CPK1 activates CNGCs through phosphorylation for Ca2+ signaling to promote root hair growth in Arabidopsis by Meijun Zhu, Bo-Ya Du, Yan-Qiu Tan, Yang Yang, Yang Zhang, Yong-Fei Wang

“…We report here that calcium dependent protein kinase 1 (CPK1) directly activates CNGC5/6/9 to promote Arabidopsis RH growth. …”
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H3K79me3T80ph is a Novel Histone Dual Modification and a Mitotic Indicator in Melanoma by Danielle R. Martinez, Hunter W. Richards, Qiushi Lin, Carlos A. Torres-Cabala, Victor G. Prieto, Jonathan L. Curry, Estela E. Medrano

“…The current study characterizes the mitosis-associated histone dual modification on the core of histone H3: trimethylation of histone H3 lysine 79 and simultaneous phosphorylation of H3 threonine 80 (H3K79me3T80ph). Through the use of protein and microscopy-based techniques, we find that H3K79me3T80ph shares a similar spatial and temporal regulation as H3S10ph but additionally requires methyltransferase activity. …”
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Mycobacterium bovis BCG Surface Antigens Expressed under the Granuloma-Like Conditions as Potential Inducers of the Protective Immunity by Yingyu Chen, Lia Danelishvili, Sasha J. Rose, Luiz E. Bermudez

“…A total of 957 surface-exposed proteins were identified for BCG cultured under laboratory condition, whereas 1,097 proteins were expressed under the granuloma-like condition. …”
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Intermittent Administration of Parathyroid Hormone Enhances Odonto/Osteogenic Differentiation of Stem Cells from the Apical Papilla via JNK and P38 MAPK Pathways by Xiyao Pang, Ying Zhuang, Zehan Li, Shuanglin Jing, Qin Cai, Fengge Zhang, Changao Xue, Jinhua Yu

“…The expression of odonto/osteogenic markers was significantly upregulated in mRNA levels and protein levels. Moreover, intermittent treatment of PTH also increased phosphorylation of JNK and P38, and the differentiation was suppressed following the inhibition of JNK and P38 MAPK pathways. …”
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Identification of quantitative trait loci of pod dehiscence in a collection of soybean grown in the southeast of Kazakhstan by B. N. Doszhanova, A. K. Zatybekov, S. V. Didorenko, T. Suzuki, Y. Yamashita, Y. Turuspekov

“…Both minor QTLs for PD were associated with calmodulin-binding protein, which presumably plays an important role in regulating PD in dry areas. …”
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High β-sitosterol-D-glucoside content in sweet potato varieties and its anti-breast cancer potential through multiple metastasis-associated signals by Jinyin Zhang, Lu Huang, Xiang Tang, Miao Pan, Xiaoli Ye, Xuegang Li, Hang Ma

“…Proteomic analysis of tumor tissues revealed that 127 of these proteins were upregulated and 80 were downregulated. …”
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Engineering synthetic signaling receptors to enable erythropoietin-free erythropoiesis by Aadit P. Shah, Kiran R. Majeti, Freja K. Ekman, Sridhar Selvaraj, Devesh Sharma, Roshani Sinha, Eric Soupene, Prathamesh Chati, Sofia E. Luna, Carsten T. Charlesworth, Travis McCreary, Benjamin J. Lesch, Tammy Tran, Simon N. Chu, Matthew H. Porteus, M. Kyle Cromer

“…Our strategy not only addresses RBC production challenges but also demonstrates how protein and genome engineering can introduce precisely regulated cellular behaviors, potentially improving scalable manufacturing of a wide range of clinically relevant cell types.…”
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Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-xL by Ruiqing Wang, Huimin Xie, Zhaofeng Huang, Weirong Shang, Zuoming Sun

“…Thus, the lifespan of double positive (CD4+CD8+; DP) thymocytes determines how many rounds of α chain rearrangement can be carried out and influences the likelihood of completing positive selection. The anti-apoptotic protein Bcl-xL is the ultimate effector regulating the survival of CD4+CD8+ thymocytes subject to the selection process, and the deletion of Bcl-xL leads to premature apoptosis of thymocytes prior to the completion of the developmental process. …”
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Siponimod supports remyelination in the non-supportive environment by Johann Krüger, Newshan Behrangi, David Schliep, Leo Heinig, Elise Vankriekelsvenne, Nicole Wigger, Markus Kipp

“…At the end of week seven, loss of myelin staining intensities was still pronounced, but anti-myelin basic protein (MBP) and myelin-associated glycoprotein (MAG) expression was significantly higher in Siponimod- versus vehicle-treated mice. …”
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Identification of bapA in Strains of Salmonella enterica subsp. enterica Isolated from Wild Animals Kept in Captivity in Sinaloa, Mexico by Gabriela Silva-Hidalgo, Martin López-Valenzuela, Nora Cárcamo-Aréchiga, Silvia Cota-Guajardo, Mayra López-Salazar, Edith Montiel-Vázquez

