Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome by Jonah J. Scott-McKean, Adriano L. Roque, Krystyna Surewicz, Mark W. Johnson, Witold K. Surewicz, Alberto C. S. Costa

“…Because 4xHFS-induced LTP had not yet been characterized in Ts65Dn mice, we also investigated the effects of picrotoxin, amyloid beta oligomers, and soluble recombinant human prion protein (rPrP) on this form of LTP. Whereas ≥10 μM picrotoxin increased LTP to control levels, it also caused seizure-like oscillations. …”
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Comparative Pharmacokinetic Study of Three Major Bioactive Components in the Normal and Different Courses of Liver-Stagnation and Spleen-Deficiency Syndrome Depressive Rats after I... by Kaiwen Luo, Mengdie Wang, Xiangxiang Pan, Yadong Xing

“…Acetonitrile solution containing 0.1% acetic acid and methyl alcohol-water (50 : 50, v/v) was chosen as the protein precipitant and redissolve solution severally; a Shim-pack GISS C18 column coupled with 0.1% aqueous acetic acid-acetonitrile in gradient elution was employed to separate the mixed constituents in plasma. …”
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Application of sewage sludge for cereal production in a Mediterranean environment (Lebanon) by Danny Romanos, Nabil Nemer, Yara Khairallah, Marie Therese Abi Saab

“…As for wheat plants' evaluation, fiber and protein contents presented an increase similar to nitrogen and phosphorus. …”
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Structure elucidation, immunomodulatory activity, antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff by Siyuan Su, Xiang Ding, Yiling Hou, Binbin Liu, Zhouhe Du, Junfeng Liu

“…The results of transcriptome sequencing analysis illustrated that total 46 genes enriched in MAPK and total 34 genes enriched in PI3K/Akt signaling pathways in BRS-X group. The protein VEGF and VEGFR expression were significantly reduced under the treatment with BRS-X. …”
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Molecular Cloning, Characterization, and mRNA Expression of Hemocyanin Subunit in Oriental River Prawn Macrobrachium nipponense by Youqin Kong, Liqiao Chen, Zhili Ding, Jianguang Qin, Shengming Sun, Ligai Wang, Jinyun Ye

“…Hemocyanin is a copper-containing protein with immune function against disease. In this study, a hemocyanin subunit named MnHc-1 was cloned from Macrobrachium nipponense. …”
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Physicochemical, Rheological, Structural, Antioxidant, and Antimicrobial Properties of Polysaccharides Extracted from Tamarind Seeds by Likun Ren, Yang Yang, Xin Bian, Xiaomei Li, Bing Wang, Dangfeng Wang, Dan Su, Linlin Liu, Dehui Yu, Xiaoxue Guo, Xiumin Zhang, Na Zhang

“…The structure was characterized by FTIR, SEM, and X-ray diffraction after removing protein and small molecule impurities. Furthermore, the rheological and bioactivity of tamarind seed polysaccharides (TSP) were also investigated. …”
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Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway by Chunxue Li, Rongrong Zhang, Yating Zhan, Jianjian Zheng

“…Res enhanced the activation of the Hippo pathway and reduced yes-associated protein (YAP) and transcriptional coactivator with the PDZ-binding motif (TAZ) expression. …”
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Chitosan Modulates Inflammatory Responses in Rats Infected with Enterotoxigenic Escherichia coli by Gang Liu, Shuai Chen, Guiping Guan, Jun Tan, Naif A. Al-Dhabi, Hongbing Wang, Veeramuthu Duraipandiyan, Jun Fang

“…Moreover, the mRNA and protein levels of IL-1β, IL-6, IL-17, IL-18, and TNF-α were significantly lower in the group of mice receiving the COS diet; also the jejunal production of toll-like receptor-4 (TLR-4) was suppressed in the COS group. …”
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Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review by Harinisubasri M, Priyadharsini Nataraj, Dineshkumar Thayalan, Divya Bose, Rameshkumar Annasamy, Rajkumar K

“…Results: All the articles included in this study included TGF-β and its related protein expression in both its pathogenesis and cancer growth.This help to bring in newer and targeted treated options. …”
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Relationship between Blood Lipid Profiles and Risk of Lupus Nephritis in Children by Jiajia Liu, Wenqi Song, Dawei Cui

“…The blood lipid levels were positively correlated with 24-hour urine protein quantification, urea, creatinine, uric acid, urinary IgG, urinary microalbumin, urinary transferrin, urinary α1 microglobulin, and urinary N-acetyl glucosidase, respectively. …”
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Increased TNF-α Initiates Cytoplasmic Vacuolization in Whole Blood Coculture with Dengue Virus by Rahmat Dani Satria, Tzu-Wen Huang, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yun-Ting Wang, Zhen-Yu Yang, Chung-Hsi Hsing, Chiou-Feng Lin

