Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway by Haini Wang, Junli Zuo

“…The underlying mechanism involves targeting survivin, which subsequently regulates the protein expression of XIAP/caspase 3/9, CDK2/4, and cyclin E/D1. …”
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Adaptive response and enlargement of dynamic range by Tamar Friedlander, Naama Brenner

“…Many membrane channels and receptors exhibit adaptive, or desensitized,response to a strong sustained input stimulus, often supported by protein activity-dependent inactivation.Adaptive response is thought to be related to various cellular functionssuch as homeostasis and enlargement of dynamic range by background compensation.…”
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Kelainan Hemostasis pada Leukemia by Zelly Dia Rofinda

“…<br />Kelainan hemostasis yang dapat terjadi pada leukemia berupa trombositopenia, disfungsi trombosit,<br />koagulasi intravaskuler diseminata, defek protein koagulasi, fibrinolisis primer dan trombosis. …”
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Bioinformatics Interpretation of Exome Sequencing: Blood Cancer by Jiwoong Kim, Yun-Gyeong Lee, Namshin Kim

“…By comparing with previous somatic mutation profiles, we had concluded that the provided data originated from acute myeloid leukemia. Protein structure modeling showed that somatic mutations in IDH2, RASGEF1B, and MSH4 can affect protein structures.…”
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The Roles of UmuD in Regulating Mutagenesis by Jaylene N. Ollivierre, Jing Fang, Penny J. Beuning

“…This paper focuses on the multiple conformations of the UmuD gene products and how their protein interactions regulate mutagenesis.…”
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Sustained Activity of Metabotropic Glutamate Receptor: Homer, Arrestin, and Beyond by Geehoon Chung, Sang Jeong Kim

“…We propose that once in a state of sustained activation, the mGlu persistently activates downstream signaling pathways, including various adaptor proteins and kinases, such as β-arrestin and mitogen-activated protein kinases. …”
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Direct measurement of the critical cooling rate for the vitrification of water by Nathan J. Mowry, Constantin R. Krüger, Marcel Drabbels, Ulrich J. Lorenz

“…This result provides important insights into the question of how closely the conformational ensembles in plunge-frozen cryo samples reflect the structure of a protein at room temperature. Moreover, our experimental approach expands the toolkit of microsecond time-resolved cryo-EM, an emerging technique, in which a cryo sample is flash melted and revitrified with a laser pulse in order to enable time-resolved observations of protein dynamics.…”
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Stress, nutrients and genotype: understanding and managing asparagine accumulation in wheat grain by Joseph Oddy, Sarah Raffan, Mark D. Wilkinson, J. Stephen Elmore, Nigel G. Halford

“…Crop management strategies and practices are discussed in the context of managing asparagine accumulation, which must be balanced against other desirable goals, such as sustainability, protein content and yield.…”
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Gene Expression in Aphelid Zoospores Reveals Their Transcriptional and Translational Activity and Alacrity for Invasion by Igor R. Pozdnyakov, Alexei O. Seliuk, Kristina O. Barzasekova, Sergey A. Karpov

“…Among the highly expressed genes with known functions, the largest functional categories were “Cellular Metabolism”, “Protein Synthesis”, “Cell State Control”, and “Nucleic Acid Processing”. …”
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Differences of type of foods consumed by households in urban and rural West Java, Indonesia by Annisa Nurhidayati Vieta, Riyadi Hadi

“…Households in low and medium dietary diversity only consumed eggs as primary protein sources. Programs promoting diverse protein source consumption could help reduce the incidence of food insecurity and stunting, especially in rural settings.…”
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When Long Noncoding RNAs Meet Genome Editing in Pluripotent Stem Cells by Fuquan Chen, Jiaojiao Ji, Jian Shen, Xinyi Lu

“…Most of the human genome can be transcribed into RNAs, but only a minority of these regions produce protein-coding mRNAs whereas the remaining regions are transcribed into noncoding RNAs. …”
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Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing by Su Ee Tan, David Strutt

“…This promotes core protein turnover at cell-cell contacts parallel to the flow direction, possibly via dissociation of transmembrane complexes by shear forces. …”
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INTERMOLECULAR INTERACTIONS IN NEURONAL FUNCTIONAL SYSTEMS by A. L. Proskura, I. A. Malachin, T. A. Zapara, I. I. Turnaev, V. V. Suslov, A. S. Ratuschnyak

“…Dendritic spines are the postsynaptic part of excitatory synapses in higher divisions of mammalian brains. Protein–protein networks of spine microdomains form the functional system of neuronal synapses. …”
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A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125 by George Karagkounis, Theodore Argyrakos, G. Charkiolakis, O. Castana, D. Rontogianni

“…Neoplastic cells have both spindle and epithelioid appearance and are characterized by the loss of the nuclear protein SMARCB1/INI1. We present the case of a distal epithelioid sarcoma arising in the thumb of a 14-year-old girl, which immunohistochemically was characterized by the loss of SMARCB1/INI1 protein as well as the expression of podoplanin (D2-40), TLE1, Glut1, and Ca 125; plus, we highlight the differential diagnosis of epithelioid sarcoma from its histological mimics.…”
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Molecular profiling and detection methods of microRNA in cancer research by Nurul-Syakima Ab Mutalib, Imilia Ismail, Hooi-Leng Ser

“… A large portion of human genome was believed to be “useless” and termed as “junk DNA” in the past, given that these sequences did not have any protein coding role. However, with more researchers dwelling into the world of these mysterious genetic codes, a group of non-protein coding RNA (ncRNA) known as microRNAs (miRNAs) is now being recognized to play important roles than they were thought to be. …”
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Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity by T. N. Sharapova, E. A. Romanova, L. P. Sashchenko, D. V. Yashin

“…We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. …”
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Cardiac Expression of Tnnt1 Requires the GATA4-FOG2 Transcription Complex by Nikolay L. Manuylov, Sergei G. Tevosian

“…Previous work by us and others has shown that the loss of interaction between GATA4 and FOG2 protein partners is embryonic lethal due to heart failure at embryonic day (E) 13.5; however, the role of this important protein duo in various cardiac compartments (e.g., myocardial, endocardial, or epicardial cells) remains to be understood. …”
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The Discovery of Novel Experimental Therapies for Inflammatory Arthritis by Charles J. Malemud

“…Over the past few years, sphingosine-1-phosphate, interleukin-7 receptor, spleen tyrosine kinase, extracellular signal-regulated kinase, mitogen-activated protein kinase 5/p38 kinase regulated/activated protein kinase, micro-RNAs, tumor necrosis factor-related apoptosis inducing ligand and the polyubiquitin-proteasome pathway were identified as promising novel targets for potential antiarthritis drug development. …”
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HER-2/neu Amplification Testing in Breast Cancer by Multiplex Ligation-Dependent Probe Amplification in Comparison with Immunohistochemistry and In Situ Hybridization by Cathy B. Moelans, Roel A. de Weger, Marja T.M. van Blokland, Chantal Ezendam, Sabrina Elshof, Marcel G. J. Tilanus, Paul J. van Diest

“…Next to immunohistochemistry (IHC) to evaluate protein overexpression, a second line gene amplification test is required for cases with equivocal protein expression. …”
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Selecting Negative Samples for PPI Prediction Using Hierarchical Clustering Methodology by J. M. Urquiza, I. Rojas, H. Pomares, J. Herrera, J. P. Florido, O. Valenzuela

“…Protein-protein interactions (PPIs) play a crucial role in cellular processes. …”
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