In Silico and In Vitro Inhibitory Activity of Indonesian Herbal Compound Extracts against SARS-COV-2 Recombinant Papain-Like Protease by Fairuz Andini Fatiningtyas, Riswanto Napitupulu, Amarila Malik, Is Helianti

“…The molecular docking method utilized the target protein PLpro (PDB ID: 7CMD), with the native ligand obtained from compounds identified in these plant extracts. …”
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Deficient Purposeful Use of Forepaws in Female Mice Modelling Rett Syndrome by Bianca De Filippis, Mattia Musto, Luisa Altabella, Emilia Romano, Rossella Canese, Giovanni Laviola

“…Mutations in the methyl CpG binding protein 2 gene (MECP2) cause more than 95% of classic cases. …”
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PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) DENGAN HYPERCOAGULABLE STATE by Fitrach Desfiyanda, Irza Wahid

“…Hal ini disebabkan oleh kelainan seluler karena mutasi somatik pada hematopoetic stem cell yang menyebabkan terjadinya defisiensi berbagai jenis protein yang diperlukan bagi pembentukan glycosylphosphatidylinositol (GPI) anchored, yakni antara lain yang tersering decay accelerating factor (DAF, CD55) dan membrane inhibitor of reactive lysis (MIRL, CD59). …”
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MacSyFinder v2: Improved modelling and search engine to identify molecular systems in genomes by Néron, Bertrand, Denise, Rémi, Coluzzi, Charles, Touchon, Marie, Rocha, Eduardo P.C., Abby, Sophie S.

“…Finally, we have updated and improved MacSyFinder popular models: TXSScan to identify protein secretion systems, TFFscan to identify type IV filaments, CONJscan to identify conjugative systems, and CasFinder to identify CRISPR associated proteins. …”
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Serum glutathione peroxidase-3 concentration at diagnosis as a biomarker for assessing disease activity and damage of antineutrophil cytoplasmic antibody-associated vasculitis at d... by Jihye Chung, Jang Woo Ha, Yong-Beom Park, Yong-Beom Park, Sang-Won Lee, Sang-Won Lee

“…Serum GPX-3 concentration at diagnosis was inversely correlated with BVAS (r = −0.280), VDI (r = −0.263), and C-reactive protein (r = −0.261) at diagnosis, whereas, it was positively correlated with haemoglobin (r = 0.255), and serum albumin (r = 0.240) at diagnosis, respectively. …”
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The Synergistic Effects of Celastrol in combination with Tamoxifen on Apoptosis and Autophagy in MCF-7 Cells by Lijun Wang, Luqun Tang, Chengyun Yao, Chunyan Liu, Yongqian Shu

“…However, in an MCF-7-implanted nude mouse model, it was possible to detect significantly decreased tumour volumes and tumour weights and decreased p-Akt and p-mTOR protein expression in the celastrol+tamoxifen group. …”
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Assessment of the CALLY Index, a Novel Immunonutrivite Marker, in Perioperatively Treated Gastric Cancer Patients by Orhun Akdoğan, Kadriye Bir Yücel, Ozan Yazıcı, Ahmet Özet, Nuriye Özdemir

“…Objective: This study aimed to investigate the prognostic significance of the C-reactive protein-albumin-lymphocyte (CALLY) index in patients with early-stage gastric cancer and compare it with other immune markers, such as systemic immune-inflammation index (SII), neutrophil lymphocyte ratio (NLR), and prognostic nutritional index (PNI). …”
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6-thioguanine inhibits EV71 replication by reducing BIRC3-mediated autophagy by Qiao You, Jing Wu, Ruining Lyu, Yurong Cai, Na Jiang, Ye Liu, Fang Zhang, Yating He, Deyan Chen, Zhiwei Wu

“…Results 6-TG significantly suppressed EV71 mRNA level, VP1 protein expression, and viral progeny production in HT-29 cells. …”
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NADPH Oxidase 2-Mediated Insult in the Auditory Cortex of Zucker Diabetic Fatty Rats by Zheng-De Du, Wei Wei, Shukui Yu, Qing-Ling Song, Ke Liu, Shu-Sheng Gong

“…The auditory brainstem response (ABR) of ZDF rats was found to be markedly elevated in low (8 kHz) and high (32 kHz) frequencies. Protein expression of NADPH oxidase 2 (NOX2) and its matching subunits P22phox, P47phox, and P67phox was increased in the auditory cortex of ZDF rats. …”
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Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study by Kaylie I. Kirkwood-Donelson, Alan K. Jarmusch, Carl D. Bortner, Bruce Alex Merrick, Birandra K. Sinha

“…Erastin (ER), a ferroptosis inducer, kills tumor cells by generating and accumulating reactive oxygen species (ROS) within the cell, resulting in an iron-dependent oxidative damage-mediated ferroptotic cell death.MethodsWe have utilized human ovarian cancer cell lines, OVCAR-8 and its adriamycin-selected, multi-drug resistance protein (MDR1)-expressing NCI/ADR-RES, both equally sensitive to ER, to identify metabolic biomarkers of ferroptosis.ResultsOur studies showed that ER treatment rapidly depleted cellular glutathione and cysteine and enhanced formation of ophthalamate (OPH) in both cells. …”
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Exploring the Hepatoprotective Effect of Agaricus bisporus Based on Network Pharmacology by WANG Jie, WANG Jinmei, LIU Hui, LIU Xuguang, GUO Wenjing, HE Hongping

