The Genetics of PTPN1 and Obesity: Insights from Mouse Models of Tissue-Specific PTP1B Deficiency by Ryan C. Tsou, Kendra K. Bence

“…The protein tyrosine phosphatase PTP1B is a negative regulator of both insulin and leptin signaling and is involved in the control of glucose homeostasis and energy expenditure. …”
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The Role of Inflammation in the Pathogenesis of Osteoarthritis by Yoke Yue Chow, Kok-Yong Chin

“…This stimulates the release of early-stage inflammatory cytokines like interleukin-1 beta (IL-1β), which in turn induces the activation of signaling pathways, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), and mitogen-activated protein kinase (MAPK). …”
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Thrombospondin-1: Multiple Paths to Inflammation by Zenaida Lopez-Dee, Kenneth Pidcock, Linda S. Gutierrez

“…Thrombospondin-1 (TSP-1) is a matricellular protein involved in angiogenesis, cancer, and inflammation. …”
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Physical Aspects of Viral Membrane Fusion by Laura Wessels, Keith Weninger

“…Large conformational changes in the proteins embedded in the viral membrane play a fundamental role in the membrane fusion process. …”
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Seizure-Induced Hemoptysis in a Pediatric Patient by Ritika Nangia, Margaret Kahwaty, Ashutosh Sachdeva, Nidhi Kotwal

“…This remains a rare clinical entity in pediatrics and we report one such case and its association with sterol carrier protein (SCP) gene mutation. We present a case of a 16-year-old male with recurrent episodes of hemoptysis following seizures. …”
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Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma by Zihao Deng, Lixia Liu, Guantai Xie, Zhenming Zheng, Jieyou Li, Wenchong Tan, Yaotang Deng, Jinxin Zhang, Manfeng Liang, Yingxia Wu, Zhifeng Zhou, Yan Li, Yukui Chen, Yaling Huang, Hairou Su, Guibing Wu, Xiongjie Shi, Shengpei Cen, Yandan Liao, Yilin Liu, Fei Zou, Xuemei Chen

“…Excessive lipid accumulation promotes the occurrence and progression of hepatocellular carcinoma (HCC), accompanied by high levels of fatty acid synthetase (FASN) and more active lipogenesis. Heat shock protein 90 (Hsp90) acts as a chaperone to maintain the stability and activity of the client proteins. …”
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甲基转移酶3对人脑血管平滑肌细胞基因表达及增殖和迁移功能的影响 Effects of Methyltransferase 3 on Gene Expression, Proliferation, and Migration Functions of Human Brain Vascular Smooth Muscle Cells... by 孟晨曦1，孙洪英2，张佳2，毛戬2，杨阳3，策乐木格3 (MENG Chenxi1, SUN Hongying2, ZHANG Jia2, MAO Jian2, YANG Yang3, Celemuge3 )

“…使用逆转录实时定量PCR（real-time reverse transcriptional PCR，RT-qPCR）检测各组细胞脑小血管病相关基因锌指蛋白395（zinc finger protein 395，ZNF395）、锌指蛋白548（zinc finger protein 548，ZNF548）、DIS3样外泌体3’-5’核糖核酸外切酶（DIS3-like exosome 3’-5’exonuclease，DIS3L）、白细胞介素增强子结合因子3（interleukin enhancer binding factor 3，ILF3）和G蛋白偶联受体107（G protein-coupled receptor 107，GPR107）的mRNA表达水平，通过RNA甲基化免疫共沉淀（methylated RNA immunoprecipitation，MeRIP）技术检测以上基因mRNA的N6-甲基腺苷（N6-methyladenosine，m6A）修饰水平，利用细胞计数试剂盒8（cell counting kit 8，CCK8）、Transwell小室实验检测各组HBVSMC的增殖和迁移能力。 …”
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油脂对植物基冰淇淋乳液性质及产品品质的影响 "Effect of vegetable oil on the properties of plant-based ice cream emulsion and the quality of products" by 张贵金1，范军营2，尹永智2，逯彩云2，张晖1， 王兴国1，吴港城1 ZHANG Guijin1, FAN Junying2, YIN Yongzhi2, LU Caiyun2, ZHANG Hui1, WANG Xingguo1, WU Gangcheng1"

“…The ice cream emulsion prepared with hydrogenated coconut oil and modified soy protein isolate had the lowest interfacial protein content, at 10.48 mg/m2, the highest degree of fat partial aggregation, at 68.89%, and the expansion rate, melting rate and melting lag time of the ice cream were 66.15%, 7.12%, and 212 s, respectively. …”
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iDIA-QC: AI-empowered data-independent acquisition mass spectrometry-based quality control by Huanhuan Gao, Yi Zhu, Dongxue Wang, Zongxiang Nie, He Wang, Guibin Wang, Shuang Liang, Yuting Xie, Yingying Sun, Wenhao Jiang, Zhen Dong, Liqin Qian, Xufei Wang, Mengdi Liang, Min Chen, Houqi Fang, Qiufang Zeng, Jiao Tian, Zeyu Sun, Juan Xue, Shan Li, Chen Chen, Xiang Liu, Xiaolei Lyu, Zhenchang Guo, Yingzi Qi, Ruoyu Wu, Xiaoxian Du, Tingde Tong, Fengchun Kong, Liming Han, Minghui Wang, Yang Zhao, Xinhua Dai, Fuchu He, Tiannan Guo

