In silico analysis of SNPs and miRNAs of KCTD13, CSDE1, SLC6A1 genes associated with autism spectrum disorder by Kübra Çoruh Kınalı, Ebru Özkan Oktay, Mesut Karahan

“…Furthermore, the predictive impact of those SNPs on protein stabilization was examined and three-dimensional protein models were created. …”
Get full text

Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral Sinularia sandensis through the MAPKs Pathway on Oral Cancer Cells by Rou-Yi Fang, Yueh-Wen Liu, Yih-Gang Goan, Jen-Jie Lin, Jui-Hsin Su, Wen-Tung Wu, Yu-Jen Wu

“…It also curtailed the expression of several key proteins including focal adhesion kinase (FAK), protein kinase C (PKC), growth factor receptor-bound protein 2 (GRB2), Rac, Ras, Rho A, mitogen-activated protein kinase kinase kinase 3 (MEKK3), and mitogen-activated protein kinase kinase 7 (MKK7). …”
Get full text

Advancing Food Security with Farmed Edible Insects: Economic, Social, and Environmental Aspects by José E. Aguilar-Toalá, Abraham M. Vidal-Limón, Andrea M. Liceaga

“…Thus, edible insects can address the future global protein demand of an ever-increasing world population. …”
Get full text

Phage display as a tool for identifying HIV-1 broadly neutralizing antibodies by A. N. Chikaev, A. P. Rudometov, Yu. A. Merkulyeva, L. I. Karpenko

“…Despite being a fairly old method, phage display is still widely used for studying protein-protein, peptide-protein and DNA-protein interactions due to its relative simplicity and versatility. …”
Get full text

Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway by Ya-Ni Wang, Ling-Ling Zhang, Xiao-Yun Fan, Sha-Sha Wu, Sheng-Quan Zhang

“…Cationic protein is a cytotoxic protein secreted by eosinophils and takes part in the damage of airway epithelium in asthma. …”
Get full text

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits by Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A. Springer

Get full text

GS-DTA: integrating graph and sequence models for predicting drug-target binding affinity by Junwei Luo, Ziguang Zhu, Zhenhan Xu, Chuanle Xiao, Jingjing Wei, Jiquan Shen

“…Besides, The three-layer GCN can captures hierarchical features of the drug through deeper propagation and feature transformation. Meanwhile, for each protein, a framework combining CNN, Bi-LSTM, and Transformer is used to extract the contextual and structural information of the protein amino acid sequences, and this combination can help to understand a comprehensive and detailed features of the protein. …”
Get full text

Curcumin Improves Epithelial Barrier Integrity of Caco-2 Monolayers by Inhibiting Endoplasmic Reticulum Stress and Subsequent Apoptosis by Xinxin Zhou, Mengting Ren, Jinpu Yang, Hanghai Pan, Mosang Yu, Feng Ji

“…After administration of curcumin (10 μM), Western blot analysis was performed to evaluate the protein levels of tight junction (TJ) proteins zonula occludens- (ZO-) 1 and claudin-1. …”
Get full text

In Vitro Study on the Regulation of Annexin IV and VEGF by hCG in the Human Endometrium by Shaoyuan Xu, Jie Li, Xiaoyan Chen, Beiyu Liu

“…Annexin IV and VEGF were analyzed by qRT-PCR (mRNA), western blot (proteins), and immunohistochemistry (proteins). Protein location was identified by immunohistochemistry. …”
Get full text

Evaluation of spring barley cultivars released in Belarus under the environmental conditions of the Northern Trans-Urals by M. N. Fomina, Yu. S. Ivanova, M. V. Bragina, O. N. Kovaleva

“…The following sources were identified among the tested cultivars: ‘Vodar’ (high yield, drought tolerance, etc.); ‘Magutny’ (high yield, and environmental plasticity); ‘Khago’ (large grain, low hull content, and increased protein and starch content levels); ‘Lipen’ (high test weight, increased starch content, and environmental plasticity); ‘Fobos’ (drought tolerance, and increased protein content); ‘Dublet’ (lodging resistance, and increased protein content); ‘Taler’ (reduced protein content, and environmental plasticity); ‘Pospekh’ (reduced protein content).…”
Get full text

