Characterisation of the antibody-mediated selective pressure driving intra-host evolution of SARS-CoV-2 in prolonged infection. by Michael Schoefbaenker, Theresa Günther, Eva Ulla Lorentzen, Marie-Luise Romberg, Marc Tim Hennies, Rieke Neddermeyer, Marlin Maybrit Müller, Alexander Mellmann, Chiara Robin Bojarzyn, Georg Lenz, Matthias Stelljes, Eike Roman Hrincius, Richard Vollenberg, Stephan Ludwig, Phil-Robin Tepasse, Joachim Ewald Kühn

“…Neutralising antibodies against the SARS-CoV-2 spike (S) protein are major determinants of protective immunity, though insufficient antibody responses may cause the emergence of escape mutants. …”
Get full text

Relationship between Serum Ferritin Levels and Sarcopenia in Transfusion-Dependent Thalassemia Patient by Rendra Prasetya Saefudin, Siprianus Ugroseno Yudho Bintoro, Sony Wibisono Mudjanarko, Merlyna Savitri, Lukita Pradhevi, Agustinus Vincent, Michael Austin Pradipta Lusida, Kartika Afrida Fauzia

“…Age (P = 0.236), duration of thalassemia (P = 0.057), frequency of transfusion (P < 0.001), type of iron chelation (P < 0.001), and smoking habits (P = 0.029) had a significant association with ferritin serum levels. Protein diet (P = 0.03) and daily physical activity (P = 0.001) are significantly associated with sarcopenia. …”
Get full text

Protective effects of resveratrol on the expression of catalase, glutathione peroxidase, and superoxide dismutase genes in the ovary and their activity in the serum of rats exposed... by Mohammad Karimian, Mozhdeh Ghadiri, Seyedeh Mahsa Poormoosavi, Hossein Najafzadehvarzi

“…Bioinformatics tools were used to evaluate Res effects on gene and protein function. Results: Lead acetate significantly downregulates Cat, Gpx, and Sod gene expression, but Res significantly upregulates gene expression, especially at doses of 40 mg/kg for Cat, 20 mg/kg and 40 mg/kg for Gpx, and 80 mg/kg for Sod. …”
Get full text

Genomic insights into the probiotic potential and genes linked to gallic acid metabolism in Pediococcus pentosaceus MBBL6 isolated from healthy cow milk. by Md Morshedur Rahman, Naim Siddique, Soharth Hasnat, Md Tanvir Rahman, Mustafizur Rahman, Munirul Alam, Ziban Chandra Das, Tofazzal Islam, M Nazmul Hoque

“…The observed bacteriocin, particularly bovicin, demonstrated the ability to disrupt the function of an essential protein, Rho factor of mastitis pathogens by blocking transcription termination process. …”
Get full text

Comparative transcriptomic analysis of primary endometrial cancer and bone metastatic cancer: metastasis-associated genes and abnormal cell cycle regulation by Qinmin Wu, Feng Li, Yunlong Zhang, Siying Li, Chuan Xiang

“…Analysis of differentially expressed genes (DEGs) revealed that these genes are involved in the regulation of post-translational modification, protein turnover, and signal transduction mechanisms. …”
Get full text

Gengnianchun Recipe Protects Ovarian Reserve of Rats Treated by 4-Vinylcyclohexene Diepoxide via the AKT Pathway by Fangui Zhao, Wenjun Wang

“…Moreover, high dose of GNC significantly increased the ovarian protein expression of mouse vasa homologue (MVH), anti-Müllerian hormone (AMH), follicle-stimulating hormone receptor (FSHR), and estrogen receptor β (ERβ) compared with that in the model group. …”
Get full text

The Neuroprotective Effects of Astragaloside IV against H2O2-Induced Damage in SH-SY5Y Cells are Associated with Synaptic Plasticity by Zurong Song, Ali Tao

“…The expression of postsynaptic density 95 (PSD-95) and growth-associated protein 43 (GAP-43) were measured by western blot (WB) and inmunofluorescence staining assay under the same treatment conditions. …”
Get full text

Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition. by Tiffany M Halvorsen, Kaitlin A Schroeder, Allison M Jones, Disa Hammarlöf, David A Low, Sanna Koskiniemi, Christopher S Hayes

“…Inhibitor cells also produce CdiI immunity proteins, which neutralize CdiA-CT toxins to prevent auto-inhibition. …”
Get full text

Biochar impact on physiological and biochemical attributes of Spinach (Spinacia oleracea L.) in nickel contaminated soil by U. Younis, M. Athar, S.A. Malik, M.H. Raza Shah, S. Mahmood

“…Higher production of chlorophyll, amino acids and protein with CSB amendment looked like alleviation in Ni toxicity.  …”
Get full text

Effect of beetroot or beetroot plus vitamin C supplementation on cardiovascular function in patients with coronary artery disease: protocol for a double-blind, placebo-controlled,... by Hamed Tabesh, Mohsen Nematy, Leila Sadat Bahrami, Mohsen Mohebaty, Seyyed Mostafa Arabi, Reza Rezvani

