Heritability Estimated Using 50K SNPs Indicates Missing Heritability Problem in Holstein Breeding by Donghyun Shin, Kyoung-Do Park, Sojoeng Ka, Heebal Kim, Kwang-hyeon Cho

“…For all three traits (milk yield, fat, and protein), we estimated a nominally significant (p = 0.1) proportion of variance explained by all SNPs on the Illumina BovineSNP50 Beadchip (h2G). …”
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Synthesis, Molecular Docking, Molecular Dynamic Simulation Studies, and Antitubercular Activity Evaluation of Substituted Benzimidazole Derivatives by Shankar Thapa, Mahalakshmi Suresha Biradar, Shachindra L. Nargund, Iqrar Ahmad, Mohit Agrawal, Harun Patel, Ashish Lamsal

“…Hydrogen bond analysis suggested that compound 7 has greater stability and affinity towards the KasA protein compared to compound 8. Moreover, both compounds (7 and 8) were safe for acute inhalation and cutaneous sensitization. …”
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Usefulness of Immunological Detection of the Human Telomerase Reverse Transcriptase by Annalisa Volpi, Sara Bravaccini, Laura Medri, Serenella Cerasoli, Michele Gaudio, Dino Amadori

“…Conclusions: Immunohistochemistry with a well characterised hTERT-specific monoclonal antibody permitted the identification of hTERT immunopositive cells in normal somatic tissues. Whether hTERT protein detected by immunostaining with hTERT-specific Tel 3 36-10 antibody is actually the degraded form of the protein that retains hTERT antigenicity but not enzymatic function, or whether it represents the real, potentially functional catalytic subunit of the enzyme, immunohistochemistry would not seem to represent a useful tool to investigate the role of telomerase and the mechanisms involved in its regulation.…”
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Infusion therapy for chronic liver diseases by I. A. Kurkina, M. V. Mayevskaya, I. N. Tikhonov, V. N. Zozulya, V. I. Leschenko

“…Addition of succinic acid-based medications to infusion therapy program for chronic liver diseases provides alleviation of basic clinical syndromes (intoxication, asthenic and autonomous nervous disorders, dyspeptic, cholestatic), and at patients with hepatocellular failure improvement of protein-synthetic liver function.…”
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Hubungan Pemberian Jenis Makanan Pendamping ASI dengan Perkembangan Bayi Umur 9-12 Bulan di Wilayah Kerja Puskesmas Lubuk Begalung Padang by Yulia Fitriani, Firdawati Firdawati, Gustina Lubis

“…Dari 37 orang bayi yang diberi MP-ASI lokal didapatkan kecukupan energi MP- ASI sesuai 51,4 % dan kecukupan protein MP-ASI sesuai 83,8 %. Simpulan: Terdapat hubungan yang significant antara kecukupan energi dan protein MP-ASI lokal dengan perkembangan sedangkan faktor lain yang mempengaruhi perkembangan adalah genetik/keturunan, ekonomi dan lingkungan.…”
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Autophagy Mediates MMP-2 Expression in Glaucomatous Trabecular Meshwork Cells by Yan-Ling Xiao, Xiao-Rui Wang, Kejing Ye, Wan-Zhu Chen, Bing-Ru Zheng, Yi-Hong Huang, Yu-Yu Wu

“…The control group was treated with a normal medium, the 3-MA group was stimulated with 3-MA, and the starvation group received nutrient depletion by replacing the normal media with Earle’s balanced salt solution. Cellular mRNA and protein were measured at different 3-MA concentrations and starvation time periods. …”
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Identification of Genetic Biomarkers for Diagnosis of Myocardial Infarction Compared with Angina Patients by Yuanyuan Zhang, Chunyang Tian, Xuejian Liu, He Zhang

“…The construction of a protein-protein network was explored by STRING. cytoHubba was utilized to screen hub genes. …”
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Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells by Katja Spiess, Mads G. Jeppesen, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Thomas N. Kledal, Mette M. Rosenkilde

“…One recent example targeted the virus-encoded G protein-coupled receptor US28 as a strategy for specific and efficient treatment of human cytomegalovirus (HCMV) infections. …”
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Glufosinate Effects on Nitrogen Nutrition, Growth, Yield, and Seed Composition in Glufosinate-Resistant and Glufosinate-Sensitive Soybean by Krishna N. Reddy, Robert M. Zablotowicz, Nacer Bellaloui, Wei Ding

“…In glufosinate-resistant soybean, chlorophyll, nitrogenase activity, root respiration, plant biomass, and yield were not affected; seed nitrogen and protein were increased; seed oil content decreased. …”
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Chronic Benign Tubular Albuminuria From Compound Heterozygous Variants in : A Case Report by Adam Pietrobon, Mark D. Elliott

“…Cubilin, encoded by CUBN , is a critical protein involved in protein reabsorption in the proximal tubule. …”
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HSP90 inhibitors promote cell death by degrading Met and BCR::ABL1 in both imatinib-resistant and -sensitive chronic myeloid leukemia cells by Masanobu Tsubaki, Taira Matsuo, Rie Komori, Noriaki Nagai, Tetsushi Yamamoto, Shozo Nishida

