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4261
Clinical study, network pharmacology, and molecular docking of Kunxian capsule in treating idiopathic membranous nephropathy
Published 2025-02-01“…We also used network pharmacology and molecular docking methods to explore the potential mechanism of action of KX in IMN.ResultsIn patients with IMN receiving KX treatment, 24 h urine protein was markedly decreased, whereas serum albumin levels increased. …”
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4262
The impact of terahertz radiation on an extremophilic archaean Halorubrum saccharovorum proteome
Published 2017-02-01“…A total of 16 differentially expressed protein fractions with at least 1.5-fold changes in expression level were detected. …”
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4263
Physico-chemical properties and structure of rice cultivars grown in Heilongjiang Province of China
Published 2021-01-01“…There were significant differences in the content of fat, protein, ash, amylose, damaged starch among 12 cultivars. …”
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4264
Serum chemokine IL-8 acts as a biomarker for identifying COVID-19-associated persistent severe acute kidney injury
Published 2024-12-01“…Additionally, the IL-8 level was associated with total protein and IL-6 levels.Conclusion Plasma IL-8 is a promising marker for the early identification of PS-AKI among COVID-19 patients. …”
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4265
Integrative analysis of single-cell and transcriptome sequencing with experimental validation reveals PKHD1L1 as a novel biomarker in lung adenocarcinoma
Published 2025-01-01“…Abstract Polycystic kidney and hepatic disease 1-like protein 1 (PKHD1L1) is predicted to encode a large type I transmembrane protein involved in hearing transmission and mediating cellular immunity under physiological conditions. …”
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4266
Mitochondrial ATP-Sensitive K+ Channel Opening Increased the Airway Smooth Muscle Cell Proliferation by Activating the PI3K/AKT Signaling Pathway in a Rat Model of Asthma
Published 2021-01-01“…This study aimed to assess whether mitochondrial ATP-sensitive K+ (mitoKATP) channels regulated the proliferation of ASMCs by regulating the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathway in asthmatic rats. …”
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4267
Dysfunctional BCAA degradation triggers neuronal damage through disrupted AMPK-mitochondrial axis due to enhanced PP2Ac interaction
Published 2025-01-01“…Our findings reveal a reduction in neuronal AMP-activated protein kinase (AMPK) activity, which disrupts autophagy in mutant brain tissues, linking BCAA imbalance to brain dysfunction. …”
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4268
Multi-functional role of apolipoprotein E in neurodegenerative diseases
Published 2025-01-01“…ApoE, a cholesterol transport protein, influences several pathways involved in neurodegeneration, particularly in AD. …”
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4269
A Network-Based Approach to Explore the Mechanism and Bioactive Compounds of Erzhi Pill against Metabolic Dysfunction-Associated Fatty Liver Disease
Published 2020-01-01“…This was carried out through target prediction, protein-protein interaction (PPI) network construction, gene ontology, KEGG pathway enrichment, and molecular docking. …”
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4270
Identification of Two Novel Mutations of ABCD1 Gene in Pedigrees with X-Linked Adrenoleukodystrophy and Review of the Literature
Published 2022-01-01“…X-linked adrenoleukodystrophy (ALD) is an inherited peroxisomal metabolism disorder, resulting from the loss-of-function mutation of ATP-binding cassette protein subfamily D1 (ABCD1) gene. The dysfunction of ALD protein, a peroxisomal ATP-binding cassette transporter, results in the excessive saturated very long-chain fatty acids (VLCFAs) accumulation in organs including the brain, spine, and adrenal cortex. …”
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4271
Biochemistry : the molecular basis of life /
