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3161
Non-histone lactylation: unveiling its functional significance
Published 2025-01-01“…Lactylation, a newly discovered protein posttranslational modification (PTM) in 2019, primarily occurs on lysine residues. …”
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3162
Practical techniques in molecular biotechnology /
Published 2021Table of Contents: “…Recombinant DNA and protein technology -- Enzyme kinetics, proteomics and mass spectrometry -- Bioanalytical techniques -- Molecular biology -- Cell culture -- Antibody technology.…”
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3163
Tissue Factor Structure and Function
Published 2012-01-01“…Tissue factor (TF) is an integral membrane protein that is essential to life. It is a component of the factor VIIa-TF complex enzyme and plays a primary role in both normal hemostasis and thrombosis. …”
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3164
Systemic and Local CC Chemokines Production in a Murine Model of <emph>Listeria monocytogenes</emph> Infection
Published 2006-01-01“…The liver-to-serum ratio was more pronounced in the case of macrophage inflammatory protein 1<mml:math> <mml:mi>α</mml:mi> </mml:math> (MIP-1<mml:math> <mml:mi>α</mml:mi> </mml:math> ), suggesting its role in the inflammatory response in the liver. …”
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3165
Palmitoylation as a Functional Regulator of Neurotransmitter Receptors
Published 2018-01-01“…The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions. …”
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3166
Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism: The Positive Side of Proteolysis in Alzheimer's Disease
Published 2011-01-01“…A𝛽-peptides are produced by aspartyl proteinase-mediated cleavage of the larger amyloid precursor protein (APP). In contrast to this detrimental “amyloidogenic” form of proteolysis, a range of zinc metalloproteinases can process APP via an alternative “nonamyloidogenic” pathway in which the protein is cleaved within its A𝛽 region thereby precluding the formation of intact A𝛽-peptides. …”
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3167
Prediction of Deleterious Nonsynonymous Single-Nucleotide Polymorphism for Human Diseases
Published 2013-01-01“…As a typical type of genetic variation, nonsynonymous single-nucleotide polymorphisms (nsSNPs) occurring in protein coding regions may alter the encoded amino acid, potentially affect protein structure and function, and further result in human inherited diseases. …”
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3168
approach to calculate the transcript capacity
Published 2019-09-01“…TC refers to the capacity that a transcript exerts in a cell as enzyme or protein function after translation. We used the genome-wide association study (GWAS) beta effect and transcription level in RNA-sequencing to estimate TC. …”
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3169
Potential of Peptides as Inhibitors and Mimotopes: Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries
Published 2012-01-01“…Inhibitors of carbohydrate-protein interactions are potential antiviral drugs. …”
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3170
Alpha II Antiplasmin Deficiency Complicating Pregnancy: A Case Report
Published 2011-01-01“…Alpha II antiplasmin is a protein involved in the inhibition of fibrinolysis. …”
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3171
Nonsecretory Multiple Myeloma and AL Amyloidosis Presenting with Nephrotic Range Proteinuria
Published 2015-01-01“…Nonsecretory multiple myeloma (NSMM) is the absence of a detectable monoclonal protein in serum and urine of a multiple myeloma (MM) patient and immunoglobulin light chain (AL) amyloidosis is a significantly rare complication. …”
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3172
Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?
Published 2016-01-01“…Hsp60 is a mitochondrial stress protein that is induced by mitochondrial impairment. …”
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3173
The Redox System in C. elegans, a Phylogenetic Approach
Published 2012-01-01“…The nematode species Caenorhabditis elegans provides an excellent model for the study of oxidative stress and redox signalling in animals. We use protein sequences from central redox systems in Homo sapiens, Drosophila melanogaster, and Saccharomyces cerevisiae to query Genbank for homologous proteins in C. elegans. …”
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3174
Mechanisms of oxidative stress-induced sperm dysfunction
Published 2025-02-01“…ROS-induced DNA fragmentation compromises genetic integrity, potentially leading to infertility and adverse offspring outcomes. Protein oxidation alters key structural proteins, impairing sperm motility and the ability to fertilize an egg. …”
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3175
An investigation of the formulation and nutritional composition of modern meat analogue products
Published 2019-12-01“…Keywords: Plant-based meat, Simulated meat, Meat alternatives, Processed foods, Protein foods…”
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3176
Psychrophilic Enzymes: From Folding to Function and Biotechnology
Published 2013-01-01“…Genome sequences, proteomic, and transcriptomic studies suggest various adaptive features to maintain adequate translation and proper protein folding under cold conditions. Most psychrophilic enzymes optimize a high activity at low temperature at the expense of substrate affinity, therefore reducing the free energy barrier of the transition state. …”
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3177
Protocol for in vivo chromatin immunoprecipitation on purified chromatin isolated from mouse liver nuclei
Published 2025-03-01“…We present a protocol to isolate fixed DNA-protein complexes from mouse liver prior to chromatin shearing. …”
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3178
Acute Liver Injury with Severe Coagulopathy in Marasmus Caused by a Somatic Delusional Disorder
Published 2011-01-01“…Marasmus is a severe form of protein-calorie malnutrition characterized by the depletion of fat stores, muscle wasting, and the lack of edema. …”
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3179
AI, big data, and robots for the evolution of biotechnology
Published 2019-11-01“…Additionally, AlphaFold, a technology resembling the AI AlphaGo for the game Go, has surpassed the limit on protein folding predictions—the most challenging problems in the field of protein biology. …”
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3180
Solid-Phase Extraction Strategies to Surmount Body Fluid Sample Complexity in High-Throughput Mass Spectrometry-Based Proteomics
Published 2015-01-01“…Obtained peptide and protein fractions can be mass analyzed by direct infusion into an electrospray ionization (ESI) source or by means of matrix-assisted laser desorption ionization (MALDI) without further need of time-consuming liquid chromatography (LC) separations.…”
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