The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis by Mingfa Liu, Zhennan Xu, Zepeng Du, Bingli Wu, Tao Jin, Ke Xu, Liyan Xu, Enmin Li, Haixiong Xu

“…Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were applied for the enriched pathways. A protein-protein interaction (PPI) network was constructed to find the hub genes. …”
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A Novel Nonsense Mutation of POU4F3 Gene Causes Autosomal Dominant Hearing Loss by Chi Zhang, Mingming Wang, Yun Xiao, Fengguo Zhang, Yicui Zhou, Jianfeng Li, Qingyin Zheng, Xiaohui Bai, Haibo Wang

“…The mutation led to a stop codon and thus a truncated protein with no functional domains remained. Transient transfection and immunofluorescence assay revealed that the subcellular localization of the truncated protein differed markedly from normal protein, which could be the underlying reason for complete loss of its normal function. …”
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The functional insight into the genetics of cardiovascular disease: results from the post-GWAS study by L. O. Bryzgalov, E. E. Korbolina, I. S. Damarov, T. I. Merkulova

“…Functional pathway enrichment and protein– protein interaction (PPI) network analyses were performed on the targets and the extended genes by STRING and DAVID. …”
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PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice by Ying Sun, Zhanjun Jia, Gang Liu, Li Zhou, Mi Liu, Baoxue Yang, Tianxin Yang

“…Strikingly, urinary PGE2 was remarkably elevated in db/db mice paralleled with the increased protein expressions of COX-2 and mPGES-1. In contrast, the protein expressions of COX-1, mPGES-2, cPGES, and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) were not altered. …”
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Analysis and Evaluation of Quality Indicators and Volatile Compounds of Different Rice Cultivars with Geographical Indication by WANG Qin, ZHOU Changyan, ZHAO Xiaoyan, LI Xiaobei, LI Xujiao, JIANG Zhenghui, ZHANG Yanmei

“…The protein content had an extremely significantly negative correlation with the aldehyde content and a significantly positive correlation with the hydrocarbon content. …”
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Comparative Analysis of Proximate Compositions, Physical Properties, and Sensory Attributes of Kersting’s Groundnut (Macrotyloma geocarpum (Harms) Maréchal & Baudet) Accessions by Finagnon Toyi Kevin Fassinou, Eric Etchikinto Agoyi, Marius Affonfere, Edmond Sacla Aide, Achille Ephrem Assogbadjo, Flora Josiane Chadare

“…Overall, accession OUA had the highest protein, medium cooking time, and highest overall acceptability score (>70%), hence recommended for wide production. …”
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The interventional effect of Polygonatum cyrtonema Hua polysaccharide on atherosclerosis in mice of different sexes by Anjun Guo, Xueying Li, Lihua Pan, Qiangming Li, Jianping Luo, Xueqiang Zha

“…Nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPKs) and protein kinase B (Akt) are 3 pivotal signaling pathways mediating the development of atherosclerosis. …”
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Diagnostic Performance of Three ELISAs for Detection of Antibodies against SARS-CoV-2 in Human Samples by Cássio Meira, Dahara Silva, Ivanilson Santos, Breno Barreto, Vinícius Rocha, Emanuelle Santos, Bruna dos Reis, Afrânio Evangelista, Ricardo Ribeiro dos Santos, Bruna Machado, Guilherme Ribeiro, Roberto Badaró, Milena Soares

“…We found specificities of 0.98, 0.98, and 0.99 and sensitivities of 0.99, 0.91, and 0.87 for the nucleocapsid (N) protein, spike protein, and receptor binding domain (RBD) fraction, respectively. …”
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Diospyros kaki and Citrus unshiu Mixture Improves Disorders of Lipid Metabolism in Nonalcoholic Fatty Liver Disease by Mi-Rae Shin, Sung Ho Shin, Seong-Soo Roh

“…Compared with HFD control mice, PCM supplementation increased phosphorylation of AMP-activated protein kinase (AMPK). Peroxisome proliferator-activated receptor (PPAR) α was significantly increased by PCM administration. …”
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Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer by Taha Umair Wani, Hyun-Yi Kim, Geum-Hwa Lee, Young Je Lim, Han-Jung Chae, Ji-Ye Kim, Hyonok Yoon

“…This was further confirmed by the protein-protein interaction (PPI) analysis where we identified that the core ECM components e.g., collagen, fibronectin, metalloproteases and integrins possessed most interactions. …”
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Mechanistic insights into pachymic acid’s action on triple-negative breast Cancer through TOP2A targeting by Ming Liu, Li Zheng, Yang Zhang, Jinhui Tian

“…The STRING interaction network analysis tool was used to create Protein-Protein Interaction (PPI) networks. Enrichment analysis included Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). …”
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Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential by Tohada M. AL-Noshokaty, Rehab Abdelhamid, Nourhan M. Abdelmaksoud, Aya Khaled, Mariam Hossam, Razan Ahmed, Toka Saber, Shahd Khaled, Shereen Saeid Elshaer, Ahmed I. Abulsoud

