Peptide Antigen Modifications Influence the On-Target and Off-Target Antibody Response for an Influenza Subunit Vaccine by Megan C. Schulte, Adam C. Boll, Agustin T. Barcellona, Elida A. Lopez, Adam G. Schrum, Bret D. Ulery

“…In this current work, the effect of native protein linkages and non-native micellizing moieties on M2 immunogenicity was studied. …”
Get full text

NEIL3 Mediates Lung Cancer Progression and Modulates PI3K/AKT/mTOR Signaling: A Potential Therapeutic Target by Hongbo Huang, Qingwang Hua

“…Quantitative real-time PCR (qRT-PCR) and western blot analyses were utilized to detect RNA and protein levels. Biological differences between groups were determined by gene set enrichment analysis (GSEA). …”
Get full text

Comparative Genomics Analysis of Two Different Virulent Bovine Pasteurella multocida Isolates by Huihui Du, Rendong Fang, Tingting Pan, Tian Li, Nengzhang Li, Qiang He, Rui Wu, Yuanyi Peng, Zeyang Zhou

“…The draft genome sequence of PmCQ6 is 2.29 Mbp and contains 1,970 protein-coding genes, 2 IS elements, and 3 prophage regions. …”
Get full text

A comprehensive review on nutritional composition, health benefits, and industrial applications of Jackfruit Seeds by Simran Dhani, Hamid, Nomali Ziphorah Ngobese, Sunny Sharma, Amit K. Jaiswal

“…Seeds of jackfruit are usually considered as waste (15 %) but are rich in protein, starch as well as various bioactive compounds. …”
Get full text

Restoration of Sestrin 3 Expression Mitigates Cardiac Oxidative Damage in Ischemia–Reperfusion Injury Model by Mina Park, Sunghye Cho, Dongtak Jeong

“…Through in silico analysis, we identified Sestrin3 (SESN3), an antioxidant protein known for its protective effects against oxidative stress, as a novel target of miR-25. …”
Get full text

Evaluation and selection of yeasts as potential aroma enhancers for the production of dry-cured ham by Xiaohui Gong, Ruifang Mi, Xi Chen, Qiujin Zhu, Suyue Xiong, Biao Qi, Shouwei Wang

“…All isolates of yeast showed enzymatic activities against milk protein and tributyrin, while only 4 strains displayed proteolytic activity on meat protein. …”
Get full text

Thrombogenic Markers in Patients with Hereditary Thrombophilia by Karima Maricel Gondres Legró, Jorge Calá Fernández, Yusmairy Matos Lores, Vivian Robert Tamayo, Lázaro Ibrahim Romero García, Yordanys Páez Candelaria

“…<br /><strong>Results:</strong> protein S deficiency ranked first with 22 (56.4 %). …”
Get full text

Unraveling the Genetic Heartbeat: Decoding Cardiac Involvement in Duchenne Muscular Dystrophy by Valeria Novelli, Francesco Canonico, Renzo Laborante, Martina Manzoni, Alessandra Arcudi, Giulio Pompilio, Eugenio Mercuri, Giuseppe Patti, Domenico D’Amario

“…Genetic alterations in the DMD gene result in the absence of functional dystrophin protein, leading to skeletal/cardiac muscle impairment. …”
Get full text

Response Surface Methodology and Textural Profile Analysis for Optimization of Fruit Peel-Based Extruded Snack (Elbow Macaroni) by Pragya Mishra, Ena Gupta, Karishma Gupta

“…The proximate composition of optimized fruit peel macaroni was reported to have 5.06, 9.7, 2.7, 1.33, 1.42, and 79.79 percent of moisture, protein, fibre, fat, ash, and carbohydrate, respectively. …”
Get full text

The Long Noncoding RNA LOXL1-AS1 Promotes the Proliferation, Migration, and Invasion in Hepatocellular Carcinoma by Jiang Liu, Chengtong Zhai, Degan Liu, Jianhua Liu

“…What is more, cell migration was also inhibited in vitro in Matrigel Transwell Assay by LOXL1-AS1 knockdown, which might be partly attributed to the reduction of MMP-2 and MMP-9 protein expressions. Finally, cell cycle analysis revealed that knockdown of LOXL1-AS1 induced significantly a G0/G1 phase cell cycle arrest, which might be partly attributed to the downregulation of Cdc2, Cdc25A, and cyclin B1 protein expression. …”
Get full text

