The role of SASP in ischemic stroke: a deep dive into cellular mechanisms by Dong Xie, Yang Liu, Fang-Biao Xu, Jin-Sheng Zhang

“…The present study endeavored to preliminarily dissect the SASP-IS nexus via combined bulk and single-cell transcriptome analysis.MethodsAggregated expression profiles from human peripheral blood bulk chips and MCAO mouse single-cell sequencing data, followed by SASP gene analysis. Executed protein interaction network and enrichment assays. …”
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Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

“…Pediatric low-grade gliomas (pLGG) are a group of tumors largely driven by alterations in a single genetic pathway, known as the RAS-RAF-mitogen-activated protein kinase (MAPK) pathway. Recent biologic insights and therapeutic targeting of MAPK-alterations have dramatically shifted the treatment approach in pLGG. …”
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FGFR antagonists restore defective mandibular bone repair in a mouse model of osteochondrodysplasia by Anne Morice, Amélie de La Seiglière, Alexia Kany, Roman H. Khonsari, Morad Bensidhoum, Maria-Emilia Puig-Lombardi, Laurence Legeai Mallet

“…We found that the expression of genes involved in autophagy and apoptosis (Smad1, Comp, Birc2) was significantly perturbed and that the Dusp3, Dusp9, and Socs3 genes controlling the mitogen-activated protein kinase pathway were overexpressed. Lastly, we found that treatment with a tyrosine kinase inhibitor (BGJ398, infigratinib) or a C-type natriuretic peptide (BMN111, vosoritide) fully rescued the defective endochondral bone repair observed in Hch mice. …”
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The role of cholesterol in modifying the lipid-lowering effects of Fuzhuan brick-tea in Caenorhabditis elegans via SBP-1/SREBP by Lianyun Pan, Yan Lu, Shen Dai, Xiangyue Tang, Ligui Xiong, Zhonghua Liu, Yushun Gong

“…Moreover, this mechanism may involve the conserved sterol regulatory element-binding protein (SREBP)/mediator-15 (MDT-15) signaling pathway and the nuclear hormone receptor NHR-80. …”
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The Role of NMP22 and CSTB Levels in Predicting Postoperative Recurrence of Bladder Cancer by Changkun Huang, Xiaolin Ai, Liping Hu, Da Ren

“…To investigate the value of preoperative urinary nuclear matrix protein 22 (NMP22) and Cystatin B (CSTB) expressions in evaluating the postoperative recurrence of bladder cancer. …”
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Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3+ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice by Yoon-Young Sung, Seung-Hyung Kim, Dong-Seon Kim, Ji-eun Lee, Ho Kyoung Kim

“…We investigated the effects of treatment on airway hyperresponsiveness, IgE production, pulmonary eosinophilic infiltration, immune cell phenotypes, Th2 cytokine production in bronchoalveolar lavage, Th1/Th2 cytokine production in splenocytes, forkhead box protein 3 (Foxp3) expression, and lung histology. …”
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Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids by Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

“…Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). …”
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Intra-uterine Growth Restriction Downregulates the Hepatic Toll Like Receptor-4 Expression and Function by Ozlem Equils, Sapna Singh, Semra Karaburun, Daning Lu, Manikkavasagar Thamotharan, Sherin U. Devaskar

“…We examined the effect of maternal starvation on Toll like receptor (TLR)4 expression in hepatic, splenic and intestinal tissues obtained from the adult IUGR offspring of prenatal calorie restricted rats. The hepatic TLR4 protein concentration was undetectable in the IUGR rats that had restricted milk intake during the suckling period (SM/SP; n = 4, p < 0.05) as compared to the normal growth controls (CM/CP; n=4), and access to ad lib milk intake during the sucking period partially corrected the hepatic TLR4 expression (SM/CP; n = 4). …”
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Prevalence of the polymorphic H-ficolin (FCN3) genes and mannosebinding lectin-associated serine protease-2 (MASP2) in indigenous populations from the Russian Arctic regions by M. V. Smolnikova, S. Yu. Tereshchenko

“…Lectins, being the main proteins of the lectin pathway activating the complement system, are encoded by polymorphic genes, wherein point mutations cause the protein conformation and expression to change, which turns out to have an effect on the functionality and ability to respond to the pathogen. …”
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Human Defence Factors in Different Gestational Week Placenta: A Pilot Study by Andris Kamergrauzis, Mara Pilmane, Anna Junga

“…Background: Numerous studies have shown the presence of multiple defence factors in placental tissue, although their role is partially understood; therefore, the aim of this study was to evaluate the expression of nuclear factor-kappa B (NF-κB); human beta-defensin 2, 3, and 4 (HBD-2,3,4); cathelicidine (LL-37); heat shock protein 60 (HSP60); and interleukin 10 (IL-10) in dissimilar gestational week placental tissue and display correlations between immunoreactive cells. …”
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Platelet-to-lymphocyte ratio as a biomarker of systemic inflammation in systemic lupus erythematosus: A meta-analysis and systematic review. by Young Ho Lee, Gwan Gyu Song

