In Silico Analysis Revealed Five Novel High-Risk Single-Nucleotide Polymorphisms (rs200384291, rs201163886, rs193141883, rs201139487, and rs201723157) in ELANE Gene Causing Autosom... by Khyber Shinwari, Mikhail A. Bolkov, Muhammad Yasir Akbar, Liu Guojun, Svetlana S. Deryabina, Irina A. Tuzankina, Valery. A. Chereshnev

“…We used cutting-edge computational techniques to investigate the effects of ELANE mutations on the sequence and structure of the protein. Our study suggested that eight nsSNPs (rs28931611, rs57246956, rs137854448, rs193141883, rs201723157, rs201139487, rs137854451, and rs200384291) are the most deleterious in ELANE gene and disturb protein structure and function. …”
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Identification and prioritization of novel therapeutic candidates against glutamate racemase from Klebsiella pneumoniae. by Ankit Kumar, Farah Anjum, Md Imtaiyaz Hassan, Anas Shamsi, Rashmi Prabha Singh

“…<h4>Methods</h4>The 3D structure of the protein was modelled using SWISS-MODEL, which utilizes the homology modelling technique. …”
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Combining extracellular matrix proteome and phosphoproteome of chickpea and meta‐analysis reveal novel proteoforms and evolutionary significance of clade‐specific wall‐associated e... by Kanika Narula, Arunima Sinha, Pooja Choudhary, Sudip Ghosh, Eman Elagamey, Archana Sharma, Atreyee Sengupta, Niranjan Chakraborty, Subhra Chakraborty

“…Modular networks of matrix protein families and hub proteins showed higher diversity across taxonomic clades than among organs. …”
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Hydrogen Sulfide Increases Nitric Oxide Production and Subsequent S-Nitrosylation in Endothelial Cells by Ping-Ho Chen, Yaw-Syan Fu, Yun-Ming Wang, Kun-Han Yang, Danny Ling Wang, Bin Huang

“…Further study indicated an increase of upstream regulator for eNOS activation, AMP-activated protein kinase (AMPK), and protein kinase B (Akt). …”
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Effect of optimized food-based recommendations on nutrient intakes, hemoglobin levels, and memory performance of adolescent girls in East Java, Indonesia by Dini Suciyanti, Risatianti Kolopaking, Annasari Mustafa, Sugeng Iwan, Fiastuti Witjaksono, Umi Fahmida

“…Results After 20 weeks, a significant increase in dietary practices (animal protein, liver, plant protein, vegetables), nutrient intakes (protein, fat, iron), and memory performance (digit span forward and backward) were found in the intervention group. …”
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Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway by Bin Yan, Canjun Zeng, Yuhui Chen, Minjun Huang, Na Yao, Jie Zhang, Bo Yan, Jiajun Tang, Liang Wang, Zhongmin Zhang

“…Interestingly, col-I protein, col-I mRNA, col-III protein, col-III mRNA, and IGF-1 protein, but not IGF-1 mRNA, were inhibited by IGF-1 neutralizing antibody. …”
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Effects of potassium lactate on sensory attributes, bacterial community succession and biogenic amines formation in Rugao ham by Renyong Liao, Ying Wang, Qiang Xia, Changyu Zhou, Fang Geng, Daodong Pan, Jinxuan Cao

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Therapeutic Effect of Gypenosides on Antioxidant Stress Injury in Orbital Fibroblasts of Graves’ Orbitopathy by Chao Ma, Haoyu Li, Wei Liu, Shuwen Lu, Xian Li, Jinyuan Chen, Kaijun Li, Wenzhan Wang

“…The expression of apoptosis-related protein mRNA was analyzed by RT-qPCR technique. ROS and SOD test suites were employed to detect the oxidative stress level in OFs. …”
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Exploring the potential effect and mechanisms of protocatechuic acid on human hair follicle melanocytes by Li Bo, Tan Jun, Zou Bosheng, Liu Xiaojia, Yu Yiling