Mechanisms for Covalent Immobilization of Horseradish Peroxidase on Ion-Beam-Treated Polyethylene by Alexey V. Kondyurin, Pourandokht Naseri, Jennifer M. R. Tilley, Neil J. Nosworthy, Marcela M. M. Bilek, David R. McKenzie

“…The enzymatic activity of covalently attached protein remained high. The long-term activity of the modified layer to attach protein is explained by stabilisation of unpaired electrons in sp2 carbon structures. …”
Get full text

Investigation of biometabolites and novel antimicrobial peptides derived from promising source Cordyceps militaris and effect of non-small cell lung cancer genes computationally. by Muhammad Afzal, Mai Abdel Haleem A Abusalah, Neelum Shehzadi, Muhammad Absar, Naveed Ahmed, Sarmir Khan, Yalnaz Naseem, Noshaba Mehmood, Kirnpal Kaur Banga Singh

“…In C. militaris, higher protein concentration was observed in 70% concentration of protein extract (500 μg/ml ± 0.025). …”
Get full text

The disappearing COVID-Naïve Population and comparative Roche vs. Abbott Test sensitivity: evidence from antibody seroprevalence in Milwaukee County, Wisconsin by Lorenzo Franchi, Vladimir Atanasov, Mark Stake, Garrett Bates, Kristen Osinski, John R Meurer, Bernard Black

“…We find that 99.4% (523/526) of the participants had positive results for antibodies to the SARS CoV2 spike protein over April-June 2022, soon after the early-2022 Omicron surge. …”
Get full text

Sestrin2 Signaling Pathway Regulates Podocyte Biology and Protects against Diabetic Nephropathy by Moein Ala

“…Sestrin2 leads to AMP-activated protein kinase- (AMPK-) and GTPase-activating protein activity toward Rags (GATOR) 1-mediated inhibition of mammalian target of rapamycin complex 1 (mTORC1), thereby enhancing autophagy. …”
Get full text

Salivary Acetylcholinesterase Activity Is Increased in Parkinson’s Disease: A Potential Marker of Parasympathetic Dysfunction by Tatyana Fedorova, Cindy Soendersoe Knudsen, Kim Mouridsen, Ebba Nexo, Per Borghammer

“…We measured salivary flow, AChE activity, and total protein concentration in 30 PD patients and 49 healthy controls. …”
Get full text

Potential Biomarkers and Signaling Pathways Associated with the Pathogenesis of Primary Ameloblastoma: A Systems Biology Approach by Zeynab Bayat, Azin Mirzaeian, Amir Taherkhani

“…The dataset GSE132472 was obtained from the GEO database, and multivariate statistical analyses were applied to identify differentially expressed genes (DEGs) in primary ameloblastoma tissues compared to the corresponding normal gingiva samples. A protein-protein interaction (PPI) map was built using the STRING database. …”
Get full text

Correlation between serum neurofilament light chain and short-term outcomes in patients with hypertensive intracerebral hemorrhage by Jun Zhou, Yulin Zhao, Lichuang Zhang, Yanrui Dong, Zehu Li, Yansong Wang, Xiangdong Wang

“…Abstract Objective To explore the correlation between changes in serum neurofilament light chain protein and clinical prognosis in patients with hypertensive intracerebral hemorrhage, combined with other clinical indicators. …”
Get full text

MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network by Katie Marchbank, Sarah Waters, Roland G. Roberts, Ellen Solomon, Caroline A. Whitehouse

“…Selective autophagy is a process whereby specific targeted cargo proteins, aggregates, or organelles are sequestered into double-membrane-bound phagophores before fusion with the lysosome for protein degradation. …”
Get full text

QCM Analysis for Two-Step Adsorption of Albumin and Fibronectin on Zirconia Surface by Masatsugu Hirota, Tohru Hayakawa

“…The adsorption of proteins on the dental implant surface is the first step in the key role of osseointegration. …”
Get full text

Differential Expression of Sphingosine-1-Phosphate Receptors in Abdominal Aortic Aneurysms by Z. Qu, Bernice L. Y. Cheuk, Stephen W. K. Cheng

“…Western blot and staining results consistently showed the down-regulation of the S1P2 protein with simultaneous up-regulation of the S1P3 protein in AAAs. …”
Get full text