“…The intricate molecular mechanisms underlying GLP-1RAs are explored, including their interactions with pathways like extracellular signal-regulated kinase 1/2 (ERK1/2), activated protein kinase (AMPK), cyclic adenine monophosphate (cAMP), mitogen-activated protein kinase (MAPK), and protein kinase C (PKC). …”
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Socio-economic inequality in the nutritional deficiencies among the world countries: evidence from global burden of disease study 2019 by Mohsen Bayati, Elham Arkia, Mehrnoosh Emadi

“…Also, the highest value of CI for prevalence was related to protein-energy malnutrition (-0.1403) and the lowest was related to vitamin A deficiency (-0.4308). …”
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Chemokines and Growth Factors Produced by Lymphocytes in the Incompetent Great Saphenous Vein by Ewa Grudzińska, Sławomir Grzegorczyn, Zenon P. Czuba

“…Eotaxin, interleukin 8 (IL-8), macrophage inflammatory protein 1 A and 1B (MIP-1A and MIP-1B), interferon gamma-induced protein (IP-10), monocyte chemoattractant protein-1 (MCP-1), interleukin 5 (IL-5), fibroblast growth factor (FGF), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), platelet-derived growth factor-BB (PDGF-BB), and vascular endothelial growth factor (VEGF) were assessed in culture supernatants by a Bio-Plex assay. …”
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Effects of Substituting Soybean Meal With Winged Bean on Growth, Physiological Function and Flesh Quality of Indian Butter Catfish (Ompok bimaculatus) by Jaya Angom, Soibam Khogen Singh, Ayam Gangarani Devi, Pronob Das, Pradyut Biswas, Gusheinzed Waikhom, Soibam Ngasotter, Reshmi Debbarma, Sourabh Debbarma, Nitesh Kumar Yadav

“…Soybean meal (SBM) remains a primary protein source in aquafeeds. This study investigated the potential of winged bean (Psophocarpus tetragonolobus) meal as a SBM replacement in diets for butter catfish (Ompok bimaculatus) juveniles (mean weight: 1.24 ± 0.23 g). …”
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Design and evaluation of bromelain-encapsulated alginate beads reinforced with gum Arabic: Formulation, characterization, and stability in simulated gastrointestinal conditions by Methavee Peanparkdee, Phornphimon Janchai, Tanwarat Aksornsri, Pilanee Vaithanomsat

“…Crude bromelain extract-loaded beads exhibited optimal protein release across pH 3–7 at 25 °C, with enhanced release following thermal treatment. …”
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Oxidative Stress, Lipid Peroxidation, and Loss of Hyaluronic Acid in the Human Vitreous Affected by Synchysis Scintillans by Loredana Bergandi, Oleksii A Skorokhod, Rosalba La Grotta, Evelin Schwarzer, Raffaele Nuzzi

“…The redox parameters thiobarbituric acid reactive substances (TBARS), a measurement of lipid peroxidation, nitrite concentration, an estimate of nitric oxide (NO) production, 4-hydroxynonenal (4-HNE)-protein conjugates, a structural protein modification by lipid peroxidation product 4-HNE, and the antioxidative activities of Cu,Zn-superoxide dismutase (SOD), and catalase were measured in aqueous and vitreous humors and compared between synchysis scintillans affected and not-affected patients. …”
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Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI3K/mTOR Signaling Pathway by Dandan Chai, Guoyu Wang, Ziyu Zhou, Hanyan Yang, Zhiwen Yu

“…To determine whether insulin affects SESN2 degradation, we assessed SESN2 turnover by applying the protein synthesis inhibitor, cycloheximide (CHX), and found that following insulin treatment SESN2 protein levels were reduced significantly slower than non-insulin-treated cells. …”
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Comparative analysis of acids and temperatures in gelatin extraction from the skin of yellowfin tuna (Thunnus albacares) by Vicky Prajaputra, Sri Agustina, Nadia Isnaini, Agillia Nabila, Hikma Kasih Margolang, Sahra Apriani, Siti Maqfirah

“…SDS-PAGE analysis revealed stronger protein bands for gelatin extracted with acetic acid, indicating higher protein content and a more efficient extraction process. …”
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An Investigation of the Anticancer Mechanism of <i>Caesalpinia sappan</i> L. Extract Against Colorectal Cancer by Integrating a Network Pharmacological Analysis and Experimental Va... by Mibae Jeong, Jaemoo Chun, Sang-Min Park, Heerim Yeo, Se Won Na, In Jin Ha, Bonglee Kim, Mi-Kyung Jeong

“…The network pharmacological approach identified 87 overlapping genes between CSE targets and CRC-related genes, with protein–protein interaction analysis highlighting 33 key target genes. …”
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