“…KW-2478 inhibited the activation of Akt, extracellular regulated protein kinase 1/2, and c-Jun N-terminal kinase 1/2 in imatinib-resistant and -sensitive CML cells by promoting Met and BCR::ABL1 degradation. …”
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Nutrition in patients with traumatic brain injury: Nutrition in patients with TBI by Stojanović Milena, Janković Radmilo, Ranđelović Milica, Vasilijić Milena, Nikolić Aleksandar, Radeka Jovan

“…Optimization in energy and protein provision has taken its place lately in the fundamental concept of treatment in critically ill patients with moderate and severe brain trauma, together with reducing intracranial pressure and prevention of hypotension and hypoxia. …”
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Increased Fat-Free Body Mass and No Adverse Effects on Blood Lipid Concentrations 4 Weeks after Additional Meat Consumption in Comparison with an Exclusion of Meat in the Diet of Y... by Klaus J. Petzke, Susen Lemke, Susanne Klaus

“…Urinary excretion of 3-methylhistidine could represent a biomarker for meat protein consumption.…”
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Antibacterial activity of palm heart extracts collected from Iraqi Phoenix dactylifera L by Sameer Mohammed Yaseen, Hussein Adil Abid, Anwar Ali Kadhim, Entesar Emhamed Aboglida

“…Distilled water extract was divided into crude, residues (after filtration), protein and non-protein parts. All extracts were investigated to determine their inhibitory activity against Staphylococcus aureus (S. aureus), Streptococcus pyogenes (S. pyogenes), Streptococcus mutans (S. mutans), Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae), Proteus mirabilis (P. mirabilis), Enterobacter aerogenes (E. aerogenes), Morganella morganii (M. morganii), and Pseudomonas aeruginosa (P. aeruginosa) using agar well diffusion method, ceftriaxone (CTR) was used as a positive control. …”
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Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment by Liriopé Toupenet Marchesi, Daniel Stockholm, Typhaine Esteves, Marion Leblanc, Nicolas Auger, Julien Branchu, Khalid Hamid El Hachimi, Giovanni Stevanin

“…Among these, spastic paraplegia type 11 (SPG11) represents a complex form of HSP caused by deleterious variants in the SPG11 gene, which encodes the spatacsin protein. Previous studies have described several potential roles for spatacsin, including its involvement in lysosome and autophagy mechanisms, neuronal and neurites development or mitochondria function. …”
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CENP-A/CENP-B uncoupling in the evolutionary reshuffling of centromeres in equids by Eleonora Cappelletti, Francesca M. Piras, Marialaura Biundo, Elena Raimondi, Solomon G. Nergadze, Elena Giulotto

“…Abstract Background While CENP-A is the epigenetic determinant of the centromeric function, the role of CENP-B, a centromeric protein binding a specific DNA sequence, the CENP-B-box, remains elusive. …”
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Comparison of IgG and Neutralizing Antibody Response After Pfizer BioNTech COVID-19 Vaccine Among Iraqi Individuals by Najat Saeed Hussein, Izzat Abdulsatar Al-Rayahi, Salwa S. Muhsin, Redhwan Abdul Kareem Alameer

“…Review of the anti-spike protein receptor-binding domain (S-RBD) a person's level of immune response to antibody strategy can be used to assess SARS-CoV-2 viral infection in 2019.  …”
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CryJ-LAMP DNA Vaccines for Japanese Red Cedar Allergy Induce Robust Th1-Type Immune Responses in Murine Model by Yan Su, Michael Connolly, Anthony Marketon, Teri Heiland

“…We utilized the lysosomal targeting property of lysosomal-associated membrane protein-1 (LAMP-1) to make DNA vaccines that encode LAMP-1 and the sequences of immunodominant allergen CryJ1 or CryJ2 from the JRC pollen. …”
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Grain Amaranth Is Associated with Improved Hepatic and Renal Calcium Metabolism in Type 2 Diabetes Mellitus of Male Wistar Rats by Keneth Iceland, Kasozi, Namubiru, Sarah, Safiriyu, Abass Alao, Ninsiima, Herbert Izo, Nakimbugwe, Dorothy, Namayanja, Monica, Valladares, Miriela Betancourt

“…Blood, renal, and hepatic tissues were collected and analyzed for calcium, s100a1 protein levels, and antioxidant and histopathological changes. …”
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TUBA1B as a novel prognostic biomarker correlated with immunosuppressive tumor microenvironment and immunotherapy response by Juntao Qi, Juntao Qi, Mingming Zhou, Na Yang, Huiyun Ma, Min He, Gujie Wu, Chang Ge, Liuyin Jin, Lin Cheng, Wei Liao, Hefei Ren, Caiyun Lei

“…Background: Tubulin alpha 1b (TUBA1B) is a key microtubule protein essential for maintaining cellular structure and function. …”
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