Circular RNA ITCH Is a Tumor Suppressor in Clear Cell Renal Cell Carcinoma Metastasis through miR-106b-5p/PDCD4 Axis by Ping Gao, Yong Huang, Yanmei Hou, Qian Li, Haimei Wang

“…Western blot was utilized to detect metastasis-related protein expression. A xenograft tumor model was established to evaluate the role of circ-ITCH in vivo. …”
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A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus by Nabia Shahreen, Jongsam Ahn, Adil Alsiyabi, Niaz Bahar Chowdhury, Dhananjay Shinde, Sujata S. Chaudhari, Kenneth W. Bayles, Vinai C. Thomas, Rajib Saha

“…This bottleneck reduces flux through the TCA cycle, making it more efficient for S. aureus to generate ATP via acetate overflow metabolism. Additionally, the protein allocation cost of maintaining ATP flux through the restricted TCA cycle is greater than that of acetate overflow metabolism. …”
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Advancing genome editing to improve the sustainability and resiliency of animal agriculture by Diane Wray-Cahen, Anastasia Bodnar, Caird Rexroad, Frank Siewerdt, Dan Kovich

“…Abstract Animal agriculture faces unprecedented challenges, including the need to increase productivity to meet increasing demands for high quality protein while combating increasing pest and disease pressures, improving animal welfare, adapting to a changing climate, and reducing the environmental impact of animal agriculture. …”
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Mitofusin2 Promotes β Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation by Li Lu, Li Zhitao, Cui Nannan, Huang Mingzhu, Hu Xiaoping, Hong Dongsheng, Pan Zongfu, Lu Xiaoyang

“…Here, we explored the potential regulatory proteins of β cell maturation process and the capacity for GSIS. …”
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Microglia and Immune cells interactions in multiple sclerosis cognitive impairment: a postmortem study by Catarina Barros, Ainhoa Alberro, Adelaide Fernandes

“…Additionally, there was an increased expression of the complement protein C1q particularly localized at inhibitory synapses within microglia cells, suggesting a preferential engulfment of complement-tagged inhibitory synapses in MSCI patients. …”
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New Insights into Behçet’s Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation by Anna Santarsiero, Pietro Leccese, Paolo Convertini, Angela Padula, Paolo Abriola, Salvatore D’Angelo, Faustino Bisaccia, Vittoria Infantino

“…Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier—SLC25A1-encoded protein—it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY). …”
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Perspectives on Adipose Tissue, Chagas Disease and Implications for the Metabolic Syndrome by Fnu Nagajyothi, Mahalia S. Desruisseaux, Linda A. Jelicks, Fabiana S. Machado, Streamson Chua, Philipp E. Scherer, Herbert B. Tanowitz

“…Adiponectin, an adipocyte specific protein, which exerts antiinflammatory effects, is reduced during the acute phase of infection. …”
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Impact of nutrient density diet with emulsifier supplementation on apparent total tract digestibility and ileal amino acid digestibility in broilers by Shanmugam Suresh Kumar, Jae Hong Park, In Ho Kim

“…However, ATTD of dry matter, nitrogen, gross energy (GE) and crude protein and essential amino acid of lysine, valine, tryptophan and total essential amino acid and non-essential amino acid of proline and alanine, AID of dry matter and GE and essential amino acid of histidine and tryptophan and non- essential amino acid of proline and alanine were significantly increase (P <0.05) in chickens fed the emulsifier compared with the nutrient density. …”
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Serum Levels of Soluble ST2 and IL-10 Are Associated with Disease Severity in Patients with IgA Nephropathy by Zhihui Zhang, Haifeng Wang, Li Zhang, Rebecca Crew, Nan Zhang, Xiaolei Liu, Yanfang Jiang

“…Serum sST2 was positively correlated with 24-hour urinary protein, serum phosphorus, and serum IgA; however, serum IL-33 was not associated with these. …”
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Effect of hot smoking on the quality of vimba (vimba vimba tenella) by Abdullah Diler, Behire Işıl Işıklı, Ahmet Güner, Yusuf Doğruer

“…On the other hand the fish were analyzed for determining some chemical and microbiological charactersitics before and after salting, important increases were seen in the ash and salt content and TBA value of fish after salting process (p<0,001, p<0.01}, Following the smoking process, moisture, fat, protein, and ash content of smoked fish showed differences in important degrees related to raw and salted fish (p<0.001, p<0.05). …”
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Possible Involvement of a Mitochondrial Translation Initiation Factor 3 Variant Causing Decreased mRNA Levels in Parkinson's Disease by Anna Anvret, Caroline Ran, Marie Westerlund, Ann-Christin Thelander, Olof Sydow, Charlotta Lind, Anna Håkansson, Hans Nissbrandt, Dagmar Galter, Andrea Carmine Belin

