The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review by Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang

“…SUMOylation is a dynamic process finely regulated by SUMOylation enzymes and proteases to maintain a balance between SUMOylation and deSUMOylation. …”
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Association Analysis of the Genomic and Functional Characteristics of Halotolerant <i>Glutamicibacter endophyticus</i> J2-5-19 from the Rhizosphere of <i>Suaeda salsa</i> by Longhao Sun, Shanshan Sun, Tianyang Liu, Xinmin Lei, Ruiqi Liu, Junyi Zhang, Shanshan Dai, Jing Li, Yanqin Ding

“…The strain was capable of growing in media with up to 13% NaCl and producing proteases, siderophores, and the plant hormone IAA. …”
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Automation-aided construction and characterization of Bacillus subtilis PrsA strains for the secretion of amylases by Felix Hamburger, Niels Schlichting, Michael Eichenlaub, Paul Igor Costea, Christopher Sauer, Stefan Jenewein, Johannes Kabisch, Johannes Kabisch

“…Following strain selection and deletion of major extracellular proteases, several hundred individual strains were created and screened using a stepwise and modular automation approach combined with amplicon sequencing. …”
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Multi-omics investigation of high-transglutaminase production mechanisms in Streptomyces mobaraensis and co-culture-enhanced fermentation strategies by Huanan Chang, Ziyu Zheng, Hao Li, Yanqiu Xu, Gengyao Zhen, Yao Zhang, Xidong Ren, Xidong Ren, Xinli Liu, Xinli Liu, Deqiang Zhu, Deqiang Zhu

“…Subsequently, the in vitro activation efficiency of TGase was further improved using co-cultivation techniques with neutral proteases secreted by Bacillus amyloliquefaciens CICC10888, and a TGase activity of 16.91 U/mL was achieved, accounting for a 22.71% increase. …”
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Optimization of Protein Hydrolysate from Earthworms (<i>Perionyx excavatus</i>) of Angiotensin-I-Converting Enzyme Inhibitory Activity by One Variable at a Time by Phong Thanh Bui, Truc Anh Hoang, My Thi Thuy Pham, Linh Le Phuong Tran, Oanh Kim Nguyen

“…This study evaluated the ACE inhibitory activity (ACEIA) of protein hydrolysate from earthworms (Perionyx excavatus) by commercial proteases. The results showed that the protein hydrolysate of earthworms gave the highest ACEIA of 85.38 ± 2.31% (at the protein concentration of 2 mg/mL) and IC50 value of 844.64 μg/mL when the earthworms were hydrolyzed with Flavourzyme® 500 MG under optimized conditions such as earthworm:phosphate buffer ratio of 1:6 (w/v), hydrolysis temperature of 50 °C, pH 7, enzyme:substrate ratio of 600 U/g protein and hydrolysis time of 2 h. …”
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Gene Expression Profiling in Dermatitis Herpetiformis Skin Lesions by M. Dolcino, E. Cozzani, S. Riva, A. Parodi, E. Tinazzi, C. Lunardi, A. Puccetti

“…DEGs also indicate overproduction of matrix proteases (MMP9, ADAM9, and ADAM19) and proteolytic enzymes (CTSG, ELA2, CPA3, TPSB2, and CMA1) that may contribute to epidermal splitting and blister formation. …”
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Usp7 contributes to the tail regeneration of planarians via Islet/Wnt1 axis by Ang Liang, Jinglong Liu, Zhiyuan Zhang, Jing Xiao, Dezeng Liu, Zimei Dong, Guangwen Chen

“…Considerable evidence suggests that ubiquitin plays an important role in maintaining homeostasis and regulating regeneration, but the function of Ubiquitin specific proteases 7 (Usp7) on regeneration in planarians remains elusive. …”
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Computational and In silico study of novel fungicides against combating root rot, gray mold, fusarium wilt, and cereal rust. by Mollah Naimuzzaman, Md Mahabub Hasan, Ajoy Kumer, Abu Yousuf Hossin, Mohammad Harun-Ur-Rashid, Swapan Kumar Roy, Abu Noman Faruq Ahmmed, Jamal Uddin

“…Next, two docking tools, such as AutoDock by PyRx and Molecular Docking by Glide from the Schrödinger suite, were used to convey the docking score, and ligand protein interactions against four main proteases, for instance 7VEM, 8H6Q, 8EBB, and 7XDS having name of pathogens: Phytophthora capsici, Botrytis cinerea, Fusarium oxysporum f. sp. lycopersici, and Puccinia graminis f. sp. tritici, respectively. …”
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The genus Entomophthora: bringing the insect destroyers into the twenty-first century by Carolyn Elya, Henrik H. De Fine Licht

“…We discuss evidence for Entomophthora’s adaptation to growth exclusively inside insects, such as producing wall-less hyphal bodies and a unique set of subtilisin-like proteases to penetrate the insect cuticle. However, we are only starting to understand the functions of unusual molecular and genomic characteristics, such as having large > 1 Gb genomes full of repetitive elements and potential functional diploidy. …”
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Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host. by Sophia J Parker-Manuel, Alasdair C Ivens, Gary P Dillon, R Alan Wilson

