Insights into the binding selectivity of harzianoic acids A and B to tetraspanin CD81 by Gérard Vergoten, Christian Bailly

“…Methods: The interaction of Hz-A/B with CD81 has been modeled, using structures of the cholesterol-bound full-length protein and a truncated protein corresponding to the LEL portion. …”
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Expression of MxA in esophageal cancer cell lines can influence sensitivity to chemotherapeutic agents but this does not require apoptosis by R. M. Hayes, T. R. O'Donovan, S. L. McKenna

“…Expression of an anti‐viral protein, myxovirus resistance protein A (MxA) is de‐regulated in many cancers, including esophageal cancer, and its activity has been linked to apoptosis. …”
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The Nutritional Composition of Maca in Hypocotyls (Lepidium meyenii Walp.) Cultivated in Different Regions of China by Longfei Chen, Jieying Li, Liuping Fan

“…Cultivation region significantly affects the compositions of maca. The protein content of maca ranged from 9.31% to 21.02% by dry basis of maca powders and Xiaopingba-Y, Yulong-Y, and Pamirs-Y have the higher protein contents. …”
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Extracellular Cardiolipin Modulates Select Immune Functions of Astrocytes in Toll-Like Receptor (TLR) 4-Dependent Manner by Taryn E. Murray, Tyler J. Wenzel, Svetlana Simtchouk, Bridget K. Greuel, Julien Gibon, Andis Klegeris

“…We demonstrate that CL upregulates MCP-1 secretion in the absence of its natural carrier protein, β2-glycoprotein 1, indicating that CL may be bioactive in the brain where this protein is not present. …”
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Natural antifibrosis potential of anthocyanin in Ipomoea batatas against Transforming Growth Factor beta Type II receptor by in silico ADMET and molecular docking study by Evi Lusiana, Ernawati Sinaga, Zen Hafy, Debby Handayati Harahap, Ramzi Amin, Irsan Saleh

“…Proteins and ligands were docked utilizing the PyRx 0.8 and visualized by Discovery Studio 4.1 software. …”
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Differences in utilisation of digestible macronutrients between two different size classes of rainbow trout (Oncorhynchus mykiss) by Ruben Groot, Philip Lyons, Johan W. Schrama

“…The aim of this study was to investigate whether fish size has an effect on the utilisation efficiency of digestible protein, digestible fat and digestible carbohydrates (Carb) for energy gain in rainbow trout. …”
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Identifying Key Biomarkers Related to Immune Response in the Progression of Diabetic Kidney Disease: Mendelian Randomization Combined With Comprehensive Transcriptomics and Single-... by Hu M, Deng Y, Bai Y, Zhang J, Shen X, Shen L, Zhou L

“…This study aimed to identify the critical genes involved in the onset and progression of DKD and to explore potential therapeutic targets of DKD.Methods: We conducted a batch of protein quantitative trait loci (pQTL) Mendelian randomization analysis to obtain a group of proteins with causal relationships with DKD and then identified key proteins through colocalization analysis to determine correlations between variant proteins and disease outcomes. …”
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Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights by Akhil Hegde, Yung-Hua Koh, Shabbir M. Moochhala, Madhav Bhatia

“…We conclude that substance P acting via neurokinin-1 receptor in sepsis initiated signaling cascade mediated mainly by protein kinase C-α, led to NF-κB and activator protein-1 activation, and further modulated proinflammatory mediators.…”
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Rapid Screening and Estimation of Binding Constants for Interactions of Fe3+ with Two Metalloproteins, Apotransferrin and Transferrin, Using Affinity Mode of Capillary Electrophore... by Mohammed Al Bratty, Hassan A. Alhazmi, Sadique A. Javed, Zia Ur Rehman, Asim Najmi, Karam A. El-Sharkawy

