Characterization of gene expression profiles in Alzheimer's disease and osteoarthritis: A bioinformatics study. by Nian Liu, Qian Deng, Zining Peng, Danning Mao, Yuanbo Huang, Fanyu Meng, Xiaoyu Zhang, Jiayan Shen, Zhaofu Li, Weitian Yan, Jiangyun Peng

“…Subsequently, the Co-DEGs were enriched, and a protein-protein interaction network was constructed to identify core genes. …”
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Biosynthesis of lactacystin as a proteasome inhibitor by Takeshi Tsunoda, Shunkichi Furumura, Haruka Yamazaki, Chitose Maruyama, Yoshimitsu Hamano, Yasushi Ogasawara, Tohru Dairi

“…We also examined the functions of the genes encoding a PKS/NRPS hybrid protein (LctA), NRPS (LctB), ketosynthase-like cyclase (LctC), cytochrome P450 (LctD), MbtH-like protein (LctE), and formyltransferase (LctF) by in vivo and in vitro experiments. …”
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Inflammatory Cytokine Pattern Is Sex-Dependent in Mouse Cutaneous Melanoma Experimental Model by Mihaela Surcel, Carolina Constantin, Constantin Caruntu, Sabina Zurac, Monica Neagu

“…Cytokine/chemokine pattern was assessed using xMAP technology and the following molecules were quantified: interleukins (IL)-1-beta, IL-6, IL-10, IL-12 (p70), interferon (IFN)-gamma, granulocyte macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor (TNF)-alpha, macrophage inflammatory protein (MIP)-1alpha, monocyte chemoattractant protein (MCP-1), and keratinocyte-derived chemokine (KC). …”
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Oxymatrine inhibits the development of radioresistance in NSCLC cells by reversing EMT through the DcR3/AKT/GSK-3β pathway by Jianming Tang, Yu Cao, Hong Zhang, Rui Wang

“…Material and methods Western blotting was conducted to quantify the protein expression of epithelial-mesenchymal transition markers E-cadherin and vimentin in the A549 cell line. …”
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Seizure-Induced Regulations of Amyloid-β, STEP61, and STEP61 Substrates Involved in Hippocampal Synaptic Plasticity by Sung-Soo Jang, Sara E. Royston, Gunhee Lee, Shuwei Wang, Hee Jung Chung

“…Here we show that a single episode of electroconvulsive seizures (ECS) increased protein expression of membrane-associated STriatal-Enriched protein tyrosine Phosphatase (STEP61) and decreased tyrosine-phosphorylation of its substrates N-methyl D-aspartate receptor (NMDAR) subunit GluN2B and extracellular signal regulated kinase 1/2 (ERK1/2) in the rat hippocampus at 2 days following a single ECS. …”
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Exploring the Nutritional Potential of Spent Coffee Grounds as a Substitute for Rice Bran in Feeds for Nile tilapia, Oreochromis niloticus: An Evaluation of Growth Performance and... by Wikit Phinrub, Sontaya Sookying, Phanit Srisuttha, Nantaporn Sutthi, Paiboon Panase

“…Conversely, serum glucose, total protein, albumin, and globulin remained unaffected by SCG replacement throughout the experiment. …”
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Network pharmacology combined with experimental verification for exploring the potential mechanism of phellodendrine against depression by Lili Hu, Na Wu, Jue Wang, Donghui Cai

“…The intersection targets between PHE and MDD were obtained to identify as targets for PHE against MDD, followed by protein–protein interaction network, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses. …”
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SPOCK2 controls the proliferation and function of immature pancreatic β-cells through MMP2 by Katarzyna Blaszczyk, Anna P. Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A. Beamish, Jolanta Chmielowiec, Omaima M. Sabek, Ashok Balasubramanyam, Sanjeet Patel, Malgorzata Borowiak

“…Through bidirectional expression modulation and single-cell RNA-seq, we identified SPOCK2, an ECM protein, as an inhibitor of immature β-cell proliferation. …”
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Identified VCAM1 as prognostic gene in gastric cancer by co-expression network analysis by Wenjuan Li, Hong Gao, Jianjun Liu

“…Co‐expression gene modules were constructed via Weighted Gene Co‐Expression Network Analysis (WGCNA), followed by deciphering gene functions and protein–protein interaction networks within significantly associated modules. …”
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Enhancing nutrient intake, egg production, and egg quality by fermented Leucaena leucocephala leaf meal in a diet of laying quail by Merry Muspita Dyah Utami, Abigeil Akbar

“…Results: FLM supplementation significantly improved energy, protein, fat, calcium, and phosphorus intake while reducing FCR. …”
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Expanding the Diversity of <i>Actinobacterial Tectiviridae</i>: A Novel Genus from <i>Microbacterium</i> by Jacqueline M. Washington, Holly Basta, Angela Bryanne De Jesus, Madison G. Bendele, Steven G. Cresawn, Emily K. Ginser

