Multi-omics analysis reveals the sensitivity of immunotherapy for unresectable non-small cell lung cancer by Rui Wu, Kunchen Wei, Xingshuai Huang, Yinge Zhou, Xiao Feng, Xin Dong, Hao Tang

“…Then we classified samples according to the follow-up results after two courses of immunotherapy and non-targeted metabolomics and proteomics analyses were performed to select different metabolites and proteins. Finally, potential biomarkers were picked out by applying machine learning methods including random forest and stepwise regression and prediction models were constructed by logistic regression.ResultsThe presence of metabolites and proteins in peripheral blood plasma was causally associated with both non-small cell lung cancer and PD-L1/PD-1 expression levels. …”
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Early Infantile Epileptic Encephalopathy in an STXBP1 Patient with Lactic Acidemia and Normal Mitochondrial Respiratory Chain Function by Dong Li, Elizabeth Bhoj, Elizabeth McCormick, Fengxiang Wang, James Snyder, Tiancheng Wang, Yan Zhao, Cecilia Kim, Rosetta Chiavacci, Lifeng Tian, Marni J. Falk, Hakon Hakonarson

“…A wide range of clinical findings have been associated with mutations in Syntaxin Binding Protein 1 (STXBP1), including multiple forms of epilepsy, nonsyndromic intellectual disability, and movement disorders. …”
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Changes in Digestive Enzyme Activities during Larval Development of Spotted Seatrout (Cynoscion nebulosus) by Martín Alberto Arenas-Pardo, Martha Gabriela Gaxiola-Cortés, Alvaro Fabricio Barreto-Altamirano, Adriana del Carmen Paredes-Medina, Iveth Gabriela Palomino-Albarrán, Patricia Margarita Balam-Uc, Juan Carlos Maldonado-Flores, Carlos Alfonso Álvarez-González

“…These results indicate that the spotted seatrout larvae have a digestive system adapted to lipids and carbohydrates at the onset of feeding, with an immediate transition to protein digestion when exogenous feeding begins. Additionally, the digestive system of the spotted seatrout may be considered mature at 25 DAH. …”
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Identifcation and fine mapping of qHSW1, a major QTL for hundred-seed weight in mungbean by Xuesong Han, Xuesong Han, Long Zhao, Juan Yu, Xingmin Wang, Shilong Zhang, Li Li, Li Li, Changyan Liu, Changyan Liu

“…Mung bean, an important economic crop, is considered a crop with relatively high levels of plant protein constituents and is consumed as both a vegetable and a grain. …”
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Artemisia capillaris with two novel active compounds, Kawarayomogin I and II, inhibits HYBID (KIAA1199) expression as well as hyaluronic acid degradation by Kazal Boron Biswas, Yuka Kawai, Satoshi Nakagawa, Kyoko Kanai, Hiroyuki Kojima, Teruaki Masutani, Masayoshi Oyama, Arunasiri Iddamalgoda, Kotaro Sakamoto

“…Abstract Hyaluronic acid (HA) is an important component of the skin’s extracellular matrix, and its degradation leads to wrinkles. Hyaluronan-binding protein involved in hyaluronan depolymerization (HYBID) is the main factor responsible for HA degradation in dermis. …”
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Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases by Chang Youn Lee, Ran Kim, Onju Ham, Jihyun Lee, Pilseog Kim, Seokyeon Lee, Sekyung Oh, Hojin Lee, Minyoung Lee, Jongmin Kim, Woochul Chang

“…In addition to treatment with drugs or overexpressed miRNA in stem cells, stem cell-derived extracellular vesicles also have therapeutic potential because they can deliver the stem cell-specific RNA and protein into the host cell, thereby improving cell viability. …”
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Systematic Administration of B Vitamins Alleviates Diabetic Pain and Inhibits Associated Expression of P2X3 and TRPV1 in Dorsal Root Ganglion Neurons and Proinflammatory Cytokines... by Duan-Duan He, Yu Gao, Shan Wang, Zhong Xie, Xue-Jun Song