“…The binding results were calculated from the mobility ratios of protein (Ri) and EOF marker (Rf) using the formula (Ri − Rf)/Rf or ∆R/Rf. …”
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Determining the Potential Roles of Branched-Chain Amino Acids in the Regulation of Muscle Growth in Common Carp (Cyprinus carpio) Based on Transcriptome and MicroRNA Sequencing by Xianglin Cao, Han Cui, Xinyu Ji, Baohua Li, Ronghua Lu, Yuru Zhang, Jianjun Chen

“…Our findings revealed the role of atg5, map1lc3c, ctsl, cdc53, psma6, psme2, myl9, and mylk in skeletal muscle growth, protein synthesis, and catabolic metabolism. Furthermore, miR-135c, miR-192, miR-194, and miR-203a may play key roles in maintaining the normal activities of the organism by regulating genes related to muscle growth, protein synthesis, and catabolism. …”
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Network analyses of brain tumor multiomic data reveal pharmacological opportunities to alter cell state transitions by Brandon Bumbaca, Jonah R. Huggins, Marc R. Birtwistle, James M. Gallo

“…By incorporating phosphoproteomic measurements from the same patients, a protein–protein interaction network (PPIN) was constructed for each cell state. …”
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Distinct patterns of prion strain deposition and toxicity in a novel whole brain organotypic slice culture system by Hailey Pineau, Valerie L. Sim

“…Abstract Prion diseases are fatal transmissible neurodegenerative diseases that affect many mammals, including humans, caused by the templated misfolding of the prion protein. Different conformations of misfolded prions can occur, leading to distinct disease phenotypes or strains and the accumulation of prions in distinct brain regions. …”
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The Neurometabolic Function of the Dopamine–Aminotransferase System by Sergey A. Apryatin

“…Another important part of energy metabolism is the dopamine-mediated regulation of protein metabolism. Methods: The review describes research results into the dopamine-mediated mechanism of metabolic regulation in humans and animals. …”
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Bulk and Surface Chemical Composition of Wheat Flour Particles of Different Sizes by Jiangtao Lin, Yujuan Gu, Ke Bian

“…Results from scanning electron microscopy and bulk chemical composition analyze showed that flour particles of different sizes differed in microstructure, protein, and starch composition. Further analysis of protein fractions with varying solubility implied that the relative smaller flour particles (diameter <48 μm) had higher gluten protein (gliadin and glutenin) ratio (60.88–64.06%). …”
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Analysis of QTLs Associated with the Rice Quality Related Gene by Double Haploid Populations by Gyu-Ho Lee, Byung-Wook Yun, Kyung-Min Kim

“…The QTLs related to amylose content were 4 QTLs, protein content was 2 QTLs, and lipid content was 2 QTLs. …”
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Glycerol Carbonate: A Novel Biosolvent with Strong Ionizing and Dissociating Powers by Guangnan Ou, Biyan He, Xuejing Li, Jianhui Lei

“…Due to the weak ionizing and dissociating powers of common organic solvents, the charge of the protein will change significantly when the protein is transferred from water to common organic solvents, resulting in protein denaturation. …”
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Genetic polymorphism of hepatitis C virus and risk of hepatocellular carcinoma by S. N. Mammayev, A. M. Karimova

“…Frequency of mutant forms of 1b genotype is related to discovery of previously unknown protein of HCV — minicor-protein with absence of N-terminal of classical Cor-protein p21.Conclusion. …”
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Signal integrator function of CXXC5 in Cancer by Zihao An, Jiepu Wang, Chengzuo Li, Chao Tang

“…Abstract CXXC type zinc finger protein 5 (CXXC5) is a member of the ZF-CXXC family and plays a pivotal role in signal integration and information transfer within cell signaling network. …”
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A Novel and Robust Method for Investigating Fungal Biofilm by Biswambhar Biswas, Shumaiza Asif, Rekha Puria, Anil Thakur

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From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases by Isabelle Acquatella-Tran Van Ba, Thibaut Imberdis, Véronique Perrier

“…In this review, we will come back to the original works that led to the discovery of prions and to the protein-only hypothesis proposed by Dr. Prusiner. …”
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