Involvement of Proteasome and Macrophages M2 in the Protection Afforded by Telmisartan against the Acute Myocardial Infarction in Zucker Diabetic Fatty Rats with Metabolic Syndrome by C. Di Filippo, C. Rossi, B. Ferraro, R. Maisto, A. De Angelis, F. Ferraraccio, A. Rotondo, M. D’Amico

“…Telmisartan treatment (7 mg/kg and 12 mg/kg) reduced the myocardial infarct size, the expression of proteasome subunits 20S and 26S, and the protein ubiquitin within the heart. The compound has led to an increased M2 macrophage phenotype within the cardiac specimens and a modification of the cardiac cytokine and chemokine profile. …”
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Determination of the Selected Heavy Metal Content and Its Associated Health Risks in Selected Vegetables Marketed in Bahir Dar Town, Northwest Ethiopia by Biset Asrade, Gebremariam Ketema

“…They contain minerals, vitamins, antioxidants, antimetabolites, protein, carbohydrates, and water. However, they are a major source of heavy metals, which contain both essential and toxic heavy metals over a wide range of concentrations. …”
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Extracellular matrix stiffness regulates colorectal cancer progression via HSF4 by Kangtao Wang, Siyi Ning, Shuai Zhang, Mingming Jiang, Yan Huang, Haiping Pei, Ming Li, Fengbo Tan

“…In vivo experiments confirmed that HSF4 promoted tumour growth and metastasis, independent of collagen protein increase. Conclusions This study reveals that tumour stiffness promotes the proliferation and metastasis of CRC by regulating EMT-related signalling pathways through HSF4. …”
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Effect of Amelogenin Solution in the Microhardness of Remineralized Enamel and Shear Bond Strength of Orthodontic Brackets by Guilherme Genovez-Júnior, Sandrine Bittencourt Berger, Lucineide Lima dos Santos, Eloisa Aparecida Carlesse Paloco, Murilo Baena Lopes, Débora Fernandes Giuliangeli, Júlia Graciela Monteiro dos Santos, Ricardo Danil Guiraldo

“…To evaluate the microhardness of tooth enamel remineralized with enamel matrix protein solution as well as the shear bond strength of orthodontic brackets bonded to this surface. …”
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Intestinal Mucosal Barrier Is Injured by BMP2/4 via Activation of NF-κB Signals after Ischemic Reperfusion by Kang Chen, Wei Xie, Binyu Luo, Weidong Xiao, Daniel H. Teitelbaum, Hua Yang, Kebin Zhang, Chaojun Zhang

“…Furthermore, recombinant BMP2/4 decreased the expression of the tight junction protein occludin via the activation of the NF-κB pathway; these effects were abolished by treatment with the BMP-specific antagonist noggin or the NF-κB inhibitor pyrrolidine dithiocarbamate (PDTC). …”
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Prognostic value of miR-223 for pregnancy outcomes in patients with in vitro fertilisation and intracytoplasmic sperm injection by Qi Song, Jiajia Liu, Chen Li, Rongrong Liu, Nan Zhang, Hongzhi Shi

“…In addition, bioinformatics analysis indicated that the target genes of miR-223 were predominantly located in the endocytic vesicle membrane and were primarily enriched in adenosine monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathways.Conclusion In this study, levels of miR-223 in the embryo culture medium predicted pregnancy outcomes in subjects undergoing IVF/ICSI. …”
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Plasma-derived extracellular vesicles prime alveolar macrophages for autophagy and ferroptosis in sepsis-induced acute lung injury by Rongzong Ye, Yating Wei, Jingwen Li, Yu Zhong, Xiukai Chen, Chaoqian Li

“…In this study, an investigation was conducted to map the miRNA and protein expression profiles of EVs derived from septic plasma. …”
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Ultrasound and Thermosonication as Promising Technologies for Processing Plant-Based Beverages: A Review by Dalia M. Sotelo-Lara, Genaro G. Amador-Espejo, Diego F. Álvarez-Araiza, Alondra K. Cordero-Rivera, Karla G. Millán-Quintero, Rocío Campos-Vega, Rita M. Velázquez-Estrada

“…Increasing number of consumers are opting for these beverages due to lactose intolerance, milk protein allergies or lifestyle. In this regard, different emerging technologies have been investigated to solve problems such as shelf life, nutritional and emulsion stability as well as sensory acceptability, without using high temperatures since heat treatments decrease the content of some bioactive compounds. …”
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The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients by Ade Yonata, Zulkhair Ali, Taufik Indrajaya, Erial Bahar, Ian Effendi, Novadian Suhaimi, Suprapti Suprapti

“…Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. …”
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Potential Candidate Genes Associated with Litter Size in Goats: A Review by Wenting Chen, Ying Han, Yinghui Chen, Xiaotong Liu, Huili Liang, Changfa Wang, Muhammad Zahoor Khan

“…Recent advancements in genetic research have identified key genes and pathways associated with reproductive traits, including gonadotropin-releasing hormone (<i>GnRH</i>), inhibin (<i>INHAA</i>), Kit ligand (<i>KITLG</i>), protein phosphatase 3 catalytic subunit alpha (<i>PPP3CA</i>), prolactin receptor (<i>PRLR</i>), POU domain class 1 transcription factor 1 (<i>POU1F1</i>), anti-Müllerian hormone (<i>AMH</i>), bone morphogenetic proteins (<i>BMP</i>), growth differentiation factor 9 (<i>GDF9</i>), and <i>KISS1</i> and suppressor of mothers against decapentaplegic (<i>SMAD</i>) family genes, among others. …”
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Influence of Dietary Chromium and Vitamin E Supplementation on Performance, Metabolism, and Physiology of Broilers Subjected to Cyclic Heat Stress by ML X Júnior, RD Bernardes, CH Oliveira, KMM Dias, BF Almeida, SO Borges, FS Dalólio, KM Gomes, CJ Rodrigues, AA Calderano