Published 2017Table of Contents: “…Machine generated contents note: -- Table of Contents -- Chapter 1 Biochemistry: An Introduction -- Chapter 2 Living Cells -- Chapter 3 Water: The Matrix of Life -- Chapter 4 Energy -- Chapter 5 Amino Acids, Peptides, and Proteins -- Chapter 6 Enzymes -- Chapter 7 Carbohydrates -- Chapter 8 Carbohydrate Metabolism -- Chapter 9 Aerobic Metabolism I: The Citric Acid Cycle -- Chapter 10 Aerobic Metabolism II: Electron Transport and Oxidative Phosporylation -- Chapter 11 Lipids and Membranes -- Chapter 12 Lipid Metabolism -- Chapter 13 Photosynthesis -- Chapter 14 Nitrogen Metabolism I: Synthesis -- Chapter 15 Nitrogen Metabolism I: Degradation -- Chapter 16 Integration of Metabolism -- Chapter 17 Nucleic Acids -- Chapter 18 Genetic Information -- Chapter 19 Protein Synthesis.…”
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4272
Biochemistry : the molecular basis of life /
Published 2017Table of Contents: “…Machine generated contents note: -- Table of Contents -- Chapter 1 Biochemistry: An Introduction -- Chapter 2 Living Cells -- Chapter 3 Water: The Matrix of Life -- Chapter 4 Energy -- Chapter 5 Amino Acids, Peptides, and Proteins -- Chapter 6 Enzymes -- Chapter 7 Carbohydrates -- Chapter 8 Carbohydrate Metabolism -- Chapter 9 Aerobic Metabolism I: The Citric Acid Cycle -- Chapter 10 Aerobic Metabolism II: Electron Transport and Oxidative Phosporylation -- Chapter 11 Lipids and Membranes -- Chapter 12 Lipid Metabolism -- Chapter 13 Photosynthesis -- Chapter 14 Nitrogen Metabolism I: Synthesis -- Chapter 15 Nitrogen Metabolism I: Degradation -- Chapter 16 Integration of Metabolism -- Chapter 17 Nucleic Acids -- Chapter 18 Genetic Information -- Chapter 19 Protein Synthesis.…”
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4273
miR-317 regulates the proliferation and apoptosis of duck follicle granulosa cells by targeting VIPR1
Published 2025-01-01“…Fluorescence quantitative PCR was used to assess the expression level of VIPR1 after miR-317 overexpression or silencing. Total protein was extracted from the follicle granulosa cells, and protein levels were analyzed via Western blotting. …”
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4274
Vaccines of the Future: The Role of Inflammation and Adjuvanticity
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4275
Hepatocyte Growth Factor in Synaptic Plasticity and Alzheimer's Disease
Published 2010-01-01“…The hepatocyte growth factor (HGF) was initially identified as a protein that promoted growth of hepatocytes. It regulates proliferation and survival of different types of cells. …”
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4276
Birt-Hogg-Dubé Syndrome: Report of a New Mutation
Published 2012-01-01“…Several distinct mutations in the folliculin gene resulting in a truncated protein have been described. The present report describes a new mutation, which has not been reported in individuals with Birt-Hogg-Dubé syndrome but is of a type predicted to cause disease.…”
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4277
PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation
Published 2016-09-01“…PF573,228 is a compound that targets focal adhesion kinase (FAK), a non-receptor protein kinase, which is over-expressed in various tumors. …”
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4278
Pureed Foods: Lentil Desserts
Published 2018-03-01“… A pureed diet may be recommended for individuals with swallowing problems; however, it can be challenging for those with a puréed diet to receive adequate protein, fiber, vitamins, and minerals. This 4-page document provides recipes made with puréed lentils, offering desserts that are both tasty and nutrient-dense. …”
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4279
Impaired cognitive function and decreased monoamine neurotransmitters in the DNAJC12 gene knockout mouse model
Published 2025-02-01“…To assess the impact of these mutations on DNAJC12 expression, we used quantitative real-time PCR and Western blotting techniques to measure mRNA and protein levels, respectively. The Morris water maze test was administered to evaluate the cognitive functions of the mice. …”
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4280
Deregulated methylation and expression of PCDHGB7 in patients with non-small cell lung cancer: a novel prognostic and immunological biomarker
Published 2025-01-01“…Plasma PCDHGB7 methylation and protein levels can be used as novel biomarkers for predicting the efficacy of immunotherapy in lung cancer.…”
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