The reliability, sensitivity and specificity of fluorescent oxidation products for measuring global oxidative stress in vivo by Bing Liang, Juan Zhang, Xue Shen, Xiaohua Zhang, Ann M. Vuong, Linghua Yang, Xinyan Shi, Xueru Ge, Huan He, Tong Liu, Shuman Yang

“…FlOP_360 (r = 0.225, P = 0.045), but not FlOP_320 and FlOP_400, were significantly correlated with c-reactive protein, a marker of inflammation. Conclusions FlOP_320 are reliable, sensitive and specific markers for measuring global oxidative stress. …”
Get full text

Myocardin-Related Transcription Factor A (MRTF-A) Regulates the Balance between Adipogenesis and Osteogenesis of Human Adipose Stem Cells by Laura Hyväri, Sari Vanhatupa, Heidi T. Halonen, Minna Kääriäinen, Susanna Miettinen

“…Additionally, MRTF-A inhibition affected the protein amounts of α-smooth muscle actin (α-SMA), myosin light chain (MLC), and phosphorylated MLC suggesting that MRTF-A would regulate differentiation through SRF activity. …”
Get full text

Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation by Nivedita U. Jerath, Cameron D. Crockett, Steven A. Moore, Michael E. Shy, Conrad C. Weihl, Tsui-Fen Chou, Tiffany Grider, Michael A. Gonzalez, Stephan Zuchner, Andrea Swenson

“…The valosin-containing protein (VCP) regulates several distinct cellular processes. …”
Get full text

Case report of neurobrucellosis: a rare complication and neuroimaging findings of a common disease by Yu Zhang, Yu Zhang, Xiao-Yi Zou, Xiao-Yi Zou, Ling Liu

“…Brucella species were isolated from blood or cerebrospinal fluid (CSF) in four patients; three patients had elevated CSF protein levels, and two had elevated CSF leukocyte counts. …”
Get full text

Genome-wide investigation of ABCB, PIN, and AUX/LAX gene families and their involvement in the formation of leaf protrusions in Sesamum indicum by Yanli Li, Yujia Ma, Huihui Gong, Xinxiao Cui, Xin Wang, Yuling Dong, Ying Chen, Junsheng Zhao

“…PAT primarily relies on three families of transporter proteins: ABCB, PIN, and AUX/LAX. However, the ABCB, PIN, and AUX/LAX protein families in Sesamum indicum have not been systematically characterized. …”
Get full text

Immunomodulatory effects of fucoidan extracted from Sargassum fusiforme in RAW 264.7 macrophages by Serim Park, Yunjin Choi, Seonmi Ji, Seonghui Kim, Seon Yeong Ji, Yung Hyun Choi, You-Jin Jeon, Bomi Ryu, Jun-Geon Je, Suengmok Cho

“…SFF also promoted the activation of nuclear factor kappa B and mitogen-activated protein kinase signaling pathways. These findings suggest that SFF exhibits potent immunomodulatory activity in the RAW 264.7 macrophage model and holds potential as a functional food to support immune health. …”
Get full text

NRBF2 plays a crucial role in the acquisition process of learning and memory, independent of the Vps34 complex by Songfen Wu, Songfen Wu, Songfen Wu, Haicai Zhuang, Haicai Zhuang, Haicai Zhuang, Xidan Zhou, Kuan Li, Kuan Li, Kuan Li

“…Employing quantitative PCR, Western blot analysis, behavioral tests, and electrophysiology, we investigated the mechanisms through which NRBF2 affects memory processing.ResultsWe observed an increase in Nrbf2 mRNA levels at 6 and 12 h, and protein levels at 6 h post fear conditioning. Depletion of NRBF2 impaired memory acquisition, short-term, and long-term memory without causing any anxiety-like behavior. …”
Get full text

Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors by Jinpu Yang, Keerat Kaur, Li Lin Ong, Carol A. Eisenberg, Leonard M. Eisenberg

“…This latter outcome was indicated by their widespread expression of the primary sarcomeric proteins muscle α-actinin and titin. MSC-derived cultures that were not initially treated with BIX01294 exhibited neither a commensurate burst of phase bright cells nor stimulation of sarcomeric protein expression. …”
Get full text

Perioperative Management of a Patient with Hereditary Angioedema and Intestinal Obstruction Secondary to an Ileal Tumor: A Case Report by Antony Peter Gatheru, Anne Kasyoka Barasa, Isaac Karogo Mwangi, Stanley Ngare, Dan Kiptoon, Edwin Oloo Walong

“…Hereditary angioedema (HAE) is a rare genetic disorder resulting from deficiency or dysfunction of the C1-esterase inhibitor (C1-INH, C1-inhibitor) protein. It manifests with recurrent cutaneous and submucosal edema involving the extremities, abdomen, and/or larynx. …”
Get full text

Chemical Composition of Date-Pits and Its Potential for Developing Value-Added Product - a Review by Hossain Mohammad Zakir, Waly Mostafa I., Singh Vandita, Sequeira Venitia, Rahman Mohammad Shafur

“…Moisture, protein, oil and carbohydrate contents of date-pits varied from 3.1-12.5, 2.3-6.9, 5.0-12.5 and 70.9-86.9 g/100 g date-pits, respectively. …”
Get full text