“…Annotation analysis determined that the novel <i>Microbacterium</i> phages all have 32–34 protein-coding genes and no tRNAs. Like other <i>Tectiviridae</i>, the phage genomes are arranged into two segments and include three highly conserved family genes that encode a DNA polymerase, double jelly-roll major capsid protein, and packaging ATPase. …”
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Knockdown of PTEN promotes colon cancer progression and induces M2 macrophage polarization in the colon cancer cell environment by Xu Han, Ting Yan, Lina Wang, Bin He, Huaxu Yu

“…The expressions of phosphate (p)-p38, c-Jun N-terminal kinase (JNK), activator protein 1 (AP-1), B-cell lymphoma-2 (Bcl-2) protein in colon cancer tissues and cells were significantly higher than in precancerous tissues or CCD-18Co cells (P-values < 0.05). …”
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An unbiased cell morphology-based screen for new, biologically active small molecules. by Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Eugeni Vaisberg, Shyam Ramachandani, Chao Zhang, Kirk C Hansen, Alma L Burlingame, Jay K Trautman, Kevan M Shokat, Cynthia L Adams

“…Principal component analysis was used to identify inhibitors of cellular components not targeted by known protein kinase inhibitors. Here we focus on a hydroxyl-substituted analog (hydroxy-PP) of the known Src-family kinase inhibitor PP2 because it induced cell-specific morphological features distinct from all known kinase inhibitors in the collection. …”
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HuR Plays a Positive Role to Strengthen the Signaling Pathways of CD4+ T Cell Activation and Th17 Cell Differentiation by Shiguang Yu, Morgan Tripod, Ulus Atasoy, Jing Chen

“…However, the role of RNA-binding protein HuR in the signaling pathways of their activation and differentiation has not been well characterized. …”
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Endoplasmic Reticulum Stress Regulates Scleral Remodeling in a Guinea Pig Model of Form-Deprivation Myopia by Chengcheng Zhu, Qingzhong Chen, Ying Yuan, Min Li, Bilian Ke

“…The sclera of FDM eyes exhibited swollen and distended ER at 4 weeks, as well as significantly increased protein expression of GRP78 and CRT at 1 week and 4 weeks, compared to the sclera of the control eyes. …”
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Anti-Inflammatory Activity of Ferula assafoetida Oleo-Gum-Resin (Asafoetida) against TNF-α-Stimulated Human Umbilical Vein Endothelial Cells (HUVECs) by Leila Mobasheri, Mohsen Khorashadizadeh, Hossein Safarpour, Maryam Mohammadi, Gholamreza Anani Sarab, Vahid Reza Askari

“…In addition, EEA pretreatment decreased TNF-α-induced mRNA expression of VCAM-1 and surface protein expression of ICAM-1 in the target cells. …”
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C-28 linker length modulates the activity of second-generation HIV-1 maturation inhibitors by K. C. Yuvraj, Aradhana Singh, Sayantani Datta, Ritika Das, Pranjal Raj Saxena, Subash Chapagain, T. J. Nitz, Carl Wild, Ritu Gaur

“…Abstract Maturation inhibitors (MIs) block HIV-1 maturation by preventing the cleavage of the capsid protein and spacer peptide 1 (CA-SP1). Bevirimat (BVM), a first-in-class MI, displayed sub-optimal efficacy in clinical trials due to presence of SP1:V7A polymorphism in the Gag protein.This polymorphism is inherently present in HIV-1 subtype C and conferred resistance to BVM. …”
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Diversification and recurrent adaptation of the synaptonemal complex in Drosophila. by Rana Zakerzade, Ching-Ho Chang, Kamalakar Chatla, Ananya Krishnapura, Samuel P Appiah, Jacki Zhang, Robert L Unckless, Justin P Blumenstiel, Doris Bachtrog, Kevin H-C Wei

“…The synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. …”
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Effects of Composition of Iron-Cross-Linked Alginate Hydrogels for Cultivation of Human Dermal Fibroblasts by Ikuko Machida-Sano, Sakito Ogawa, Hiroyuki Ueda, Yoshitaka Kimura, Nao Satoh, Hideo Namiki

“…High-G and high-M Fe-alginate gels showed comparable efficacy in promoting initial cell adhesion and similar protein adsorption capacities, but superior cell proliferation was observed on high-G than on high-M Fe-alginate as culture time progressed. …”
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Egg Freshness Indexes Correlations with Ovomucin Concentration during Storage by Yajun Jiang, Dandan Fu, Ming Ma

“…The relationship between protein changes and egg quality during storage is a critical area of investigation in both basic science and egg product preservation. …”
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