“…bapA, previously named stm2689, encodes the BapA protein, which, along with cellulose and fimbriae, constitutes biofilms. …”
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Modulation of Preactivation of PPAR-β on Memory and Learning Dysfunction and Inflammatory Response in the Hippocampus in Rats Exposed to Global Cerebral Ischemia/Reperfusion by Ge Kuang, Qin He, Yunmei Zhang, Ruichun Zhuang, Anling Xiang, Qingsong Jiang, Ying Luo, Junqing Yang

“…Moreover, the mRNA and protein expressions of PPAR-β were significantly decreased in GCIRI + GW0742 groups when compared with those in GCIRI group. …”
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Severe central nervous system injury in 9 children with COVID-19 by Peipei Zhang, Meiyun Xin, Yingge Bai, Xueyun Ren, Na Li

“…A low cerebrospinal fluid protein level may be a protective factor for children with severe nervous system injury caused by COVID-19.…”
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Testosterone and Adipokines are Determinants of Physical Performance, Strength, and Aerobic Fitness in Frail, Obese, Older Adults by Lina E. Aguirre, Irum Zeb Jan, Kenneth Fowler, Debra L. Waters, Dennis T. Villareal, Reina Armamento-Villareal

“…Among the adipokines, high sensitivity C-reactive protein (Hs-CRP) and leptin negatively correlated with the modified physical performance testing (PPT), knee flexion, knee extension, 1-RM, and VO2 peak. …”
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Synthesis of Some Metal Complexes with New Heterocyclic Ligand (5-(((2-(3-(1<i>H</i>-indol-3-yl)acryloyl)phenyl)amino)methylene)-2-thiooxodihydropyrimidine-4,6(1<i>H</i>,5<i>H</i>)... by Thanaa Abdul Ameer Hilal, Ibtihal Kadhim Kareem

“…This indicates that the [Au(L1)Cl]Cl2 complex has a strong affinity for the protein kinase (1HK7). Significant antiproliferative activity was seen in it against human breast cancer (MCF-7) and normal cell lines (MCF-10), as evidenced by the IC50 and selective indices (SI) values. …”
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Role of Inflammation Markers and Osteopontin in the Prediction of Fetal Stress by Betül Tokgöz Çakır, Hande Esra Koca, Elif Akkaş Yılmaz, Tuncay Küçüközkan

“…Objective: To determine the possible association between acute fetal stress during labor and maternal blood levels of osteopontin (OPN), white blood cells, sedimentation, and C-reactive protein (CRP). Methods: The study included women with a term pregnancy (37 weeks or more) who had a cesarean section during the active phase of labor. …”
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MFG-E8 Exerts Neuroprotection in Neural Stem Cells Induced by Anesthetic Sevoflurane via Regulating the PI3K/AKT Pathways by Minmin Cai, Liufang Sheng

“…The pharmacological experiments suggested that both mRNA and protein expression of MFG-E8 were significantly decreased after 24 h, 48 h, and 72 h treatment with SEV, and the Western blot results displayed that 50 and 100 μg/ml rhMFG-E8 could evidently promote the expression of MFG-E8 in NSCs induced by SEV. …”
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Do antibody CDR loops change conformation upon binding? by Chu’nan Liu, Lilian M. Denzler, Oliver E.C. Hood, Andrew C.R. Martin

“…With an increasing number of antibodies where both free and complexed structures have been deposited in the Protein Data Bank, a large-scale survey of CDR conformational change during binding is now possible. …”
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Genome-wide identification and expression analysis of GRAS transcription factors under cold stress in diploid and triploid Eucalyptus by Jiannan Liu, Hao Chen, Chenhe Li, Kang Du, Jun Yang

“…Gene structure analysis found similar intron-exon structures in EgrGRAS genes. Protein motif analysis revealed that proteins within the same subfamily have certain structural similarities. …”
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Dysregulation of Metabolic Peptides Precedes Hyperinsulinemia and Inflammation Following Exposure to Rotenone in Rats by Vandana Zaman, Denise Matzelle, Naren L. Banik, Azizul Haque

“…It is a classical, high-affinity mitochondrial complex I inhibitor that causes not only oxidative stress, α-synuclein phosphorylation, DJ-1 (Parkinson’s disease protein 7) modifications, and inhibition of the ubiquitin-proteasome system but it is also widely considered an environmental contributor to Parkinson’s disease (PD). …”
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Current Status of Treatment of Spinal and Bulbar Muscular Atrophy by Fumiaki Tanaka, Masahisa Katsuno, Haruhiko Banno, Keisuke Suzuki, Hiroaki Adachi, Gen Sobue

“…Androgen receptor (AR), a disease-causing protein of SBMA, is a well-characterized ligand-activated transcription factor, and androgen binding induces nuclear translocation, conformational change and recruitment of coregulators for transactivation of AR target genes. …”
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