Heterologous Expression and Functional Analysis of <i>Exiguobacterium</i> Algin Lyase Gene by <i>Pichia pastoris</i> by Hanwen Wu, Kai Hou, Yutong Jiang, Mingjian Luan, Yuxia Sun, Xi He, Xiangzhong Zhao

“…The activity of the recombinant enzyme in 5 L high-density fermentation reached 1306 U/mg protein, 3.9 times that of the original <i>Exiguobacterium</i> strain. …”
Get full text

MicroRNA-Based Markers of Oral Tongue Squamous Cell Carcinoma and Buccal Squamous Cell Carcinoma: A Systems Biology Approach by Setareh Shojaei, Pouya Menbari, Shokoofeh Jamshidi, Amir Taherkhani

“…With the use of the STRING database, a protein interaction map (PIM) was created. Using the Cytoscape program, hub genes and clusters within the PIM were shown. …”
Get full text

Utilisation of an in vivo malaria model to provide functional proof for RhopH1/CLAG essentiality and conserved orthology with P. falciparum by Mitchell L. Trickey, Mrittika Chowdury, Georgina Bramwell, Natalie A. Counihan, Tania F. de Koning-Ward

“…The NPPs of the human parasite, P. falciparum, have been linked to the RhopH complex, with the monoallelic paralogues clag3.1 and clag3.2 encoding the protein RhopH1/CLAG3 that likely forms the NPP channel-forming component. …”
Get full text

Decoding the effects of brining time on the sensory quality, physicochemical properties and flavor characteristics of marinated grass carp meat by Lu Zhang, Yaqin Yu, Qinhui Wen, Shi Nie, Yang Hu, Chunming Tan, Zongcai Tu

“…The moisture content increased significantly with the extension of brining time, while the salt content, protein content, thiobarbituric acid reactive substances (TBARS), and total volatile basic‑nitrogen (TVB-N) decreased (p < 0.05). …”
Get full text

Scoulerine promotes cytotoxicity and attenuates stemness in ovarian cancer by targeting PI3K/AKT/mTOR axis by Wang Fang, Zhang Yang, Pang Rui, Shi Shaohong, Wang Ran

“…Epithelial to mesenchymal transition (EMT) and stemness-related protein markers were monitored by real-time PCR analysis and immunoblotting. …”
Get full text

The BES1/BZR1 transcriptional factor SlBES2 regulates photosynthetic apparatus in tomato fruit by Ming Huang, Wenjing Liu, Deding Su, Ghassen Abid, Baowen Huang, Zhengguo Li

“…Further verification revealed that SlBES2 can significantly repress the transcriptional activity of SlNYC1 and Green-Flesh, and physically interact with protein SlHY5. Conclusions Collectively, this study demonstrated that SlBES2 plays an important role in regulating fruit photosynthetic apparatus development through either transcriptional repression of genes involved in chlorophyll breakdown, or posttranscriptional regulation of proteins associated with plant photomorphogenesis and chloroplast development. …”
Get full text

Effect of Exogenous Melatonin on the Quality of Soybean and Natto Products under Drought Stress by Liang Cao, Fang Kou, Mingcong Zhang, Xijun Jin, Chunyuan Ren, Gaobo Yu, Yuxian Zhang, Mengxue Wang

“…The results showed that compared with soybeans under normal conditions, those grown under drought stress had reduced yield and carbohydrate, protein, essential amino acid, soybean isoflavone, and other nutrient contents. …”
Get full text

Investigation of intracellular signals generated by γ-interferon and IL-4 leading to the induction of class II antigen expression by S. Vassiliadis, N. Kyrpides, D. Stravopodis, M. Grigoriou, I. Athanassakis, J. Papamatheakis

“…Determination of the pathway followed by various cytokines can be achieved using specific inhibitors which include theophylline (TPH), TMB-8 and W7 that hinder calmodulin binding to Ca2+; sphingosine (SPH), H7 and staurosporine that inhibit protein kinase C (PKC) activation; and mevalonate (MEV) or the anti-p21ras antibody which block G-proteins. …”
Get full text

Physicochemical, Functional, Microbial, and Sensory Characteristics of Precooked Complementary Flour Produced from Yellow Maize Enriched with Roasted Cashew Almonds and Baobab Pulp by Wilfred Ngaha Damndja, Aurelie Solange Agume Ntso, Thérèse Josiane Ngatchic Metsagang, Hermionne Djello Nkali

“…The proximate composition (moisture content, total ash, total carbohydrate, crude protein, crude fat, and crude fiber), soluble sugar, some minerals (iron and calcium) and vitamins (A and C), the functional properties (water absorption capacity (WAC) and water solubility index (WSI)), and the microbial characteristics of formulated flours were determined. …”
Get full text

Dystonia caused by ANO3 variants is due to attenuated Ca2+ influx by ORAI1 by Jiraporn Ousingsawat, Khaoula Talbi, Hilario Gómez-Martín, Anne Koy, Alberto Fernández-Jaén, Hasan Tekgül, Esra Serdaroğlu, Juan Darío Ortigoza-Escobar, Rainer Schreiber, Karl Kunzelmann

“…Furthermore, the data provide a first indication of a possible regulation of protein expression in the plasma membrane by ANO3, as has been described for other anoctamins.…”
Get full text