Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data by Gabriel Morey-León, Paulina M. Mejía-Ponce, Juan Carlos Fernández-Cadena, Evelyn García-Moreira, Derly Andrade-Molina, Cuauhtémoc Licona-Cassani, Pablo Fresia, Luisa Berná

“…Our results revealed significant genomic diversity among the isolates, particularly in the genes related to protein processing, carbohydrate metabolism, lipid metabolism, and xenobiotic biodegradation and metabolism. …”
Get full text

Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ by Jinsai Shang, Douglas J Kojetin

Get full text

Mitochondrial-ER Contact Sites and Tethers Influence the Biosynthesis and Function of Coenzyme Q by Noelle Alexa Novales, Hadar Meyer, Yeynit Asraf, Maya Schuldiner, Catherine F. Clarke

“…In Saccharomyces cerevisiae (yeast), CoQ biosynthesis occurs exclusively in the mitochondrial matrix via a large protein-lipid complex, the CoQ synthome, comprised of CoQ itself, late-stage CoQ-intermediates, and the polypeptides Coq3-Coq9 and Coq11. …”
Get full text

GWAS of a soybean breeding collection from South East and South Kazakhstan for resistance to fungal diseases by A. Zatybekov, S. Abugalieva, S. Didorenko, A. Rsaliyev, Y. Turuspekov

“…In Kazakhstan the area under soybean is increasing every year, helping to solve the problem of protein deficiency in human nutrition and animal feeding. …”
Get full text

Computational antidiabetic assessment of Salvia splendens L. polyphenols: SMOTE, ADME, ProTox, docking, and molecular dynamic studies by Hatun A. Alomar, Wafaa M. El Kady, Asmaa A. Mandour, Amany A. Naim, Neveen I. Ghali, Taghreed A. Ibrahim, Noha Fathallah

“…Molecular docking studies on α-glucosidase and protein tyrosine phosphatase 1B revealed that compound 4 had the highest binding energy, surpassing that of the standard drug rosiglitazone. …”
Get full text

Effect of Zinc and Magnesium Fertilizers on the Yield and Some Characteristics of Wheat (Triticum aestivum L.) Seeds in Two Years by Farhad Sadeghi, Abbas Rezeizad, Mehdi Rahimi

“…The parameters studied included germination, plant height, tillering, 1000-seed weight, hectoliter weight, concentrations of zinc and magnesium in seeds, protein content, and yield. The effects of zinc sulfate and magnesium sulfate for most traits were significant (p<0.01). …”
Get full text

The Protective Effect of Low-Dose Ethanol on Myocardial Fibrosis through Downregulating the JNK Signaling Pathway in Diabetic Rats by Ying Yu, Xian-Jie Jia, Wei-ping Zhang, Ting-ting Fang, Jie Hu, Shan-Feng Ma, Qin Gao

“…The mRNA expression of ALDH2 was assessed with Real-Time PCR. The protein expressions of p-JNK and JNK were evaluated using western blot. …”
Get full text

Disomic chromosome 3R(3B) substitution causes a complex of meiotic abnormalities in bread wheat <i>Triticum aestivum</i> L. by А. А. Zhuravleva, О. G. Silkova

“…Employing immunostaining with antibodies against microtubule protein, α-tubulin, and the centromerespecific histone (CENH3), as well as FISH, we analyzed microtubule cytoskeleton dynamics and wheat and rye 3R chromosomes behavior in 3R(3B) (Triticum aestivum L. variety Saratovskaya 29 × Secale cereale L. variety Onokhoiskaya) meiosis. …”
Get full text

Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs by Ming-Xia Duan, Heng Zhou, Qing-Qing Wu, Chen Liu, Yang Xiao, Wei Deng, Qi-Zhu Tang

“…The expression of vascular endothelial growth factor (VEGF) protein, a vital factor in angiogenesis, was improved by Andr treatment under HG stimulation. …”
Get full text

Patient stratification by genetic risk in Alzheimer's disease is only effective in the presence of phenotypic heterogeneity. by Jack Euesden, Muhammad Ali, Chloe Robins, Praveen Surendran, Padhraig Gormley, Alzheimer’s Disease Neuroimaging Initiative (ADNI), David Pulford, Carlos Cruchaga

“…Genome-wide association studies identified no loci associated with progression at genome-wide significance (α = 5×10-8); MR analyses provided no significant evidence of an association between cognitive decline in AD patients and protein levels in brain, cerebrospinal fluid (CSF), and plasma. …”
Get full text

Dickkopf-1 Is a Biomarker for Systemic Lupus Erythematosus and Active Lupus Nephritis by Jing Xue, Jiali Yang, Lijuan Yang, Shaolan Zhou, Chen Ji, Xuemei Wang, Nan Yu, Xiaoming Liu, Shuhong Chi

“…Intriguingly, concentrations of above examined proteins in SLE patients showed no correlation between serum and urine. …”
Get full text

Serum Levels of Mitochondrial Fission- and Fusion-Related Genes of Coal Workers’ Pneumoconiosis and Risk Factor Analysis Based on a Generalized Linear Model by Xiao-Yu Li, Jing-Lin Wei, Yong-Xin Xie, Ji Zhao, Li-Ya Ma, Na Zhang, Hui-Fang Yang