“…ABSTRACT This experiment evaluated the influence of chromium (Cr) and vitamin E (VitE) supplementation on the performance, glucose levels, thyroid hormone levels, immune and oxidative response, and 70 kilodalton heat shock protein (HSP70) mRNA expression of broilers under heat stress (HS). …”
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Extracellular Vesicles and Tunnelling Nanotubes as Mediators of Prostate Cancer Intercellular Communication by Jessica K. Heatlie, Joanna Lazniewska, Courtney R. Moore, Ian R. D. Johnson, Bukuru D. Nturubika, Ruth Williams, Mark P. Ward, John J. O’Leary, Lisa M. Butler, Doug A. Brooks

“…TNTs and EVs have been reported to transfer critical cargo involved in cellular functions and signalling, prompting us to investigate the extent of organelle and protein transfer in PCa cells and the potential involvement of the androgen receptor. …”
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The assessment of chemical composition and biological activity of faba bean pods as a potential feed additive utilized in piglets nutrition by Inna Vlasova, Philip Krüsselmann, Yuliia Kostenko, Maciej Obrębski, Sebastian Granica, Wilfried Vahjen, Jürgen Zentek, Marcin Równicki, Jakub P. Piwowarski

“…Air-dried FBP from the cultivar ‘Bizon’ contained high levels of crude protein (144 g/kg), dietary fibre (413 g/kg), potassium (27.8 g/kg), and iron (126 mg/kg). …”
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Salivary proteomics and metaproteomics identifies distinct molecular and taxonomic signatures of type-2 diabetes by Diana Samodova, Evelina Stankevic, Mathilde Sonne Søndergaard, Naiyu Hu, Tarunveer S. Ahluwalia, Daniel R. Witte, Daniel Belstrøm, Anniek Frederike Lubberding, Pratik D. Jagtap, Torben Hansen, Atul S. Deshmukh

“…Abstract Background Saliva is a protein-rich body fluid for noninvasive discovery of biomolecules, containing both human and microbial components, associated with various chronic diseases. …”
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Long non-coding RNA CAR10 promotes angiogenesis of lung adenocarcinoma by mediating nuclear LDHA to epigenetically regulate VEGFA/C by Xiaolu Ge, Chao Du, Li Fang, Wei Xu, Juanjuan Xiang, Jiheng Liu, Ming Zhou, Yuejun Chen, Ziyao Wang, Zheng Li

“…Mechanistically, CAR10 could bind to Lactate Dehydrogenase A (LDHA) protein to regulate the phosphorylation and acetylation of LDHA and increase the dimerization of LDHA to promote its nuclear translocation, which increased the H3K79 methylation in Vascular Endothelial Growth Factor A (VEGFA) and Vascular Endothelial Growth Factor C (VEGFC) gene interval. …”
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Risk factors analysis of hypokalemia after radical resection of esophageal cancer and establishment of a nomogram risk prediction model by Guanqiang Yan, Jingxiao Li, Yiji Su, Guosheng Li, Guiyu Feng, Jun Liu, Xiang Gao, Huafu Zhou

“…The hemoglobin levels, total serum protein, serum albumin, calcium ion concentration, direct bilirubin, prothrombin time (PT), and activated partial thromboplastin time (APTT) were related (p &lt; 0.05). …”
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RNF138 contributes to cisplatin resistance in nasopharyngeal carcinoma cells by Hangyu Xu, Qing Yin, Linna Fan, Yating Zhao, Biying Song, Qifan Xu, Jie Zhu, Meifen Xu

“…This study is aimed to evaluate the effects of RING finger protein 138 (RNF138) in the development of cisplatin resistance to NPC. …”
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Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells by Marjan Nokhbehsaim, Sigrun Eick, Andressa Vilas Boas Nogueira, Per Hoffmann, Stefan Herms, Holger Fröhlich, Søren Jepsen, Andreas Jäger, Joni Augusto Cirelli, James Deschner

“…NAMPT also increased significantly the MMP-1 and CCL2 protein synthesis. NAMPT was significantly induced by interleukin-1β and the periodontal microorganism P. gingivalis. …”
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MicroRNA-33 regulates the synaptic plasticity-related gene ARC in temporal lobe epilepsy by Yuchen Xu, Lily Zhang, Yan Yan, Wenbiao Xiao, Wei Zou, Zhaohui Luo, Bo Xiao, Hongyu Long

“…Following the transfection of HEK cells with a miR-33 mimic, there was a decrease in both ARC mRNA and protein levels, whereas the group treated with a miR-33 inhibitor displayed the opposite effect. …”
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Protease shaving of Mycobacterium tuberculosis facilitates vaccine antigen discovery and delivery of novel cargoes to the Mtb surface by Bianca A. Lepe, Christine R. Zheng, Owen K. Leddy, Benjamin L. Allsup, Sydney L. Solomon, Bryan D. Bryson

“…Pairing quantitative mass spectrometry with the construction of validation strains, we revealed several novel Mtb proteins on the Mtb surface largely derived from the PE/PPE class of Mtb proteins, including PPE18, a component of a leading Mtb vaccine candidate. …”
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