“…Pulse wave velocity, Augmentation Index, heart rate, volume of oxygen (VO2) max/VO2 peak, peak heart rate, blood pressure, interleukin 6 (IL-6), high sensitivity C reactive protein, intercellular adhesion molecule, vascular cell adhesion molecule, lipid profile and anthropometry will be measured at the beginning and end of the intervention.Ethics and dissemination This study was approved by the Ethics Committee of Mashhad University of Medical Sciences (IR.MUMS.MEDICAL.REC.1399.717). …”
Get full text

Mitochondrial- and Endoplasmic Reticulum-Associated Oxidative Stress in Alzheimer's Disease: From Pathogenesis to Biomarkers by E. Ferreiro, I. Baldeiras, I. L. Ferreira, R. O. Costa, A. C. Rego, C. F. Pereira, C. R. Oliveira

“…Stimuli that enhance expression of normal and/or folding-defective proteins activate an adaptive unfolded protein response (UPR) that, if unresolved, can cause apoptotic cell death. …”
Get full text

Sparse Gene Coexpression Network Analysis Reveals EIF3J-AS1 as a Prognostic Marker for Breast Cancer by Xin Chen, Zuyuan Yang, Chao Yang, Kan Xie, Weijun Sun, Shengli Xie

“…In this paper, we used weighted correlation network analysis (WGCNA) to construct networks containing noncoding and protein-coding genes based on their expression in 1097 breast cancer patients. …”
Get full text

胎鼠肺泡Ⅱ型上皮细胞分离、原代培养与鉴定 by 王振花, 张建平, 杨冬梓

“…培养的 24～48 h, 细胞连接成单层, 胞浆内颗粒明显, 培养的 6~7 d 细胞内颗粒大量减少; 免疫细胞化学鉴定细胞肺表面活性特异蛋白A( surfactant protein A, SP- A) 染色阳性, 透射电镜可见观察到细胞内板层小体, 培养液中 SP- A 含量随培养时间延长逐渐增多, 于培养 36 h 达峰值, 为 80 ng/mL; 细胞纯度达(92±2)%, 产量为(18.6±7)×106。…”
Get full text

Reversible Manifestations of Hypothyroidism causing Diagnostic Dilemma: A Case Series by Kaushik Hazra, Somnath Maitra, Sunetra Roy, Isha Ghosh

“…Ascites in hypothyroidism responds to treatment and can help avoid unnecessary investigations; however, since this presentation is rare, clinicians should remain alert for low Serum Ascites Albumin Gradient (SAAG) with high protein ascites. myxoedema coma was diagnosed after excluding cerebrovascular accident, sepsis and dyselectrolytemia, with low body temperature serving as a diagnostic clue. …”
Get full text

Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization by Alejandro Alvarez-Arce, Irene Lee-Rivera, Edith López, Arturo Hernández-Cruz, Ana María López-Colomé

“…The serine protease thrombin activates Protease-Activated Receptors (PARs), a family of G-protein-coupled receptors (GPCRs) activated by the proteolytic cleavage of their extracellular N-terminal domain. …”
Get full text

CCN3: lactational bone booster by Nathan Xu, Kyle Yang, Mengjie Wang

“…Classically, increased bone resorption via increased parathyroid hormone-related protein and low estrogen levels is the main source of calcium for milk production during lactation. …”
Get full text

Aquatic Invertebrate Antimicrobial Peptides in the Fight Against Aquaculture Pathogens by Tomás Rodrigues, Francisco Antonio Guardiola, Daniela Almeida, Agostinho Antunes

“…This study compiles and analyzes data from AMP databases and over 200 scientific sources, identifying approximately 350 AMPs derived from aquatic invertebrates, mostly cationic and α-helical, across 65 protein families. While in vitro assays highlight their potential, limited in vivo studies hinder practical application. …”
Get full text

Characterization of tumor prognosis and sensitive chemotherapy drugs based on cuproptosis-related gene signature in ovarian cancer by Wei Tan, Fangfang Dai, Qinyu Ci, Zhimin Deng, Hua Liu, Yanxiang Cheng

“…Abstract Background Cuproptosis is a novel form of cell death, acting on the tricarboxylic acid cycle in mitochondrial respiration and mediated by protein lipoylation. Other cancer cell death processes, such as necroptosis, pyroptosis, and ferroptosis, have been shown to play crucial roles in the therapy and prognosis of ovarian cancer. …”
Get full text

Enhancing Venous Thromboembolism Risk Prediction through Novel Biomarkers and Inflammatory Indicators by Zainab Wahab Al-Maaroof

“…This study aims to evaluate the potential of new biomarkers, such as thrombin generation, microRNAs (miRNAs), Factor VIII, and inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6), to enhance the prediction of VTE risk, thereby facilitating earlier and more precise interventions. …”
Get full text

CRISPR/Cas genome editing for cotton precision breeding: mechanisms, advances, and prospects by Vijay Sheri, Harikrishnan Mohan, Phanikanth Jogam, Anshu Alok, Gulab Khan Rohela, Baohong Zhang

“…Genome editing technology, specifically with clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) tools, has opened new possibilities for trait development in cotton. …”
Get full text