“…Western blot analysis and immunohistochemistry were used to analyze protein expressions in DRG and ELISA to measure the proinflammatory cytokines in the spinal cord. …”
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Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis by You Wu, Yong-Ming Yao, He-Liang Ke, Lan Ying, Yao Wu, Guang-Ju Zhao, Zhong-Qiu Lu

“…Several studies have demonstrated that Mdivi-1, which is a selective inhibitor of the dynamin-related protein 1 (Drp1), attenuates apoptosis of myocardial cells and neurons during various pathologic states. …”
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Development of Diagnostic Biomarkers for Detecting Diabetic Retinopathy at Early Stages Using Quantitative Proteomics by Jonghwa Jin, Hophil Min, Sang Jin Kim, Sohee Oh, Kyunggon Kim, Hyeong Gon Yu, Taesung Park, Youngsoo Kim

“…Although further validation with a larger sample size is needed, the 4-protein marker panel (APO4, C7, CLU, and ITIH2) could represent a useful multibiomarker model for detecting the early stages of DR.…”
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Comparative Analysis of Seventeen Mitochondrial Genomes of Mileewinae Leafhoppers, Including the Unique Species Mileewa digitata (Hemiptera: Cicadellidae: Mileewinae) From Xizang,... by Hongli He, Bin Yan, Xiaofei Yu, Maofa Yang

“…Each genome contains 13 protein‐coding genes (PCGs), 22 transfer RNA genes (tRNAs), and 2 ribosomal RNA genes (rRNAs). …”
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Testing of artificial feed by using raw material from Euthynnus affinis waste flour for gourami (Osphronemus gourami) by Nazlia Suraiya, Ismarica Ismarica, Alfarizy Muhammad, Aufari Hatfan, Syauqi Muhammad, Purnama Febri Suri, Rezvani Aprita Ika, Muhardina Virna

“…The results of chemical tests (proximate) showed that feed without the addition of waste flour and feed with the addition of waste flour provided protein content values of 20.89% and 30-32%. In biological studies, the addition of waste flour to feed had no significant impact (P>0.05) on gourami survival, but it had an important effect (P<0.05) on weight. …”
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Mitochondrial chaperonin DNAJC15 promotes vulnerability to ferroptosis of chemoresistant ovarian cancer cells by Stefano Miglietta, Manuela Sollazzo, Iacopo Gherardi, Sara Milioni, Beatrice Cavina, Lorena Marchio, Monica De Luise, Camelia Alexandra Coada, Marco Fiorillo, Anna Myriam Perrone, Ivana Kurelac, Giuseppe Gasparre, Luisa Iommarini, Anna Maria Ghelli, Anna Maria Porcelli

“…Recently, it has been proposed that the loss of DNAJC15 correlates with cisplatin (CDDP)-resistance onset in ovarian cancer (OC), suggesting this protein as a potential prognostic factor during OC progression. …”
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Smoking Induces the Circulating Levels of Matrix Metalloproteinase-9 and Its Association with Cardiovascular Risk in Young Smokers by Dinesh NATH, Meera SHIVASEKAR, V. M. VINODHINI

“…The serum MMP-9, high-sensitivity C-reactive protein (hs-CRP), and apolipoprotein-E (APO-E) levels were analyzed using the ELISA method, and the lipid levels were measured enzymatically using AU480 automatic analyzer (Beckman Coulter). …”
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Predictive value of epicardial fat thickness for left ventricular reverse remodeling after radiofrequency ablation in atrial fibrillation patients with left ventricular hypertrophy by Ke Hu, Wenhui Wang, Junping Zhen, Chunsong Kang

