Nanotechnology-assisted cryopreservation of ovine semen: evaluation of Thymus vulgaris essential oil as a natural antioxidant by Samia Khnissi, Rania Maaloul, Hela Chalouati, Laura Mara, Dorra Aouadi, Basma Adouani, Maria Dattena, Ikram Khémiri, Sami Fattouch

“…In addition, the nanoemulsion significantly (p<0,05) decreased the malondialdehyde concentration, increased the total protein and the glucose contents, the lactate dehydrogenase activity. …”
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Decoding nature: multi-target anti-inflammatory mechanisms of natural products in the TLR4/NF-κB pathway by Yue Zhao, Yue Zhao, Jiacai Wu, Xiaolan Liu, Xiaolan Liu, Xu Chen, Xu Chen, Juan Wang, Juan Wang

“…In light of these considerations, this review comprehensively synthesizes recent research findings concerning the TLR4/NF-κB signaling pathway, including the translocation of TLR4 activation to lysosomes within the cytoplasm, the assembly of protein complexes mediated by ubiquitin chains K63 and K48, and the deacetylation modification of p65. …”
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Cardiac safety of gamithromycin in ewes by Orhan Corum, Burak Dik, Emre Bahcican, Emre, Hatice Eser, Hatice, Ayse Er, Enver Yazar

“…Statistically significant (P<0.05) fluctuations were determined in the total bilirubin, total protein, creatinine and white blood cell counts, but these results were within the normal ranges.…”
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Oncogene mutations in non-small cell lung cancer patients in Iran: a study of their association with programmed death ligand-1 expression by Zahra Abrehdari-Tafreshi, Majid Pirestani, Zahra Mosaferi, Nasser Rakhshani, Ehsan Arefian

“…The overall prevalence of PD-L1 protein expression was 36.85%. Notably, PD-L1 expression was detected in 24.8% of cases with EGFR mutations, 20% of cases with KRAS mutations, 64.7% of cases with ALK rearrangements, and in 100% of cases with ROS1 rearrangements. …”
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Antioxidant Bio-Compounds from Chestnut Waste: A Value-Adding and Food Sustainability Strategy by Roberta Barletta, Alfonso Trezza, Andrea Bernini, Lia Millucci, Michela Geminiani, Annalisa Santucci

“…In silico docking simulations further validated the biological relevance of these compounds by predicting strong hydrophobic and polar interactions with oxidative stress-related protein targets. Overall, this study demonstrates the antioxidant properties of chestnut byproducts. …”
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First Report of CTNS Mutations in a Chinese Family with Infantile Cystinosis by Yong-jia Yang, Yuan Hu, Rui Zhao, Xinyu He, Liu Zhao, Ming Tu, Lijun Zhou, Jihong Guo, Linqian Wu, Tantai Zhao, Yi-min Zhu

“…Infantile cystinosis (IC) is a rare autosomal recessive disorder characterized by a defect in the lysosomal-membrane transport protein, cystinosin. It serves as a prototype for lysosomal transport disorders. …”
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Intestinal Microbiota in Patients with Chronic Heart Failure and Systolic Dysfunction by M. V. Fadeeva, A. V. Kudryavtseva, G. S. Krasnov, M. R. Skhirtladze, V. T. Ivashkin

“…The levels of the N-terminal fragment of the cerebral natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) were determined. Echocardiographic examination and, if indicated, Holter ECG monitoring were performed. …”
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Closing the loop: establishing an autonomous test-learn cycle to optimize induction of bacterial systems using a robotic platform by Jan Benedict Spannenkrebs, Aron Eiermann, Thomas Zoll, Silke Hackenschmidt, Johannes Kabisch, Johannes Kabisch, Johannes Kabisch

“…As a target product the readily measurable green fluorescent reporter protein (GFP) is produced over multiple, consecutive iterations of testing. …”
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Mapping C. difficile TcdB interactions with host cell-surface and intracellular factors using proximity-dependent biotinylation labeling by Jennifer S. Ward, Karl J. Schreiber, John Tam, Ji-Young Youn, Roman A. Melnyk

“…Further characterizing the intoxication mechanisms of these proteins is important for the development of vaccines and treatments for toxin-mediated disease. …”
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Aqueous Extract of Leaves and Flowers of Acmella caulirhiza Reduces the Proliferation of Cancer Cells by Underexpressing Some Genes and Activating Caspase-3 by Huiny Miriane Tienoue Fotso, Mary-Ann Mbong Angie, Françoise Raïssa Ntentie, Inelle Makamwe, Ferdinand Lanvin Edoun Ebouel, Emmerencia Kenjing Ndansack, Enyong Julius Oben

