PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury by Juhyun Song, So Yeong Cheon, Won Taek Lee, Kyung Ah Park, Jong Eun Lee

“…The cyclic AMP-dependent protein kinase (PKA), which activates prosurvival signaling proteins, has been implicated in the expression of long-term potentiation and hippocampal long-term memory. …”
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Selection of DNA Aptamers for Ovarian Cancer Biomarker CA125 Using One-Pot SELEX and High-Throughput Sequencing by Delia J. Scoville, Tae Kyu Brian Uhm, Jamie A. Shallcross, Rebecca J. Whelan

“…Accurate detection of this large, complex protein in patient samples is of great clinical relevance. …”
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lncRNA HOTTIP Recruits EZH2 to Inhibit PTEN Expression and Participates in IM Resistance in Chronic Myeloid Leukemia by Jing Liu, Lin Yang, Xiaojun Liu, Lu Liu, Menghan Liu, Xuefeng Feng, Jianmin Luo

“…Mechanistically, highly expressed HOTTIP is involved in the biological process of IM resistance by recruiting Zeste homologous protein 2 enhancer (EZH2) to inhibit the expression of phosphatase and Tensin homologous protein (PTEN) genes. …”
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Proteotranscriptomic Profiling of the Toxic Mucus of <i>Kulikovia alborostrata</i> (Pilidiophora, Nemertea) by Vasiliy G. Kuznetsov, Daria I. Melnikova, Sergey V. Shabelnikov, Timur Yu. Magarlamov

“…Overall, this supports the idea that the mucus of nemerteans is a valuable source of peptide and protein toxins.…”
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An In Silico Study of the Interactions of Alkaloids from Cryptolepis sanguinolenta with Plasmodium falciparum Dihydrofolate Reductase and Dihydroorotate Dehydrogenase by Lois Kwane Kyei, Edward Ntim Gasu, Gilbert Boadu Ampomah, Jehoshaphat Oppong Mensah, Lawrence Sheringham Borquaye

“…Also, our results show that alkaloids of the pg class can inhibit PfDHODH as FMN decoys, as well as direct enzyme inhibitors, thereby halting crucial protein function.…”
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Lipoprotein Nanoplatform for Targeted Delivery of Diagnostic and Therapeutic Agents by Jerry D. Glickson, Sissel Lund-Katz, Rong Zhou, Hoon Choi, I-Wei Chen, Hui Li, Ian Corbin, Anatoliy V. Popov, Weiguo Cao, Liping Song, Chenze Qi, Diane Marotta, David S. Nelson, Juan Chen, Britton Chance, Gang Zheng

“…Loading of contrast or therapeutic agents onto or into these particles has been achieved by protein loading (covalent attachment to protein side chains), surface loading (intercalation into the phospholipid monolayer), and core loading (extraction and reconstitution of the triglyceride/cholesterol ester core). …”
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Analysis of Puerarin and Chemical Compositions Changes in Kudzu Root during Growth Period by Yiguo Zhao, Mei Xu, Zhinneg You, Dongsheng Li, Mingquan Zhou, Yupeng Zhu, Chao Wang

“…The trend of protein content coincided with the total content of free amino acids, in contrast to lipid. …”
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Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution by Xiaohui Tong, Nianjun Yu, Rongchun Han, Tongsheng Wang

“…Therefore, much interest has been paid to the research of this protein as well as its products like microRNAs (miRNAs). …”
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Sialidase NEU3 dynamically associates to different membrane domains specifically modifying their ganglioside pattern and triggering Akt phosphorylation. by Dario Bonardi, Nadia Papini, Mario Pasini, Loredana Dileo, Flavia Orizio, Eugenio Monti, Luigi Caimi, Bruno Venerando, Roberto Bresciani

“…The local enrichment in sphingolipids and cholesterol together with the low protein content allows their separation by density gradient flotation after extraction with non-ionic detergent at low temperature. …”
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Plasma macrophage colony-stimulating factor levels during cardiopulmonary bypass with extracorporeal circulation by Y. Denizot, P. Fixe, E. Cornu, N. Nathan

