Molecular insights into the unique properties of the blood‐circulating proteasome by Yegor Leushkin, David Morgenstern, Shifra Ben‐Dor, Rebecca Haffner‐Krausz, Katharina Zittlau, Gili Ben‐Nissan, Michal Sharon

“…Abstract Proteasomes are essential for protein degradation and maintaining cellular balance, yet their roles in extracellular fluids are not well understood. …”
Get full text

Effect of physical activity on structural asymmetry of mouse hippocampus by T. A. Zapara, A. V. Romashchenko, A. L. Proskura, A. S. Ratushnyak

“…The reconstruction and analysis of protein­protein interactions that ensure the survival of a large number of new neurons and their integration into existing neural networks in the hippocampus have been carried out. …”
Get full text

Identification of Diagnostic Genes and Effective Drugs Associated with Osteoporosis Treatment by Single-Cell RNA-Seq Analysis and Network Pharmacology by Zhanyue Zhang, Tingbao Zhang, Liangshuang Zhou, Jianzhong Guan

“…Key drugs were determined by proteins-proteins interaction and molecular docking. …”
Get full text

Effect of Codonopsis pilosula Polysaccharides on the Growth and Motility of Hepatocellular Carcinoma HepG2 Cells by Regulating β-Catenin/TCF4 Pathway by Yuan-yuan Zhang, Ying-mei Zhang, Hai-yan Xu

“…Other than that, downregulation of β-catenin, TCF4, and c-Myc protein expression (P<0.05) was observed as well. …”
Get full text

Exploring Seipin: From Biochemistry to Bioinformatics Predictions by Aquiles Sales Craveiro Sarmento, Lázaro Batista de Azevedo Medeiros, Lucymara Fassarella Agnez-Lima, Josivan Gomes Lima, Julliane Tamara Araújo de Melo Campos

“…Seipin is a nonenzymatic protein encoded by the BSCL2 gene. It is involved in lipodystrophy and seipinopathy diseases. …”
Get full text

Proteomics and Its Current Application in Biomedical Area: Concise Review by Semira Gobena, Bemrew Admassu, Mebrie Zemene Kinde, Abebe Tesfaye Gessese

“…Within this realm, proteomics stands out as a pivotal technology, focusing on extensive studies of protein composition, structure, function, and interactions. …”
Get full text

Characterization of two neutralizing monoclonal antibodies with conformational epitopes against porcine deltacoronavirus by Wan Lu, Hongtao Cao, Yongle Yang, Yangyang Sun, Dong Yang, Priscilla F. Gerber, Xiangdong Li, Yaowei Huang, Bin Wang

“…In this study, two monoclonal antibodies (mAbs), 1C2 and 5H5, were generated and showed high specificity for the PDCoV S protein. Both mAbs displayed high-titer neutralizing capabilities, suggesting their potential for passive immunotherapy. …”
Get full text

Analisis pengaruh penambahan tepung okra dan tepung porang terhadap komposisi proksimat dan organoleptik foodbars by Erwin Nofiyanto, Aldila Sagitaning Putri

“…The variables observed were water content, ash, crude fiber, fat, protein, carbohydrates, and preference test. The data obtained were analyzed for variance and if there were differences between treatments, they were further tested using the Duncan Multiple Range Test (DMRT) at the 5% level. …”
Get full text

freeQuant: A Mass Spectrometry Label-Free Quantification Software Tool for Complex Proteome Analysis by Ning Deng, Zhenye Li, Chao Pan, Huilong Duan

“…It adopts spectral count for quantitative analysis and builds a new method for shared peptides to accurately evaluate abundance of isoforms. For proteins with low abundance, MS/MS total ion count coupled with spectral count is included to ensure accurate protein quantification. …”
Get full text

System Review about Function Role of ESCC Driver Gene KDM6A by Network Biology Approach by Jihua Ran, Hui Li, Huiwu Li

“…In order to provide more biological insights into KDM6A, in this paper, we treat PPI (protein-protein interaction) network derived from KDM6A as a conceptual framework and follow it to review its biological function. …”
Get full text

Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway by Sang-Hoon Lee, Sung-Hwan Eom, Na-Young Yoon, Moon-Moo Kim, Yong-Xin Li, Sang Keun Ha, Se-Kwon Kim

“…An enzyme-linked immunosorbent assay and cytometric bead array assay demonstrated that FF significantly reduced the production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor-α, and that of the monocyte chemoattractant protein-1. Moreover, FF reduced the activation of nuclear factor κB (NF-κB) and mitogen-activated protein kinases (MAPKs). …”
Get full text

Activation of TLR4-Mediated NF𝜅B Signaling in Hemorrhagic Brain in Rats by Weiyu Teng, Lishu Wang, Weishuang Xue, Chao Guan

“…Compared with saline control, the TLR4 mRNA and protein significantly increased starting at 6 hours after ICH, peaked on the 3rd day after ICH, and then decreased but still maintained at a higher level on the 7th day after ICH (𝑃<.05). …”
Get full text

Proteomic Profiling and Functional Analysis of B Cell-Derived Exosomes upon Pneumocystis Infection by Dan Ma, Qian-Yu Zhang, Heng-Mo Rong, Kan Zhai, Zhao-Hui Tong

“…Exosomes are nanoscale small extracellular vesicles abundant with protein cargo and can mediate immune response during infectious disease. …”
Get full text

Use of Posttranscription Gene Silencing in Squash to Induce Resistance against the Egyptian Isolate of the Squash Leaf Curl Virus by Omnia Taha, Inas Farouk, Abdelhadi Abdallah, Naglaa A. Abdallah

“…The first fragment was 348 bp from replication associated protein gene (Rep). The second fragment was 879 bp representing the full sequence of the movement protein gene (BC1). …”
Get full text

Lutein Leads to a Decrease of Factor D Secretion by Cultured Mature Human Adipocytes by Yuan Tian, Aize Kijlstra, Johan Renes, Martin Wabitsch, Carroll A. B. Webers, Tos T. J. M. Berendschot

“…A cell line of mature human adipocytes was incubated with 50 μg/mL lutein for 24 and 48 h, whereafter FD mRNA and protein expression were measured. Results. Lutein significantly inhibited adipocyte FD mRNA expression and FD protein release into adipocyte culture supernatants. …”
Get full text

Rosavin exerts an antitumor role and inactivates the MAPK/ERK pathway in small-cell lung carcinoma in vitro by Liu Rui, Jiang Cuihong, Zhao Zhizheng, Lv Yutong, Wang Gaoxing

“…Wound healing and transwell assays were performed to evaluate the migration and invasion of SCLC cells. Besides, protein levels of p-ERK, ERK, p-MEK and MEK were determined using Western blot analysis. …”
Get full text

The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives by Winda Ariyani, Noriyuki Koibuchi

“…Soybean is a source of protein, fibers, and phytochemical isoflavones which are considered to have numerous health benefits for children and adulthood. …”
Get full text

In Silico Analysis on the Interaction of Haloacid Dehalogenase from Bacillus cereus IndB1 with 2-Chloroalkanoic Acid Substrates by Enny Ratnaningsih, Saepulloh Saepulloh

“…Structure prediction revealed that Bcfd1 protein consist of two domains. The main domain consists of seven β-sheets connected by six α-helices and four 310-helices forming a Rossmannoid fold. …”
Get full text

The Role of Some Chemokines from the CXC Subfamily in a Mouse Model of Diabetic Neuropathy by Magdalena Zychowska, Ewelina Rojewska, Dominika Pilat, Joanna Mika

“…Using Antibody Array techniques, the increases in CXCL1 (KC), CXCL5 (LIX), CXCL9 (MIG), and CXCL12 (SDF-1) protein levels were detected in STZ-injected mice. …”
Get full text

Association of Toll-Like Receptor 2 (TLR2) Expression in Placenta and Intrauterine Exposure to Hepatitis B Virus by Dian Utami, Maisuri T. Chalid, Rina Masadah, Rizalinda Sjahril, Andi Dwi Bahagia Febriani

“…The expression of TLR2 protein in the placenta was performed using immunohistochemistry analysis. …”
Get full text