“…At one day postinfection, there was viral nonstructural protein NS1 but no further virus replication measured in the whole blood culture. …”
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NERVE 2.0: boosting the new enhanced reverse vaccinology environment via artificial intelligence and a user-friendly web interface by Andrea Conte, Nicola Gulmini, Francesco Costa, Matteo Cartura, Felix Bröhl, Francesco Patanè, Francesco Filippini

“…Conclusions With its redesigned and updated environment, NERVE 2.0 allows customisable and refinable bacterial protein vaccine analyses to all different kinds of users.…”
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ATF4-mediated expression of NOXA is critical for necroptosis driven by glucose deprivation by Sasiprapa Sonkaew, Sasiprapa Sonkaew, Ruwaida Rajna, Yeon-Ji Park, Jiong Yan, Zhaoshan Liu, Siriporn Jitkaew, Zheng-Gang Liu, Swati Choksi

“…Our previous findings suggested that the mitochondrial protein, Noxa, may be involved in mediating the release of mitochondrial DNA during GD-induced ZBP1-dependent necroptotic pathway. …”
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Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MS/MS: Application to Comparative Pharmacokinetic and Brain Distribution St... by Bo Li, Min Lu, Lei Jin, Maoen Zheng, Peilu Sun, Shanshan Lei, Shan Xiong, Suhong Chen

“…Detections were performed using a TSQ Quantum Ultra mass spectrometric detector with electrospray ionization (ESI) interface, which was operated in the positive ion mode. A simple protein precipitation preparation process was used. …”
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IFNγ regulates ferroptosis in KFs by inhibiting the expression of SPOCD1 through DNMT3A by Xiuxia Wang, Yating Yang, Xianyu Zhou, Shun Yu, Xusong Luo, Lin Lu, Zhen Gao, Jun Yang

“…Here, we discover interferon (IFN)γ could induce KFs ferroptosis through inhibiting SPOC domain-containing protein 1 (SPOCD1), serving as a mode of action for CD8+T cell (CTL)-mediated keloid killing. …”
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TNF-α Regulates Natriuretic Peptides and Aquaporins in Human Bronchial Epithelial Cells BEAS-2B by Letizia Mezzasoma, Lucio Cagini, Cinzia Antognelli, Francesco Puma, Eugenio Pacifico, Vincenzo Nicola Talesa

“…In particular, we found that TNF-α induced a decrease of arial natriuretic peptide, natriuretic peptide receptor-1, aquaporin-1 and aquaporin-5 and an increase of brain natriuretic peptide with a different involvement of nuclear factor-κB and mitogen-activated protein kinases signaling pathway activation. Moreover, the observed changes in NPs expression, demonstrate inflammation as an additional cause of brain natriuretic peptide elevation, adding an important piece of information in the novel area of study regarding NPs and inflammation. …”
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Biomolecular Triconjugates Formed between Gold, Protamine, and Nucleic Acid: Comparative Characterization on the Nanoscale by Robert K. DeLong, Lisa Cillessen, Chris Reynolds, Adam Wanekaya, Tiffany Severs, Kartik Ghosh, Michael Fisher, Stephanie Barber, John Black, Ashley Schaeffer, Kristin J. Flores

“…The data presented herein may be useful in the future development of pharmaceutical and biotechnology formulations, processes, and analyses concerning protein, DNA, or RNA bionanoconjugates.…”
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UV-C Radiation as a Factor Reducing Microbiological Contamination of Fish Meal by Krzysztof Skowron, Justyna Bauza-Kaszewska, Zbigniew Dobrzański, Zbigniew Paluszak, Karolina Jadwiga Skowron

“…Fish meals, added to feeds as a source of protein, may contain pathogenic bacteria. Therefore, effective methods for their sanitizing, such as UV-C radiation, are needed to minimize the epidemiological risk. …”
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Grazing-Induced Habitat Degradation: Challenges to Giant Panda Survival Resulting from Declining Bamboo and Soil Quality by Huawei Tian, Ying Zeng, Zejun Zhang, Ming Lu, Wei Wei

“…Additionally, the soil water content has decreased, while soil bulk density, total N, available N, and pH have significantly increased. Reductions in crude protein and ether extract, along with increased crude fiber and ash, have lowered bamboo’s nutritional value and palatability. …”
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Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis by Zhenzhen Su, Jie Chen, Junlong Zhang, Yunfei An, Yun Liao, Xiaojuan Wu, Chuanmin Tao, Lanlan Wang, Bei Cai

“…In patients with chronic hepatitis B, interferon-γ-inducible protein-10 (IP-10) levels significantly increased in the group of abnormal liver function (P=0.006). …”
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