“…Normal primary HFM were isolated and cultured till logarithmic period of second passage, then treated with different concentrations of PCA (0.1–200 μmol L−1) to study the cell proliferation, melanin contents, tyrosinase activity and protein and mRNA expression of melanogenic genes (tyrosinase-related protein 1 (TRP-1), tyrosinase-related protein 2 (TRP-2), and microphthalmia-associated transcription factor (MITF)) in the cultured HFM. …”
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Association of inflammatory markers and endothelial dysfunction with depression in patients with ischemic cerebrovascular disease by Julcileia Imara D De Carvalho Muenho, Marisol Peña Sanchez, Alina González-Quevedo Monteagudo, Danay Martínez Puentes, Sergio González García, Marianela Arteche Prior, Asdrubal Arias Morales

“…C-reactive protein and C3 were statistically correlated with the Hamilton test score. …”
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Barlow Twins deep neural network for advanced 1D drug–target interaction prediction by Maximilian G. Schuh, Davide Boldini, Annkathrin I. Bohne, Stephan A. Sieber

“…In a novel approach, BarlowDTI, we utilise the powerful Barlow Twins architecture for feature-extraction while considering the structure of the target protein. Our method achieves state-of-the-art predictive performance against multiple established benchmarks using only one-dimensional input. …”
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Climate-smart livestock nutrition in semi-arid Southern African agricultural systems by Felix Fushai, Teedzai Chitura, Oyegunle Emmanuel Oke

“…Feedstuffs for potential circular feeding systems include the oilseed cakes from the macadamia (Macadamia integrifolia) nut, the castor (Ricinus communis), and Jatropha (Jatropha curcas) beans, which are rich in protein and energy, insect feed protein and energy, primarily the black soldier fly larvae (Hermetia illucens), and microbial protein from phototrophic algae (Spirulina, Chlorella), and yeasts (Saccharomyces cerevisiae). …”
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Linking machine learning and biophysical structural features in drug discovery by Armin Ahmadi, Shivangi Gupta, Vineetha Menon, Jerome Baudry

“…IntroductionMachine learning methods were applied to analyze pharmacophore features derived from four protein-binding sites, aiming to identify key features associated with ligand-specific protein conformations.MethodsUsing molecular dynamics simulations, we generated an ensemble of protein conformations to capture the dynamic nature of their binding sites. …”
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Effect of Cannabis seeds on Some biomedical parameters in male rats by Karwan Anwar Hassan

“…Level of Cholesterol, triglyceride and c-reactive protein were significantly (p<0.05) reduced. Serum total protein, albumin and globulin were significantly (p<0.05) elevated in treatment group comparing to control group. …”
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Combined Raman Spectroscopy and Digital Holographic Microscopy for Sperm Cell Quality Analysis by A. De Angelis, S. Managò, M. A. Ferrara, M. Napolitano, G. Coppola, A. C. De Luca

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Identification and Characterization of a Novel Rat MAVS Variant Modulating NFκB Signaling by Ihsan Nalkiran, Hatice Sevim Nalkiran

“…Mitochondrial antiviral-signaling protein (MAVS) acts as a pivotal adaptor protein in the RIG-I pathway. …”
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Inhibition of TNF-α and JNK Signaling Pathway Can Reduce Paclitaxel-Induced Apoptosis of Mouse Cardiomyocytes by Shuang Ren, Tianwen Huang, Danyan Ou, Luhuai Feng, Sisi Huang, Chaonan Zhou, Lianying Ge

“…The protein levels of Bax, p-JNK, and TNF-α in cardiomyocytes were reduced, while there was a relative increase in the Bcl-2 protein level. …”
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Effect of Cannabis seeds on Some biomedical parameters in male rats by Karwan Anwar Hassan

“…Level of Cholesterol, triglyceride and c-reactive protein were significantly (p<0.05) reduced. Serum total protein, albumin and globulin were significantly (p<0.05) elevated in treatment group comparing to control group. …”
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Locally activated semisynthetic fluorescent biosensors for imaging cellular biochemistry by Coïs, Justine, Dumat, Blaise

“…Alternatively, semisynthetic fluorescent biosensors that combine a small chemical indicator with a self-labeling protein tag benefit from the versatility of molecular engineering and from the selectivity of genetic encoding of the recombinant protein. …”
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Effect of Cannabis seeds on Some biomedical parameters in male rats by Karwan Anwar Hassan

“…Level of Cholesterol, triglyceride and c-reactive protein were significantly (p<0.05) reduced. Serum total protein, albumin and globulin were significantly (p<0.05) elevated in treatment group comparing to control group. …”
Get full text