DOR activation inhibited HMGB1 secretion and its translocation from nuclear to cytoplasm. …”
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Engineering a phi15-based expression system for stringent gene expression in Pseudomonas putida by Eveline-Marie Lammens, Daniel C. Volke, Alison Kerremans, Yannick Aerts, Maarten Boon, Pablo I. Nikel, Rob Lavigne

“…Moreover, by successfully decoupling cell growth and protein production using phi15 gp16, a host RNAP inhibitor, expression levels could be enhanced further (20%). …”
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Analysis of Drug Effects on Primary Human Coronary Artery Endothelial Cells Activated by Serum Amyloid A by K. Lakota, D. Hrušovar, M. Ogrič, K. Mrak-Poljšak, S. Čučnik, M. Tomšič, B. Božič, P. Žigon, S. Sodin-Semrl

“…Serum amyloid A (SAA) is an acute-phase protein, upregulated in sera of RA patients. Aim. …”
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Comparative transcriptomic and phenotypic analysis of monoclonal and polyclonal Populus deltoides genotypes by Macy Gosselaar, Macy Gosselaar, Mark A. Arick, Chuan-Yu Hsu, Heidi Renninger, Courtney M. Siegert, Waqar Shafqat, Daniel G. Peterson, Austin Himes

“…RNA sequencing revealed upregulation of key genes such as exocyst subunit exo70 family protein H7 (EXO70H7), NDH-dependent cyclic electron flow 5 (NDF5), and expansin-like A3 (EXLA3). …”
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