“…The mRNA expression levels of OPA1, Drp1, MFN2, Fis1, Col I, Col III, and α-SMA were determined by q-PCR. The protein expression levels of OPA1, Drp1, MFN2, Fis1, Col I, Col III, and α-SMA were detected by western blot. …”
Get full text

The EGF Receptor and HER2 Participate in TNF-α-Dependent MAPK Activation and IL-8 Secretion in Intestinal Epithelial Cells by Humberto B. Jijon, Andre Buret, Christina L. Hirota, Morley D. Hollenberg, Paul L. Beck

“…TNF-α activates multiple mitogen-activated protein kinase (MAPK) cascades in intestinal epithelial cells (IECs) leading to the secretion of interleukin 8 (IL-8), a neutrophil chemoattractant and an angiogenic factor with tumor promoting properties. …”
Get full text

Enzymatic Activity Analysis and Catalytic Essential Residues Identification of Brucella abortus Malate Dehydrogenase by Xiangan Han, Yongliang Tong, Mingxing Tian, Yuxi Zhang, Xiaoqing Sun, Shaohui Wang, Xusheng Qiu, Chan Ding, Shengqing Yu

“…In this study, the recombinant MDH protein (His-MDH) of Brucella abortus was purified and its ability to catalyze the conversion of oxaloacetate (OAA) to L-malate (hereon referred to as MDH activity) was analyzed. …”
Get full text

Nanocomposite treatment of hospital wastewater; Prophylaxis toxicity in the freshwater crayfish muscles and hepatopancreas by Hend A. Sabry, Sally M. Salaah, Marwa M. El-Naggar, Elham H.A. Ali, Magdy T. Khalil, Amal A.E. Ibrahim, Amr B. Mostafa

“…This improvement was attained by reducing the HP and muscles' toxicity through lowering nitric oxide contents, lipid peroxidation, protein carbonyl, and 8‑hydroxy- deoxyguanosine, while decreasing total antioxidant capacities, cytochrome P450, adenosine triphosphate, and calcium. …”
Get full text

SPD_0410 negatively regulates capsule polysaccharide synthesis and virulence in Streptococcus pneumoniae D39 by Ye Tao, Li Lei, Shuhui Wang, Xuemei Zhang, Yibing Yin, Yuqiang Zheng

“…In this study, we used electrophoretic mobility shift assays and DNA enzyme footprinting to identified the hypothetical protein SPD_0410 as a negative regulator of cps locus. …”
Get full text

A narrative review on the role of cognition, nutrition and energy availability in athletes of competitive sports to combat RED-S by Subalatha M., Dhanush Rachaveti, Amutha S., Ponpandi M.

“…Nutritional intakes, such as caffeinated, carbohydrate, alkaline, and protein-based supplements and diets, also significantly affect athletes’ cognitive and motor abilities. …”
Get full text

Emerging Anthelmintic Resistance in Poultry: Can Ethnopharmacological Approaches Offer a Solution? by Zirintunda, Gerald, Biryomumaisho, Savino, Keneth Iceland, Kasozi, Batiha, Gaber El-Saber, Kateregga, John, Vudriko, Patrick, Nalule, Sarah, Olila, Deogracious, Mariam Kajoba, Mariam, Matama, Kevin, Kwizera, Mercy Rukundo, Ghoneim, Mohammed M., Abdelhamid, Mahmoud, Alshehri, Sultan, Abdelgawad, Mohamed A., Acai-Okwee, James, Zaghlool, Sameh S.

“…Benzyl isothiocyanate glucosinolates interfere with DNA replication and protein expression, while isoflavones from Acacia oxyphylla cause helminth flaccid paralysis, inhibit energy generation, and affect calcium utilization. …”
Get full text

Unveiling neurogenic biomarkers for the differentiation between sepsis patients with or without encephalopathy: an updated meta-analysis by Jiyun Hu, Wenchao Li, Shucai Xie, Ya Liao, Tao Chen, Xinrun Wang, Weiping Xia, Fang Huang, Zhaoxin Qian, Lina Zhang

“…A meta-analysis was conducted to comprehensively and critically evaluate the existing body of evidence regarding the use of serum neurogenic biomarkers: neuron-specific enolase (NSE), ubiquitin C-terminal hydrolase-L1 (UCH-L1), Tau, S100 calcium-binding protein β (S100β), and glial fibrillary acidic protein (GFAP) for the diagnosis and risk assessment of fatality in SAE. …”
Get full text

Newly identified c-di-GMP pathway putative EAL domain gene STM0343 regulates stress resistance and virulence in Salmonella enterica serovar Typhimurium by Kaifeng Chen, Lili Li, Nanwei Wang, Zhouping Zhou, Peng Pan, Chenggang Xu, Dage Sun, Jiayi Li, Changzhi Dai, Dai Kuang, Ming Liao, Jianmin Zhang

“…Specifically, it exhibited increases of 95.74% in extracellular protein and 35.96% in exopolysaccharide production by upregulating the expression of relevant genes. …”
Get full text