“…Furthermore, a meta-analysis was conducted on correlation coefficients between PLR and various parameters in SLE patients, including the SLE Disease Activity Index (SLEDAI), C3, C4, anti-dsDNA, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP).<h4>Results</h4>In total, fifteen studies comprising 1,522 SLE patients and 1,424 controls were eligible for inclusion. …”
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Different functions of PHF10 isoforms – subunits of the PBAF chromatin remodeling complex by A. A. Sheynov, V. V. Tatarskiy, A. M. Azieva, S. G. Georgieva, N. V. Soshnikova

“…The core consists of ATPase and structure subunits, specific subunits of the module are necessary for chromatin binding. PHF10 (PHD finger protein 10) is a subunit of the PBAF (polybromo-associated BAF) chromatin remodelling complex subfamily. …”
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Isolation and optimization of Bacillus thuringiensis BRB-3 isolated from germinated black upland rice seeds for GABA production by Rungnapha Wannasutta, Sophon Boonlue, Nuntavun Riddech, Wiyada Mongkolthanaruk

“…Under optimal conditions of 3 % soy protein as the nitrogen source, 2 % sucrose, no added MSG at 30 °C, pH 6.5 for 12 days, B. thuringiensis BRB-3 achieved a high GABA yield of 25.06 g/L (242.9 mM). …”
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Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells by Stefanie Hoyer, Kerstin F. Gerer, Isabell A. Pfeiffer, Sabrina Prommersberger, Sandra Höfflin, Tanushree Jaitly, Luca Beltrame, Duccio Cavalieri, Gerold Schuler, Julio Vera, Niels Schaft, Jan Dörrie

“…None of those RNAs induced changes in the expression of CD25, CD40, CD83, CD86, and CD70 or the secretion of the cytokines IL-8, IL-6, and TNFα of more than 1.5-fold compared to the control condition, while an mRNA encoding an NF-κB-activation protein as positive control induced massive secretion of the cytokines. …”
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Mitogenomic Phylogenetic Analyses Reveal New Insights into the Taxonomy and Evolution of Parnassiinae Swallowtail Butterflies (Lepidoptera: Papilionidae) by Lu Song, Xiaoxiao Chen, Xiushan Li, Raul Narciso C. Guedes, Youssef Dewer, Suqin Shang, Jingjiang Zhou

“…Both mitogenomes are circular, double-stranded molecules, measuring 15,377 bp and 15,348 bp in length, each encoding 37 standard mitochondrial genes: 13 protein-coding genes (PCGs), 22 transfer RNA genes, 2 ribosomal RNA genes, and an A + T-rich control region. …”
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Pulsed Electromagnetic Field-Assisting Reduced Graphene Oxide-Incorporated Nanofibers for Osteogenic Differentiation of Human Dental Pulp Stem Cells by Juo Lee, Sungmin Lee, Iksong Byun, Myung Chul Lee, Jungsil Kim, Hoon Seonwoo

“…RGO-NFs exhibited higher osteogenesis-related protein expression than PCL-only scaffolds, further enhanced by pulsed electromagnetic field (PEMF) application. …”
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Synergistic Antitumor Effects of Anlotinib Combined with Oral 5-Fluorouracil/S-1 via Inhibiting Src/AKT Signaling Pathway in Small-Cell Lung Cancer by Xinhang Xia, Wenhu Pi, Yanli Lan, Xiaomai Wu, Dongqing Lv, Yinnan Meng, Haihua Yang, Wei Wang

“…Western blot was performed to determine the protein levels of the combined action of the two drugs. …”
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Augmented immunogenicity of the HPV16 DNA vaccine via dual adjuvant approach: integration of CpG ODN into plasmid backbone and co-administration with IL-28B gene adjuvant by Yan Zhou, Ting Zhang, Zhirong Wang, Xuemei Xu

“…We have previously developed an HPV 16 DNA vaccine encoding a modified E7/HSP70 (mE7/HSP70) fusion protein, which demonstrated significant antitumor effects in murine models. …”
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Prediction of Genes Related to Positive Selection Using Whole-Genome Resequencing in Three Commercial Pig Breeds by HyoYoung Kim, Kelsey Caetano-Anolles, Minseok Seo, Young-jun Kwon, Seoae Cho, Kangseok Seo, Heebal Kim

“…To understand how these single nucleotide polymorphisms (SNPs) related positive selection affect protein function, we analyzed the effect of non-synonymous SNPs. …”
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Clinical Traits of SARS-CoV-2 Infection by O. Yu. Zolnikova, N. L. Dzhakhaya, N. D. Potskherashvili, K. B. Puzakov, O. Yu. Кiseleva, N. I. Kokina, E. R. Buklis, T. V. Roshchina, I. I. Коmkova

“…Patients infected with SARS-CoV-2 usually exhibit lymphopenia (p ≤ 0.001), leucocytosis, the elevated neutrophils (p ≤ 0.05), neutrophil-lymphocyte ratio (p ≤0,05), C-reactive protein (p ≤ 0.05), ferritin (p ≤ 0.05), D-dimer (p ≤ 0.05) and fibrinogen (p ≤ 0.05), altered prothrombin time (p ≤ 0.05) and INR (p ≤ 0.05). …”
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