“…A large number of genes encoding elastases and invadolysins, and some venom allergen-like proteins were up-regulated in the germ ball, those encoding cysteine and aspartic proteases in the cercaria and schistosomulum. Micro exon genes encoding variant secreted proteins were highly up-regulated in the schistosomulum along with tegument and gut-associated genes, coincident with remodelling of the parasite body. …”
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IL-31 and IL-8 in Cutaneous T-Cell Lymphoma: Looking for Their Role in Itch by Maria Abreu, Marta Miranda, Mafalda Castro, Iolanda Fernandes, Renata Cabral, Ana Helena Santos, Sónia Fonseca, João Rodrigues, Magdalena Leander, Catarina Lau, Inês Freitas, Susana Coimbra, Alice Santos-Silva, Margarida Lima

“…Increased serum IL-8 observed in some patients may be related to concomitant infections, and its role in exacerbating itch by recruiting neutrophils and promoting the release of neutrophil proteases deserves further investigation.…”
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<i>Vibrio vulnificus</i>—A Review with a Special Focus on Sepsis by Marcello Candelli, Marta Sacco Fernandez, Cristina Triunfo, Andrea Piccioni, Veronica Ojetti, Francesco Franceschi, Giulia Pignataro

“…The pathogenicity of <i>V. vulnificus</i> is mediated by an array of virulence factors, including hemolysins, proteases, and capsular polysaccharides, as well as mechanisms facilitating iron acquisition and immune system evasion. …”
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Bioactive potential and storage behavior of low molecular mass peptides in Pilsner and IPA style craft beers by Roberta Nogueira Pereira da Silva, Angelica Priscila Parussolo Tonin, Gabriela Soares Macello Ramos, Juliana Furtado Dias, Eduardo Cesar Meurer, Maria Gabriela Bello Koblitz

“…Pilsner beers, typically clear due to added chill-proofing proteases, showed reduced peptide intensity over time, whereas IPA, which often remains hazy and lacks such enzymes, exhibited increased peptide levels. …”
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Cancer-associated fibroblasts and their role in tumor progression by M. S. Ermakov, A. A. Nushtaeva, V. A. Richter, O. A. Koval

“…In activated CAFs, alpha-smooth muscle actin (α-SMA) is synthetized de novo and various proteases and fibronectin are produced. Since CAFs are found in all types of carcinomas, these cells are potential targets for the development of new approaches for anticancer therapy. …”
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The genomes of Scedosporium between environmental challenges and opportunism by Francesco Venice, Federica Spina, Domenico Davolos, Stefano Ghignone, Giovanna Cristina Varese

“…By contrast, several features in Microascaceae and Scedosporium were detected that might have a dual role in responding to environmental challenges and allowing colonization of the human body, including chitin, melanin and other cell wall related genes, proteases, glutaredoxins and magnesium transporters. …”
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IgE-based analysis of sensitization and cross-reactivity to yellow mealworm and edible insect allergens before their widespread dietary introduction by Majsiak Emilia, Choina Magdalena, Gromek Weronika, Wykrota Julia, Kozłowska Danuta, Swadźba Jakub, Cukrowska Bożena, Kowal Krzysztof

“…Patients with sIgE against TM were most likely sensitised to tropomyosins (49.1% of patients), Niemann-Pick C2 protein (43.8%), group 5/21 allergen (38.6%), class III chitinases (37.1%), and cysteine proteases (34.1%). Based on the serum asIgE levels to TM prior to this ingredient being introduced as a food in Poland, we hypothesised that this primary sensitization may be associated with invertebrate allergies. …”
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Functional Profile of Enzymatic Hydrolysates in Food Proteins by Svetlana N. Lebedeva, Bulat A. Bolkhonov, Sesegma D. Zhamsaranova, Bayana A. Bazhenova, Svetlana Yu. Leskova

“…The egg albumin and soy protein were hydrolyzed by sequentially adding the proteases, i.e., pepsin and trypsin. The degree of protein hydrolysis was calculated against total nitrogen and its contents in non-hydrolyzed raw materials and hydrolysate. …”
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Pain in pancreatitis: issue and ways out by A. V. Okhlobystin

“…The high contents of proteases in the drug «Ermital» allows to relieve pain effectively, reduce number of taken capsules per day. …”
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Effect of Biofloc Culture on the Daily Rhythmicity of the Activity and Expression of Digestive Enzymes in Tilapia, Oreochromis niloticus by María del Carmen Monroy-Dosta, Daniel Becerril-Cortés, Juan Pablo Lazo, Arturo Mena-López, Pilar Negrete-Redondo, Eliasid Nogueda-Torres, Carmen Navarro-Guillén, José Antonio Mata-Sotres

“…The enzyme activity of trypsin (try), chymotrypsin (chy), leucine aminopeptidase (lap), alkaline proteases (alk), lipase (lip), and amylase (amy), along with the gene expression of trypsin (try), chymotrypsin (chy), pepsin (pep), amylase (amy), and phospholipase (pla) were measured throughout a daily cycle. …”
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Application of Food-Grade Proteolytic Enzyme for the Hydrolysis of Regenerated Silk Fibroin from Bombyx mori by Ji An Joung, Mi Na Park, Ji Young You, Bong Joon Song, Joon Ho Choi

“…FoodPro and Alcalase that are classified as alkaline proteases are selected as two of the best candidate enzymes for hydrolysis of SF. …”
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