Altered Hepatic Lipid Metabolism Contributes to Nonalcoholic Fatty Liver Disease in Leptin-Deficient Ob/Ob Mice by James W. Perfield, Laura C. Ortinau, R. Taylor Pickering, Meghan L. Ruebel, Grace M. Meers, R. Scott Rector

“…Here we examined genes and proteins involved in hepatic oxidation and lipogenesis in 14-week-old leptin-deficient Ob/Ob mice, a commonly studied model of obesity and hepatic steatosis. …”
Get full text

Excessive Weight Gain During Pregnancy Increased Ponoxarase 1 Level in Neonatal Cord Blood by Serhat Ege, Hasan Akduman, Ayşegül Aşır, Tuğcan Korak

“…A total of 24 common protein interactors associated with PON1, obesity, and oxidative stress were identified. …”
Get full text

Stability of Encapsulated Lactobacillus reuteri during Harsh Conditions, Storage Period, and Simulated In Vitro Conditions by Abdolazim Soltani Lak, Mohammad Hossein Marhamatizadeh, Hossein Fattahi

“…In the present work, we encapsulated Lactobacillus reuteri within whey protein isolate (WPI), soy protein isolate (SPI), WPI + inulin (WPI4I), and SPI + inulin (SPI4I) through spray drying method and investigated the efficiency of the microcapsules on the protection of the cells under different conditions (heat, salt, bile salt, penicillin, pH, simulated gastrointestinal condition, and storage). …”
Get full text

Response of Rice Nitrogen Physiology to High Nighttime Temperature during Vegetative Stage by Song Chen, Xiaoguo Zhang, Xia Zhao, Danying Wang, Chunmei Xu, Chenglin Ji, Xiufu Zhang

“…Moreover, leaf GS activity under HNT was increased at 160 mg N/L compared with that under CK, which might partly explain the positive effect of HNT on soluble protein and carbohydrate content.…”
Get full text

Human APP Gene Expression Alters Active Zone Distribution and Spontaneous Neurotransmitter Release at the Drosophila Larval Neuromuscular Junction by Ekaterina A. Saburova, Alexander N. Vasiliev, Violetta V. Kravtsova, Elena V. Ryabova, Andrey L. Zefirov, Olga I. Bolshakova, Svetlana V. Sarantseva, Igor I. Krivoi

“…The total number of active zones, detected by Bruchpilot protein puncta distribution, remained unchanged; however, the average number of active zones per bouton decreased. …”
Get full text

Potential Piperolactam A Isolated From Piper betle as Natural Inhibitors of Brucella Species Aminoacyl‐tRNA Synthetase for Livestock Infections: In Silico Approach by Diding Latipudin, Sefren Geiner Tumilaar, Yoga Ramdani, Dudi Dudi, Dikdik Kurnia

“…The urgency of discovering new drug candidates to combat Brucella’s infection necessitates the exploration of novel alternative agents with unique protein targets. Aminoacyl‐tRNA synthetases (aaRSs), which have fundamental functions in translation, inhibit this process, stop protein synthesis and ultimately inhibit bacterial growth. …”
Get full text

Edible portions of precooked blue swimming crab: Chemical composition and effect of chitooligosaccharide conjugate and high-pressure processing on microbial inactivation by Khaettareeya Pimsannil, Suriya Palamae, Xinru Fan, Qiancheng Zhao, Bin Zhang, Soottawat Benjakul

“…Myosin heavy chain and actin constituted as key proteins in meat, but the protein pattern of roe was completely different. …”
Get full text

β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC by Ernst Fredericks, Gill Dealtry, Saartjie Roux

“…Results. β-catenin mRNA and protein expression progressively increased from the Normal group, through IBS and IBD reaching statistical significance in CRC. …”
Get full text

New cultivars of vegetable cowpea (<i>Vigna unguiculata</i> (L.) Walp.) developed at VIR by M. V. Gurkina, M. O. Burlyaeva

“…The pod yield of ‘Pasta Grin’ is 24.68–25.84 t/ha, seed yield is 0.82–1.04 t/ha, protein content is 29.1% in pods and 23.6% in seeds. …”
Get full text

A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A by Ibrahim M. Sabbarini, Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I. Shakhnovich, Andrew W. Murray, Vladimir Denic

“…Our work shows that an ATP-independent chaperone can drive vectorial folding of nascent chains by co-opting G protein nucleotide binding.…”
Get full text