“…Results also showed that AE-Ac downregulated the expression of inflammation (IL-1b p=0.017 and IL-6 p=0.028), growth factors (PDGF p=0.039, IGF p=0.034, E2F1p=0.038, and E2F2p=0.016), and antiapoptotic protein genes (Bcl-2 p=0.028 and Bcl-6 p=0.039). The cleaved caspase-3 was positively modulated by the AE-Ac inducing thus cell death by apoptosis. …”
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Rapamycin Improves Palmitate-Induced ER Stress/NF κ B Pathways Associated with Stimulating Autophagy in Adipocytes by Jiajing Yin, Liping Gu, Yufan Wang, Nengguang Fan, Yuhang Ma, Yongde Peng

“…Rapamycin attenuated PA-induced PERK and IRE1-associated UPR pathways, evidenced by decreased protein levels of eIF2α phosphorylation, ATF4, CHOP, and JNK phosphorylation. …”
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Transcriptome Analysis of the Effect of Acute Ammonia Stress on <i>Pseudobagrus ussuriensis</i> Liver Tissue by Shun Shi, Xiaohui Sun, Chunnuan Zhang, Chenran Lv, Yajuan Liu, Juan Du, Qian Qi

“…Especially, the phosphatidylinositol 3-kinase/protein kinase B (PI3K-Akt) signaling pathway had the maximum quantity of DEGs in all the three groups. …”
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Effects of Biogas Slurry Drip Irrigation on Growth Performance of Brassica chinensis L. and Soil Nutrient Dynamics by DongXue Yin, Jiajun Qin, Dongdong Chen, Baozhong Wang, Wei Liu, Yingxian Wang, Weijuan Lan, Zhihao Wang, Jiachen Wang

“…The highest plant height, fresh weight, dry weight, soluble sugar content, and protein content of 25.2 cm, 16.7 g, 1.10 g, 0.61 g/100 g, and 1.90 mg/g, respectively, were obtained under the BS-5 treatment. …”
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Prediabetes: Challenges, Novel Solutions, and Future Directions by Monique E Francois, Katie M Oetsch

“…Synergistic use of the available novel and promising interventions including low carbohydrate diets, higher protein diets, time restricted feeding, and high intensity interval training may help time-poor individuals achieve improvements in risk-factors including weight loss and glycaemic control (HbA1c and fasting plasma glucose). …”
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Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential by Masayo Aoki, Hiroaki Aoki, Rajesh Ramanathan, Nitai C. Hait, Kazuaki Takabe

“…S1P regulates diverse physiological processes by binding to specific G protein-binding receptors, S1P receptors (S1PRs) 1–5, through a process coined as “inside-out signaling.” …”
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Exploring purine analogues as inhibitors against Katanin, a microtubule severing enzyme using molecular modeling approach by Vibhuti Saxena, Pruthanka Patil, Purva Khodke, Bajarang Vasant Kumbhar

“…Abstract Katanin, a key protein in cellular architecture, plays a crucial role in severing microtubules, which are vital components of the cytoskeleton. …”
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New method for cytological evaluation using direct nipple discharge without aspiration by Jiang Zhu, Han Cong, Xiaotong Zhang, Xiaoya Dong, Song Zhao, Chaolu Hu, Jude Ranchu Maimo, Yawen Wang, Kai Zhang, Jianli Wang, Pengyu Li, Rong Ma

“…Following centrifugation to remove blood cells and protein contaminants, the sample of each nipple discharge was analyzed by light microscopy. …”
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Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels by Kirsten K. Ahring, Allan M. Lund, Erik Jensen, Thomas G. Jensen, Karen Brøndum-Nielsen, Michael Pedersen, Allan Bardow, Jens Juul Holst, Jens F. Rehfeld, Lisbeth B. Møller

“…Management of phenylketonuria (PKU) is achieved through low-phenylalanine (Phe) diet, supplemented with low-protein food and mixture of free-synthetic (FS) amino acid (AA). …”
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Growth and viability of juvenile humpback grouper (Cromileptes altivelis) supplemented with inorganic and organic selenium by Muhaimin Hamzah, Muhammad Agus Suprayudi, Nur Bambang Priyo Utomo, Wasmen Manalu

“…On the contrary, supplementation of selenomethionine up to 4 mg Se/kg did not show any signs of toxicity and the survival was on 86.11 to 97.22%. Feed efficiency, protein retention, lipid retention, and Se retention indicated that a dosage of 4 mg Se/kg selenomethionine supplementation was the best dosage. …”
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Neutrophil extracellular traps are associated with airways inflammation and increased severity of lung disease in cystic fibrosis by Sheonagh M. Law, Gareth Hardisty, Jonathan L. Gillan, Nicola J. Robinson, Donald J. Davidson, Moira K.B. Whyte, Ian Dransfield, Robert D. Gray

“…This was highly correlated with sputum calprotectin, a known NET-associated protein. Using a histone-calprotectin NET ELISA, we demonstrated higher levels of NETs in the CF airway. …”
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