Functional Characterization of the Canine Heme-Regulated eIF2α Kinase: Regulation of Protein Synthesis by Kimon C. Kanelakis, Jayashree Pyati, Pamela C. Wagaman, Jui Chang Chuang, Young Yang, Nigel P. Shankley

“…The heme-regulated inhibitor (HRI) negatively regulates protein synthesis by phosphorylating eukaryotic initiation factor-2α (eIF2α) thereby inhibiting protein translation. …”
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Expression of Angiogenesis Regulatory Proteins and Epithelial-Mesenchymal Transition Factors in Platelets of the Breast Cancer Patients by Hui Han, Fang-Li Cao, Bao-Zhong Wang, Xue-Ru Mu, Guang-Yao Li, Xiu-Wen Wang

“…Angiogenesis-associated expression of VEGF (2.1 pg/106 platelets versus 0.9 pg/106 platelets, P < 0.001), PF4 (21.2 ng/106 platelets versus 10.2 ng/106 platelets, P < 0.001), PDGF-BB (42.9 pg/106 platelets versus 19.1 pg/106 platelets, P < 0.001), and TGF-β1 (15.3 ng/106 platelets versus 4.3 ng/106 platelets, P < 0.001) differed in the PP samples of cancer and control subjects. In addition, protein concentrations were associated with clinical characteristics (P<0.05). …”
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Exploring force-driven stochastic folding dynamics in mechano-responsive proteins and implications in phenotypic variation by Pritam Saha, Vishavdeep Vashisht, Ojas Singh, Amin Sagar, Gaurav Kumar Bhati, Surbhi Garg, Sabyasachi Rakshit

“…Here we study three such genetic variants of a mechano-responsive protein, cadherin-23, that uphold the structural integrity of the protein, but showcase distinct genotypes and phenotypes. …”
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Sequence-structure based prediction of pathogenicity for amino acid substitutions in proteins associated with primary immunodeficiencies by Ekaterina S. Porfireva, Anton D. Zadorozhny, Anastasia V. Rudik, Dmitry A. Filimonov, Alexey A. Lagunin, Alexey A. Lagunin

“…A key aspect of PID diagnosis is identifying specific amino acid substitutions in the proteins related with heritable diseases. In this study, we have developed classification sequence-structure-property relationships (SSPR) models for predicting the pathogenicity of amino acid substitutions (AAS) in 25 proteins associated with the most important and genetically studied PIDs and encoded genes: IL2RG, JAK3, RAG1, RAG2, ADA, DCLRE1C, CD40LG, WAS, ATM, STAT3, KMT2D, BTK, FOXP3, AIRE, FAS, ELANE, ITGB2, CYBB, G6PD, GATA2, STAT1, IFIH1, NLRP3, MEFV, and SERPING1.MethodsThe data on 4825 pathogenic and benign AASs in the selected proteins were extracted from ClinVar and gnomAD. …”
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Gall bladder wall thickness and C-reactive protein as a predictor of difficult laparoscopic cholecystectomy by Nair A, Appukuttan A, Mathew J, Oommen AN, Joseph A

“…In this study, we hypothesized that increased gallbladder wall thickness and elevated preoperative C-reactive protein (CRP) levels, which are objective markers of inflammation or fibrosis, would be linked to increased difficulty in laparoscopic cholecystectomy. …”
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PENGEMBANGAN BAHAN AJAR BERBASIS PENELITIAN KARAKTERISASI PROTEIN MEMBRAN SPERMA PADA MATAKULIAH BIOTEKNOLOGI by Ika Oktaviana, Sutiman B Sumitro, Umie Lestari

Subjects: “…characterization of membrane proteins…”
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Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis by Outi E. Päiväniemi, Paula K. Maasilta, Tiina L. S. Vainikka, Hanni S. Alho, Pekka J. Karhunen, Ulla-Stina Salminen

“…The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). …”
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Identification and Expression Profiling of the BTB Domain-Containing Protein Gene Family in the Silkworm, Bombyx mori by Daojun Cheng, Wenliang Qian, Meng Meng, Yonghu Wang, Jian Peng, Qingyou Xia