“…Detection of the mRNA and protein expression levels of relevant genes was performed using real-time quantitative polymerase chain reaction (PCR) and Western blot techniques, showing that compared with the model group, the expression of the Bcl-2 in the high-dose group significantly increased (P < 0.001), while the expression of MYC, NF-κB1, RELA and MMP9 significantly decreased (P < 0.01). …”
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Development of a Novel Sensor System Based on Magnetic Microspheres to Detect Cardiac Troponin T by Junrong Zhang, Hongxiang Liu, Baofeng Xu, Sijun Huang, Rui Liu, Jinming Zhu, Yi Guo, Li Xu

“…The present study is aimed at exploring a novel sensing system with high specificity and precision based on magnetic microspheres developed to detect cardiac troponin T (cTnT), which is the most specific diagnostic marker for AMI in cardiovascular diseases. Naive human cTnT protein in serum samples and antigens on functional magnetic microspheres will competitively bind with limited specific antibodies. …”
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Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models by Shengying Lin, Roy Wai-Lun Tang, Yutong Ye, Chenxi Xia, Jiahui Wu, Ran Duan, Ka-Wing Leung, Tina Ting-Xia Dong, Karl Wah-Keung Tsim

“…Three flavonoids, namely, farrerol, ononin and (−)-epicatechin, were shown to express binding affinities to VEGF protein and inhibit VEGF-mediated biological activities. …”
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Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase by Keiichi Mitsuyama, Nobuo Tomiyasu, Kosuke Takaki, Junya Masuda, Hiroshi Yamasaki, Kotaro Kuwaki, Teiko Takeda, Shigehiko Kitazaki, Osamu Tsuruta, Michio Sata

“…A time course study showed that in patients with UC and CD, serum concentrations of IL-6 and C-reactive protein increased during the acute phase and returned to normal as patients go into remission. …”
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Anti-HMGB1 Neutralizing Antibody Ameliorates Neutrophilic Airway Inflammation by Suppressing Dendritic Cell-Mediated Th17 Polarization by Fang Zhang, Gang Huang, Bo Hu, Li-Ping Fang, E-Hong Cao, Xiao-Feng Xin, Yong Song, Yi Shi

“…We demonstrate that high mobility group box 1 protein (HMGB1) directs Th17 skewing by regulating dendritic cell (DC) function. …”
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Assessment of infectious diseases in commercial frozen semen straws of water buffalo bulls. Preliminary results by Rosaura Pérez-Gil

“…The detection of antibodies against the gB glycoprotein of the IBR virus and the p80 protein of the BVDV and against Neospora caninum was performed using the ELISA technique according to the detection kit manufacturer IDvet and IDEXX specifications. …”
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Potential involvement of cuproptosis induced by m6A-modified autophagy gene ATG10 in KICH by Qingyun Zhu, Daiquan Fu, Zhaohui Zhu, Jian Wu, Chenxi Li, Jiajun Chen, Chuan Chen, Yanxiang Li, Yuehui Guo, Xiangqi Li

“…ATG10’s involvement in the protein lipidation pathway, essential for cuproptosis, was identified. …”
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Immunomodulation effects of collagen hydrogel encapsulating extracellular vesicles derived from calcium silicate stimulated-adipose mesenchymal stem cells for diabetic healing by Yen-Hong Lin, Yeh Chen, En-Wei Liu, Mei-Chih Chen, Min-Hua Yu, Cheng-Yu Chen, Chia-Che Ho, Tai-Yi Hsu-Jiang, Jian-Jr Lee, Der-Yang Cho, Ming-You Shie

“…CSEV exhibited enhanced protein content, surface marker expression, and bioactive cargo enriched with pro-angiogenic and anti-inflammatory factors. …”
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Integrating anaerobic co-digestion and BSF larvae cultivation: A sustainable approach to fish innards and food waste management by Riris Waladatun Nafi'ah, Sri Suhartini, Nur Hidayat, Yusuf Wibisono, Nimas Mayang Sabrina Sunyoto, Lailia Alfisya, Rohmi Nadi Wilujeng, Nur Anisah Rizky Harahap, Hanna Syakira Salsabila, Novita Ainur Rohma, Andhika Putra Agus Pratama, Khairil Anas Md Rezali

“…The integration of ACoD and BSF larvae cultivation provides multiple advantages, including the production of renewable energy, biofertilizers, and high-protein larvae, while reducing organic waste and minimizing environmental impacts. …”
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Effects of aluminum on metabolism of reactive oxygen species and reactive nitrogen species in root tips of different Eucalyptus species by Zilong Ouyang, Bing Liu, Tangkan Li, Tiandao Bai, Weichao Teng

“…In addition to suppressions of root relative elongation and root activity, the accumulations of soluble sugar, soluble protein, and proline can be used as indicators of Al sensitivity in Eucalyptus species. …”
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