“…Mitochondrial translation initiation factor 3 (MTIF3) is a nuclear encoded protein required for the initiation of complex formation on mitochondrial ribosomes. …”
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Exendin-4 Protects MIN6 Cells from t-BHP-Induced Apoptosis via IRE1-JNK-Caspase-3 Signaling by Wen-Jia Chen, Lin-Xi Wang, Yan-Ping Wang, Zhou Chen, Xiao-Ying Liu, Xiao-Hong Liu, Li-Bin Liu

“…Exendin-4 also inhibited the endoplasmic reticulum transmembrane protein IRE1, the apoptosis-related signaling molecule JNK, and c-Jun activation. …”
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Analysis of genetic diversity in sesame (Sesamum indicum L.) germplasm lines based on agro-morphological traits and SSR markers by Md. Ashfaq1*, K. Jhansi Rani2, D. Padmaja3, Praduman Yadav4 and Usha Kiran Betha5

“…Quantitative traits, namely plant height (67.8-147.2 cm), number of capsules per plant (36-89), number of seeds per capsule (46-70), seed yield per plant (3.20-10.89 g), oil content (40.64-50.51 %), protein content (20.5-32.42 %), oleic acid content (31.25-42.85 %) and linoleic acid content (40.39-54.11 %) showed a significant amount of variation. …”
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Empagliflozin Reverses Oxidized LDL-Induced RECK Suppression, Cardiotrophin-1 Expression, MMP Activation, and Human Aortic Smooth Muscle Cell Proliferation and Migration by Bysani Chandrasekar, Srinivas Mummidi, Vincent G. DeMarco, Yusuke Higashi

“…Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is a membrane-anchored MMP inhibitor. …”
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Deciphering the Molecular Mechanism of Peracetic Acid Response in Listeria monocytogenes by Marianna Arvaniti, Ahmed Gaballa, Renato H. Orsi, Panagiotis Skandamis, Martin Wiedmann

“…Our analysis revealed 12 differentially expressed protein-coding genes, of which nine were upregulated (ohrR, ohrA, rpsN, lmo0637, lmo1973, fur, lmo2492, zurM, and lmo1007), and three were down-regulated (argG, lmo0604 and lmo2156) in PAA-treated samples compared to the control samples. …”
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STRUCTURAL AND FUNCTIONAL CONDITION OF THE KNEE JOINT IN PATIENTS WITH MONOGONARTHROSIS IN THE STAGE OF EXACERBATION by Taras Khanyk

“…Research methods: questionnaire, orthopedic examination, X-ray diagnostics, arthroscopy, laboratory diagnostics of blood (determination of C-reactive protein (CRP) as a serological marker of inflammation), synovial fluid (analyses of physical properties, biochemical, cytological, bacteriological), statistical. …”
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Characterization and phylogenetic analysis of the chloroplast genome of endangered Impatiens chishuiensis by LAN Wenxiang, MO Qing, HUANG Haiquan, HUANG Meijuan

“…It encodes a total of 120 genes, including 95 protein-coding genes, 8 rRNA genes, and 17 tRNA genes. (2) A total of 87 SSR sequences was detected. 20 327 codons were detected, with leucine (Leu) being the most abundant and tryptophan (Trp) being the least. (3) Impatiens was divided into two subgenera, including subg. …”
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Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy by Zixuan Tan, Fang Dong, Linyu Wu, Yashuo Feng, Min Zhang, Feng Zhang

“…Moreover, western blot was performed to detect the related protein expression, including Bcl-2, Bax, TXNIP, GSDMD, caspase-1, NLRP3, BRCC3, HIF-1α, BNIP3, LC3, and P62. …”
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Curcumin Attenuation of Wear Particle-Induced Osteolysis via RANKL Signaling Pathway Suppression in Mouse Calvarial Model by Tao Cheng, Yaochao Zhao, Bin Li, Mengqi Cheng, Jiaxing Wang, Xianlong Zhang

“…Furthermore, CUR downregulated the osteoclast-specific gene expression and reversed the receptor activator of nuclear factor kappa-B ligand (RANKL)/osteoprotegerin messenger RNA and protein ratio in PMMA particle-stimulated mice. These results suggest that CUR attenuated PMMA particle-induced inflammatory osteolysis by suppressing the RANKL signaling pathway in the murine calvarium, which could be a candidate compound to prevent and treat AL.…”
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Chromosome-level genome assembly of Malus niedzwetzkyana, the mother of Rosybloom crabapple by Ruizhen Wang, Jian Quan, Boyang Liu, Yu Wei, Hengxing Liu, Ran He, Ling Guo, Leiming Dong

“…Moreover, our assembly has captured 28 telomeres. A total of 43,813 protein-coding genes was annotated in the MN genome. …”
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