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Proteomics profiling of inflammatory responses to elexacaftor/tezacaftor/ivacaftor in cystic fibrosis by Hazel Ozuna, Hazel Ozuna, Dinesh Bojja, Santiago Partida-Sanchez, Luanne Hall-Stoodley, Amal Amer, Rodney D. Britt, Rodney D. Britt, Shahid Sheikh, David A. Frank, Weiyuan Wang, Bum-Yong Kang, Bum-Yong Kang, Irina Miralda, Irina Miralda, Samantha L. Durfey, Samantha L. Durfey, Benjamin T. Kopp, Benjamin T. Kopp

“…Protein screening was performed with an inflammation panel (Target 96, Olink®). …”
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Palmitic Acid Methyl Ester Induces G2/M Arrest in Human Bone Marrow-Derived Mesenchymal Stem Cells via the p53/p21 Pathway by Jian-Hong Lin, Pei-Ching Ting, Wen-Sen Lee, Hung-Wen Chiu, Chun-An Chien, Chin-Hung Liu, Li-Yi Sun, Kun-Ta Yang

“…Moreover, the level of Mdm2 protein decreased, while the levels of p21 and p53 protein increased in the PAME-treated hBM-MSCs. …”
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms by Manish Kumar, Abhishek Singh Sengar, Anushree Lye, Pranesh Kumar, Sukhes Mukherjee, Dinesh Kumar, Priyadip Das, Suvro Chatterjee, Adele Stewart, Biswanath Maity

“…Here, we demonstrate that fibronectin type III domain-containing protein 5 (FNDC5), the precursor protein for myokine irisin, is depleted in the hearts of human cancer patients or mice exposed to chemotherapeutics. …”
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Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes by Jin Lin, Ye Yu, Xuanwei Wang, Yini Ke, Chuanyin Sun, Lihuan Yue, Guanhua Xu, Bei Xu, Liqin Xu, Heng Cao, Danyi Xu, Nancy Olsen, Weiqian Chen

“…MMP-1, MMP-3, MMP-9, Interleukin-6 (IL-6), and monocyte chemoattractant protein-1 mRNA and protein levels were all decreased after treatment with iguratimod. …”
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Bioinformatics combining machine learning and single-cell sequencing analysis to identify common mechanisms and biomarkers of rheumatoid arthritis and ischemic heart failure by Ziyi Sun, Jianguo Lin, Xiaoning Sun, Zhangjun Yun, Xiaoxiao Zhang, Siyu Xu, Jinlong Duan, Kuiwu Yao

“…One hundred and seventy-seven common differentially expressed genes (CDEGs) were identified, with enrichment analysis highlighting pathways related to sarcomere organization, ventricular myocardial tissue morphogenesis, chondrocyte differentiation, prolactin signaling, hematopoietic cell lineage, and protein methyltransferases. Five hub genes (CD2, CD3D, CCL5, IL7R, and SPATA18) were identified through protein-protein interaction (PPI) network analysis and machine learning. …”
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MBD2 Regulates Th17 Cell Differentiation and Experimental Severe Asthma by Affecting IRF4 Expression by Aijun Jia, Yueling Wang, Wenjin Sun, Bing Xiao, Yan Wei, Lulu Qiu, Lin Mu, Li Xu, Jianmin Li, Xiufeng Zhang, Da Liu, Cong Peng, Dongshan Zhang, Xudong Xiang

“…Methyl-CpG binding domain protein 2 (MBD2) expression increased in CD4+ T cells in peripheral blood samples of asthma patients. …”
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Comparison of sialic acid content in bovine and buffalo milk and meat by Michela Contò, Simona Rinaldi, Sebastiana Failla

“…Neu5Ac content was significantly higher in buffalo milk than in cow milk (1045 vs. 906 μg/g protein). In contrast, Neu5Gc content was significantly lower in buffalo milk than in cow milk (58 vs. 106 μg/g protein). …”
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Beetroot (Beta vulgaris L.) Extract Ameliorates Gentamicin-Induced Nephrotoxicity Associated Oxidative Stress, Inflammation, and Apoptosis in Rodent Model by Ali A. El Gamal, Mansour S. AlSaid, Mohammad Raish, Mohammed Al-Sohaibani, Shaza M. Al-Massarani, Ajaz Ahmad, Mohamed Hefnawy, Mohammed Al-Yahya, Omer A. Basoudan, Syed Rafatullah

“…In addition, BVEE treatment significantly reduced the amount of cleaved caspase 3 and Bax, protein expression and increased the Bcl-2 protein expression. …”
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Survival and growth responses of snakehead fish Channa striata Bloch. juvenile in aerated and unaerated acid sulfate water by , Purnamawati, Daniel Djokosetiyanto, Kukuh Nirmala, Enang Harris Surawidjaja, Ridwan Affandi

“…The fishes were fed with commercial feed with protein content about 40%, feeding two times a day (morning and afternoon) were at satiation. …”
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Foxtail millet supplementation improves glucose metabolism and gut microbiota in rats with high-fat diet/streptozotocin-induced diabetes by Xin Ren, Linxuan Wang, Zenglong Chen, Min Zhang, Dianzhi Hou, Yong Xue, Xianmin Diao, Ruihai Liu, Qun Shen

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Glycogen and proximate content of white shrimp fed on different carbohydrate level and feeding frequency by , Zainuddin, , Haryati, Siti Aslamyah

“…One problem that commonly faced by pond farmer is the high price of feed with high protein content. This research was to identify the optimal level of carbohydrate and feeding frequency on glycogen deposit and chemical composition of white shrimp juvenile. …”
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