Showing 141 - 160 results of 587 for search '"protease"', query time: 0.06s Refine Results
  1. 141

    SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL by E. L. Mishchenko, N. V. Ivanisenko, I. R. Akberdin, P. S. Demenkov, V. A. Likhoshvai, N. A. Kolchanov, V. A. Ivanisenko

    Published 2014-12-01
    “…Astochastic mathematical model for subgenomic HCVreplicon replication in Huh-7 cells with the presence ofthe HCVNS3 protease inhibitor SCH 503034 is proposed. The model describes the experimental kinetic curves ofviral RNAsuppression at various SCH 503034 concentrations. …”
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  2. 142

    Evaluation of Melongosides as Potential Inhibitors of NS2B-NS3 Activator-Protease of Dengue Virus (Serotype 2) by Using Molecular Docking and Dynamics Simulation Approach by Partha Biswas, Ommay Hany Rumi, Dhrubo Ahmed Khan, Md Nasir Ahmed, Nusratun Nahar, Rownak Jahan, Md Nazmul Hasan Zilani, Tridib K Paul, Anamul Hasan, Tohmina Afroze Bondhon, Khoshnur Jannat, Md Nazmul Hasan, Mohammed Rahmatullah

    Published 2022-01-01
    “…All the melongosides interacted with the NS3 protease part of NS2B-NS3. Melongosides B, F, and N showed interactions with His51, while melongoside G interacted with Asp75 of NS3, to be noted, these are important amino acid residues in the catalytic site of the NS3 protease. …”
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    Enhanced Expression and Bioactivity Assessment of Recombinant SUMO-Protease-1 in E. coli BL21 (DE3) via Cleavage of His6-SMT3-SDF-1 Fusion Protein by Farzad Sadri, Hossain Safarpour, Zahra Ansari, Yazdan Ebrahimpour, Mohammad Feriedouni

    Published 2024-01-01
    “…The SUMO fusion system is advantageous in improving the solubility and correct folding of proteins that are difficult to produce. SUMO-protease-1 (Ulp1) is a key enzyme in this system, and its proper expression and purification in Escherichia coli BL21 (DE3) are critical to its efficiency. …”
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    In Silico Identification of New Anti-SARS-CoV-2 Main Protease (Mpro) Molecules with Pharmacokinetic Properties from Natural Sources Using Molecular Dynamics (MD) Simulations and Hierarchical Virtual Screening by Harrison Onyango, Patrick Odhiambo, David Angwenyi, Patrick Okoth

    Published 2022-01-01
    “…This candidate drug was used to perform MD simulations, and the outcomes revealed that ZINC000072307130 formed a stable complex with the viral main protease. Consequently, ZINC000072307130 emerges as a potential anti-SARS-CoV-2 Mpro inhibitor for the production of new COVID 19 drugs.…”
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