“…The BTB domain is a conserved protein-protein interaction motif. In this study, we identified 56 BTB domain-containing protein genes in the silkworm, in addition to 46 in the honey bee, 55 in the red flour beetle, and 53 in the monarch butterfly. …”
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Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan by Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou

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Enhanced sampling of protein conformational changes via true reaction coordinates from energy relaxation by Huiyu Li, Ao Ma

“…Abstract The bottleneck in enhanced sampling lies in finding collective variables that effectively accelerate protein conformational changes; true reaction coordinates that accurately predict the committor are the well-recognized optimal choice. …”
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The secreted host-cell protein clusterin interacts with PmpD and promotes Chlamydia trachomatis infection by Fabienne Kocher, Johannes H. Hegemann

“…Chlamydia trachomatis (Ctr) possesses a family of nine polymorphic membrane proteins (Pmps), which have been shown to be crucial for adhesion and internalization. …”
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Transient degradation of NF-κB proteins in macrophages after interaction with mast cell granules by Noriko Ito, Yuai Li, Tsuneo Suzuki, Daniel J. Stechschulte, Kottarappat N. Dileepan

“…In comparison to J774 cells, incubation of m ouse peritoneal macrophages with MCG resulted in more extensive alterations to NF-κB proteins. The alterations in NF-κB proteins did not affect the expression of inducible nitric oxide synthase (iNOS) or TNF-α mRNA in J774 cells. …”
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Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive Leukemias by Alessandro Morotti, Giovanna Carrà, Cristina Panuzzo, Sabrina Crivellaro, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio

“…Here, we review the role of BCR-ABL/protein kinase CK2 interaction in BCR-ABL leukemias, with potentially relevant implications for therapy.…”
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Optimal protein requirement for rapid and coordinated test growth of juvenile sea urchin (Strongylocentrotus intermedius) by Panke Gong, Haijing Liu, Dan Gou, Weixiao Di, Huinan Zuo, Jun Ding, Yaqing Chang, Rantao Zuo

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Functional Prediction of Hypothetical Proteins from and Validation of the Predicted Models by Using ROC Curve Analysis by Md. Amran Gazi, Sultan Mahmud, Shah Mohammad Fahim, Mohammad Golam Kibria, Parag Palit, Md. Rezaul Islam, Humaira Rashid, Subhasish Das, Mustafa Mahfuz, Tahmeed Ahmeed

Subjects: “…hypothetical protein…”
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The Diagnostic Role of Serum Inflammatory and Soluble Proteins on Dementia Subtypes: Correlation with Cognitive and Functional Decline by Candan Öztürk, Aynur Özge, Osman Özgür Yalın, &Idot;. Arda Yılmaz, Nuran Delialioglu, Çilem Yıldız, Bahar Tesdelen, Cigdem Kudiaki

“…There are also no reliable data regarding the relationship between the overlapping protein levels and cognitive or functional decline. …”
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Low Density Lipoprotein Receptor Related Proteins as Regulators of Neural Stem and Progenitor Cell Function by Loic Auderset, Lila M. Landowski, Lisa Foa, Kaylene M. Young

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Effect Of Zinc And Ingredients Of Protein Supplement On Sperm Parameters And Male Reproductive Hormones- An RCT Study by Saira Safdar, Irfan Afzal Mughal, Noor Ul Ain, Sidra Jabeen, Muhammad Hassaan Farooq, Asma Irfan

“…Keywords: Protein supplements, Soy Protein, Silicon dioxide, Zinc, Sperm parameters, Testosterone, Follicle stimulating hormone, Luteinizing hormone. …”
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Corrigendum to “Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia” by Efrat Broide, Ram Reifen, Shay Matalon, Zipi Berkovich, Maya Moshe, Haim Shirin

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Effects of Different Heat Treatments on the Structure and Physicochemical Properties of Proteins from Skimmed Camel’s Milk by WANG Tao, WANG Danlin, HE Jing, JI Rimutu

Subjects: “…heat treatment; camel’s milk proteins; physicochemical properties; protein structure…”
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