“…[Results] A total of 28 patients who did not achieve reverse remodeling were included in the control group, and 22 patients who achieved reverse remodeling were included in the reverse remodeling group.There were significant differences in age, atrial fibrillation classification, duration of atrial fibrillation, left atrial diameter (LAD), left ventricular end-diastolic diameter, left ventricular end-diastolic diameter index (LVEDI), neutrophil to lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hsCRP), platelet distribution width(PDW), red cell distribution width, fibrinogen to albumin ratio (FAR) and EFT between the two groups (P<0.05).Multivariate logistic regression analysis showed that EFT, LAD, LVEDI, NLR, hsCRP, PDW and FAR were independent factors for left ventricular reverse remodeling(P<0.05).The cut-off value of EFT for predicting postoperative left ventricular reverse remodeling was 0.848, sensitivity was 95.5%, specificity was 89.3%, and AUC was 0.937 (95% CI: 0.868-0.983). …”
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The Impact of Selenium on the Physiological Activity of Yeast Cells Saccharomyces cerevisiae ATCC 7090 and Rhodotorula glutinis CCY 20-2-26 by Wioletta Sęk, Anna M. Kot, Marek Kieliszek

“…Furthermore, selenium in the tested concentration range increased protein content in the cellular biomass but did not affect intracellular lipid production.…”
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The Level of hs-CRP in Coronary Artery Ectasia and Its Response to Statin and Angiotensin-Converting Enzyme Inhibitor Treatment by Yilmaz Ozbay, Mehmet Akbulut, Mehmet Balin, Hidayet Kayancicek, Adil Baydas, Hasan Korkmaz

“…Coronary artery ectasia (CAE) was thought of as a variant of atherosclerosis. C-reactive protein (CRP) which is among the most sensitive markers of systemic inflammation, and elevation of systemic and local levels of this inflammatory marker which has been associated with an increased risk for cardiovascular disease in the obstructive coronary artery disease (O-CAD) are well known, but little was known in CAE. …”
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Digestive Fermentation, Antioxidant Status, and Haemato-Biochemical Indices of Growing Rabbits Fed on Diets Supplemented with Ziziphus spina-christi Leaf by Suha Hashim Abduljawad

“…These observations of total protein and albumin within the range of reference values were reported in healthy rabbits, while glucose significantly decreased with the addition of ZL and AST in the blood increased significantly. …”
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The immunohistochemical combination of low SGLT2 expression and high PRDX4 expression independently predicts shortened survival in patients undergoing surgical resection for hepato... by Yao Liu, Jia Han, Akihiro Shioya, Yang-Xian Zhang, Vu Anh Dung, Takeru Oyama, Xin Guo, Qian Yang, Tohru Ito, Sohsuke Yamada

“…Sodium glucose cotransporter 2 (SGLT2) is a glucose transporter protein present in the proximal renal tubules. Studies have shown that SGLT2 is associated with the occurrence of tumors and is upregulated in various tumors. …”
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Effect of titin phosphorylation on degradation of titin from skeletal muscles by Ying Wang, Xin Li, Dequan Zhang, Zheng Li, Baocai Xu, Jie Zhu

“…This study aimed to investigate effect of phosphorylation on titin degradation. Protein kinase A (PKA) and alkaline phosphatase (AP) were added to crude titin extracted from ovine longissimus lumborum (LL) muscles. …”
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Severe Diabetic Ketoacidosis in Children with Type 1 Diabetes: Ongoing Challenges in Care by Simone Foti Randazzese, Mariarosaria La Rocca, Bruno Bombaci, Alessandra Di Pisa, Elèna Giliberto, Teresa Inturri, Daniel Militi, Fortunato Lombardo, Eloisa Gitto, Giuseppina Salzano, Stefano Passanisi

“…Pathogenesis is linked to insulin deficiency and an excess of counter-regulatory hormones, which disrupt glucose, protein, and lipid metabolism, causing hyperglycemia, ketosis, acidosis, dehydration, and electrolyte imbalances. …”
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