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2701
Studies of the Kinetic Characteristics of HSA Adsorption by Different Types of Activated Carbon Fibres
Published 2000-06-01“…This phenomenon may be explained, on the one hand, by the energetic heterogeneity of the protein–surface interaction and, on the other hand, by the possibility of alterations in the conformations of the protein molecules at the interface. …”
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2702
Technologies for Proteome-Wide Discovery of Extracellular Host-Pathogen Interactions
Published 2017-01-01“…Pathogens have evolved unique mechanisms to breach the cell surface barrier and manipulate the host immune response to establish a productive infection. Proteins exposed to the extracellular environment, both cell surface-expressed receptors and secreted proteins, are essential targets for initial invasion and play key roles in pathogen recognition and subsequent immunoregulatory processes. …”
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2703
Tetrahydroxy Cyclic Urea-Potent Inhibitor for HIV-1 Protease Wild Type and Mutant Type—A Computational Design
Published 2008-01-01“…The designed molecules were compared with the known cyclic urea molecules by performing docking studies on six of wild type protein and three mutant protein varieties and calculating their ADME properties. …”
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2704
Pengembangan pemakaian hasil samping agroindustri berbahan dasar jagung sebagai alternatif bahan baku pakan ikan kerapu tikus Cromileptes altivelis
Published 2015-03-01“…Tiga macam pakan digunakan dalam penelitian ini dengan kadar protein 47% dan rasio energi protein 10 kkal/g protein. …”
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2705
Growth performance of African catfish (Clarias sp.) juvenile fed on the diets containing various chromium content
Published 2007-07-01“…Based on the evaluation of protein level of the whole body, protein and lipid retention, daily growth rate and feed efficiency, it was concluded that the optimum dietary chromium level for catfish juvenile was 2.60 mg/kg diet. …”
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2706
A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress
Published 2025-01-01“…These small genetic elements are important regulators of protein expression. They are particularly important for the regulation of stress-responsive protein synthesis. …”
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2707
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2708
Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.
Published 2025-01-01“…Elevated mitochondria Ca2+ further activates the Ca2+/CaM-dependent protein kinase kinase β (CaMKKβ)-AMP-activated protein kinase (AMPK)-dynamin-related protein 1 (DRP1) signaling pathway, which interacts with mitochondrial fission protein 1 (FIS1) and mitochondrial dynamics proteins of 49 kDa (MiD49) to promote mitochondrial fission. …”
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2709
Narrowing the gap between machine learning scoring functions and free energy perturbation using augmented data
Published 2025-02-01“…Here, we address these issues by first introducing a novel attention-based graph neural network model called AEV-PLIG (atomic environment vector–protein ligand interaction graph). Second, we introduce a new and more realistic out-of-distribution test set called the OOD Test. …”
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2710
Anti-Inflammatory Prostanoids: Focus on the Interactions between Electrophile Signaling and Resolution of Inflammation
Published 2010-01-01“…In light of the growing number of cyPG protein targets identified, cyPG resemble other pleiotropic mediators acting through protein modification. …”
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2711
Rab7 Investigation Insights into the Existence of White Spot Syndrome Virus in Crustaceans: An In Silico Approach
Published 2022-01-01“…Protein-protein docking showed that active residues were there in the binding interfaces of Rab7 from organisms of seven different phyla and VP28 of WSSV. …”
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2712
FTO effects the proliferation, invasion, and glycolytic metabolism of colon cancer by regulating PKM2
Published 2025-01-01“…The Fat mass and obesity-associated protein (FTO), a genetic variant associated with obesity, significantly impact the energetic metabolism of mechanical tumors. …”
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2713
Elucidating the potential of EGFR mutated NSCLC and identifying its multitargeted inhibitors
Published 2025-01-01“…Molecular docking studies revealed that the ligands curcumin (-6.9 kcal/mol) and CB[2]UN (-8.1 kcal/mol) bound more strongly to the EGFR-mutant NSCLC proteins with 2ITX and 2ITV, respectively. Molecular dynamics simulation (50 ns) investigation of protein-ligand complexes using RMSD, RMSF, Rg, and SASA indicated that curcumin and CB[2]UN with EGFR-mutant proteins are kinetically stable. …”
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2714
Proteomic Analysis of Hippocampus and Cortex in Streptozotocin-Induced Diabetic Model Mice Showing Dementia
Published 2018-01-01“…These identified proteins and phosphoproteins could be functionally classified as cytoskeletal protein, oxidoreductase, protein deubiquitination, energy metabolism, GTPase activation, heme binding, hydrolase, iron storage, neurotransmitter release, protease inhibitor, transcription, glycolysis, antiapoptosis, calcium ion binding, heme metabolic process, protein degradation, vesicular transport, and unknown in the hippocampus or cortex. …”
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2715
Update on the Progress of Musashi-2 in Malignant Tumors
Published 2025-01-01“…In recent years, research on the MSI protein has advanced, and many novel viewpoints and drug resistance attempts have been derived; for example, tumor protein p53 mutations and MSI-binding proteins lead to resistance to protein arginine N-methyltransferase 5-targeted therapy in lymphoma patients. …”
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2716
Immunization against Lamb Haemonchosis with a Recombinant Somatic Antigen of Haemonchus contortus (rHcp26/23)
Published 2010-01-01“…Recombinant DNA technology was applied to obtain a synthetic protein (rHcp26/23). Immunological assays (ELISA, Western blotting, and immunolocalization), using sera from lambs immunized with p26/23, confirmed the identity of the recombinant protein and demonstrated that the synthetic protein is equivalent to the purified protein employed in the previous immunoprophylaxis studies. …”
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2717
Hepatic Overexpression of GRP94 in a Rabbit Model of Parenteral Nutrition-Associated Liver Disease
Published 2015-01-01“…To use a rabbit model of parenteral nutrition-associated liver disease (PNALD) to study changes of the endoplasmic reticulum stress (ERS) marker glucose regulatory protein 94 (GRP94) and determine its role in the pathogenesis of PNALD. …”
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2718
Loss of correlated proteasomal subunit expression selectively promotes the 20SHigh state which underlies luminal breast tumorigenicity
Published 2025-01-01“…Abstract Why cancer cells disproportionately accumulate polyubiquitinated proteotoxic proteins despite high proteasomal activity is an outstanding question. …”
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2719
Optimizing the Extraction of Keratin from Cattle Hoof Using Central Composite Design
Published 2022-01-01“…It can be successfully converted into keratin protein. Keratin extracted using alkali hydrolysis has a better conservancy of keratin structure. …”
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2720
Arginine–NO pathway modulated energy metabolism in the hepatopancreas and muscle of female Litopenaeus vannamei
Published 2025-03-01“…Dietary arginine increased muscle crude protein content, decreased hepatopancreas crude protein content and activated the target of rapamycin 1 pathway. …”
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