“…Plasma M-CSF concentrations were stable during ECC and increased at the 6th (7.3 ± 0.7 IU/μg protein) and 24th (8.6 ± 0.8 IU/μg protein) postoperative hour compared with pre-ECC values (4.9 ± 0.5 IU/μg protein). …”
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A Unique Trinucleotide-Bloc Mutation-Based Two SARS-CoV-2 Genotypes with Potential Pathogenic Impacts by Mustak Ibn Ayub

“…Potential drug and vaccine development should also keep the 28881–28883 region of the N protein under consideration.…”
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Regulation of modular Cyclin and CDK feedback loops by an E2F transcriptionoscillator in the mammalian cell cycle by Orit Lavi, Doron Ginsberg, Yoram Louzoun

“…The modular description of the cell cycle resolves the gap between cyclic models, solely based on protein-protein reactions and transcription reactions based models. …”
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Proinflammatory Cytokines Increase Vascular Endothelial Growth Factor Expression in Alveolar Epithelial Cells by James P. Maloney, Li Gao

“…A mix of IL-1, IL-6, and IL-8 had effects similar to IL-1. TNF-α increased protein expression as early as 4 hours and had a sustained effect at 16 hours, whereas IL-1 did not increase protein expression. …”
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Agronomic performance, biomass production, and nutrient value of three napier grass cultivars (Pennisetum purpureum) in highland area by Sidik Prasojo Yogi, Pastawan Viagian, Prasetyo Bayu, Kamal Mustafa, Khoirul Anwar Muhammad, Adi Prastyo Riski, Iqbal Faruqi Muhammad, Ishigaki Genki

“…Napier grass was harvested to investigate the biomass production and nutrient values, including organic matter, crude protein, crude protein yield, crude fibre, and crude fat. …”
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Endoplasmic Reticulum Stress: Its Role in Disease and Novel Prospects for Therapy by Axel H. Schönthal

“…The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis, calcium storage, and protein folding and processing. A number of physiological and pathological conditions, as well as a variety of pharmacological agents, are able to disturb proper ER function and thereby cause ER stress, which severely impairs protein folding and therefore poses the risk of proteotoxicity. …”
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Plant Polyphenols and Oxidative Metabolites of the Herbal Alkenylbenzene Methyleugenol Suppress Histone Deacetylase Activity in Human Colon Carcinoma Cells by Isabel Anna Maria Groh, Chen Chen, Claudia Lüske, Alexander Thomas Cartus, Melanie Esselen

“…Concomitantly, a significant decrease of the HDAC1 protein level was observed after incubation with EGCG and GEN, whereas the investigated ME metabolites did not affect HDAC1 protein status. …”
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Synthesis and Experimental Validation of New PDI Inhibitors with Antiproliferative Activity by Mariateresa Badolato, Gabriele Carullo, Francesca Aiello, Antonio Garofalo

“…Protein disulfide isomerase (PDI) is a member of the thioredoxin superfamily of redox enzymes. …”
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Downregulation of DJ-1 Fails to Protect Mitochondrial Complex I Subunit NDUFS3 in the Testes and Contributes to the Asthenozoospermia by Yupeng Wang, Yi Sun, Xin Zhao, Renpei Yuan, Hui Jiang, Xiaoping Pu

“…In this study, we found that compared to the patients without AS, the expression of mitochondrial protein nicotinamide adenine dinucleotide dehydrogenase (ubiquinone) Fe-S protein 3 (NDUFS3) was also significantly decreased in the sperm of patients with AS. …”
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The Mechanism of Scopolamine’s Effect on Migration Function of Lung Cancer Cells: A Network Pharmacology and Bioinformatics Perspective by Yang Xiao, Mengcong Ma, Qing Gu, Yunfeng Xiao

“…The analysis involved protein-protein interaction (PPI) networks topology analysis to identify these genes, and subsequent differential analysis and survival analysis were conducted using gene expression profile interaction analysis (GEPIA). …”
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The Immunotherapeutic Effect of SIRPα-Silenced DCs against Cervical Cancer by Xiaojie Li, Wenying Zhou, Yanlan Liang, Changzhi Xu, Zhizhi Xie, Jiayin Liang, Bo Hu

“…Signal regulatory protein α (SIRPα), a transmembrane protein that is predominantly expressed in dendritic cells (DCs) or macrophages, interacts with CD47 that is overexpressed in almost all types of tumor cells. …”
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